Course Overview

Winner of the Best New Postgraduate Course 2020 award in the Grad Ireland Higher Education Awards.  To read more about this accolade, click here.

Why choose this programme?

“Cell and gene therapy comprise an extraordinary range of technologies that are already having an impact on patients and society and, in many ways, represent the future of medicine.   However, these products present many challenges in terms of advanced manufacturing strategies, aseptic processing, automation and product characterisation.  This MSc course provides the skills needed to address these challenges “

- Prof Frank Barry, Scientific Director of the Regenerative Medicine Institute

Cell and gene therapy was identified as the most exciting therapeutic innovation by 79% of the 151 international biopharmaceutical manufacturers surveyed by the NIBRT, the Irish National Institute for Bioprocessing Research and Training (Trends in Manufacturing Report).  The same organizations have difficulty filling available positions, specifically citing the need to hire bioprocess engineers and automation engineers. 

The primary objectives of the MSc in Cellular Manufacturing & Therapy at the National University of Ireland Galway is to A) provide formal training in cellular bioprocessing for clinical application and B) cultivating a rigorous scientific underpinning for the development of a cellular therapy.  The course curriculum balances the scientific aspects of cellular therapy (in 3 modules), bioprocessing and manufacturing regulation (in 2 modules) and offers optional modules in cancer biology, business, clinical trials and bio-ethics.  A student’s practical skills are developed beyond the classroom laboratory activities with supplemental activities such as workshops in sterile gowning and a 4-month work or laboratory placement, thereby gaining research or enterprise-centric skills. When launching, this MSc programme was the first of its kind worldwide.  

Richa Krishna Poster Day

Richa Krishna, MSc student, Cellular Manufacturing & Therapy, pictured at Poster Day.

Unique position

The MSc in Cellular Manufacturing and Therapy is the one and only course in Ireland offering the following opportunities in support of a career in cellular therapy:

  1. Instruction in the clinical-grade manufacturing of therapeutic cells for clinical application.
  2. Modules in the biology underpinning the therapeutic application of mesenchymal stromal cells, immunotherapy and induced pluripotent stem cells, three types of cellular therapy currently in translation for clinical application.
  3. Instruction by a multidisciplinary team of experts, the first to translate cellular therapies from the bench to clinical application in Ireland.
  4. Four-month work placements where student are embedded in a host environment corresponding to their carer of choice.

New skills

Through the course activities, students will have the opportunity to develop both technical and transferrable skills.  Technical skills will be acquired through practical activities and module assessments, including aseptic technique in mammalian cell culture; cryopreserving and thawing cryopreserved cells; plating and expanding adherent and mammalian cells; quantifying cell number, viability, density; pipetting large and small volumes; sterile gowning; data collection, presentation and analysis and technical writing.  Transferable skills will be developed through course workshops and group activities, including the ability to meet deadlines; adaptability and flexibility, analysis and decision making, critical thinking and evaluation of the literature, research/scientific integrity, team leadership, networking, organization, public speaking, time management and written communication.

Allied NUI Galway course  

  • MSc in Regenerative Medicine.  Click here to learn more.

  • MSc in Microscopy and Imaging.  Click here to learn more

Scholarships available

Find out about our Postgraduate Scholarships here.

Applications and Selections

Applications are made online via the NUI Galway Postgraduate Applications System

Who Teaches this Course

Collaborative Delivery of Course Content

The MSc in Cellular Manufacturing & Therapy is delivered by experts in the field of cellular manufacturing and pre-clinical research supporting the development of new therapies; those directly responsible for pioneering cellular manufacturing and therapy in Ireland.  As an example, the Centre for Cell Manufacturing Ireland (CCMI) team (Ireland’s first centre for cell manufacturing) are active instructors in the Cellular Manufacturing 1 and 2 modules where the learning activities are centred around bioprocessing and its regulatory and quality oversight.  Professors O’Brien, Barry and Griffin, pioneering coordinators of the first cellular therapy clinical trials in Ireland, deliver an in-depth lecture series in the Mesenchymal Stem Cell Therapy module where they describe the pre-clinical and clinical aspects of developing cellular therapies. 

Developing, producing and applying a cellular therapy clinically is a multidisciplinary challenge.  We rely on collaboration with experts in each of these fields to contribute their knowledge and insight within this programme.  Examples of these collaborative activities in the past include:

Industrial Collaboration

  • Project managers from Cell Medica UK host a CV and interview skills workshop
  • Bioreactor workshop hosted by Terumo technicians provided training on novel equipment.
  • Guest lecturing from Biostor Ireland on cell bank storage and worldwide distribution for scientific research and clinical application.  
  • Staff from ONK Therapeutics providing immunotherapy practical activities, upskilling students in non-adherent cell culture, characterization and cryopreservation.
  • Dissertation placements hosted by Regeneron, Avectas, Intas Pharmaceuticals, Aerogen, Charles River, Stempeutics, Galway Blood and Tissue Establishment (GBTE), Centre for Cellular Manufacturing Ireland, etc.

Academic Collaboration

  • Lecturing and workshops provided by the scientists within the Regenerative Medicine Institute specializing in discovering novel applications for cellular therapies and understanding their mechanism of action
  • Lecturing and gowning activities by the Centre for Cell Manufacturing Ireland who produce cellular therapies for clinical application
  • Guest lecturing visionaries in the field, such as Prof. Martin Leahy (Chair of Applied Physics at NUIG), emphasizing the advantages of multidisciplinary collaboration to investigate biologic queries
  • Dissertation placements hosted by scientists and primary investigators including Dr. Roisin Dwyer (cellular therapy for breast cancer), Dr. Kasia Whysall (muscle-derived progenitor therapy), Dr. Daniel O’Toole (cellular therapy for acute repertory distress) or at Hebei Medical University in China by Dr. Jun Ma (cellular therapy for neural disorders)

Collaborations with Clinicians and Patients

  • Lecturing and mentoring by scientist clinicians, the first in Ireland to translate cellular therapies to clinical trials
  • Assessment of scientific poster presentations describing ongoing clinical trials by the clinical trial recruitment specialists at (Galway University Hospitals)
  • Module coordination by Dr. Veronica McInerney (Cellular Therapy Clinical Trials Manager), offering a unique insight into initiating first in man clinical investigations
  • Dissertation placements hosted by Cancer Trials Ireland (CTI), Prof. Timothy O’Brien (coordinator of two cellular therapy clinical trials) and Prof. O’Dwyer (coordinator of trials in multiple myeloma)

Requirements and Assessment

Key Facts

Entry Requirements

Students must have completed one of the following ;
1) An undergraduate degree in medicine, pharmacy, manufacturing, biology, engineering.
2) An equivalent biomedical science-related undergraduate degree with a minimum of 2nd Class Honours. 

Applicants from non-biomedical science related backgrounds will be considered on a case-by-case basis at the discretion of the coordinators.  Students who have a degree without Honours in a related area and have 3+ years of practical experience in the subject area will also be considered for this programme. 

 For applicants where English is a second language, we will adhere to NUI Galway guidelines of requiring IELTS scores of 6.5, TOEFL scores of 88 and/or Pearson PTE scores of 61 with no less than 6.5 in any component.

 Initially a short listing procedure will be applied to prioritise applicants.  Those who do not meet the primary entry criteria as described above will be declined entry into the programme.  The remaining applicants will be reviewed in closer detail.  Significant weight will be placed on A) the applicant’s essay describing their motivation for applying for this course and their career aspirations following the successful completion of the MSc, B) the applicant’s referee’s comments and C) the applicant’s previous academic performance.  An interview may be conducted.


Additional Requirements

Duration

1 year full-time; 2 years, part-time

Next start date

September 2020

A Level Grades ()

Average intake

15–18

Closing Date

 Please view the offer rounds website.

NFQ level

Mode of study

ECTS weighting

90 ECTS

Award

CAO

Course code

1CMT1, 1CMT2, 2CMT2

Course Outline

Programme Curriculum:

The Cellular Manufacturing & Therapy suite of programmes are available in a 1-year full time format that suit individuals completing their BSc or transitioning between careers.  Courses are also available in a 2-year part time format or in “microcredits” making it available to employed individuals hoping to upskill while continuing employment.  The modules are available in a variety of formats giving accessibility to a wide range of students with different learning styles, including a lecture-based format, a flipped classroom format, in blended learning and fully online.

The Cellular Manufacturing & Therapy suite of courses are on offer as an MSc programme (90 ECTS), as a post-graduate diploma programme (60 ECTS) or as a post-graduate certificate programme (30 ECTS).  Both the MSc and post-graduate diploma are available in a 1-year full time capacity or 2-year part time capacity.  To see the proposed core and optional modules available in each programme starting in the next academic yaer, please click here

Curriculum Information

Curriculum information relates to the current academic year (in most cases).
Course and module offerings and details may be subject to change.

Curriculum Information

Curriculum information relates to the current academic year (in most cases).
Course and module offerings and details may be subject to change.

Glossary of Terms

Credits
You must earn a defined number of credits (aka ECTS) to complete each year of your course. You do this by taking all of its required modules as well as the correct number of optional modules to obtain that year's total number of credits.
Module
An examinable portion of a subject or course, for which you attend lectures and/or tutorials and carry out assignments. E.g. Algebra and Calculus could be modules within the subject Mathematics. Each module has a unique module code eg. MA140.
Optional
A module you may choose to study.
Required
A module that you must study if you choose this course (or subject).
Semester
Most courses have 2 semesters (aka terms) per year.

Year 1 (90 Credits)

Required MD1521: Cellular Manufacturing I


Semester 1 | Credits: 10

The production of cellular therapeutics, a defining technology of the next century, presents a unique, complex challenge combining expertise in biology, engineering, regulatory oversight and quality assurance. This course aims to instil a fundamental, working knowledge of tissue procurement, cellular expansion and biobanking and advances in bioreactor technology. The overall scope of the module is broad, ranging from the fundamental biology of mammalian cell culture to engineering advancements leading to automated biomanufacturing of clinical therapies with constant emphasis on the production of advanced medicinal products. The principals gained from participating in this course provide an overall reference for the biomanufacturing process underpinning the production of cellular therapeutics. This module is a pre-requisite for Cellular Biomanufacturing II.
(Language of instruction: English)

Learning Outcomes
  1. Apply fundamental knowledge of therapeutic tissue procurement and cellular isolation, expansion and cryopreservation to biomanufacturing a clinical therapeutic.
  2. Recognize and evaluate advancements in bioreactor technology, strategic scale-up technologies and process design to improve biomanufacturing processes.
  3. Identify, interpret and utilize good manufacturing practice policies to produce a cellular therapy.
  4. Extrapolate foundational knowledge of adult human cellular biomanufacturing to additional applications of therapeutic manufacturing.
Assessments
  • Continuous Assessment (50%)
  • Oral, Audio Visual or Practical Assessment (50%)
Module Director
Lecturers / Tutors
The above information outlines module MD1521: "Cellular Manufacturing I" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Required MD1522: Cellular Immunotherapy


Semester 1 | Credits: 10

Adoptive cell therapy (ACT) offers the chance to utilize a patient’s own immune cells to effectively recognize and eliminate cancer cells. The most effective modality of ACT employs genetically modified chimeric antigen receptor expressing T cells (CAR T) to target surface proteins overexpressed on cancer cells. This strategy is unique from other forms of ACT, as target recognition is not MHC restricted. CAR T cells have demonstrated significant clinical potency in the treatment of certain leukemias, and trials targeting solid tumour indications are now commencing. The module is designed to deliver the current theory, practices and future perspectives in regard to collection, expansion, modification and clinical application of cancer immune cell therapy, specifically, but not limited to T cells. The following topics will be presented: history of CAR T development, strategies for effective gene delivery, cell production platforms and processes, initial clinical results associated toxicities and clinical management, challenges associated with targeting solid tumour antigens, novel CAR designs and technologies. The module will include also introduction to haematopoietic stem cell transplantation.
(Language of instruction: English)

Learning Outcomes
  1. Demonstrate in depth knowledge of basic immunology and types and sources of immune cell
  2. Present practical knowledge of heamatopoietic stem cell transplantation
  3. Demonstrate understanding of immune cell collection and expansion methods
  4. Demonstrate knowledge of methods of cell isolation, characterization and banking
  5. Evaluation of safety and efficacy specific to immune cellular products
  6. Discuss and practically implement the use of CAR T cell technology in the design of cellular immune therapeutics
  7. Critical review of current and future therapeutics applications of CAR technology in malignant disorders
Assessments
  • Continuous Assessment (55%)
  • Oral, Audio Visual or Practical Assessment (15%)
  • Department-based Assessment (30%)
Module Director
Lecturers / Tutors
Reading List
  1. "Developments in T Cell Based Cancer Immunotherapies" by Paolo A. Ascierto
The above information outlines module MD1522: "Cellular Immunotherapy" and is valid from 2017 onwards.
Note: Module offerings and details may be subject to change.

Required MD1523: Cellular Manufacturing and Therapy Dissertation


15 months long | Credits: 30

The aim of this module is for students to A) gain relevant working experience within the field of cellular manufacturing and therapy or B) evaluate and critically assess the state of the art of specialized areas of cellular biomanufacturing and therapy. If the student is entering into a ~4 month work experience programme, this placement may be in an academic or industrial setting. Depending on the placement host, the student may be located in Galway or may be required to transfer domestically or internationally as required. Alternatively, students have the option to create a literature-based review of an area relevant to cellular manufacturing and therapy where they will be instructed in technical writing, the peer review process as well as oral and written presentation skills.
(Language of instruction: English)

Learning Outcomes
  1. Present a comprehensive review of 1) a research organization or company advancing the state of the art in cellular manufacturing and therapy or 2) assessing the published state of the art in a specialized area of cellular biomanufacturing and therapy.
  2. Discuss, present and defend their 1) contribution to an organization during a 4 month work placement or 2) literature review and critical analysis.
  3. Demonstrate competence and professionalism in oral and written communications.
Assessments
  • Continuous Assessment (100%)
Module Director
Lecturers / Tutors
The above information outlines module MD1523: "Cellular Manufacturing and Therapy Dissertation" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Required MD1524: Cellular Manufacturing II


Semester 2 | Credits: 10

In Cellular Manufacturing II students will be learning about the complexity of translation of practical knowledge acquired in module I into patient deliverable therapy. The module will cover the complex regulatory environment and national and international requirements. The management of cellular manufacturing facility, including operation management, staffing, planning, scheduling, budgeting, quality and role of master file will be included. This module will also deliver on key aspects of clinical trials design, trial approval and Good Clinical Practice requirements. The modules I and II should prepare a student to take on relevant roles in cell manufacturing organisations.
(Language of instruction: English)

Learning Outcomes
  1. Discuss the regulations and guidelines for cell isolation, freezing, thawing and administration of cellular products
  2. Recognise key aspects of National, European and International regulatory affairs.
  3. Describe key aspects of planning, costing of goods, operations management, health systems and policy (reimbursement)
  4. Design of GCP-compliant preclinical studies
  5. Design of bioprocesses for autologous/allogeneic therapies
  6. Perform risk-based assessment of GMP-compliant processes for the production of cell-based therapies.
  7. Discuss compliance and accreditation procedure for quality assurance standards (JACIE and others).
Assessments
  • Continuous Assessment (55%)
  • Oral, Audio Visual or Practical Assessment (15%)
  • Department-based Assessment (30%)
Module Director
Lecturers / Tutors
Reading List
  1. "Cell Therapy: cGMP Facilities and Manufacturing" by Adrian Gee
    Publisher: SPRINGER
  2. "Guide to Cell Therapy GxP: Quality Standards in the Development of Cell-Based Medicines in Non-pharmaceutical Environments" by J. Vives
  3. "Advances In Pharmaceutical Cell Therapy: Principles Of Cell-Based Biopharmaceuticals" by R. Huss,
  4. "Cell Therapy : cGMP Facilities and Manufacturing" by Adrian Gee
    Publisher: Springer
  5. "WHO good manufacturing practices for sterile pharmaceutical products" by World Health Organisation, Annex 6
The above information outlines module MD1524: "Cellular Manufacturing II" and is valid from 2017 onwards.
Note: Module offerings and details may be subject to change.

Required MD1526: Mesenchymal Stromal Cell Therapy


Semester 2 | Credits: 10

The successful application of mesenchymal stromal cells (MSCs) as an advanced medicinal product is reliant upon selecting the appropriate cell source and its therapeutic mechanism of action complimenting the intended application. This course aims to instil a fundamental, working knowledge of cellular procurement, the ongoing application of MSCs in clinical trials and the next generation of cellular therapeutics. The overall scope of the module is broad, ranging from the fundamental biology of mesenchymal stromal cells and their therapeutic applications to evaluating recent advancements in MSC preclinical trials to develop the next therapy. Included are hands on, laboratory-based skills including cell culture. The principals gained from participating in this course provide an overall reference for the evaluation of current literature to identify an appropriate cell source, to comprehend its mechanism of action and create a path to examine its pre-clinical efficacy in support of a regulatory submission.
(Language of instruction: English)

Learning Outcomes
  1. Compare and contrast the qualities of progenitor cells from various tissue sources in relation to their intended application.
  2. Demonstrate practical competence in mesenchymal stromal culture expansion and cryopreservation.
  3. Evaluation of the current literature regarding the safety and efficacy of mesenchymal stromal cells in pre-clinical and clinical applications.
  4. Acquire a basic understanding of the key Good Manufacturing Practices (GMP) that are required in the manufacture (expansion) of stem cells.
Assessments
  • Oral, Audio Visual or Practical Assessment (100%)
Module Director
Lecturers / Tutors
The above information outlines module MD1526: "Mesenchymal Stromal Cell Therapy" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Required MD1529: Induced Pluripotent Stem Cell Therapy


Semester 2 | Credits: 10

The Induced Pluripotent Stem Cell module is aimed to provide theoretical and practical background of the fast developing field of iPS cell research and at giving participants practical experience in derivation of induced pluripotent stem cell lines, maintenance in the culture, cell characterisation, expansion of iPS cells and differentiation into neuronal, cardiac and other tissues. The module will provide current knowledge of key scientific discoveries leading to development of reprogramming protocols and iPS technology. During the lectures, the ethics of iPS research and therapies, role of iPS in disease modelling, regeneration and therapy of hereditary (neurodegenerative and others) and acquired (heart failure, diabetes, cancer) disorders will also be discussed.
(Language of instruction: English)

Learning Outcomes
  1. Describe the process of cell reprogramming.
  2. Understand the critical steps in iPSC differentiation into different cells.
  3. Provide a global view on the current and future clinical and research applications of IPS cells.
  4. Discuss ethical aspects of iPS research and clinical applications.
Assessments
  • Continuous Assessment (55%)
  • Oral, Audio Visual or Practical Assessment (15%)
  • Department-based Assessment (30%)
Module Director
Lecturers / Tutors
Reading List
  1. "Induced Pluripotent Stem (iPS) Cells: Methods and Protocols (Methods in Molecular Biology)" by n/a
    ISBN: 1493930540.
The above information outlines module MD1529: "Induced Pluripotent Stem Cell Therapy" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Optional IE446: Project Management


Semester 1 | Credits: 5

Project management is a means to an end and not an end in itself. The purpose of project management is to foresee or predict as many of the potential pitfalls and problems as soon as possible and to plan, organise and control activities so that the project is successfully completed in spite of any difficulties and risks. This process starts before any resources are committed, and must continue until all the work is completed. The primary aim of this course is to improve the effectiveness of people engaged in project management. It focuses on the essential concepts and practical skills required for managing projects in dynamic environments. This course aims to provide learners with a solid understanding of the fundamentals of project management and to equip them with simple yet powerful tools that will empower them to meet their full potential in the area of project management thus enabling them to implement successful projects on time, within budget and to the highest possible standard.
(Language of instruction: English)

Learning Outcomes
  1. Understand the critical influencing factors for successful project management and execution.
  2. Understand the key reasons for failure and to comprehend the impact and implications of project failure on the individual, team and organisation.
  3. Specify an effective project plan, which is consistent with the business plan of the company
  4. Demonstrate the ultimate success of the plan through successful project implementation
  5. Be capable of using appropriate tools to schedule a project and associated activities and tasks
  6. Be capable of using tools to analyse the health of a project portfolio and to select relevant projects that align with the overall portfolio.
  7. Understand the concept of cross functional team working
  8. Gain a solid grounding in transferable skills such as problem specification, team working, and the ability to synthesise and apply acquired knowledge to the solution of problems
Assessments
  • Continuous Assessment (100%)
Module Director
Lecturers / Tutors
Reading List
  1. "Project Management: A Managerial Approach" by Meredith, J.R. and Mantel, S.J.
  2. "A Guide to the Project Management Body of Knowledge (PMBOK® Guide)" by Project Management Institute
The above information outlines module IE446: "Project Management" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Optional BI460: Molecular and Cellular Biology of Cancer


Semester 1 | Credits: 10

The module aims to give students the opportunity to gain in depth and advanced understanding of the causes of tumour formation and the molecular mechanism behind cancer development (tumourigenesis) in line with the current state of the art. Through the module, the students can attain a comprehensive understanding of the molecular and cellular processes relevant to tumour development, growth and survival, including the processes that lead to genetic instability, drive tumour growth, cause resistance to therapeutics or help the tumour cells to escape from detection by the immune system.
(Language of instruction: English)

Learning Outcomes
  1. Describe the mechanism and steps of tumour formation and understand the difference between the processes that drive the development vs. survival of a tumour
  2. Discuss the signal transduction pathways and molecular processes that drive tumour formation, growth and survival
  3. Analyse how aberrations in a molecular pathway may influence tumour development/growth
  4. Source and analyse information from the literature and relay the gained knowledge to their peers through a seminar presentation
Assessments
  • Continuous Assessment (100%)
Module Director
Lecturers / Tutors
The above information outlines module BI460: "Molecular and Cellular Biology of Cancer" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Optional EC584: Economic Evaluation in Health Care


Semester 1 | Credits: 10

The module examines the theory and practice of economic evaluation as it applies to health and social care interventions. Topics covered include the rationale for economic evaluation; formulating a health evaluation problem; identifying and measuring outcomes and effectiveness; identifying, enumerating, and valuing the inputs to form an economic measure of costs; measuring the benefits of health interventions using contingent valuation and discrete choice experiments
(Language of instruction: English)

Learning Outcomes
  1. Understand the variety of economic evaluation techniques used to evaluate health interventions
  2. Critically assess the different theoretical rationales for health interventions
  3. Understand the different ways for measuring and valuing costs
  4. Understand the various methods for measuring outcomes in cost effectiveness and cost utility analysis
  5. Critically assess the advantages and disadvantages of QALYs
  6. Understand the use of contingent valuation in health economics
  7. Understand the use of experimental techniques to measure the value of interventions in health care
  8. Conduct a literature search and review of CEA and CUA studies in a particular health intervention
Assessments
  • Written Assessment (100%)
Module Director
Lecturers / Tutors
Reading List
  1. "Methods for the Economic Evaluation of Health Care Programmes" by Drummond, Michael F. et al.
    Publisher: Oxford University Press
  2. "Applied Methods of Cost-effectiveness Analysis in Health Care" by Alastair Gray et al.
    Publisher: Oxford University Press
  3. "Applied Methods of Cost-Benefit Analysis in Health Care" by McIntosh, Emma et al.
    Publisher: Oxford University Press
  4. "The Elgar Companion to Health Economics" by Jones, Andrew M. et al.
    Publisher: Edmund Elgar
The above information outlines module EC584: "Economic Evaluation in Health Care" and is valid from 2019 onwards.
Note: Module offerings and details may be subject to change.

Optional PM208: Fundamental Concepts in Pharmacology


Semester 1 | Credits: 5

This module introduces students to fundamental pharmacological concepts of pharmacodynamics and pharmacokinetics. A combination of lectures, tutorials and workshops will be used.

Learning Outcomes
  1. describe the main drug targets
  2. interpret dose response curves for agonists, antagonists, inverse agonists
  3. calculate molarities, concentrations, volumes required in making solutions
  4. access and critically analyse and interpret pharmacological data
  5. describe the processes of absorption, distribution, metabolism and excretion for specific drugs
  6. explain the effects of different routes of administration on absorption of drugs, and effects of food and drug interactions on drug disposition
  7. derive pharmacokinetic data and use them to predict clinical properties of drugs
Assessments
  • Continuous Assessment (30%)
  • Computer-based Assessment (70%)
Module Director
Lecturers / Tutors
Reading List
  1. "Pharmacology" by Rang, H.P., Dale, Ritter, Flower & Henderson
    Publisher: Churchill Livingstone
  2. "Principles of Pharmacology" by Golan, D.E., et al
  3. "Lippincott’s Illustrated Reviews Pharmacology" by Harvey, R.A.
The above information outlines module PM208: "Fundamental Concepts in Pharmacology" and is valid from 2016 onwards.
Note: Module offerings and details may be subject to change.

Optional MG529: Introduction To Business


Semester 1 | Credits: 10

Assessments
    Module Director
    Lecturers / Tutors
    The above information outlines module MG529: "Introduction To Business" and is valid from 2014 onwards.
    Note: Module offerings and details may be subject to change.

    Optional MD1528: First in Human, Early Phase Clinical Trials


    Semester 1 | Credits: 10

    This course will introduce researchers to the fundamental elements necessary to conduct First in Man, Early Phase Research in adherence to Good Clinical Practice guidelines using didactic and practical teaching, experiential learning ,inquiry-based and a cooperative learning approach. Researchers will be guided though the meaning of early phase research, study design, safety and clinical oversight, statistical considerations, emergency training, biological specimen management and clinical site preparation with the objective to enable researchers conduct early phase research to standards that surpass audit and inspection requirement.
    (Language of instruction: English)

    Learning Outcomes
    1. Understand and describe the process of translating novel drug/ device from the bench to the bedside
    2. Draft essential documents necessary for the conduct of phase 1 FIM Clinical Trials
    3. Describe dose escalation and dose expansion
    4. define and differentiate pharmacokinetics and pharmacodynamics and the implications of biological specimen management
    5. Identify challenges of conducting phase 1 trials and methods to overcome these
    6. demonstrate an in-depth knowledge of measures to ensure patient safety which includes safety event clinical management, data capture and reporting, Data Safety Monitoring Board Coordination, Investigator Brochure and Data Safety Update Reporting
    Assessments
    • Continuous Assessment (85%)
    • Oral, Audio Visual or Practical Assessment (15%)
    Module Director
    Lecturers / Tutors
    The above information outlines module MD1528: "First in Human, Early Phase Clinical Trials" and is valid from 2018 onwards.
    Note: Module offerings and details may be subject to change.

    Optional BME511: Tissue Engineering


    Semester 2 | Credits: 5

    This course integrates the principles and methods if engineering and life sciences towards the fundamental understanding if structure-function relationships in normal and pathological mammalian tissues especially as they relate to the development of biological tissues to restore, maintain, or improve tissue/organ function.
    (Language of instruction: English)

    Learning Outcomes
    1. Specify the different types of biodegradable biomaterials that can be used in tissue engineering applications.
    2. Discuss the complex interactions between biomaterials, cells and signals in biological systems.
    3. Demonstrate awareness in contemporary topics such as gene therapy, stem cells, proteonomics, genomics and bioreactors.
    4. Demonstrate their capability in conducting a multidisciplinary project.
    Assessments
    • Continuous Assessment (100%)
    Module Director
    Lecturers / Tutors
    The above information outlines module BME511: "Tissue Engineering" and is valid from 2015 onwards.
    Note: Module offerings and details may be subject to change.

    Why Choose This Course?

    Career Opportunities

    Why Choose This Course?

    Potential employers are seeking graduates of this course to fill gaps in their current staffing.  To that end, students enrolled in the MSc programme will complete a 4-month long dissertation project that will enable them to develop technical and transferrable skills while networking within a successful organization.  Historically, our students were placed in organizations such as the Centre for Cellular Manufacturing Ireland, Galway Blood and Tissue Establishment, Charles River, Stempeutics, Avectas, Cancer Trials Ireland, Regeneron, Intas Pharmaceuticals, Aerogen, Hebei Medical University, Alexion Pharmaceuticals, Hi-Tech Health and Valitacell.

    Our graduates have successfully secured employment as plant technologists, production assistants, manufacturing biotech associates, cell culture scientists, cell culture technical support, in quality assurance and assay development or as research assistants.   They are employed by world leading organizations such as Takeda, Autolus, NUI Galway, Fuji Diosynth Biotechnologies, Avectas, Abace-Biology and Charles River laboratories.

    Potential employers have the following comments regarding the Cellular Manufacturing and Therapy programme at NUI Galway:

    “The students from the MSc in Cellular Manufacturing and Therapy at NUI Galway [have an] excellent understanding of cell culture, cryopreservation and aseptic techniques and ability to work independently. This allowed for the [placement] student to generate high quality data key for the next step of our research programme.”

    -        Dr. Kasia Whysall, Irish Research Council Laureate, NUI Galway

    “A student from the MSc in Cellular Manufacturing and Therapy at NUI Galway has joined our team at AVECTAS with a deep understanding of both the practical and theory aspects of cellular therapies, as well as familiarity with issues pertaining to quality and GMP. This knowledge has led to rapid integration of the student into the team to the benefit of both the business and the student.”

    -        Dr. Shirley O’Dea, Chief Scientific Officer, Avectas 

    “ The MSc in Cellular Manufacturing and Therapy at NUI Galway is a wonderful programme providing graduates with the professional skills they require for employment in the research, development, translation and manufacturing of novel advanced therapeutic products. In particular, this course provides the laboratory-based skills and training in the practical techniques required for GMP-manufacturing of cell products. It delivers a solid scientific rationale underpinning the development of cellular therapies, the very skills and knowledge that I require in future employees”

    -        Andrew Finnerty, General Manager, Centre for Cellular Manufacturing Ireland

    “Students from the MSc in Cellular Manufacturing & Therapy arrive in their placements with a very acute work ethics and professionalism, eager to learn and very aware of the importance of a high standard aseptic technique, mind-sets that are pivotal when constructing cell banks.”

    -        Dr. Silvia Almeida, Virologist at Charles River

     

     

     

     

     

     

     

    Who’s Suited to This Course

    Learning Outcomes

     

    Work Placement

    Study Abroad

    Related Student Organisations

    Course Fees

    Fees: EU

    €8,760 p.a. FT; €4,435 p.a. PT: 2020/21

    Fees: Tuition

    €8,536 p.a. FT; €4,267 p.a. PT: 2020/21

    Fees: Student levy

    €224 p.a. 2020/21

    Fees: Non EU

    €17,510 p.a. FT; €8,810 PT: 2020/21

     2020/21:  1CMT2 part time = €4,435. 

     

     

     

     

     

     

    Find out More

    Cynthia Coleman   
    E: cynthia.coleman@nuigalway.ie

    Janusz Krawczyk
    E: janusz.krawczyk@nuigalway.ie

     

     

     

     

     

     

     

    Andrew

    Andrew Finnerty |   General Manager, Centre for Cell Manufacturing Ireland

    The MSc in Cellular Manufacturing and Therapy at NUI Galway is a wonderful programme providing graduates with the professional skills they require for employment in the research, development, translation and manufacturing of novel advanced therapeutic products. In particular, this course provides the laboratory-based skills and training in the practical techniques required for GMP-manufacturing of cell products. It delivers a solid scientific rationale underpinning the development of cellular therapies; the very skills and knowledge that I require in future employees.
    in Connect with Andrew
    Richa

    Richa Krishna |   MSc student, Cellular Manufacturing & Therapy

    Hailing from a clinical background and being aware of its current traditional therapy limitations, I opted for Cellular Manufacturing & Therapy to explore the future of advanced cell therapy. This field has a lot of potential due to current clinical trials and research advances. This course gave me an opportunity to gain knowledge of the state of the art of the cellular therapies transitioning into the health care systems around the globe. If this area interests you, NUIG would lend you a perfect platform from where you can shape your career in the research field or industry. Needless to add Galway is very friendly place for international students with support to help along your academic journey.
    Rory

    Rory Rafferty |   MSc student, Cellular Manufacturing & Therapy

    I chose this course because after spending 3 years working in the medical device industry I knew that I needed a chance in scenery. The reputation of NUIG as one of the colleges at the forefront of research, clinical trials, cellular manufacturing and GMP in the field of regenerative medicines naturally attracted me to the course. I felt that it was the perfect stepping stone that would allow me to greatly improve my CV. I feel the course has given me invaluable transferable skills. It has also given me a true insight into the workings of clinical research and Good Manufacturing Practices that I feel will allow me to leave my own lasting mark in the scientific world.
    in Connect with Rory
    Ti

    Ti Zhang |   MSc student, Cellular Manufacturing & Therapy

    A one-year taught master programme, Cellular Manufacturing & Therapy focuses on translating innovative biological therapies to clinical applications, especially in the stem cell area. This course has a close relationship with the Regenerative Medicine Institute scientists and Centre for Cellular Manufacturing Ireland staff. Participating in this course will significantly improve your academic performance and capability in the laboratory. Our extremely friendly lecturers will bring engaging classroom activities and the small class size includes students from different backgrounds, makes learning approachable.
    James

    James O'Brien |   MSc student, Cellular Manufacturing & Therapy

    During my Biotechnology undergraduate degree, I was generally most interested in the modern medical aspects, especially regenerative medicine, gene therapy and cell therapy. Unsurprisingly, when I heard that this new MSc. program was being set up, I immediately made inquiries, and found myself excited about applying. So far, this course has given me enormous insight into the scientific background of modern cellular therapies and has also provided practical industrial skills and knowledge. The course is well-structured, and the co-ordinators and lecturers have vast experience and excellent portfolios in the field. I feel my overall skillset has been specialized abundantly in just a short time by this course, and I feel like I will be more confident when applying for industrial jobs in the cellular therapy domain.

    Higher Education Awards 2020

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    Downloads

    • MSc Cellular Manufacturing and Therapy Brochure

      MSc Cellular Manufacturing and Therapy Brochure PDF (1.35MB)

    • Postgraduate Taught Prospectus 2020

      Postgraduate Taught Prospectus 2020 PDF (21 MB)