Professor Laoise McNamara’s research group use multidisciplinary approaches to understand mechanobiology and how this process contributes to bone development and osteoporosis.
They have developed novel multiphysics and multiscale computational modelling techniques and have applied these methods to derive an understanding of the mechanical stimuli that bone cells experience in vivo in healthy and osteoporotic bone tissue
Her research group use experimental techniques to identify the specific mechanosensation and mechanotransduction mechanisms by which bone cells sense mechanical stimuli. These studies have contributed a novel understanding of changes in bone mechanobiology during osteoporosis. This research has been applied to understand the role of mechanical stimulation in bone regeneration and she develops in vitro tissue regeneration strategies that exploit mechanobiological responses to overcome challenges in the field of bone tissue engineering.
Professor McNamara collaborates with the medical device companies applying her expertise in computational and experimental biomechanics to the pre-clinical assessment of various surgical and minimally invasive devices.
Professor McNamara’s research is informing the generation of novel therapeutic approaches for osteoporosis. Her research also strives to provide an understanding of the long term performance of transcatheter heart valve technologies for the treatment of aortic valve stenosis.
Professor McNamara was awarded an Irish Research Council (IRC) Laureate Award in 2018, an SFI Investigators Grant in 2015 and a European Research Council Starting Independent Researcher Award in 2011. For her research she has been awarded the ‘Bone and Joint Decade’ New Investigator Award by the Orthopaedic Research Society, and the Harold B. Frost Young Investigator Award by the American Society for Bone and Mineral Research (ASBMR).
Professor McNamara’s research has published more than 70 research articles in various high Impact Factor journals; PNAS, European Cells and Materials, the Journal of the Royal Society Interface, Bone, Tissue Engineering Part A and the Biophysical Journal, among many others.
Professor McNamara is a reviewer for over 20 peer-reviewed international journals. She has also acted as a Royal Academy of Engineering (UK) reviewer for the Irish Research Council for Science and Engineering Technology (IRCSET) Postdoctoral Fellowships scheme.
Link to Research Gate profile
+353 (0) 91 495833