Professor Paul V Murphy is an Established Professor of Chemistry and has research interests in Organic Synthesis and Medicinal Chemistry with a focus on Carbohydrates.
Professor Murphy’s research outputs include:
- synthesis of important natural products & their analogues
- synthesis method development including investigation of flow chemistry
- glycomimetic research to develop inhibitors of carbohydrate binding proteins
- synthesis of frameworks/scaffolds for drug discovery
- glycoclusters as inhibitors/ligands of biomedically important lectins, with a view to developing inhibitors or molecules for targeting cells.
The clinical targets to benefit from this research include: galectins, human macrophage galactose C-type lectin, fascin, CD1D, influenza hemagglutinin and glycoprocessing enzymes such as glycosidases. These various targets are relevant to infection, immunology, fibrosis & cancer and thus compounds developed could have potential for translation into the clinic in these areas.
Professor Murphy is currently the Irish representative to both International Carbohydrate Organization (ICO) & European Carbohydrate Organisation (ECO). He has been admitted as a Fellow of the Royal Society of Chemistry and of the Institute of Chemistry of Ireland. He is a Member of the American Chemical Society.
Professor Murphy has obtained a number of awards and has chaired/co-chaired a number of international meetings and has been invited to contribute reviews and articles to a number of special issues of Journals. He has co-edited Volume 4, Carbohydrate Chemistry: Proven Synthetic Methods and was previously an Editorial Board Member of the journal Carbohydrate Research.
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