Dr Róisín Dwyer is a Senior Lecturer in Translational Science and a PI in the Discipline of Surgery at NUI Galway. Her research focuses on cell communication in the breast tumour microenvironment, with a view to harnessing this knowledge for development of novel gene therapy approaches for advanced breast cancer.
Tumours actively recruit stromal cells including Mesenchymal Stromal Cells (MSCs), and stromal-epithelial crosstalk plays a critical role in tumour development and progression. Dr Dwyer is interested in paracrine and autocrine mediators of this crosstalk, including chemokines/cytokines, microRNAs and extracellular vesicles (EVs). Understanding this environment will facilitate harnessing the potential of MSCs or their secreted EVs as vehicles for targeted delivery of therapy to breast tumours. In Vivo imaging to track MSC/EV migration is an important element of this.
Multidisciplinary collaboration is key to Dr Dwyer’s work and she is a member of national and international research consortia, including Precision Oncology Ireland and the Celtic Advanced Life Science Innovation Network (CALIN). Her research has been recognised through a variety of honours including the inaugural Irish Cancer Society Researcher of the Year award. She has published 50 papers (h-index 26) in respected journals such as Clinical Cancer Research, Molecular Therapy and Oncogene. She is a named inventor on patents, and works closely with industry collaborators to develop therapeutic EVs for a range of disease indications.
Along with a current team of 4 PhD students and one postdoctoral scientist, Dr Dwyer has supervised 10 PhD and 5MD students to completion, and mentored postdoctoral scientists and research assistants. Her team also hosts MSc students, and undergraduate research students annually. Dr Dwyer is actively involved in science outreach and routinely communicates research progress with patients, school children and the general public.
Dr Dwyer has been an invited expert grant reviewer for many international agencies including the French National Cancer Institute, Polish National Science Centre, and UK Breast Cancer Now. She is also a regular peer reviewer for a range of respected journals in the fields of cell and gene therapy, breast cancer, EVs and microRNAs.
NBCI Publication List: https://www.ncbi.nlm.nih.gov/myncbi/1VWn6ijKs7lAP/bibliography/public/
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