Dr Karen Doyle

B.Sc., Ph.D.

Contact Details

Senior Lecturer
Dept. of Physiology
Human Biology Building
NUI Galway
T: Ext. 3665
E: karen.doyle@nuigalway.ie
 
researcher
 

Biography

Dr Doyle is a Senior Lecturer in Physiology and Principal Investigator. Her research involves studying neurovascular stress, the causes of neuronal loss and investigating novel strategies to protect brain tissue from damage.  Dr Doyle’s focus is on understanding the pathophysiology of occlusive stroke, the characteristics of human blood clots that cause occlusive strokes and also the effect of cerebral hypoperfusion and reperfusion strategy on the survival of brain tissue.       

Dr Doyle is the founder leader of Galway Neuroscience Centre (2004 – 2009), is a former Vice President of Neuroscience Ireland (2007–2009) and Vice Dean for Graduate Studies in the College of Medicine, Nursing & Health Sciences, NUI Galway (2011–2015). Dr Doyle is a member of The Physiological Society, Neuroscience Ireland, British Neuroscience Association, European Stroke Organisation and World Stroke Organisation and is a member of the Editorial Board of Physiology News and PlosOne. Dr Doyle is a previous recipient of the Presidents Award for Teaching Excellence in NUI Galway (2015) and winner of a National Teaching Experts Award, from the National Forum for the Enhancement of Teaching and Learning in Higher Education (2015).    

Research Interests

Research Interests: 
My research focus is on understanding neurovascular stress, the pathophysiology of stroke and the characteristics of acute ischaemic stroke blood clots.

My current work through CURAM,working with clinical collaborators and a local medical device company, Neuravi, correlates biomarkers we have identified in acute ischaemic stroke (AIS) blood clots with clinical procedural data and patient outcome. The composition of blood clots can vary considerably, and clot composition has an immense impact on how readily an AIS clot can be dissolved by thrombolytics, or physically removed by mechanical thrombectomy medical devices. The aim of this work is to identify biomarkers that will guide clinical interventionists on the best approach in order to most efficiently remove an AIS clot following a stroke, and to inform future medical device design, particularly to improve the recanalisation of cerebral vessels blocked by difficult to remove clots.

My research also focuses on understanding the causes of neuronal death, and novel neuroprotective strategies to prevent neuronal death, particularly related to stroke and chronic cerebral hypoperfusion. My previous work has touched on an array of neurological and psychiatric conditions including epilepsy, bipolar depression and the brain damage caused by drugs of abuse. In particular I have made a substantial contribution to the fields of polyamine and stroke research.


Research Projects

  Project Start Date End Date
CURAM SPOKE NEURAVI LIMITED - 1 of 2 01-SEP-16 30-SEP-21
CURAM SPOKE NEURAVI LIMITED - 2 of 2 01-SEP-16 30-SEP-21
Impact of different Reperfusion Approach on Haemorrhagic Transformation Development Following an Aute Occlusive Stroke 01-MAR-15 31-MAY-17
Neuravi Ltd - EI IP 01-MAR-15 31-MAY-19
GALWAY N KAREN DOYLE 20-MAY-09 01-DEC-11
BEAUTY NEUROSCIENCE K DOYLE 01-FEB-09 30-SEP-09

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Sean Fitzgerald Acute ischaemic stroke clot pathology Postdoctoral Scientist Science Foundation Ireland (SFI)
Mr Andrew Douglas Acute ischaemic stroke clot pathology Research Assistant Science Foundation Ireland (SFI)
Mr Andrew Douglas Does different reperfusion approach have an impact on haemorrhage transformation development following an acute occlusive stroke? Research Assistant
Dr Jennifer Shearer Does different reperfusion approach have an impact on haemorrhage transformation development following an acute occlusive stroke? Postdoctoral Scientist Enterprise Ireland (EI)

Peer Reviewed Journals

  Year Publication
(2021) 'Large Artery Atherosclerotic Clots are Larger than Clots of other Stroke Etiologies and have Poorer Recanalization rates'
Fitzgerald, S;Rossi, R;Mereuta, OM;Molina, S;Okolo, A;Douglas, A;Jabrah, D;Pandit, A;McCarthy, R;Gilvarry, M;Ceder, E;Dehlfors, N;Dunker, D;Nordanstig, A;Redfors, P;Jood, K;Magoufis, G;Psychogios, K;Tsivgoulis, G;Alderson, J;O'Hare, A;Power, S;Brennan, P;Nagy, A;Vadasz, A;Brinjikji, W;Kallmes, D;Szikora, I;Tatlisumak, T;Rentzos, A;Thornton, J;Doyle, KM (2021) 'Large Artery Atherosclerotic Clots are Larger than Clots of other Stroke Etiologies and have Poorer Recanalization rates'. Journal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National Stroke Association, 30 [DOI] [Details]
(2021) 'A novel rabbit thromboembolic occlusion model'
Ding YH;Fitzgerald S;Liu Y;Dai D;Jakaitis D;Doyle K;Brinjikji W;Kallmes DF;Savastano L;Kadirvel R; (2021) 'A novel rabbit thromboembolic occlusion model'. Journal Of Neurointerventional Surgery, [DOI] [Details]
(2021) 'Characterizing blood clots using acoustic radiation force optical coherence elastography and ultrasound shear wave elastography'
Liu HC;Abbasi M;Ding YH;Roy T;Capriotti M;Liu Y;Fitzgerald S;Doyle KM;Guddati M;Urban MW;Brinjikji W; (2021) 'Characterizing blood clots using acoustic radiation force optical coherence elastography and ultrasound shear wave elastography'. Physics In Medicine And Biology, 66 (3) [DOI] [Details]
(2021) 'The Relationship Between Cerebral Reperfusion And Regional Expression Of Matrix Metalloproteinase-9 In Rat Brain Following Focal Cerebral Ischemia'
Douglas AS;Shearer JA;Okolo A;Pandit A;Gilvarry M;Doyle KM; (2021) 'The Relationship Between Cerebral Reperfusion And Regional Expression Of Matrix Metalloproteinase-9 In Rat Brain Following Focal Cerebral Ischemia'. Neuroscience, 453 [DOI] [Details]
(2020) 'High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke'
Mereuta OM;Fitzgerald S;Christensen TA;Jaspersen AL;Dai D;Abbasi M;Puttappa T;Kadirvel R;Kallmes DF;Doyle KM;Brinjikji W; (2020) 'High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke'. Journal Of Neurointerventional Surgery, [DOI] [Details]
(2020) 'Clot permeability and histopathology: is a clot's perviousness on CT imaging correlated with its histologic composition?'
Benson, JC;Fitzgerald, ST;Kadirvel, R;Johnson, C;Dai, DY;Karen, D;Kallmes, DF;Brinjikji, W (2020) 'Clot permeability and histopathology: is a clot's perviousness on CT imaging correlated with its histologic composition?'. Journal Of Neurointerventional Surgery, 12 :38-42 [DOI] [Details]
(2020) 'Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition'
Fitzgerald S;Rossi R;Mereuta OM;Jabrah D;Okolo A;Douglas A;Molina Gil S;Pandit A;McCarthy R;Gilvarry M;Dunker D;Nordanstig A;Ceder E;Redfors P;Jood K;Dehlfors N;Magoufis G;Tsivgoulis G;Brinjikji W;Kallmes DF;O'Hare A;Power S;Brennan P;Alderson J;Nagy A;Vadász Á;Psychogios K;Szikora I;Tatlisumak T;Rentzos A;Thornton J;Doyle KM; (2020) 'Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition'. Journal Of Neurointerventional Surgery, [DOI] [Details]
(2020) 'The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome'
Rossi, R;Fitzgerald, S;Molina, S;Mereuta, OM;Douglas, A;Pandit, A;Santos, AMS;Murphy, B;Alderson, J;Brennan, P;Power, S;O'Hare, A;Gilvarry, M;McCarthy, R;Psychogios, K;Magoufis, G;Tsivgoulis, G;Nagy, A;Vadasz, A;Szikora, I;Jood, K;Redfors, P;Nordanstig, A;Ceder, E;Dehlfors, N;Dunker, D;Tatlisumak, T;Rentzos, A;Thornton, J;Doyle, KM (2020) 'The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome'. Journal Of Thrombosis And Thrombolysis, [DOI] [Details]
(2020) 'Storage of blood clots for histological analysis: how long is too long in saline and paraformaldehyde?'
Douglas, A;Fitzgerald, S;Pandit, A;Doyle, KM (2020) 'Storage of blood clots for histological analysis: how long is too long in saline and paraformaldehyde?'. Histology And Histopathology, 35 :313-320 [DOI] [Details]
(2020) 'Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes'
Douglas, A;Fitzgerald, S;Mereuta, OM;Rossi, R;O'Leary, S;Pandit, A;McCarthy, R;Gilvarry, M;Holmegaard, L;Abrahamsson, M;Jerndal, M;Dehlfors, N;Brennan, P;Power, S;O'Hare, A;Griffin, E;Kallmes, DF;Brinjikji, W;Szikora, I;Tatlisumak, T;Rentzos, A;Thornton, J;Doyle, K (2020) 'Platelet-rich emboli are associated with von Willebrand factor levels and have poorer revascularization outcomes'. Journal Of Neurointerventional Surgery, 12 :557-562 [DOI] [Details]
(2020) 'Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure'
Santos, AMD,Gorman, AM,Kelly, JP,Doyle, KM (2020) 'Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure'. Neuroscience Letters, 715 [DOI] [Details]
(2020) 'Development of an in vitro model of calcified cerebral emboli in acute ischemic stroke for mechanical thrombectomy evaluation'
Johnson S;McCarthy R;Fahy B;Mereuta OM;Fitzgerald S;Gaudirc J;Remadi JP;Shotar E;Sourour NA;Doyle K;Gilvarry M;McGarry P;McHugh PE;Clarençon F; (2020) 'Development of an in vitro model of calcified cerebral emboli in acute ischemic stroke for mechanical thrombectomy evaluation'. Journal Of Neurointerventional Surgery, 12 :1002-1007 [DOI] [Details]
(2019) 'Review of external referrals to a regional stroke centre: it is not just about thrombectomy'
Adams, NC;Griffin, E;Motyer, R;Farrell, T;Carmody, E;O'Shea, A;Murphy, B;O'Hare, A;Looby, S;Power, S;Brennan, P;Doyle, KM;Thornton, J (2019) 'Review of external referrals to a regional stroke centre: it is not just about thrombectomy'. Clinical Radiology, 74 :950-955 [DOI] [Details]
(2019) 'Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots'
Fitzgerald, S;Wang, SL;Dai, DY;Murphree, DH;Pandit, A;Douglas, A;Rizvi, A;Kadirvel, R;Gilvarry, M;McCarthy, R;Stritt, M;Gounis, MJ;Brinjikji, W;Kallmes, DF;Doyle, KM (2019) 'Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots'. Plos One, 14 [DOI] [Details]
(2019) 'Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations'
Staessens, S;Fitzgerald, S;Andersson, T;Clarencon, F;Denorme, F;Gounis, M;Hacke, W;Liebeskind, DS;Szikora, I;van Es, ACGM;Brinjikji, W;Doyle, KM;Meyer, SF (2019) 'Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations'. International Journal Of Stroke, [DOI] [ARAN Link] [Details]
(2019) 'Clots retrieved by mechanical thrombectomy from acute ischemic stroke patients show no evidence of bacteria'
Khashim, Z;Fitzgerald, S;Kadirvel, R;Dai, D;Doyle, KM;Brinjikji, W;Kallmes, DF (2019) 'Clots retrieved by mechanical thrombectomy from acute ischemic stroke patients show no evidence of bacteria'. Interventional Neuroradiology, 25 :502-507 [DOI] [Details]
(2019) 'A Standardized Aspiration-First Approach for Thrombectomy to Increase Speed and Improve Recanalization Rates'
O'Neill, D,Griffin, E,Doyle, KM,Power, S,Brennan, P,Sheehan, M,O'Hare, A,Looby, S,Santos, AMD,Rossi, R,Thornton, J (2019) 'A Standardized Aspiration-First Approach for Thrombectomy to Increase Speed and Improve Recanalization Rates'. American Journal Of Neuroradiology, 40 :1335-1341 [DOI] [Details]
(2019) 'Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome'
Fitzgerald, S;Mereuta, OM;Doyle, KM;Dai, DY;Kadirvel, R;Kallmes, DF;Brinjikji, W (2019) 'Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome'. JOURNAL OF NEUROSURGICAL SCIENCES, 63 :292-300 [DOI] [Details]
(2019) 'Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source'
Fitzgerald, S;Dai, DY;Wang, SL;Douglas, A;Kadirvel, R;Layton, KF;Thacker, IC;Gounis, MJ;Chueh, JY;Puri, AS;Almekhlafi, M;Demchuk, AM;Hanel, RA;Sauvageau, E;Aghaebrahim, A;Yoo, AJ;Kvamme, P;Pereira, VM;Kayan, Y;Almandoz, JED;Nogueira, RG;Rabinstein, AA;Kallmes, DF;Doyle, KM;Brinjikji, W (2019) 'Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source'. Stroke, 50 :1907-1910 [DOI] [Details]
(2019) 'Acute ischemic stroke secondary to cardiac embolus of a 'foreign body' material after a redo sternotomy for mitral valve replacement: A case report'
Fitzgerald, S,Rizvi, A,Dai, DY,Williamson, EE,Lanzino, G,Doyle, KM,Kalimes, DF,Brinjikji, W (2019) 'Acute ischemic stroke secondary to cardiac embolus of a 'foreign body' material after a redo sternotomy for mitral valve replacement: A case report'. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 25 :208-211 [DOI] [Details]
(2019) 'Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain'
Santos, AMD,Kelly, JP,Dockery, P,Doyle, KM (2019) 'Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 89 :303-309 [DOI] [ARAN Link] [Details]
(2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'
Kennedy, D,Mnich, K,Oommen, D,Chakravarthy, R,Almeida-Souza, L,Krols, M,Saveljeva, S,Doyle, K,Gupta, S,Timmerman, V,Janssens, S,Gorman, AM,Samali, A (2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'. Cell Death & Disease, 8 [DOI] [Details]
(2017) 'Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain'
Santos, AMD,Kelly, JP,Doyle, KM (2017) 'Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain'. Neuropsychobiology, 75 :63-71 [DOI] [Details]
(2017) 'Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design'
Shearer, JA, Douglas, AS, Kirby BP, Tatlisumak T & Doyle KM (2017) 'Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design'. Current Vascular Pharmacology, [ARAN Link] [Details]
(2016) 'Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's Disease'
Devadasan, C, Starr, B & Doyle KM (2016) 'Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's Disease'. Neuroreport, 27 (17):1243-1247 [ARAN Link] [Details]
(2015) 'Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation'
Bailey, D,Kirby, BP,Atkinson, J,Fixon-Owoo, S,Henman, MC,Shaw, GG,Doyle, KM (2015) 'Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation'. Pharmacology Biochemistry And Behavior, 133 :57-64 [DOI] [ARAN Link] [Details]
(2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'
Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 [DOI] [ARAN Link] [Details]
(2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'
Butler, RK;Ford, GK;Hogan, M;Roche, M;Doyle, KM;Kelly, JP;Kendall, DA;Chapman, V;Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91 [DOI] [ARAN Link] [Details]
(2011) 'Recent Advances in Psychoneuroimmunology: Inflammation in Psychiatric Disorders'
Debnath, M,Doyle, KM,Langan, C,McDonald, C,Leonard, B,Cannon, DM (2011) 'Recent Advances in Psychoneuroimmunology: Inflammation in Psychiatric Disorders'. Translational Neuroscience, 2 (2):121-137 [DOI] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal Of Cellular And Molecular Medicine, [Details]
(2009) 'Serum BDNF levels in euthymic bipolar disorder: preliminary results from the Galway Bipolar Study'
Langan, C.,Doyle, K.,Kelly, J.,Emsell, L.,Skinner, R.,McDonald, C. (2009) 'Serum BDNF levels in euthymic bipolar disorder: preliminary results from the Galway Bipolar Study'. Bipolar Disorders, 11 :56-56 [Details]
(2009) 'Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord'
Hynes, J.,Bourke, E.,Deering, E. M.,Doherty, G.,Murray, A.,Dockery, P.,Doyle, K.,Gorman, A.,Barry, F. P.,McMahon, S. S. (2009) 'Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord'. Journal of Anatomy, 214 (55):793-793 [Details]
(2009) 'Considerations and recent advances in neuroscience'
Gorman, A. M.,Doyle, K. M. (2009) 'Considerations and recent advances in neuroscience'. Biochemical Society Transactions, 37 :299-302 [Details]
(2007) 'Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia'
Li J, Doyle, K.M. & Tatlisumak T (2007) 'Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia'. Curr Med Chem, 14 (17):1807-1813 [ARAN Link] [Details]
(2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'
Li, J;Henman, MC;Atkinson, J;Fixon-Owoo, S;Tatlisumak, T;Shaw, GG;Doyle, KM (2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'. Brain Research, 1076 :209-215 [DOI] [Details]
(2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'
Kavanagh, ET,Loughlin, JP,Herbert, KR,Dockery, P,Samall, A,Doyle, KM,Gorman, AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochemical And Biophysical Research Communications, 351 :890-895 [DOI] [Details]
(2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'
Li, J,Henman, MC,Atkinson, J,Fixon-Owoo, S,Tatlisumak, T,Shaw, GG,Doyle, KM (2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'. Brain Research, 1076 :209-215 [DOI] [Details]
(2005) 'Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo'
Doyle, KM;Kirby, BP;Murphy, D;Shaw, GG (2005) 'Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo'. Neuroscience Letters, 380 :247-251 [DOI] [Details]
(2004) 'The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N-1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice'
Li, J;Henman, MC;Doyle, KM;Strbian, D;Kirby, BP;Tatlisumak, T;Shaw, GG (2004) 'The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N-1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice'. Brain Research, 1029 :84-92 [DOI] [Details]
(2004) 'Preliminary characterisation of an in vitro paradigm for the study of the delayed effects of organophosphorus compounds: hen embryo brain spheroids'
Sales, KM;Kingston, ST;Doyle, KM;Purcell, WM (2004) 'Preliminary characterisation of an in vitro paradigm for the study of the delayed effects of organophosphorus compounds: hen embryo brain spheroids'. Toxicology, 195 :187-202 [DOI] [Details]
(1998) 'Investigation of the actions and antagonist activity of some polyamine analogues in vivo'
Doyle, K.M.,Shaw, G.G. (1998) 'Investigation of the actions and antagonist activity of some polyamine analogues in vivo'. British Journal Of Pharmacology, 124 :386-390 [Details]
(1998) 'Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour'
Doyle, K.M., Feerick, S., Kirkby, D.L., Eddleston, A. & Higgins, G.A. (1998) 'Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour'. Behavioural Pharmacology, 9 :671-681 [Details]
(1996) 'Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo'
Doyle, K.M. : Shaw, G.G. (1996) 'Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo'. British Journal Of Pharmacology, 117 :1803-1808 [Details]
(1996) 'Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex'
Purcell, W.M., Doyle, K.M., Westgate, C. : Atterwill, C.K (1996) 'Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex'. Journal Of Neuroimmunology, 65 :49-53 [Details]
(1994) 'Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?'
Purcell, W.M., Doyle, K.M., Bagga, L. : Derks, M. (1994) 'Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?'. Biochemical Society Transactions, 22 [Details]
(1994) 'The mechanism of the neurotoxic effects of spermidine'
Doyle, K.M.,Shaw, G.G. (1994) 'The mechanism of the neurotoxic effects of spermidine'. Biochemical Society Transactions, 22 [Details]

Conference Publications

  Year Publication
(2020) EMBC 2020 Montreal
Adam Santorelli, Sean Fitzgerald, Andrew Douglas, Karen M. Doyle & Martin O’Halloran (2020) Dielectric profile of blood clots to inform ischemic stroke treatments EMBC 2020 Montreal [DOI] [ARAN Link] [Details]
(2018) International Stroke Conference
Fitzgerald, S and Rizvi, A and Michalak, G and Kadirvel, R and Doyle, K and Brinjikji, W and Kallmes, D (2018) P-024 Dual-energy CT-based characterization of experimental human clot analogues with different compositions created under dynamic flow conditions: an in vitro stroke study International Stroke Conference [Details]
(2018) European Stroke Organisation Conference 2018
Douglas, AD; Shearer, J; Pandit, A; Doyle, K (2018) THE EFFECT OF MECHANICAL REPERFUSION OUTCOME FOLLOWING AN OCCLUSIVE STROKE ON THE REGIONAL EXPRESSION OF MATRIX METALLOPROTEINASE-9 IN RAT BRAIN European Stroke Organisation Conference 2018 [Details]
(2019) BNA 2019 Festival of Neuroscience
Okolo, A; Shearer, J; Prendergast, J; Douglas, A; McMahon, J; Fitzgerald, U; Doyle, K (2019) Change in ATF6 and CHOP expression in the brain following ischemic stroke and reperfusion BNA 2019 Festival of Neuroscience Dublin, Ireland, , 14-APR-19 - 17-APR-19 [Details]
(2019) European Stroke Organisation Conference 2019
Douglas, A; Fitzgerald, S; Rentzos, A; Thornton, J; Tatlisumak, T; Pandit, A; Silva Santos, A; Rossi, R; Mereuta, OM; Doyle, K (2019) Platelets and von Willebrand factor are key components in acute ischemic stroke clots European Stroke Organisation Conference 2019 [Details]
(2019) ESOC, European Stroke Organisation Conference
Silva Santos, AM; Rossi R; Pandit, A; Fitzgerald, S; Mereuta, OM; Douglas, A; Thornton, J; Brennan, P; Power, S; O’ Hare, A; Rentzos, A; Ceder, E; Tatlisumak, T; Jood, K; Redfors, P; Nordanstig, A; Duffy, S; Gilvarry, M; McCarthy, R; Doyle, KM. (2019) ESOC Abstracts Supplement 2019 ESOC, European Stroke Organisation Conference [ARAN Link] [Details]
(2019) WFITN, World Federation of Interventional and Therapeutic Neuroradiology Congress
Rossi, R; Fitzgerald, S; Mereuta, OM; Douglas, A; Pandit, A; Szikora, I; Tsivgoulis, G; Psychogios, K; Murphy, B; Brennan, P; Power, S; O'Hare, A; Thornton, J; Rentzos, A; Tatlisumak, T; Doyle, KM (2019) The impact of occlusion location and bridging therapy in patients affected by Acute Ischemic Stroke in determining the total number of passes required to remove the clot and the final revascularization outcome WFITN, World Federation of Interventional and Therapeutic Neuroradiology Congress [ARAN Link] [Details]
(2019) 5th European Stroke Organisation Conference (ESOC)
Mereuta, OM; Fitzgerald, S; Douglas, A; Rossi, R; Silva Santos, AM; Pandit, A; Thornton, J; O'Hare, A; Power, S; Brennan, P; Rentzos, A; Tatlisumak, T; Gunnarsson, T; Davidson, M; Brederlau, A; Allardt, A; Brinjikji, W; Kallmes, DF; Doyle, KM (2019) Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke . In: European Stroke Journal 2019 (volume 4, 1S) eds. 5th European Stroke Organisation Conference (ESOC) , pp.3-95 [DOI] [ARAN Link] [Details]
(2019) BNA Festival of Neuroscience
Mereuta, OM; Fitzgerald, S; Douglas, A; Rossi, R; Silva Santos, AM; Pandit, A; Thornton, J; Rentzos, A; Tatlisumak, T; Doyle, KM (2019) Histological characterization of ‘white’ clots retrieved by mechanical thrombectomy from acute ischemic stroke patients . In: Brain and Neuroscience Advances Journal 2019 (volume 3) eds. BNA Festival of Neuroscience [DOI] [ARAN Link] [Details]
(2019) British Neuroscience Association
Prendergast, J., Okolo, A., Douglas, A., Shearer, J., Roche, M. and Doyle, K. (2019) Cyclooxygenase-2 Expression in the Brain Following Ischemic Stroke and its Effects on Glial Cells British Neuroscience Association [Details]
(2019) British Neuroscience Association
Adaobi Okolo; J. Shearer; J. Prendergast; A. Douglas; U. Fitzgerald; Doyle, KM (2019) Change in ATF6 expression in the brain, following ischemic stroke and reperfusion British Neuroscience Association [Details]
(2019) British Neuroscience Association
Adaobi Okolo; J. Shearer; J. Prendergast; A. Douglas; U. Fitzgerald; Doyle, KM (2019) Change in ATF6 expression in the brain, following ischemic stroke and reperfusion British Neuroscience Association [Details]
(2019) British Neuroscience Association
2. Adaobi Okolo; J. Shearer; J. Prendergast; A. Douglas; U. Fitzgerald; Doyle, KM (2019) Change in ATF6 expression in the brain, following ischemic stroke and reperfusion British Neuroscience Association [Details]
(2019) British Neuroscience Association
2. Adaobi Okolo; J. Shearer; J. Prendergast; A. Douglas; U. Fitzgerald; Doyle, KM (2019) Change in ATF6 expression in the brain, following ischemic stroke and reperfusion British Neuroscience Association [Details]
(2019) International Stroke Conference
1. Michel Muster; Sean Fitzgerald; Doyle, KM; K. Lövblad (2019) MicroCT data can distinguish between in vitro clot types of different composition International Stroke Conference [Details]
(2018) Society of Neurointerventional Surgery
Seán Fitzgerald; Asim Rizvi; Gregory Michalak; Ramanathan Kadirvel; Doyle, Karen M.; Waleed Brinjikji; David F. Kallmes (2018) Dual-energy CT-based Characterization of Experimental Human Clot Analogues with Different Compositions Created Under Dynamic Flow Conditions: An In Vitro Stroke Study Society of Neurointerventional Surgery [Details]
(2018) World Congress of Biomechanics
Seán Fitzgerald; Shunli Wang; Daying Dai; Abhay Pandit; Andrew Douglas; Ramanathan Kadirvel; Waleed Brinjikji; David F. Kallmes; Doyle, Karen M. (2018) Identification of platelet rich clots following mechanical thrombectomy may identify patients who would benefit from anti-platelet therapy to prevent a recurrent ischaemic stroke World Congress of Biomechanics [Details]
(2018) European Stroke Organisation Conference
Andrew Douglas; Sean Fitzgerald; Abhay Pandit; Doyle, Karen M. (2018) Storage of blood clots for histological analysis: how long is too long in saline and formalin? European Stroke Organisation Conference [Details]
(2018) European Stroke Organisation Conference
Jennifer Shearer; Andrew Douglas; Abhay Pandit; Doyle, Karen M. (2018) The effect of mechanical reperfusion outcome following an occlusive stroke on the regional expression of matrix metalloproteinase-9 in rat brain European Stroke Organisation Conference [Details]
(2018) European Stroke Organisation Conference
Seán Fitzgerald; Daying Dai; Shunli Wang; Abhay Pandit; Andrew Douglas; Ramanathan Kadirvel; Matthew J. Gounis; Waleed Brinjikji; David F. Kallmes; Doyle Karen M. (2018) Initial findings from the CURAM and Mayo Clinic International Acute Ischaemic Stroke clot registry European Stroke Organisation Conference [Details]
(2018) International Stroke conference
Seán Fitzgerald; Shunli Wang; Daying Dai; Andrew Douglas; Ramanathan Kadirvel; Waleed Brinjikji; David F. Kallmes; Doyle, Karen M. (2018) Machine-Learned Characterization of Acute Ischemic Stroke Clots reveals a Correlation between Clot Composition and Density on CT International Stroke conference [Details]
(2017) Effect of mechanical reperfusion outcome on the expression of matrix metalloproteinase-9 (MMP-9) in rat brain following an acute occlusive stroke
Shearer, J; Douglas, A; Pandit, A; Doyle, K (2017) JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Effect of mechanical reperfusion outcome on the expression of matrix metalloproteinase-9 (MMP-9) in rat brain following an acute occlusive stroke , pp.440-440 [Details]
(2010) METHAMPHETAMINE EFFECTS ON CELL VIABILITY, BDNF LEVELS AND NEURITE OUTGROWTH IN PC12 CELLS
Santos, AM,Kelly, JP,Doyle, KM (2010) IRISH JOURNAL OF MEDICAL SCIENCE METHAMPHETAMINE EFFECTS ON CELL VIABILITY, BDNF LEVELS AND NEURITE OUTGROWTH IN PC12 CELLS , pp.139-139 [Details]
(2009) BIOCHEMICAL SOCIETY TRANSACTIONS
Gorman, AM;Doyle, KM (2009) Considerations and recent advances in neuroscience BIOCHEMICAL SOCIETY TRANSACTIONS , pp.299-302 [DOI] [Details]
(2003) Investigation of the antagonist action of novel polyamine analogues on spermine induced CNS excitation in mice in vivo
Murphy, DH,Shaw, GG,Atkinson, J,Fixon-Owoo, S,Henman, M,Doyle, KM (2003) BRITISH JOURNAL OF PHARMACOLOGY Investigation of the antagonist action of novel polyamine analogues on spermine induced CNS excitation in mice in vivo [Details]
(2002) Protein expression in rat liver: Response to short term treatment with phenobarbital using two-dimensional gel electrophoresis
Pantasri, P,Rapley, R,Hoffman, R,Walker, JM,Lord, PG,Skehel, MJ,Kramer, K,Doyle, KM (2002) BRITISH JOURNAL OF PHARMACOLOGY Protein expression in rat liver: Response to short term treatment with phenobarbital using two-dimensional gel electrophoresis [Details]
(2001) The effect of the co-administration of eliprodil with memantine in naive and reserpinised mice
Devadasan, C,Starr, BS,Doyle, KM (2001) BRITISH JOURNAL OF PHARMACOLOGY The effect of the co-administration of eliprodil with memantine in naive and reserpinised mice [Details]
(2017) 28th International Symposium on Cerebral Blood Flow, Metabolism & Function
Shearer, J; Douglas, A; Pandit, A; Doyle, KM (2017) Effect of mechanical reperfusion outcome on the expression of matrix metalloproteinase-9 in rat brain following an acute occlusive stroke 28th International Symposium on Cerebral Blood Flow, Metabolism & Function [Details]
(2016) The Physiological Society
Shearer, JA; Douglas, AS; Kirby BP; Pandit A; Doyle KM (2016) The relationship between cerebral reperfusion after an occlusive stroke and the development of haemorrhage transformation in otherwise healthy rats The Physiological Society The Physiological Society Transactions ID: 2531424, [DOI] [Details]

Other Journals

  Year Publication
(2021) 'Time is of the essence: New developments in Acute Ischaemic Stroke Treatment'
Rossi R, Douglas A, Tierney C, Doyle K (2021) 'Time is of the essence: New developments in Acute Ischaemic Stroke Treatment' Physiology News, . [Details]
(2020) 'Book Review: How to live in space by Colin Stewart'
Doyle KM (2020) 'Book Review: How to live in space by Colin Stewart' Physiology News, (117) :15-16. [DOI] [Details]
(2016) 'Physiology at NUI Galway'
M Kane, K Doyle & T Wheatley (2016) 'Physiology at NUI Galway' Physiology News, (104) :12-14. [Details]
(2016) 'Editorial'
K Doyle (2016) 'Editorial' Physiology News, (104) :5-5. [Details]

Honours and Awards

  Year Title Awarding Body
2015 Presidents Award for Teaching Excellence NUI Galway
2015 National Teaching Experts Award National Forum for the Enhancement of Teaching and Learning in Higher Education (in Ireland)

Professional Associations

  Association Function From / To
Neuroscience Ireland Full Member 2006 and Vice President 2007 - 2009 /
European Stroke Organisation Member /
World Stroke Organisation Member 29-NOV-17 /
The Physiological Society Ordinary Member 2002 /
British Neuroscience Association Full Member 1999 /

Committees

  Committee Function From / To
College of Science Research Committee Member 01-JAN-17 /
Iontas Alliance Member 01-JAN-17 /
School of Medicine Institutional Review of Research Performance committee Chair 01-JAN-12 / 31-DEC-12
School of Medicine Postgraduate Research Committee Chair 01-JAN-10 / 31-DEC-15
Neuroscience Ireland Executive Member 01-JAN-07 / 31-DEC-09
University Ethics Committee Member 01-JAN-06 / 31-DEC-09
Galway Neuroscience Centre Founder member. Group Leader (2004 - 2009) 01-JAN-04 /
Graduate Studies Board Vice Dean for Graduate Studies, College of Medicine Nursing & Health Sciences 01-JAN-11 / 31-DEC-15

Education

  Year Institution Qualification Subject
1989 University College Dublin BSc (Hons) Pharmacology
1994 Trinity College Dublin PhD Neuroscience
2016 NUI Galway Higher Diploma Academic Practice

Community Engagement

  Title Type From / To
Outreach Neuroscience at the Science Festival 01-NOV-14 / 01-JAN-18
Outreach A Tiny Spark 01-DEC-18 /
Outreach Brain Awareness Week 16-MAR-09 / 01-JAN-19

Reviews

  Journal Role
Brain Research Reviewer
Journal Of Neuroscience Research Reviewer
Scientific reports Reviewer
Journal Of Cellular And Molecular Medicine Reviewer
European Psychiatry Reviewer
Neuroscience Letters Reviewer

Other Activities

  Description

Neuroscience Ireland conference local organising committee lead organiser 2008 2017

Appointed a member of the Iontas Alliance (2017); A forum of National Awardees of Teaching Excellence in Higher Education in Ireland, for the enhancement of Teaching and Learning nationally and showcasing the Higher Education sector internationally

Teaching Interests

Neurophysiology
Central Nervous System
Advanced Neurophysiology
Scientific Writing and Communication

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2009 Edel Kavanagh PhD
2001 Carol Devadasan PhD Y
2004 Prayed Pantasri PhD
1999 Kevin Sales PhD
2004 John Loughlin Msc
2005 Jun Li PhD
2006 Desiree Murphy PhD
2012 Geraldine Lavelle Msc
2010 Andreia Moreira Da Silva Santos PhD Y
2010 Camilla Langan PhD
2014 Donna Kennedy PhD
2008 Sarath Kiran Msc Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
1/2017 Neurophysiology SI311/ SI209
1/2017 Advanced Neurophysiology SI422
1/2017 Scientific Communication SI4102
1/2017 Central Nervous System MD224

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Prof Turgut Tatlisumak University of Gothenburg SWEDEN
Stroke research
Dr John Thornton Beaumont Hospital Dublin IRELAND
Prof Istvan Szikora National Institute of Clinical Neuroscience HUNGARY
Dr Alexandros Rentzos Sahlgrenska Hospital, Gothenburg SWEDEN
Dr Simon De Meyer KU Leuven BELGIUM
Stroke Clot Research
Dr Waleed Brinjikji Mayo Clinic U.S.A.
Prof David Kallmes Mayo Clinic U.S.A.
Stroke Clot Research
Prof Brian Kirby RCSI IRELAND