Dr Michelle Roche

BSc., MSc., PhD.

Contact Details

Senior Lecturer
Physiology
Rm2002 Human Biology Building
National University of Ireland G
University Road
T: Ext. 5427
E: michelle.roche@nuigalway.ie
 
researcher
 

Biography

Dr Roche graduated in 1999 with a B.Sc. (Hons.) degree in Physiology at NUI Galway following which she undertook an M.Sc. in Neuropharmacology (1999-2001). Her interest in stress-related disorders began during her time as a research assistant in Prof Rita Valentino laboratory in Philadelphia (2001) where she examined the neural circuitry underlying stress-induced changes in the serotonergic system. She subsequently pursued a Ph.D. (2002-2005) characterizing behavioural and physiological responses in models of depression at the Department of Pharmacology, NUI Galway. Following a year as a contract lecturer, Dr Roche undertook a post-doctoral research (2005-2008) position focused on the role of the endocannabinoid system on conditioned stress-induced changes in pain responding and inflammation. In September 2008, Dr Roche was appointed Lecturer in Physiology at NUI Galway. 

Research Interests

Dr Roches research interests include

   The role of the cannabinoid system in regulating of neuroinflammation and immune function
   Neural substrates underpinning stress, depression and pain and their interaction
   Neurobiology underlying autism spectrum disorders

The Roche Lab employs a whole systems approach to addressing research questions in the aforementioned areas. A wide range of in vivo, ex vivo and in vitro methodologies are utilized to examine the role of a number of neurotransmitter systems including monoamines, endocannabinoids and neuropeptides, neuroendocrine and immune processes in physiological and behavioural responses.


Peer Reviewed Journals

  Year Publication
(2020) 'Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats'
O'Sullivan, G,Humphrey, RM,Thornton, AM,Kerr, DM,McGuire, BE,Caes, L,Roche, M (2020) 'Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats'. Behavioural Brain Research, 392 [DOI] [Details]
(2020) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'
Ferdousi MI;Calcagno P;Clarke M;Aggarwal S;Sanchez C;Smith KL;Eyerman DJ;Kelly JP;Roche M;Finn DP; (2020) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'. Pain, [DOI] [ARAN Link] [Details]
(2020) 'Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex'
Okine, BN,Mc Laughlin, G,Gaspar, JC,Harhen, B,Roche, M,Finn, DP (2020) 'Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex'. Neuroscience, 443 :19-29 [DOI] [ARAN Link] [Details]
(2020) 'Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats'
Jarrin, S,Pandit, A,Roche, M,Finn, DP (2020) 'Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats'. Frontiers In Behavioral Neuroscience, 14 [DOI] [ARAN Link] [Details]
(2020) 'Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid'
Hughes, EM,Thornton, AM,Kerr, DM,Smith, K,Sanchez, C,Kelly, JP,Finn, DP,Roche, M (2020) 'Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid'. Neuroscience, 444 :9-18 [DOI] [Details]
(2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'
Hughes EM;Calcagno P;Clarke M;Sanchez C;Smith K;Kelly JP;Finn DP;Roche M; (2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'. Brain Research, doi: 10.1016/j.brainres.2020.146675 [DOI] [Details]
(2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'
Corcoran L;Mattimoe D;Roche M;Finn DP; (2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'. British Journal Of Pharmacology, doi: 10.1111/bph.14976 [DOI] [ARAN Link] [Details]
(2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'
O'Sullivan G;McGuire B;Roche M;Caes L; (2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'. Psychology & Health, doi: 10.1080/08870446.2019.1707830 [DOI] [ARAN Link] [Details]
(2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'
Fitzgibbon, M,Kerr, DM,Henry, RJ,Finn, DP,Roche, M (2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'. Brain Behavior And Immunity, 82 :372-381 [DOI] [ARAN Link] [Details]
(2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'
Burke NN, Li Y, Deaver DR, Finn DP, Roche M, Eyerman DJ, Sanchez C, Kelly JP. (2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'. Journal Of Psychopharmacology, [Details]
(2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'
Rea, K,McGowan, F,Corcoran, L,Roche, M,Finn, DP (2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'. British Journal Of Pharmacology, 176 :1492-1505 [DOI] [ARAN Link] [Details]
(2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'
Burke, NN,Ferdousi, M,Deaver, DR,Finn, DP,Roche, M,Kelly, JP (2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'. Neuropharmacology, 146 :327-336 [DOI] [ARAN Link] [Details]
(2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'
Burke, NN,Li, Y,Deaver, DR,Finn, DP,Roche, M,Eyerman, DJ,Sanchez, C,Kelly, JP (2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'. Journal Of Psychopharmacology, [DOI] [ARAN Link] [Details]
(2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'
Flannery LE, Henry RJ, Kerr DM, Finn DP, Roche M (2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'. Journal Of Neuroscience Research, 96 (6) [DOI] [Details]
(2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'
Buckley, DA,Jennings, EM,Burke, NN,Roche, M,McInerney, V,Wren, JD,Finn, DP,McHugh, PC (2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'. Molecular Neurobiology, 55 :2420-2430 [DOI] [ARAN Link] [Details]
(2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'
Flannery, LE,Kerr, DM,Finn, DP,Roche, M (2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'. Behavioural Brain Research, 353 :11-20 [DOI] [ARAN Link] [Details]
(2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'
Liu, M,Fitzgibbon, M,Wang, YQ,Reilly, J,Qian, XH,O'Brien, T,Clapcote, S,Shen, SB,Roche, M (2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'. Translational Psychiatry, 8 [DOI] [ARAN Link] [Details]
(2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'
Henry, RJ,Kerr, DM,Flannery, LE,Killilea, M,Hughes, EM,Corcoran, L,Finn, DP,Roche, M (2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'. Brain Behavior And Immunity, 62 :318-331 [DOI] [ARAN Link] [Details]
(2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke, NN;Finn, DP;McGuire, BE;Roche, M (2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. J Neurosci Res, 95 (6):1257-1270 [DOI] [Details]
(2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'
Okine, BN;Gaspar, JC;Madasu, MK;Olango, WM;Harhen, B;Roche, M;Finn, DP (2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'. Brain Research, 1657 :185-192 [DOI] [ARAN Link] [Details]
(2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'
Jennings, EM,Okine, BN,Olango, WM,Roche, M,Finn, DP (2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :181-189 [DOI] [ARAN Link] [Details]
(2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'
Burke, NN,Coppinger, J,Deaver, DR,Roche, M,Finn, DP,Kelly, J (2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'. Physiology & Behavior, 167 :28-34 [DOI] [ARAN Link] [Details]
(2016) '6-iodonordihydrocapsaicin'
Roche M (2016) '6-iodonordihydrocapsaicin'. Reference Module in Biomedical Sciences, doi.org/10.1016/B978-0-12-801238-3.99373-5 [DOI] [Details]
(2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'
Dyall, SC,Mandhair, HK,Fincham, REA,Kerr, DM,Roche, M,Molina-Holgado, F (2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'. Neuropharmacology, 107 :387-395 [DOI] [ARAN Link] [Details]
(2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'
Henry, RJ,Kerr, DM,Finn, DP,Roche, M (2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :167-180 [DOI] [ARAN Link] [Details]
(2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'
Okine, BN;Madasu, MK;McGowan, F;Prendergast, C;Gaspar, JC;Harhen, B;Roche, M;Finn, DP (2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'. Pain, 157 :2687-2696 [DOI] [ARAN Link] [Details]
(2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'
Moriarty, O,Gorman, CL,McGowan, F,Ford, GK,Roche, M,Thompson, K,Dockery, P,McGuire, BE,Finn, DP (2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'. Scandinavian Journal Of Pain, 10 :61-73 [DOI] [ARAN Link] [Details]
(2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'
Bree, D,Moriarty, O,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'. Cns Neuroscience & Therapeutics, 22 :146-153 [DOI] [ARAN Link] [Details]
(2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke NN;Finn DP;McGuire BE;Roche M; (2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. Journal Of Neuroscience Research, 95 (6):1257-1270 [DOI] [ARAN Link] [Details]
(2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'
Kerr, DM; Gilmartin, A; Roche, M; (2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'. Pharmacological Research, 113 (Pt A):228-235 [DOI] [ARAN Link] [Details]
(2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'
Madasu MK;Okine BN;Olango WM;Rea K;Lenihan R;Roche M;Finn DP; (2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'. Pharmacological Research, 113 (Pt A):44-54 [DOI] [ARAN Link] [Details]
(2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'
Fitzgibbon, M; Finn, DP; Roche, M (2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'. International Journal Of Neuropsychopharmacology, 5:19 (3) [ARAN Link] [Details]
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'. International Review Of Neurobiology, 125 :203-255 [DOI] [ARAN Link] [Details]
(2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'
Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'. Research In Autism Spectrum Disorders, 10 :78-92 [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree, D,Moriarty, O,Mahony, CM,Morris, B,Bannerton, K,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, 16 :421-435 [DOI] [ARAN Link] [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree D, Moriarty O, O'Mahony CM, Morris B, Bannerton K, Broom DC, Kelly JP, Roche M, Finn DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, [Details]
(2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'
Burke, NN,Finn, DP,Roche, M (2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'. Behavioural Brain Research, 278 :193-201 [DOI] [ARAN Link] [Details]
(2014) 'Stress-induced hyperalgesia'
Jennings EM, Okine BN, Roche M, Finn DP (2014) 'Stress-induced hyperalgesia'. Progress In Neurobiology, 64 :1-18 [DOI] [Details]
(2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'
Rea, K,Olango, WM,Okine, BN,Madasu, MK,McGuire, IC,Coyle, K,Harhen, B,Roche, M,Finn, DP (2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'. Pain, 155 :69-79 [DOI] [Details]
(2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'
Olango, WM,Geranton, SM,Roche, M,Hunt, SP,Finn, DP (2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'. European Journal Of Pain, 18 :182-191 [DOI] [Details]
(2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'
Rea, K,Ford, GK,Olango, WM,Harhen, B,Roche, M,Finn, DP (2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'. European Journal Of Neuroscience, 39 :435-443 [DOI] [Details]
(2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'
Okine BN, Rea K, Olango WM, Price J, Roche M, Finn DP (2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'. British J Pharmacology, [Details]
(2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'
Burke, NN,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'. Brain Behavior And Immunity, 42 :147-156 [DOI] [ARAN Link] [Details]
(2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'
Okine, BN,Rea, K,Olango, WM,Price, J,Herdman, S,Madasu, MK,Roche, M,Finn, DP (2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'. British Journal Of Pharmacology, 171 :1462-1471 [DOI] [ARAN Link] [Details]
(2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'
Henry RJ, Kerr DM, Finn DP, Roche M (2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'. Journal Of Neuroimmunology, 276 (1-2):126-134 [DOI] [Details]
(2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'
Burke, NN,Llorente, R,Marco, EM,Tong, K,Finn, DP,Viveros, MP,Roche, M (2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'. Journal Of Pain, 14 :1173-1184 [DOI] [ARAN Link] [Details]
(2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'
Burke, NN,Geoghegan, E,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 12 :705-713 [DOI] [ARAN Link] [Details]
(2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'
Kerr, DM,Harhen, B,Okine, BN,Egan, LJ,Finn, DP,Roche, M (2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 :808-819 [DOI] [Details]
(2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'
Kerr, DM,Downey, L,Conboy, M,Finn, DP,Roche, M (2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'. Behavioural Brain Research, 249 :124-132 [DOI] [Details]
(2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'
Kerr DM, Henry R, Roche M (2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'. Anatomy and Physiology, 4 (e) [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, Kieran and Olango, Weredeselam M and Harhen, Brendan and Kerr, Daniel M and Galligan, Rachel and Fitzgerald, Sean and Moore, Maeve and Roche, Michelle and Finn, David P (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 (4):576-585 [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, K,Olango, WM,Harhen, B,Kerr, DM,Galligan, R,Fitzgerald, S,Moore, M,Roche, M,Finn, DP (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 :576-585 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [ARAN Link] [Details]
(2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'
Olango, WM,Roche, M,Ford, GK,Harhen, B,Finn, DP (2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'. British Journal Of Pharmacology, 165 :2549-2560 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr, DM;Burke, NN;Ford, GK;Connor, TJ;Harhen, B;Egan, LJ;Finn, DP;Roche, M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [DOI] [Details]
(2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'
Moriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8 [DOI] [ARAN Link] [Details]
(2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'
Butler, RK,Ford, GK,Hogan, M,Roche, M,Doyle, KM,Kelly, JP,Kendall, DA,Chapman, V,Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91 [DOI] [ARAN Link] [Details]
(2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'
Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 (0):91-98 [DOI] [ARAN Link] [Details]
(2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'
Rea, K,Roche, M,Finn, DP (2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'. Journal Of Pain, 12 :712-721 [DOI] [ARAN Link] [Details]
(2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'
Roche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals, :2517-2553 [DOI] [ARAN Link] [Details]
(2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'
Burke, NN,Hayes, E,Calpin, P,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'. Neuroscience, 171 (0):1300-1313 [DOI] [ARAN Link] [Details]
(2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'
Roche, M,Johnston, P,Mhuircheartaigh, ON,Olango, WM,Mackie, K,Finn, DP (2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'. European Journal Of Pain, 14 :487-495 [DOI] [Details]
(2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'
Smith, KL,Roche, M,Jessop, DS,Finn, DP (2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'. European Neuropsychopharmacology, 19 :371-380 [DOI] [Details]
(2009) '6-iodonordihydrocapsaicin'
Roche M, Finn DP (2009) '6-iodonordihydrocapsaicin'. Xpharm; Executive Eds: Sj Enna And Db Bylund; Publisher, Elsevier, Inc., New York, :0-0 [DOI] [ARAN Link] [Details]
(2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'
Roche M, Shanahan E, Harkin A, Kelly JP (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacological Reports, 60 (0):404-408 [DOI] [Details]
(2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'
Roche M, Kelly JP, O'Driscoll M, Finn DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 (2):263-271 [DOI] [Details]
(2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'
Roche, M., Harkin, A., Kelly, J. P. (2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'. Neuropsychopharmacology, 32 (6):1312-1320 [ARAN Link] [Details]
(2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'
Rea K, Roche M, Finn DP (2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'. British Journal Of Pharmacology, 152 (5):633-648 [DOI] [Details]
(2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'
Roche M, O’Connor E, Diskin C, Finn DP. (2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'. European Journal Of Neuroscience, 26 (9):2643-2653 [DOI] [Details]
(2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'
Roche M, Diamond M, Kelly JP, Finn DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 (1-2):57-67 [DOI] [Details]
(2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'
Zueger, A,Urani, A,Chourbaji, S,Zacher, C,Roche, M,Harkin, A,Gass, P (2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'. Neuroscience Letters, 374 :142-146 [DOI] [Details]
(2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'
Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997 [ARAN Link] [Details]

Book Chapters

  Year Publication
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran. L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress' In: International Review of Neurobiology, Endocannabinoids. US: Elsevier Inc. [ARAN Link] [Details]
(2015) 'Neuroinflammatory mechanisms linking Pain and Depression'
Burke N.N., Finn DP, Roche M (2015) 'Neuroinflammatory mechanisms linking Pain and Depression' In: Pain in Psychiatric Disorders: Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2015) 'Supraspinal TRPV1 in pain and psychiatric disorders'
Madasu M, Roche M, Finn DP (2015) 'Supraspinal TRPV1 in pain and psychiatric disorders' In: Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2011) 'The Olfactory Bulbectomised Mouse'
Roche M (2011) 'The Olfactory Bulbectomised Mouse' In: In Mood and Anxiety Related Phenotypes in Mice. USA: Humana Press. [ARAN Link] [Details]

Editorial

  Year Publication
(2020) Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults.
Caes, L,Roche, M (2020) Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults. Editorial [DOI] [Details]

Education

  Year Institution Qualification Subject
2015 National Univeristy of Ireland Galway POSTGRAD CERT OF EDUCATION Teaching and Learning
2005 National University of Ireland, Galway PhD Pharmacology
2001 National University of Ireland, Galway MASTERS OF SCIENCE Neuropharmacology
1999 National University of Ireland, Galway BACHELOR OF SCIENCE Physiology

Employment

  Employer Position From / To
National University of Ireland Galway Senior Lecturer 01-OCT-20 /
NUI Galway Lecturer in Physiology (above the bar) 01-MAY-12 / 01-OCT-20
Physiology, NUI Galway Lecturer (below the bar) 01-SEP-08 / 01-MAY-12
Pharmacology and Therapeutics, NUI Galway Post Doctoral researcher 01-SEP-05 / 01-SEP-08
Pharmacology and Therapeutics, NUI Galway Contract Lecturer 01-SEP-04 / 01-SEP-05
Children's Hospital of Philadelphia, USA Research Assistant 18-JAN-01 / 18-DEC-01

Professional Associations

  Association Function From / To
European College of Neuropsychopharmacology Scientific Advisory Panel member 01-JAN-17 / 01-JAN-20
European College of Neuropsychopharmacology Member of the scientific programme committee ECNP congress 2019 01-JUN-17 / 31-DEC-19
Neuroscience Ireland Communications Officer 01-JAN-19 /
Irish Pain Society Council Member 01-JAN-14 /
Royal Academy of Medicine in Ireland, Biomedical Sciences Section Council Member 01-JUL-11 /
Irish Pain Research Network Council member 26-SEP-15 /

Committees

  Committee Function From / To
Centre for Pain Research, NUI Galway Co-Director 01-DEC-20 /
Galway Neuroscience Centre Deputy Director 01-JAN-21 /
School of Medicine Athena Swan Committee Chair of Career Development Group 01-JAN-20 /
College of Medicine, Nursing and Health Science Graduate Studies Committee member 14-JAN-16 / 15-JAN-17
College of Science Research Committee Committee Member 01-SEP-11 / 02-MAR-15
College of Science Teaching and Learning Committee member 01-SEP-09 / 01-SEP-10
Galway Neuroscience Centre Secretary and Executive Council member 01-SEP-08 /
Graduate Research Committee (GRC) GRC member for 6 PhD students 01-JAN-09 /

Community Engagement

  Title Type From / To
Outreach Involved in NUI Galway undergraduate and postgraduate open days, providing information regarding studying Physiology, Science and Biomedical Science /
Outreach Public outreach at Brain Awareness Week and Science Festival /
Outreach Representing Neuroscience research interests at NUI Galway to delegations from pharmaceutical and biomedical companies /

Teaching Interests

I currently supervise a team of 1 Post doctoral researcher, 5 PhD students (2 as primary supervisor), and an MSc research student.  To date, I have successfully supervised 17 PhD and 3 MSc research student to completion.

I am the overall year coordinator for 3rd year Physiology (B.Sc. and B.Sc. Biomedical Science).

Module coordinator for Neurophysiology (SI311); Endocrinology (SI312/SI3102); Advanced Neurophysiology (SI422)

I use a multitude of teaching methodologies and formats from lectures and seminars, practicals and lab based projects, small group teaching, flipped classroom teaching, poster and oral presentations and case studies in my teaching.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2020 Aoife Thornton PhD Y
2019 Emer Power PhD
2020 Sarah Jarrin PhD
2020 Mehnaz Ferdousi PhD
2020 Kelly McHugh PhD
2019 James Prendergast Msc
2020 Grace O'Sullivan PhD
2020 Patricia Calcagno
2020 Edel Hughes PhD Y
2019 Jessica Gaspar PhD
2019 Darragh Mattimoe Msc
2018 Louise Corcoran PhD
2018 MaryKate Killilea PhD
2017 Lisa Flannery PhD Y
2016 Manish Kumar Madasu
2015 Elaine Jennings PhD N
2015 Rebecca Henry PhD Y
2015 Marie Fitzgibbon PhD Y
2015 Fiona Mc Gowan N
2014 Dara Bree  PhD Y
2014 Daniel Kerr PhD Y
2013 Nikita Burke PhD Y
2011 Werede Olango PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Rachel Humphrey Doctorate - Structured Ph.D (Medicine) Supervisor
Grace O Sullivan Doctorate - Structured PhD in Psychology & Health Co-supervisor (1)
Brendan Harhen Doctorate - Ph.D. Co-supervisor (1)
Aoife Thornton Doctorate - Structured Ph.D (Medicine) Supervisor

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2009-present Biological Sciences III NU306 Lectures on physiology of the endocrine and central nervous systems - 3rd yr Nursing students
2008-present The Cenrtral Nervous System MD224 Physiological functions of the brain and spinal cord - 2nd year medical students
2015-present Case-based Physiology SI4101 Integrative case-studies on pathophysiological conditions - 4th year Physiology Science students
2015-present Pathophysiology SI432 Lecture series on pathophysiology of CNS disorders - 4th yr Physiology Science students
2008-present Research Project SI435 Supervise final year BSc and Biomedical science research projects - 4th yr Physiology Science students
2008-present Endocrinology SI312/SI3102 Physiological functions of hormones - 3rd year Science students and 2nd year podiatry students
2008-present Advanced Neurophysiology SI422 Pathophysiology underlying neurological, psychiatric and neurodegenerative disorders
2008-present Neurophysiology SI311/SI209 Understanding the physiologial action of neurons, glia and the physiological processes underlying movement, sensation, hearing, vision, emotion, speech and language - 3rd year Sceince students and 2nd year Speech and Language & ocupational Therapty students
2009-2015 Advanced Research Methods SI442