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Engineering & Informatics

Dr Manus Biggs

Ph.D

Contact Details

Lecturer In Biomedical Engineering
Network of Excellence for Functional Biomaterials (NFB)
Bioscience Research Building
Newcastle Road
Dangan

 
researcher

Biography

Peer Reviewed Journals

  Year Publication
(2015) 'Sensing the Difference: The Influence of Anisotropic Surfaces on Cell Behavior'
Ballester-Beltrán J, Biggs M, Dalby MJ, Salmeron-Sanchez M, and Leal-Egaña A. (2015) 'Sensing the Difference: The Influence of Anisotropic Surfaces on Cell Behavior'. Frontiers In Bioscience, 2 (39) [DOI] [Details]
(2015) 'An academic, clinical and industrial update on electro-spun, additive manufactured and imprinted medical devices'
Ryan CNM, Fuller KP, Larrañaga A, Biggs M, Bayon Y, Sarasua JR, Pandit A, Zeugolis D. (2015) 'An academic, clinical and industrial update on electro-spun, additive manufactured and imprinted medical devices'. Expert Review Of Medical Devices, [Details]
(2015) 'Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis'
English A, Azeem A, Biggs M, Jones E, Tripathi B, Basu N, Rooney N, Riley G, O'Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis DI, (2015) 'Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis'. Acta Biomaterialia, [Details]
(2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'
Azeem, A,English, A,Kumar, P,Satyam, A,Biggs, M,Jones, E,Tripathi, B,Basu, N,Henkel, J,Vaquette, C,Rooney, N,Riley, G,O'Riordan, A,Cross, G,Ivanovski, S,Hutmacher, D,Pandit, A,Zeugolis, D (2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'. Nanomedicine, 10 :693-711 [DOI] [Details]
(2015) 'Nanoscale neuroelectrode modification through self-assembly of block copolymers'
Mokarian-Tabari P, Vallejo-Giraldo C, Fernandez-Yague M, Cummins C, Morris MA, Biggs M.J. (2015) 'Nanoscale neuroelectrode modification through self-assembly of block copolymers'. Journal Of Materials Science: Materials In Medicine, 26 (120):1-5 [Details]
(2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'
Azeem A, English E, Biggs M, Jones E, Tripathi B, Henkel J, Vaquette C, Rooney N, Riley G, O’Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis D (2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'. Nanomedicine (London, England), 10 (5):693-711 [Details]
(2015) 'Special Focus on Nanoscale Regeneration'
Dalby MJ, Biggs MJ (2015) 'Special Focus on Nanoscale Regeneration'. Nanomedicine (London, England), 10 (5):677-680 [Details]
(2014) 'Biofunctionalisation of electrically conducting polymers'
Vallejo-Giraldo C, Kelly A, Biggs MJ (2014) 'Biofunctionalisation of electrically conducting polymers'. Drug Discovery Today, [Details]
(2014) 'Osteogenic Lineage Restriction by Osteoprogenitors Cultured on Nanometric Grooved Surfaces – the Role of Focal Adhesion Maturation'
Cassidy JW, Roberts JN, Smith C, Robertson M, White K, Biggs MJ, Oreffo RO, Dalby MJ (2014) 'Osteogenic Lineage Restriction by Osteoprogenitors Cultured on Nanometric Grooved Surfaces – the Role of Focal Adhesion Maturation'. Acta Biomateriala, [Details]
(2014) 'Cellular response to ferroelectric PVDF-TrFE surfaces of varying polymer concentration'
Biggs MJ, Parisi-Capdevila E, Valejo-Giraldo C, Wind SJ (2014) 'Cellular response to ferroelectric PVDF-TrFE surfaces of varying polymer concentration'. Journal Of Biomedical Nanotechnology, [Details]
(2014) 'Biomimetic Approaches in Bone Tissue Engineering: Integrating Biological and Physicomechanical Strategies'
Fernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A, * Biggs MJ (2014) 'Biomimetic Approaches in Bone Tissue Engineering: Integrating Biological and Physicomechanical Strategies'. Advanced Drug Delivery Reviews, [DOI] [Details]
(2014) 'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine'
Lobo J, See E, Biggs MJ, Pandit A. (2014) 'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine'. Journal Of Tissue Engineering And Regenerative Medicine, [DOI] [Details]
(2014) 'The past, present and future in scaffold-based tendon treatments'
Lomas, A. J. Ryan, C. N. Sorushanova, A. Shologu, N. Sideri, A. I. Tsioli, V. Fthenakis, G. C. Tzora, A. Skoufos, I. Quinlan, L. R. O'Laighin, G. Mullen, A. M. Kelly, J. L. Kearns, S. Biggs, M. Pandit, A. Zeugolis, D. I. (2014) 'The past, present and future in scaffold-based tendon treatments'. Advanced Drug Delivery Reviews, [Details]
(2014) 'Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs'
Chao J, Biggs MJ, Pandit A. (2014) 'Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs'. Expert Opinion On Drug Delivery, 11 (11):1687-1695 [Details]
(2012) 'The role of microtopography in cellular mechanotransduction'
McNamara LE, Burchmore R, Riehle MO, Herzyk P, Tsimbouri PM, Biggs MJP, Wilkinson CDW, Curtis ASG, Dalby MJ. (2012) 'The role of microtopography in cellular mechanotransduction'. Biomaterials, [Details]
(2011) 'High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’'
Biggs MJ, Gondarenko A, Milone MC, Santos L, Wind SJ (2011) 'High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’'. Journal Of The Royal Society Interface, [Details]
(2010) 'Focal adhesions in osteoneogenesis'
Biggs MJ, Dalby MJ (2010) 'Focal adhesions in osteoneogenesis'. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, [Details]
(2010) 'Nanotopographical modification: a regulator of cellular function through focal adhesions'
Biggs MJ, Dalby MJ. (2010) 'Nanotopographical modification: a regulator of cellular function through focal adhesions'. Nanomedicine: Nanotechnology, Biology, And Medicine, [Details]
(2010) 'Nanotopographical control of stem cell differentiation'
McNamara L, McMurray RJ, Biggs MJ, Kantawong F, Oreffo ROC, Dalby MJ (2010) 'Nanotopographical control of stem cell differentiation'. Tissue Engineering, [Details]
(2009) 'The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells'
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo RO, Dalby MJ. (2009) 'The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells'. Biomaterials, [Details]
(2009) 'Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage'
Biggs MJ, Richards RG, Gadegaard N, McMurray RJ, Affrossman S, Wilkinson CD, Oreffo RO, Dalby MJ. (2009) 'Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage'. J. Biomedical Materials Research- Part A, [Details]
(2008) 'Focal adhesion interactions with nanostructures: A novel method for immuno-SEM labelling of focal adhesions in S-phase cells'
Biggs MJ, Richards RG, Wilkinson CD, Dalby MJ. (2008) 'Focal adhesion interactions with nanostructures: A novel method for immuno-SEM labelling of focal adhesions in S-phase cells'. Journal Of Microscopy-Oxford, [Details]
(2008) 'Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves'
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo ROC, Affrossman S, Dalby MJ. (2008) 'Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves'. Journal Of The Royal Society Interface, [Details]
(2007) 'The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading'
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ (2007) 'The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading'. Journal Of Material Science: Materials In Medicine, [Details]
(2006) 'Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning'
Dalby MJ, Biggs MJ, Gadegaard N, Kalna G, Wilkinson CD, Curtis AS (2006) 'Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning'. Journal Of Cellular Biochemistry, [Details]
(2006) 'Regulation of implant surface cell adhesion: characterization and quantification of S-phase primary osteoblast adhesions on biomimetic nanoscale substrates'
Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ (2006) 'Regulation of implant surface cell adhesion: characterization and quantification of S-phase primary osteoblast adhesions on biomimetic nanoscale substrates'. Journal Of Orthopaedic Research, [Details]

Book Chapters

  Year Publication
(2015) 'On the use of stereology in tissue scaffolds'
Dockery, P & Biggs, M. (2015) 'On the use of stereology in tissue scaffolds' In: Characterisation and design of Tissue Scaffolds. UK: Wiley. [Details]
(2015) 'in Tendon regeneration: Understanding tissue physiology and development to engineer functional substitutes'
Lomas, A., English, A., Biggs, M., Pandit, A., Zeugolis, D.I. (2015) 'in Tendon regeneration: Understanding tissue physiology and development to engineer functional substitutes' In: Engineering anisotropic 2D and 3D structures for tendon repair and regeneration. UK: Elsevier Science. [Details]
(2013) 'The Modulation of Skeletal Stem Cell Function Through Nanoscale Topography'
Biggs MJ, McNamara L. (2013) 'The Modulation of Skeletal Stem Cell Function Through Nanoscale Topography' In: Stem Cells & Bone Tissue. Boca Raton, FL: CRC Press. [Details]
(2012) 'Cellular response to nanoscale features'
Biggs MJ, Dalby MJ, Wind SJ (2012) 'Cellular response to nanoscale features' In: The Nanobiotechnology Handbook. Boca Raton, FL: CRC Press. [Details]
(2011) 'Using immuno-scanning electron microscopy for simultaneous observation of cell adhesion interaction at the nano/microscale in S-phase cells'
Biggs MJ, Richards RG, Dalby (2011) 'Using immuno-scanning electron microscopy for simultaneous observation of cell adhesion interaction at the nano/microscale in S-phase cells' In: Methods in Molecular Biology 3D Cell Culture. New York, NY 10013-1578: Humana Press. [Details]

Conference Publications

  Year Publication
(2014) TISSUE ENGINEERING AND REGENERATIVE MEDICINE
MJP Biggs, C Vallejo-giraldo, A Pandit (2014) Morphological modification of conducting polymers TISSUE ENGINEERING AND REGENERATIVE MEDICINE [Details]
(2012) AMERICAN SOCIETY FOR CELL BIOLOGY Meeting
LC Santos, M Biggs, S Wind, M Dustin, M Sheetz (2012) Rigidity Sensing in T cells by Actin-Dependent Phosphorylation of Src Family Kinase Substrate Cas-L AMERICAN SOCIETY FOR CELL BIOLOGY Meeting [Details]
(2007) Comparative Biochemistry and Physiology, Part A
M Biggs, M Dalby, C Wilkinson, N Gadegaard, G Richards (2007) The influence of nanoscale structures on osteoblast adhesion Comparative Biochemistry and Physiology, Part A [Details]

Conference Poster

  Year Publication
(2005) Cholecyst Derived Extracellular Matrix, a Potential Scaffold. 19th European Conference on Biomaterials.
Anilkumar, T., Biggs, M., and Pandit A (2005) Cholecyst Derived Extracellular Matrix, a Potential Scaffold. 19th European Conference on Biomaterials. Sorrento, Italy: Conference Poster [Details]