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About NUI Galway
About NUI Galway
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Medicine
Dr Declan Patrick Mc Kernan
B.Sc, Ph.D
Contact Details
Lecturer Above The Bar
Pharmacology & Therapeutics
Room 114
Experimental Medicine Building
NUI Galway
T: Ext. 3826
E: declan.mckernan@nuigalway.ie
Pharmacology & Therapeutics
Room 114
Experimental Medicine Building
NUI Galway
T: Ext. 3826
E: declan.mckernan@nuigalway.ie
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W: Google Scholar: https://scholar.google.com/citations?user=t7qrtgEAAAAJ&hl=en
Biography
Research Interests
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2017) | 'Time-course of striatal Toll-like receptor expression in neurotoxic, environmental and inflammatory rat models of Parkinson's disease'
McCabe K, Concannon RM, McKernan DP, Dowd E (2017) 'Time-course of striatal Toll-like receptor expression in neurotoxic, environmental and inflammatory rat models of Parkinson's disease'. Journal Of Neuroimmunology, 310 :103-106 [DOI] [Details] |
|
| (2016) | 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague-Dawley rats'
Buckley, MM,O'Brien, R,Devlin, M,Creed, AA,Rae, MG,Hyland, NP,Quigley, EMM,McKernan, DP,O'Malley, D (2016) 'Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in Sprague-Dawley rats'. Experimental Physiology, 101 :1477-1491 [DOI] [Details] |
|
| (2017) | 'Understanding the regulation of pattern recognition receptors in inflammatory diseases - a 'Nod' in the right direction'
Feerick CL;McKernan DP; (2017) 'Understanding the regulation of pattern recognition receptors in inflammatory diseases - a 'Nod' in the right direction'. Immunology, 150 (3):237-247 [DOI] [Details] |
|
| (2016) | 'Leptin modifies the pro-secretory and pro-kinetic effects of the inflammatory cytokine, interleukin-6 on colonic function in Sprague Dawley rats'
Buckley MM;O'Brien R;Devlin M;Creed AA;Rae MG;Hyland NP;Quigley EM;McKernan DP;O'Malley D; (2016) 'Leptin modifies the pro-secretory and pro-kinetic effects of the inflammatory cytokine, interleukin-6 on colonic function in Sprague Dawley rats'. Experimental Physiology, 101 (12):1477-1491 [DOI] [Details] |
|
| (2016) | 'Epigenetics and innate immunity: The 'unTolld' story'
Hennessy C & McKernan DP (2016) 'Epigenetics and innate immunity: The 'unTolld' story'. Immunology and Cell Biology, 94 (7):631-639 [DOI] [Details] |
|
| (2015) | 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'
O'Malley, D,Buckley, MM,McKernan, DP,Quigley, EMM,Cryan, JF,Dinan, TG (2015) 'Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons'. Brain Behavior And Immunity, 44 :57-67 [DOI] [Details] |
|
| (2015) | 'The intestinal epithelial cell cycle: uncovering its 'cryptic' nature'
McKernan DP, Egan LJ. (2015) 'The intestinal epithelial cell cycle: uncovering its 'cryptic' nature'. Current Opinion In Gastroenterology, 31 (2):124-129 [DOI] [Details] |
|
| (2014) | 'Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis'
Bashashati, M,Rezaei, N,Shafieyoun, A,McKernan, DP,Chang, L,Ohman, L,Quigley, EM,Schmulson, M,Sharkey, KA,Simren, M (2014) 'Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis'. Neurogastroenterology and Motility, 26 :1036-1048 [DOI] [Details] |
|
| (2013) | 'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'
O' Mahony SM, Clarke G, McKernan DP, Bravo JA, Dinan TG, Cryan JF. (2013) 'Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain'. Behavioural Brain Research, [DOI] [Details] |
|
| (2013) | 'An apPEAling new therapeutic for ulcerative colitis?'
McKernan, D.P. & Finn D.P. (2013) 'An apPEAling new therapeutic for ulcerative colitis?'. Gut, [DOI] [Details] |
|
| (2012) | 'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'
Dennison, U,McKernan, D,Cryan, J,Dinan, T (2012) 'Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype'. Psychological Medicine, 42 :1865-1871 [DOI] [Details] |
|
| (2012) | 'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'
Clarke G, McKernan DP, Gaszner G, Quigley EM, Cryan JF, Dinan TG. (2012) 'A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome'. Frontiers in Pharmacology, 3 [DOI] [Details] |
|
| (2012) | 'Menstrual Cycle Influences Toll-Like Receptor Responses'
Dennison U, McKernan DP, Scully P, Clarke G, Cryan JF, Dinan TG (2012) 'Menstrual Cycle Influences Toll-Like Receptor Responses'. Neuroimmunomodulation, 19 :171-179 [DOI] [Details] |
|
| (2011) | 'Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma'
Guerin, MB,Donovan, M,McKernan, DP,O'Brien, CJ,Cotter, TG (2011) 'Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma'. Clinical And Experimental Ophthalmology, 39 :243-251 [DOI] [Details] |
|
| (2011) | 'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'
McKernan, DP,Gaszner, G,Quigley, EM,Cryan, JF,Dinan, TG (2011) 'Altered peripheral toll-like receptor responses in the irritable bowel syndrome'. Alimentary Pharmacology & Therapeutics, 33 :1045-1052 [DOI] [Details] |
|
| (2011) | 'Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype'
McKernan DP, Dennison U, Gaszner G, Cryan JF, Dinan, TG (2011) 'Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype'. Translational Psychiatry, 1 [DOI] [Details] |
|
| (2010) | 'Plasma cytokine profiles in females with Irritable Bowel Syndrome and extra-intestinal co-morbidity'
Scully P, McKernan DP, Keohane J, Groeger D, Shanahan F, Dinan TG & Quigley EMM (2010) 'Plasma cytokine profiles in females with Irritable Bowel Syndrome and extra-intestinal co-morbidity'. American Journal Of Gastroenterology, [Details] |
|
| (2010) | 'The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat'
McKernan DP, Fitzgerald P, Dinan TG & Cryan JF (2010) 'The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat'. Neurogastroenterology and Motility, [Details] |
|
| (2009) | 'Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome'
McKernan DP, Nolan A, Brint EK, O'Mahony SM, Hyland NP, Cryan JF, Dinan TG. (2009) 'Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome'. Plos One, 4 (12) [Details] |
|
| (2009) | '“Killing the Blues”: A role for cellular suicide in depression and the antidepressant response'
McKernan DP, Dinan TG & Cryan JF (2009) '“Killing the Blues”: A role for cellular suicide in depression and the antidepressant response'. Progress In Neurobiology, [Details] |
|
| (2007) | 'A Critical role for Bim in retinal ganglion cell death'
McKernan, DP,Cotter, TG (2007) 'A Critical role for Bim in retinal ganglion cell death'. Journal Of Neurochemistry, 102 :922-930 [DOI] [Details] |
|
| (2007) | 'A key role for calpains in retinal ganglion cell death'
McKernan DP, Guerin MB, O’Brien CJ, Cotter TG (2007) 'A key role for calpains in retinal ganglion cell death'. Investigative Ophthalmology & Visual Science, [Details] |
|
| (2006) | 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'
McKernan DP, Caplis C, Donovan M, O'Brien CJ, Cotter TG. (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology & Visual Science, [Details] |
|
| (2006) | 'Retinal Ganglion Cells: Dying to survive'
Guerin MB, McKernan DP, O’Brien CJ, Cotter TG (2006) 'Retinal Ganglion Cells: Dying to survive'. International Journal Of Developmental Biology, [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2017) | 'eLS'
O'Connell, S & McKernan D.P. (2017) 'eLS' In: Toll-like receptors. Chichester: John Wiley & Sons, Ltd. [DOI] [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2014) | Pharmacology 2014
Clarke, M., Hennessy, C., McKernan, D.P. (2014) Investigation of the Role of DNA Methylation in Regulating Toll-Like Receptor Activity Pharmacology 2014 [Details] |
|
| (2014) | Pharmacology 2014
Hennessy, C., McKernan, D.P. (2014) Histone Deacetylase Complex Inhibitors and DNA Methylation Alters Toll Like Receptor 3 Expression In an Intestinal Epithelial Cell Line Pharmacology 2014 [Details] |
|
| (2013) | British Pharmacological Society
Lynskey, T., O'Connell, S. & McKernan, D.P. (2013) Pharmacological Inhibition of DNA Methyltransferases alters Toll-Like Receptor Expression British Pharmacological Society [Details] |
|
| (2013) | British Pharmacological Society
O'Connell, S. & McKernan, D.P. (2013) The Role of DNA Methylation in Toll-Like Receptor 3 Expression British Pharmacological Society [Details] |
|
| (2013) | British Pharmacological Society
Feerick, C.L. O'Connell, S. & McKernan D.P. (2013) The Role of DNA Methyltransferase Inhibitors in the Regulation of NOD-like Receptor Expression and Activity in Monocytes British Pharmacological Society [Details] |
|
| (2012) | British Pharmacological Society
O'Leime C, McKernan DP (2012) Alteration of Toll-like receptor expression in a monocytic cell line following glucocorticoid treatment in two different cell culture conditions British Pharmacological Society [Details] |
|
| (2011) | Digestive Disease Week
Clarke G, McKernan DP, Gaszner G,. Quigley EMM, Cryan JF, Dinan TG (2011) Increased Kynurenine Production Following Toll-Like Receptor (TLR) Activation: A Novel Role for TIr8 in Irritable Bowel Syndrome (IBS) Digestive Disease Week [Details] |
|
| (2010) | Neuroscience Ireland
McKernan DP, Dennison, U, Cryan JF, Dinan TG (2010) Altered Toll-like receptor signalling in Schizophrenia and Bipolar Disorder patients Neuroscience Ireland [Details] |
|
| (2010) | Digestive Disease Week
McKernan, D. (2010) Enhanced release of specific TLR-agonist mediated pro-inflammatory cytokines in irritable bowel syndrome (IBS) Digestive Disease Week [Details] |
|
| (2010) | Psychoneuroimmunology Research Society
McKernan DP, Gaszner G, Quigley EMM, Cryan JF, Dinan TG (2010) Enhanced immune activation in adulthood following childhood trauma: A role for Toll-like receptors Psychoneuroimmunology Research Society [Details] |
|
| (2009) | Digestive Disease Week
McKernan DP, Nolan A, Brink EK, O’Mahony SM, Hyland NP, Cryan JF & Dinan TG (2009) Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models of chronic stress - Relevance to Irritable Bowel Syndrome Digestive Disease Week [Details] |
|
| (2009) | Neuroscience Ireland
McKernan DP, Fitzgerald P, Dinan TG & Cryan JF (2009) The Probiotic Bifidobacterium infantis 35624 Reduces Visceral Hypersensitivity in the rat Neuroscience Ireland [Details] |
|
| (2008) | International Symposium on Neuroimmunology
McKernan DP, O’Connor RM, Browne CA, Dinan TG, Cryan JF (2008) Genetic Influences on Hippocampal Susceptibility to Cell Death Following Immune Activation International Symposium on Neuroimmunology [Details] |
|
| (2008) | Society for Neuroscience
McKernan DP, O’Connor RM, Browne CA, Dinan TG, Cryan JF (2008) Genetic Influences on hippocampal susceptibility to cell death Society for Neuroscience [Details] |
|
| (2008) | Neuroscience Ireland
McKernan DP, O’Connor RM, Browne CA, Dinan TG, Cryan JF (2008) Genetic Influences on Hippocampal Susceptibility to Cell Death Following Immune Activation Neuroscience Ireland [Details] |
|
| (2007) | Keystone Symposia on Cell Death
McKernan, D. (2007) A critical role for Bim in retinal ganglion cell death Keystone Symposia on Cell Death [Details] |
|
| (2006) | Neuroscience Ireland
McKernan DP & Cotter TG (2006) A critical role for Bim in retinal ganglion cell death Neuroscience Ireland [Details] |
|
| (2006) | Association for Researcg in Vision and Ophtalmology
McKernan DP, Caplis C, Donovan M, O'Brien CJ, Cotter TG. (2006) Age-dependent susceptibility of retinal ganglion cells to cell death Association for Researcg in Vision and Ophtalmology [Details] |
|
| (2005) | Association for Research in Vision & Ophthalmology
McKernan, D. (2005) Differential susceptibility of retinal ganglion cells to apoptosis in development and degeneration using in vitro explant cultures Association for Research in Vision & Ophthalmology [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2016) | NOD-Like Receptor Expression in Intestinal Epithelial and Monocytic Cell Lines can be Altered by DNA Methylation.
Feerick, CL,McKernan, DP (2016) NOD-Like Receptor Expression in Intestinal Epithelial and Monocytic Cell Lines can be Altered by DNA Methylation. Abstract [Details] |
|
| (2016) | The Role of DNA Methylation in Toll-Like Receptor 3 Expression.
O'Connell, S,McKernan, DP (2016) The Role of DNA Methylation in Toll-Like Receptor 3 Expression. Abstract [Details] |
|
| (2015) | The Role of Calpains in Apoptosis of a Rat Retinal Ganglion Cells: Implications for Glaucoma.
Guerin, M,McKernan, D,Donovan, M,O'Brien, C,Cotter, TG (2015) The Role of Calpains in Apoptosis of a Rat Retinal Ganglion Cells: Implications for Glaucoma. Abstract [Details] |
|
| (2011) | ALTERED TOLL-LIKE RECEPTOR RESPONSES IN SCHIZOPHRENIA AND BIPOLAR DISORDER PATIENTS.
McKernan, DP,Dennison, U,Cryan, JF,Dinan, TG (2011) ALTERED TOLL-LIKE RECEPTOR RESPONSES IN SCHIZOPHRENIA AND BIPOLAR DISORDER PATIENTS. Abstract [Details] |
Editorial
| Year | Publication | |
|---|---|---|
| (2014) | An apPEAling new therapeutic for ulcerative colitis?.
McKernan, DP,Finn, DP (2014) An apPEAling new therapeutic for ulcerative colitis?. Editorial [DOI] [Details] |
Meeting
| Year | Publication | |
|---|---|---|
| (2010) | BIFIDOBACTERIUM INFANTIS 35624 REDUCES VISCERAL HYPERACTIVITY IN A RAT MODEL OF CHRONIC STRESS.
McKernan, DP,Bongiovanni, C,Fitzgerald, P,Dinan, TG,Cryan, JF (2010) BIFIDOBACTERIUM INFANTIS 35624 REDUCES VISCERAL HYPERACTIVITY IN A RAT MODEL OF CHRONIC STRESS. Meeting [Details] |
|
| (2010) | Animal models of co-morbid depression and irritable bowel syndrome.
Cryan, J,Bravo, JA,Clarke, G,Hyland, NP,O'Malley, D,O'Mahony, D,Julio-Pieper, M,McKernan, DP,Tramullas, M,Dinan, TG (2010) Animal models of co-morbid depression and irritable bowel syndrome. Meeting [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2015) | The intestinal epithelial cell cycle: uncovering its 'cryptic' nature.
McKernan, DP,Egan, LJ (2015) The intestinal epithelial cell cycle: uncovering its 'cryptic' nature. Reviews [DOI] [Details] |
|
| (2009) | Killing the Blues: A role for cellular suicide (apoptosis) in depression and the antidepressant response?.
McKernan, DP,Dinan, TG,Cryan, JF (2009) Killing the Blues: A role for cellular suicide (apoptosis) in depression and the antidepressant response?. Reviews [DOI] [Details] |
|
| (2006) | Retinal ganglion cells: dying to survive.
Guerin, MB,McKernan, DP,O'Brien, CJ,Cotter, TG (2006) Retinal ganglion cells: dying to survive. Reviews [DOI] [Details] |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| American Society for Pharmacology and Experimental Therapeutics | Member | / | |
| British Pharmacological Society | Member | / | |
| Neuroscience Ireland | Member | / | |
| Irish Society of Toxicology | Member | / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| University Exam Security Group | Member | 01-MAY-17 / | |
| School of Medicine Research | Member | 01-FEB-17 / | |
| Food Safety Authority of Ireland Chemical Safety | Member | 01-NOV-16 / | |
| BSc Biomedical Science Programme Board | Member | 01-MAY-14 / | |
| College of Science Internationalization | Committe member | 02-SEP-13 / |
Community Engagement
| Title | Type | From / To | |
|---|---|---|---|
| Outreach | Science Week Festival | 01-MAR-14 / | |
| Outreach | Brain Awareness Week | 01-NOV-14 / |
Reviews
| Journal | Role | |
|---|---|---|
| Alimentary Pharmacology & Therapeutics | Reviewer | |
| Gut | Reviewer | |
| Brain Research | Reviewer | |
| British Journal Of Pharmacology | Reviewer | |
| Journal Of Affective Disorders | Reviewer | |
| Journal of Neuroinflammation | Reviewer | |
| Journal Of Digestive Diseases | Reviewer | |
| Neuropharmacology | Reviewer | |
| Nutritional Neuroscience | Reviewer | |
| Psychoneuroendocrinology | Reviewer | |
| Scientific Reports | Reviewer | |
| Toxicology and applied pharmacology | Reviewer | |
| World Journal Of Gastroenterology | Reviewer |
Teaching Interests
Recent Postgraduate Students
| Graduation | Name | Degree | Primary Supervisor | |
|---|---|---|---|---|
| 2014 | Ms. Sarah O'Connell | Msc | Y |
Current Postgraduate Students (Research)
| Student | Degree Type | Type | |
|---|---|---|---|
| Conor Hennessy | Doctorate - Structured PhD (Science) | Supervisor | |
| Kiah Mc Cabe | Doctorate - Structured Ph.D (Medicine) | Co-supervisor (1) | |
| Claire Feerick | Doctorate - Structured Ph.D (Medicine) | Supervisor | |
| Laura Olsen | Doctorate - Structured Ph.D (Medicine) | Supervisor |
Modules Taught
| Term/Year | Module Title | Module Code | Subject / Desc | |
|---|---|---|---|---|
| 1 | Introduction to Pharmacology | MD214 | ||
| 1 | Applied Concepts in Pharmacology | PM209 | ||
| 1 | Introduction to Toxicology | PM311 | ||
| 1 | Experimental Methods in Pharmacology | PM5102 | ||
| 2 | Molecular Pharmacology & Signalling | PM210 | ||
| 2 | Drugs & Disease | PM310 | ||
| 2 | Applied Pharmacology | PM312 | ||
| 2 | Advanced Technologies for Therapeutics | PM435 | ||
| 2 | Advanced Toxicology | PM436 | ||
| 2 | Experimental Neuropharmacology | PM5103 | ||
| 2 | Current Topics in Neuropharmacology | PM5104 | ||
| 2 | Neuropharmacology & Therapeutics | PM5105 | ||
| 2 | Experimental Toxicology | PM5109 | ||
| 2 | Current Topics in Toxicology | PM5110 | ||
| 2 | Advanced Toxicology | PM5111 |
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