Dr Eilís Dowd

B.Sc, Ph.D

Contact Details

Senior Lecturer
Dept of Pharmacology
NUI, Galway.

T: Ext. 2776
E: eilis.dowd@nuigalway.ie
 
researcher

Biography

Eilís Dowd was appointed as a Lecturer in Pharmacology in NUI, Galway in September 2006. Prior to that, Eilís completed six years of post-doctoral research in Cardiff University, McGill University (Montreal), and Cambridge University. Her PhD research was conducted in the Department of Pharmacology at Edinburgh University, and was awarded in 1999. 

Within the Department of Pharmacology at NUI, Galway, Eilís is currently involved in teaching pharmacology to undergraduate science and medical students, as well as post-graduate science students. 

Eilís’ current research is focused on developing and validating novel pharmacological, cell and gene therapies for Parkinson’s disease. Her current research is funded by the Irish Health Research Board, Science Foundation Ireland, the Irish Research Council, and the Irish Research Council for Science, Engineering and Technology. Some of Eilís’ previous research projects were funded by the Wellcome Trust (UK) and the Parkinson’s Disease Society (UK).

Research Interests

Parkinson’s disease is a motor disorder and the main symptoms of the disease are caused by the progressive degenerative of dopamine-containing neurons from a discrete region of the brain. Current therapy only provides relief from the symptoms of the disease - it does not offer a ’cure’, nor does it halt the unrelenting degeneration of the dopaminergic neurons.

Eilís’ research is focused on experimental approaches that offer the possibility of halting the degenerative process or even ’curing’ the disease. These include developing and validating novel neuroprotective or neuroreparative pharmacotherapies, gene therapies or cell-based therapies.
 
Current PhD Students 
2014: Ms Niamh Moriarty
2014: Ms. Laura Olsen (co-supervisor with Dr. Declan McKernan)
2013: Ms. Kiah McCabe 
2013: Ms. Juhi Samal (co-supervisor with Prof. Abhay Pandit)
2012: Ms. Ruth Concannon
2012: Ms. Carol Naughton
2011: Ms. Catalina Giraldo (co-supervisor with Dr. Manus Biggs)

Former Research Students 
2015: Dr. Deirdre Hoban
2013: Dr. Ben Newland (co-supervisor with Prof. Abhay Pandit)
2012: Dr. Pádraig Mulcahy
2011: Dr. Sinead Walsh 
2011: Ms. Rhona Hyland (MSc)
2010: Dr. Teresa Moloney 

Former Taught MSc Students 
2013: Ms. Christina Ryan 
2013: Ms. Klaudia Lipinska
2012: Mr. Brendan Gaughan
2012: Ms. Lindsay Potter
2010: Ms. Alison Smith
2010: Ms. Michelle Coughlan
2009: Ms. Marie O'Connell
2009: Mr. Niall Commins
2008: Ms. Carol Murray
2008: Ms. Lan Xie
2007: Mr. Killian Riddell 
2007: Ms. Sinead Walsh 
 
 
 

Research Projects

  Project Start Date End Date
IRC POSTGRADUATE K MCCABE E DOWD 01-OCT-13 30-SEP-17
ADULT STEM CELLS AS VECHICLES FOR DELIVERY OF NEUROTROPIC FACTORS TO THE DEGENERATING BRAIN NIAMH MORIARTY 01-OCT-14 30-SEP-18
24th ANNUAL MEETING OF NETWORK FOR CNS TRANSPLANTATION AND REPAIR NECTAR EILIS DOWD 01-JUN-14 30-NOV-15
NECTAR EILIS O DOWD 28-MAR-14 27-NOV-14
HARNESSING THE ANTI INFLAMMATORY POTENTIAL OF CANNABINOID CB2 RECEPTORS FOR DISEASE MODIFICATION IN PARKINSON DISEASE HRB HRA EILIS DOWD 01-OCT-12 30-SEP-16
IRC EMBARK CAROL NAUGHTON EILIS DOWD 01-SEP-12 31-AUG-15
MF07-P27 DEV. A ROTENONE MODEL OF PARKINSONS DISEA 14-JAN-08 13-JAN-09
IRCSET EMBARK 2007-2010 SINEAD WALSH 01-OCT-07 30-SEP-12
HARNESSING ADULT STEM CELLS FOR NEUROTROPHIN DELIVERY TO THE DEGENERATING BRAIN DR EILISH DOWD SFI RFP 11/RFP.1/NES/3183 01-SEP-11 31-AUG-16
CHARACTERISATION OF A NOVEL MODEL OF PARKINSON'S D 01-SEP-08 01-NOV-14
HEATSHOCK PROTEINS FOR PARKINSON'S DISEASE E DOWD 01-SEP-07 28-FEB-11
HRB RP 2006 221 PARKINSONS DISEASE EILIS DOWD 01-OCT-06 31-MAR-10

Peer Reviewed Journals

  Year Publication
(2016) 'Differential pattern of motor impairments in neurotoxic, environmental and inflammation-driven rat models of Parkinson's disease'
Naughton, C,Moriarty, N,Feehan, J,O'Toole, D,Dowd, E (2016) 'Differential pattern of motor impairments in neurotoxic, environmental and inflammation-driven rat models of Parkinson's disease'. Behavioural Brain Research, 296 :451-458 [DOI] [Details]
(2015) 'Differential upregulation of the cannabinoid CB2 receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease'
Concannon, RM,Okine, BN,Finn, DP,Dowd, E (2015) 'Differential upregulation of the cannabinoid CB2 receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease'. Experimental Neurology, 269 :133-141 [DOI] [Details]
(2015) 'Fibrin as a Scaffold for Delivery of GDNF Overexpressing Stem Cells to the Adult Rat Brain'
Moloney, T., Kulkarni, M., Ní Fhlathartaigh, M., Pandit, A. and Dowd, E (2015) 'Fibrin as a Scaffold for Delivery of GDNF Overexpressing Stem Cells to the Adult Rat Brain'. ACS Biomaterials Science & Engineering, 1 (7):559-566 [Details]
(2015) 'Fibrin-based microsphere reservoirs for delivery of neurotrophic factors to the brain'
Samal, J,Hoban, DB,Naughton, C,Concannon, R,Dowd, E,Pandit, A (2015) 'Fibrin-based microsphere reservoirs for delivery of neurotrophic factors to the brain'. Nanomedicine, 10 :765-783 [DOI] [Details]
(2015) 'GDNF-SECRETING MESENCHYMAL STEM CELLS PROVIDE LOCALIZED NEUROPROTECTION IN AN INFLAMMATION-DRIVEN RAT MODEL OF PARKINSON'S DISEASE'
Hoban, DB,Howard, L,Dowd, E (2015) 'GDNF-SECRETING MESENCHYMAL STEM CELLS PROVIDE LOCALIZED NEUROPROTECTION IN AN INFLAMMATION-DRIVEN RAT MODEL OF PARKINSON'S DISEASE'. Neuroscience, 303 :402-411 [DOI] [Details]
(2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'
Moloney, TC,Hyland, R,O'Toole, D,Paucard, A,Kirik, D,O'Doherty, A,Gorman, AM,Dowd, E (2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'. Cns Neuroscience & Therapeutics, 20 :50-58 [DOI] [Details]
(2014) 'Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain'
Newland, B,Aied, A,Pinoncely, AV,Zheng, Y,Zhao, T,Zhang, H,Niemeier, R,Dowd, E,Pandit, A,Wang, W (2014) 'Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain'. Nanoscale, 6 :7526-7533 [DOI] [Details]
(2014) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'
Hoban D, Newland B, Moloney T, Howard L, Pandit A, Dowd, E. (2014) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'. Biomaterials, 34 (37):9420-9429 [Details]
(2013) 'GDNF Gene Delivery via a 2-(Dimethylamino)ethyl Methacrylate Based Cyclized Knot Polymer for Neuronal Cell Applications'
Newland, B,Abu-Rub, M,Naughton, M,Zheng, Y,Pinoncely, AV,Collin, E,Dowd, E,Wang, W,Pandit, A (2013) 'GDNF Gene Delivery via a 2-(Dimethylamino)ethyl Methacrylate Based Cyclized Knot Polymer for Neuronal Cell Applications'. Acs Chemical Neuroscience, 4 :540-546 [DOI] [Details]
(2013) 'The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel'
Hoban, DB,Newland, B,Moloney, TC,Howard, L,Pandit, A,Dowd, E (2013) 'The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel'. Biomaterials, 34 :9420-9429 [DOI] [Details]
(2013) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'
Hoban, D.B.; Newland, B., Moloney, T.C., Howard, L., Pandit, A., Dowd, E. (2013) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'. Biomaterials, [Details]
(2013) 'The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats'
Mulcahy, P,O'Doherty, A,Paucard, A,O'Brien, T,Kirik, D,Dowd, E (2013) 'The behavioural and neuropathological impact of intranigral AAV-alpha-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats'. Behavioural Brain Research, 243 :6-15 [DOI] [Details]
(2013) 'Further characterisation of the LPS model of Parkinson's disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat'
Hoban, DB,Connaughton, E,Connaughton, C,Hogan, G,Thornton, C,Mulcahy, P,Moloney, TC,Dowd, E (2013) 'Further characterisation of the LPS model of Parkinson's disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat'. Brain Behavior And Immunity, 27 :91-100 [DOI] [Details]
(2013) 'The neurotoxicity of gene vectors and its amelioration by packaging with collagen hollow spheres'
Newland, B,Moloney, TC,Fontana, G,Browne, S,Abu-Rub, MT,Dowd, E,Pandit, AS (2013) 'The neurotoxicity of gene vectors and its amelioration by packaging with collagen hollow spheres'. Biomaterials, 34 :2130-2141 [DOI] [Details]
(2013) 'Biomaterial Approaches to Gene Therapies for Neurodegenerative Disorders of the CNS'
Newland, B., Dowd, E. and Pandit, A. (2013) 'Biomaterial Approaches to Gene Therapies for Neurodegenerative Disorders of the CNS'. Biomaterials, [Details]
(2012) 'Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells'
Moloney, TC,Hoban, DB,Barry, FP,Howard, L,Dowd, E (2012) 'Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells'. Protein Science, 21 :904-909 [DOI] [Details]
(2012) 'DEVELOPMENT AND CHARACTERISATION OF A NOVEL RAT MODEL OF PARKINSON'S DISEASE INDUCED BY SEQUENTIAL INTRANIGRAL ADMINISTRATION OF AAV-alpha-SYNUCLEIN AND THE PESTICIDE, ROTENONE'
Mulcahy, P,O'Doherty, A,Paucard, A,O'Brien, T,Kirik, D,Dowd, E (2012) 'DEVELOPMENT AND CHARACTERISATION OF A NOVEL RAT MODEL OF PARKINSON'S DISEASE INDUCED BY SEQUENTIAL INTRANIGRAL ADMINISTRATION OF AAV-alpha-SYNUCLEIN AND THE PESTICIDE, ROTENONE'. Neuroscience, 203 :170-179 [DOI] [Details]
(2011) 'Human Amniocytes Regulate Serotonin Levels by Active Uptake and Express Genes Suggestive of a Wider Role in Facilitating Neurotransmitter Regulation in the Fetal Environment'
Pfeiffer, S,Boyle, J,Daly, S,Dowd, E,Haase, J,McLaughlin, D (2011) 'Human Amniocytes Regulate Serotonin Levels by Active Uptake and Express Genes Suggestive of a Wider Role in Facilitating Neurotransmitter Regulation in the Fetal Environment'. Stem Cells And Development, 20 :341-349 [DOI] [Details]
(2011) 'TIME-COURSE OF NIGROSTRIATAL NEURODEGENERATION AND NEUROINFLAMMATION IN THE 6-HYDROXYDOPAMINE-INDUCED AXONAL AND TERMINAL LESION MODELS OF PARKINSON'S DISEASE IN THE RAT'
Walsh, S,Finn, DP,Dowd, E (2011) 'TIME-COURSE OF NIGROSTRIATAL NEURODEGENERATION AND NEUROINFLAMMATION IN THE 6-HYDROXYDOPAMINE-INDUCED AXONAL AND TERMINAL LESION MODELS OF PARKINSON'S DISEASE IN THE RAT'. Neuroscience, 175 :251-261 [DOI] [Details]
(2011) 'CHARACTERISATION OF A NOVEL MODEL OF Parkinson's DISEASE BY INTRA-STRIATAL INFUSION OF THE PESTICIDE ROTENONE'
Mulcahy, P,Walsh, S,Paucard, A,Rea, K,Dowd, E (2011) 'CHARACTERISATION OF A NOVEL MODEL OF Parkinson's DISEASE BY INTRA-STRIATAL INFUSION OF THE PESTICIDE ROTENONE'. Neuroscience, 181 :234-242 [DOI] [Details]
(2010) 'The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats'
Walsh, S,Gorman, AM,Finn, DP,Dowd, E (2010) 'The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats'. Brain Research, 1363 :40-48 [DOI] [Details]
(2010) 'Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'
Moloney TC, Dockery P, Windebank AJ, Barry FP, Howard L, Dowd E (2010) 'Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'. Neurorehabil Neural Repair, 24 (7):645-656 [DOI] [Details]
(2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson’s disease in the rat'
Walsh S, Mnich K, Mackie K, Gorman AM, Finn DP, Dowd E (2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson’s disease in the rat'. Brain Research Bulletin, 81 (6):543-548 [DOI] [Details]
(2010) 'Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain'
Moloney, TC,Dockery, P,Windebank, AJ,Barry, FP,Howard, L,Dowd, E (2010) 'Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain'. Neurorehabilitation And Neural Repair, 24 :645-656 [DOI] [Details]
(2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'
Mnich, K., Finn, D., Dowd, E., & Gorman, A. (2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'. International Journal Of Cell Biology, 818497 [ARAN Link] [Details]
(2010) 'Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain'
Moloney, T.C., G.E. Rooney, F.P. Barry, L. Howard, and Dowd, E., (2010) 'Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain'. Brain Research, :33-43 [Details]
(2008) 'Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease'
Torres, EM,Dowd, E,Dunnett, SB (2008) 'Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease'. Neuroscience, 154 :631-640 [DOI] [Details]
(2008) 'Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat'
Grealish, S,Xie, L,Kelly, M,Dowd, E (2008) 'Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat'. Brain Research Bulletin, 77 :312-319 [DOI] [Details]
(2007) 'Movement without dopamine: Striatal dopamine is required to maintain but not to perform learned actions'
Dowd, E., Dunnett, S.B. (2007) 'Movement without dopamine: Striatal dopamine is required to maintain but not to perform learned actions'. Biochemical Society Transactions, :428-432 [Details]
(2006) 'Further validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: Restoration of bilateral food retrieval by dopamine receptor agonism'
Fitzsimmons, DF,Moloney, TC,Dowd, E (2006) 'Further validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: Restoration of bilateral food retrieval by dopamine receptor agonism'. Behavioural Brain Research, 169 :352-355 [DOI] [Details]
(2005) 'Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model'
Dowd E, Monville C, Torres EM, Azzouz, M, Wong, LF, Mazarakis, ND & Dunnett SB. (2005) 'Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model'. European Journal Of Neuroscience, 22 :2587-2595 [Details]
(2005) 'Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility'
Eilís Dowd & Stephen B. Dunnett (2005) 'Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility'. Behavioural Brain Research, [Details]
(2005) 'Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats'
Dowd, E. & Sunnett, S.B. (2005) 'Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats'. Behavioural Brain Research, :153-161 [Details]
(2005) 'The corridor task: a simple spontaneous behavioural test sensitive to unilateral dopaminergic deafferentation and graft-derived dopamine replacement in the striatum'
Dowd E, Monville C, Torres EM & Dunnett SB. (2005) 'The corridor task: a simple spontaneous behavioural test sensitive to unilateral dopaminergic deafferentation and graft-derived dopamine replacement in the striatum'. Brain Research Bulletin, 68 :24-30 [Details]
(2004) 'Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants'
Dowd, E. & Dunnett, S.B. (2004) 'Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants'. European Journal Of Neuroscience, :1953-1959 [Details]
(2004) 'Altered mitogen-activated kinase, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the b-amyloid peptide intracellularly in hippocampal and cortical neurons'
Echeverria V, Ducatenzeiler A, Dowd E, Jänne J, Grant SM, Szyf M, Wandosell F, Avila J, Grimm H, Dunnett SB, Hartmann T, Alhonen L : Cuello AC. (2004) 'Altered mitogen-activated kinase, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the b-amyloid peptide intracellularly in hippocampal and cortical neurons'. Neuroscience, 129 (583) [Details]
(1998) 'P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint'
Dowd, E., McQueen, D.S., Chessell, I.P. & Humphrey, P.P. (1998) 'P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint'. British Journal Of Pharmacology, :341-346 [Details]
(1998) 'Adenosine A1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic rat knee joint'
Dowd, E., McQueen, D.S., Chessell, I.P. & Humphrey, P.P. (1998) 'Adenosine A1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic rat knee joint'. British Journal Of Pharmacology, :1267-1271 [Details]
(1998) 'Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats'
McQueen, D.D., Bond, S.M., Moores, C., Chessell, I., Humphrey, P.P. & Dowd, E. (1998) 'Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats'. Journal Of Physiology, :843-855 [Details]

Book Chapters

  Year Publication
(2015) 'Cannabinoids in Parkinson’s disease'
Concannon RM, Finn DP, Dowd E. (2015) 'Cannabinoids in Parkinson’s disease' In: Cannabinoids in Neurological and Mental Disease. USA: Elsevier. [Details]
(2012) 'Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?'
M.J. Lelos, E. Dowd and S.B. Dunnett (2012) 'Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?' In: Functional Neural Transplantation III. Primary and Stem Cell Transplantation for Brain Repair. S.B. Dunnett and A. Björklund (eds.) . Ireland: Elsevier. [Details]

Conference Publications

  Year Publication
(2013) Irish Journal of Medical Science
Hoban, D.B., B. Newland, T.C. Moloney, L. Howard, A. Pandit, and Dowd, E. (2013) Assessment of an injectable matrix for ex vivo neurotrophin gene therapy in the rat Irish Journal of Medical Science , pp.182: S130-S131 [Details]
(2013) Irish Journal of Medical Science
Moloney, T., R. Hyland, D. O'Toole, A. Paucard, D. Kirik, A.O. Doherty, A. Gorman, and Dowd, E. (2013) HSP70 reduces alpha-synuclein-induced neuronal pathology in the alpha-synuclein viral gene transfer rat model of Parkinson's disease Irish Journal of Medical Science , pp.182: S121-S122 [Details]
(2013) Irish Journal of Medical Science
Moloney, T., M. Kulkarni, A. Pandit, and Dowd, E., (2013) An investigation of the translatability of the topical fibrin scaffold system for neural application Irish Journal of Medical Science , pp.182: S139-S140 [Details]
(2012) Movement Disorders
Newland, B., Dowd, E., W. Wang, and A. Pandit (2012) Cyclic polymer structure shows high potential for neuronal transfection Movement Disorders , pp.27: S493-S493 [Details]
(2012) Movement Disorders
Mulcahy, P.J., A. O'Doherty, T. O'Brien, D. Kirik, and Dowd, E. (2012) Development and characterisation of a novel model of Parkinson's disease by sequential intra-nigral administration of AAV-alpha-synuclein and the pesticide, rotenone, in the rat Movement Disorders , pp.27: S491-S491 [Details]
(2012) Movement Disorders
Hoban, D., E. Connaughton, C. Connaughton, G. Hogan, C. Thornton, and Dowd, E. (2012) Modelling Parkinson's disease by direct intranigral administration of lipopolysaccaharide Movement Disorders , pp.27: S424-S424 [Details]
(2012) Movement Disorders
Newland, B., T. Moloney, P. Mulcahy, Dowd, E., and A. Pandit (2012) A biomaterials approach to modulate striatal toxicity of gene vectors: A comparative study Movement Disorders , pp.27: S148-S148 [Details]
(2012) Journal of Tissue Engineering and Regenerative Medicine
Newland, B., T. Moloney, D. Hoban, Dowd, E., and A. Pandit (2012) Self-assembled hydrogels enhance bone marrow derived-mesenchymal stem cell distribution and retention following transplantation to the intact rat striatum Journal of Tissue Engineering and Regenerative Medicine , pp.6: 272-273 [Details]
(2012) Movement Disorders
Mulcahy, P.J., A. O'Doherty, T. O'Brien, D. Kirik, and Dowd, E. (2012) Modelling Parkinson's disease by chronic systemic exposure of alpha-synuclein overexpressing rats to the pesticide, rotenone Movement Disorders , pp.27: S491-S491 [Details]
(2011) Irish Journal of Medical Science
Hyland, R., A.M. Gorman, A. O'Doherty, and Dowd, E. (2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE Irish Journal of Medical Science , pp.180: 18-19 [Details]
(2011) Irish Journal of Medical Science
Walsh S, Finn DP, Gorman AM and Dowd E. (2011) The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model Irish Journal of Medical Science , pp.180: 20-20 [Details]
(2011) Irish Journal of Medical Science
Mulcahy, P.J., A. O'Doherty, T. O'Brien, D. Kirik, and Dowd, E. (2011) SYSTEMIC ROTENONE DOES NOT ENHANCE PARKINSONIAN PATHOLOGY CAUSED BY INTRACEREBRAL alpha-SYNUCLEIN IN RATS Irish Journal of Medical Science , pp.180: 18-19 [Details]
(2010) Irish Journal of Medical Science
Mulcahy, P.J., A. Paucard, S. Walsh, and Dowd, E. (2010) INTRACEREBRAL INFUSION OF ROTENONE INTO THE STRIATUM OR SUBSTANTIA NIGRA CAUSES BEHAVIOURAL DEFICITS AND NIGROSTRIATAL DEGENERATION ASSOCIATED WITH PARKINSON'S DISEASE Irish Journal of Medical Science , pp.179: S127-S128 [Details]
(2010) Irish Journal of Medical Science
Walsh, S., K. Mnich, D.P. Finn, A.M. Gorman, K. Mackie, and Dowd, E. (2010) CANNABINOID CB1 RECEPTOR EXPRESSION IS REDUCED FOLLOWING TERMINAL LESION OF THE NIGROSTRIATAL PATHWAY IN THE RAT Irish Journal of Medical Science , pp.179: S144-S144 [Details]
(2010) Irish Journal of Medical Science
Moloney, T.C., P. Dockery, F.P. Barry, A.J. Windebank, L. Howard, and Dowd, E. (2010) MESENCHYMAL STEM CELLS FROM THE GREEN FLUORESCENT PROTEIN TRANSGENIC RAT ARE HYPOIMMUNOGENIC FOLLOWING TRANSPLANTATION TO THE INTACT ADULT RAT STRIATUM Irish Journal of Medical Science , pp.179: S127-S127 [Details]
(2002) Society for Neuroscience Abstract Viewer and Itinerary Planner
Echeverria, V., Dowd, E., L. Alhonen, K. Duff, A. Ducantenzeiler, S. Grant, M. Szyf, F. Wandossel, J. Avila, and A.C. Cuello (2002) A RAT TRANSGENIC MODEL OVER EXPRESSING INTRANEURONAL HUMAN ABETA PEPTIDE SHOWS TAU HYPERPHOSPHORYLATION AND MAPK ACTIVATION Society for Neuroscience Abstract Viewer and Itinerary Planner , pp.Abstract 522.3-Abstract 522.3 [Details]
(2002) Neurobiology of Aging
Echeverria, V., Dowd, E., A. Ducatenzeiler, S. Grant, M. Szyf, A.C. Cuello, L. Alhonen, J. Janne, A. Muro, F. Baralle, F. Wandosell, and J. Avila (2002) A rat transgenic model expressing human amyloidgenic A beta peptide intraneuronarly in the hippocampus and cortex shows up-regulation of activated MAPKs and tau phosphorylation Neurobiology of Aging , pp.23(1): S235-S235 [Details]
(2002) Society for Neuroscience Abstract Viewer and Itinerary Planner
Dowd, E., S.B. Dunnett, and A.C. Cuello (2002) POOR SPATIAL LEARNING IN TRANSGENIC RATS THAT ACCUMULATE Abeta INTRACELLULARLY IN THE HIPPOCAMPUS AND CORTEX BUT DO NOT DEVELOP EXTRACELLULAR PLAQUES Society for Neuroscience Abstract Viewer and Itinerary Planner , pp.Abstract 881.5-Abstract 881.5 [Details]
(1998) Journal of Physiology-London
Dowd, E., D.S. McQueen, I.P. Chessell, and P.P.A. Humphrey (1998) Adenosine excites nociceptive afferents of the rat knee joint via adenosine A(1) receptors Journal of Physiology-London , pp.162P-163P [Details]
(1997) British Journal of Pharmacology
Dowd, E., J. Gallar, D.S. McQueen, I.P. Chessell, P.P.A. Humphrey, and C. Belmonte (1997) Nociceptors of the cat and rat cornea are not excited by P2X purinoceptor agonists British Journal of Pharmacology , pp.U96-U96 [Details]
(1997) British Journal of Pharmacology
McQueen, D.S., C. Moores, Dowd, E., S.M. Bond, I.P. Chessell, and P.P.A. Humphrey (1997) P2X receptor activation evokes a Bezold-Jarisch-like reflex in anaesthetised rats British Journal of Pharmacology , pp.U45-U45 [Details]
(1997) British Journal of Pharmacology
J. Gallar, D.S. McQueen, I.P. Chessell, P.P.A. Humphrey, and C. Belmonte (1997) Nociceptors of the cat and rat cornea are not excited by P2X purinoceptor agonists British Journal of Pharmacology , pp.348P-348P [Details]
(1997) British Journal of Pharmacology
Dowd, E., D.S. McQueen, I.P. Chessell, and P.P.A. Humphrey (1997) Activation by P2X purinoceptor agonists of sensory nerves innervating the rat knee joint British Journal of Pharmacology , pp.286P-286P [Details]
(1997) British Journal of Pharmacology
McQueen, D.S., C. Moores, Dowd, E., S.M. Bond, I.P. Chessell, and P.P.A. Humphrey (1997) P2X receptor activation evokes a Bezold-Jarisch-like reflex in anaesthetised rats British Journal of Pharmacology , pp.246P-246P [Details]

Conference Paper

  Year Publication
(2015) Fibrin-based Hollow Microsphere Reservoirs for Controlled Delivery of Neurotrophic Factors to the Brain.
Samal, J., Moriarty, N., Hoban, D.B., Naughton, C., Concannon, R., Dowd, E. and Pandit, A. (2015) Fibrin-based Hollow Microsphere Reservoirs for Controlled Delivery of Neurotrophic Factors to the Brain. Conference Paper [Details]
(2015) Delivery of Neurotrophic Factors to the Brain using Fibrin-based Hollow Microsphere Reservoirs.
Samal, J., Hoban, D.B., Naughton, C., Concannon, R., Dowd, E. and Pandit, A. (2015) Delivery of Neurotrophic Factors to the Brain using Fibrin-based Hollow Microsphere Reservoirs. Conference Paper [Details]
(2014) Fibrin-based Microsphere Reservoirs for Delivery of Neurotrophic Factors.
Samal, J., Dowd, E. and Pandit, A. (2014) Fibrin-based Microsphere Reservoirs for Delivery of Neurotrophic Factors. Conference Paper [Details]
(2014) Fibrin-based Microsphere Reservoirs for Delivery of Neurotrophic Factors.
Samal, J., Dowd, E. and Pandit, A. (2014) Fibrin-based Microsphere Reservoirs for Delivery of Neurotrophic Factors. Conference Paper [Details]

Conference Poster

  Year Publication
(2012) An Investigation of the Translatability of the Topical Fibrin Scaffold System for Neural Application.
Moloney, T., Kulkarni, M., Pandit, A. and Dowd, E. (2012) An Investigation of the Translatability of the Topical Fibrin Scaffold System for Neural Application. Conference Poster [Details]

Reviews

  Year Publication
(2013) Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS.
Newland, B,Dowd, E,Pandit, A (2013) Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS. Reviews [DOI] [Details]
(2012) Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?.
Lelos, MJ,Dowd, E,Dunnett, SB,Dunnett, SB,Bjorklund, A (2012) Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?. Reviews [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2013 IRC Fellowship (K McCabe) Irish Research Council
2012 IRCSET Fellowship (C Naughton) Irish Council for Science, Engineering & Technology
2012 HRB Health Research Award Health Research Board
2011 SFI Research Frontiers Programme Award Science Foundation Ireland
2008 SFI Research Frontiers Programme Award Science Foundation Ireland
2007 SFI Research Frontiers Programme Award Science Foundation Ireland
2007 IRCSET Fellowship (S Walsh) Irish Council for Science, Engineering & Technology
2006 HRB Health Research Award Health Research Board
2003 PDS Project Grant Parkinson's Disease Society, UK
2000 Wellcome Trust Postdoctoral Travelling Research Fellowship Wellcome Trust

Professional Associations

  Association Function From / To
British Neuroscience Association Former member /
Parkinson's Disease Society Former member /
Neuroscience Ireland Member /
Network of European CNS Transplantation & Repair (NECTAR) Board member /
Federation of European Neurosciences (FENS) Member /