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Medicine

Dr Lieve Desbonnet

PhD

Contact Details

LECTURER BELOW THE BAR
E: lieve.desbonnet@nuigalway.ie
 
researcher
 

Biography

Lieve is currently a Lecturer in the Department of Pharmacology & therapeutics in NUI Galway, and a member of the Galway Neuroscience Centre. Before this she worked as a lecturer in Neuroscience in the University of Glasgow for 4 years. Lieve received her PhD in Neuroscience from University College Cork in 2007, after completing a BSc in Anatomy, and MSc in Neuropharmacology in NUI Galway. Following her PhD, Lieve spent 4 years as a postdoctoral researcher in the Royal College of Surgeons in Ireland (RCSI) working on gene-environment models of schizophrenia, and a further 2 years as a senior postdoctoral researcher focusing on the role of the gut microbiota in neurodevelopment and behaviour. More recently she worked as a senior researcher in the iRELATE group in NUI Galway investigating the role of the immune system activation during early life in neurodevelopment and cognitive symptoms of schizophrenia.

Peer Reviewed Journals

  Year Publication
(2019) 'Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes'
Desbonnet, L. and O'Tuathaigh, C. M. and O'Leary, C. and Cox, R. and Tighe, O. and Petit, E. I. and Wilson, S. and Waddington, J. L. (2019) 'Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes'. J Psychopharmacol, 33 (12):1610-1619 [DOI] [Details]
(2017) 'Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1'
O'Tuathaigh, C. M. and Fumagalli, F. and Desbonnet, L. and Perez-Branguli, F. and Moloney, G. and Loftus, S. and O'Leary, C. and Petit, E. and Cox, R. and Tighe, O. and Clarke, G. and Lai, D. and Harvey, R. P. and Cryan, J. F. and Mitchell, K. J. and Dinan, T. G. and Riva, M. A. and Waddington, J. L. (2017) 'Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1'. Schizophr Bull, 43 (1):214-225 [DOI] [Details]
(2017) 'Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1'
Desbonnet, L. and Cox, R. and Tighe, O. and Lai, D. and Harvey, R. P. and Waddington, J. L. and O'Tuathaigh, C. M. (2017) 'Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1'. Behav Brain Res, 320 :113-118 [DOI] [Details]
(2017) 'Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes'
Moloney, G. M. and O'Leary, O. F. and Salvo-Romero, E. and Desbonnet, L. and Shanahan, F. and Dinan, T. G. and Clarke, G. and Cryan, J. F. (2017) 'Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes'. Behav Brain Res, 334 :50-54 [DOI] [Details]
(2016) 'Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models'
Moran, P. and Stokes, J. and Marr, J. and Bock, G. and Desbonnet, L. and Waddington, J. and O'Tuathaigh, C. (2016) 'Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models'. Neural Plast, 2016 [DOI] [Details]
(2015) 'Re: Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour'
Desbonnet, L. and Clarke, G. and O'Sullivan, O. and Cotter, P. D. and Dinan, T. G. and Cryan, J. F. (2015) 'Re: Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour'. Brain Behav Immun, 50 :335-336 [DOI] [Details]
(2015) 'Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour'
Desbonnet, L. and Clarke, G. and Traplin, A. and O'Sullivan, O. and Crispie, F. and Moloney, R. D. and Cotter, P. D. and Dinan, T. G. and Cryan, J. F. (2015) 'Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour'. Brain Behav Immun, 48 :165-73 [DOI] [Details]
(2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'
Golubeva, A. V. and Crampton, S. and Desbonnet, L. and Edge, D. and O'Sullivan, O. and Lomasney, K. W. and Zhdanov, A. V. and Crispie, F. and Moloney, R. D. and Borre, Y. E. and Cotter, P. D. and Hyland, N. P. and O'Halloran, K. D. and Dinan, T. G. and O'Keeffe, G. W. and Cryan, J. F. (2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'. Psychoneuroendocrinology, 60 :58-74 [DOI] [Details]
(2014) 'The microbiome: stress, health and disease'
Moloney, R. D. and Desbonnet, L. and Clarke, G. and Dinan, T. G. and Cryan, J. F. (2014) 'The microbiome: stress, health and disease'. Mamm Genome, 25 (1-2):49-74 [DOI] [Details]
(2014) 'Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms'
O'Tuathaigh, C. M. and Desbonnet, L. and Waddington, J. L. (2014) 'Genetically modified mice related to schizophrenia and other psychoses: seeking phenotypic insights into the pathobiology and treatment of negative symptoms'. Eur Neuropsychopharmacol, 24 (5):800-21 [DOI] [Details]
(2014) 'Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1'
O'Leary, C. and Desbonnet, L. and Clarke, N. and Petit, E. and Tighe, O. and Lai, D. and Harvey, R. and Waddington, J. L. and O'Tuathaigh, C. (2014) 'Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1'. Neuroscience, 277 :294-305 [DOI] [Details]
(2012) 'Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice'
Desbonnet, L. and Tighe, O. and Karayiorgou, M. and Gogos, J. A. and Waddington, J. L. and O'Tuathaigh, C. M. (2012) 'Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice'. Behav Brain Res, 228 (2):351-8 [DOI] [Details]
(2012) 'Catechol-O-methyl transferase as a drug target for schizophrenia'
O'Tuathaigh, C. M. and Desbonnet, L. and Lee, P. and Waddington, J. L. (2012) 'Catechol-O-methyl transferase as a drug target for schizophrenia'. CNS Neurol Disord Drug Targets, 11 (3):282-91 [DOI] [Details]
(2012) 'Modeling schizophrenia: uncovering novel therapeutic targets'
Desbonnet, L. and O'Tuathaigh, C. M. and Waddington, J. L. (2012) 'Modeling schizophrenia: uncovering novel therapeutic targets'. Expert Rev Clin Pharmacol, 5 (6):667-76 [DOI] [Details]
(2012) 'Mutant mouse models in evaluating novel approaches to antipsychotic treatment'
O'Tuathaigh, C. M. and Desbonnet, L. and Waddington, J. L. (2012) 'Mutant mouse models in evaluating novel approaches to antipsychotic treatment'. Handb Exp Pharmacol, (213):113-45 [DOI] [Details]
(2012) 'Susceptibility genes for schizophrenia: mutant models, endophenotypes and psychobiology'
O'Tuathaigh, C. M. and Desbonnet, L. and Moran, P. M. and Waddington, J. L. (2012) 'Susceptibility genes for schizophrenia: mutant models, endophenotypes and psychobiology'. Curr Top Behav Neurosci, 12 :209-50 [DOI] [Details]
(2012) 'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction'
Desbonnet, L. and O'Tuathaigh, C. and Clarke, G. and O'Leary, C. and Petit, E. and Clarke, N. and Tighe, O. and Lai, D. and Harvey, R. and Cryan, J. F. and Dinan, T. G. and Waddington, J. L. (2012) 'Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction'. Brain Behav Immun, 26 (4):660-71 [DOI] [Details]
(2012) 'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'
O'Tuathaigh, C. M. and Clarke, G. and Walsh, J. and Desbonnet, L. and Petit, E. and O'Leary, C. and Tighe, O. and Clarke, N. and Karayiorgou, M. and Gogos, J. A. and Dinan, T. G. and Cryan, J. F. and Waddington, J. L. (2012) 'Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes'. Int J Neuropsychopharmacol, 15 (9):1331-42 [DOI] [Details]
(2012) 'Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis'
Walsh, J. and Desbonnet, L. and Clarke, N. and Waddington, J. L. and O'Tuathaigh, C. M. (2012) 'Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis'. J Neurosci Res, 90 (7):1445-53 [DOI] [Details]
(2011) 'Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges'
O'Tuathaigh, C. M. and Desbonnet, L. and Moran, P. M. and Kirby, B. P. and Waddington, J. L. (2011) 'Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges'. Curr Top Behav Neurosci, 7 :87-119 [DOI] [Details]
(2010) 'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression'
Desbonnet, L. and Garrett, L. and Clarke, G. and Kiely, B. and Cryan, J. F. and Dinan, T. G. (2010) 'Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression'. Neuroscience, 170 (4):1179-88 [DOI] [Details]
(2010) 'Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes'
O'Tuathaigh, C. M. and Hryniewiecka, M. and Behan, A. and Tighe, O. and Coughlan, C. and Desbonnet, L. and Cannon, M. and Karayiorgou, M. and Gogos, J. A. and Cotter, D. R. and Waddington, J. L. (2010) 'Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes'. Neuropsychopharmacology, 35 (11):2262-73 [DOI] [Details]
(2009) 'Neuregulin-1 signaling in schizophrenia: 'Jack of all trades' or master of some?'
O'Tuathaigh, C. M. and Desbonnet, L. and Waddington, J. L. (2009) 'Neuregulin-1 signaling in schizophrenia: 'Jack of all trades' or master of some?'. Expert Rev Neurother, 9 (1):1-3 [DOI] [Details]
(2009) 'Mutant models for genes associated with schizophrenia'
Desbonnet, L. and Waddington, J. L. and O'Tuathaigh, C. M. (2009) 'Mutant models for genes associated with schizophrenia'. Biochem Soc Trans, 37 (Pt 1):308-12 [DOI] [Details]
(2009) 'Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?'
Desbonnet, L. and Waddington, J. L. and Tuathaigh, C. M. (2009) 'Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?'. Behav Brain Res, 204 (2):258-73 [DOI] [Details]
(2008) 'Sexually dimorphic effects of maternal separation stress on corticotrophin-releasing factor and vasopressin systems in the adult rat brain'
Desbonnet, L. and Garrett, L. and Daly, E. and McDermott, K. W. and Dinan, T. G. (2008) 'Sexually dimorphic effects of maternal separation stress on corticotrophin-releasing factor and vasopressin systems in the adult rat brain'. Int J Dev Neurosci, 26 (3-4):259-68 [DOI] [Details]
(2008) 'The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat'
Desbonnet, L. and Garrett, L. and Clarke, G. and Bienenstock, J. and Dinan, T. G. (2008) 'The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat'. J Psychiatr Res, 43 (2):164-74 [DOI] [Details]
(2008) 'Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study'
Van den Hove, D. L. and Blanco, C. E. and Scheepens, A. and Desbonnet, L. and Myint, A. M. and Leonard, B. E. and Prickaerts, J. and Steinbusch, H. W. (2008) 'Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study'. Neonatology, 93 (1):52-5 [DOI] [Details]
(2006) 'Gestational stress leads to depressive-like behavioural and immunological changes in the rat'
O'Mahony, S. M. and Myint, A. M. and van den Hove, D. and Desbonnet, L. and Steinbusch, H. and Leonard, B. E. (2006) 'Gestational stress leads to depressive-like behavioural and immunological changes in the rat'. Neuroimmunomodulation, 13 (2):82-8 [DOI] [Details]
(2005) 'Prenatal restraint stress and long-term affective consequences'
Van den Hove, D. L. and Blanco, C. E. and Aendekerk, B. and Desbonnet, L. and Bruschettini, M. and Steinbusch, H. P. and Prickaerts, J. and Steinbusch, H. W. (2005) 'Prenatal restraint stress and long-term affective consequences'. Dev Neurosci, 27 (5):313-20 [DOI] [Details]
(2004) 'Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent'
Desbonnet, L. and Temel, Y. and Visser-Vandewalle, V. and Blokland, A. and Hornikx, V. and Steinbusch, H. W. (2004) 'Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent'. Brain Res, 1008 (2):198-204 [DOI] [Details]
(2004) 'Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage'
Temel, Y. and Visser-Vandewalle, V. and van der Wolf, M. and Spincemaille, G. H. and Desbonnet, L. and Hoogland, G. and Steinbusch, H. W. (2004) 'Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage'. Neurosci Lett, 367 (1):92-6 [DOI] [Details]