Dr Michelle Roche

BSc., MSc., PhD.

Contact Details

Lecturer Above The Bar
Dept of Physiology
NUI Galway

T: Ext. 5427
E: michelle.roche@nuigalway.ie
 
researcher

Biography

Dr Roche graduated in 1999 with a B.Sc. (Hons.) degree in Physiology at NUI Galway following which she undertook an M.Sc. in Neuropharmacology (1999-2001). Her interest in stress-related disorders began during her time as a research assistant in Prof Rita Valentino laboratory in Philadelphia (2001) where she examined the neural circuitry underlying stress-induced changes in the serotonergic system. She subsequently pursued a Ph.D. (2002-2005) characterizing behavioural and physiological responses in models of depression at the Department of Pharmacology, NUI Galway. Following a year as a contract lecturer, Dr Roche undertook a post-doctoral research (2005-2008) position focused on the role of the endocannabinoid system on conditioned stress-induced changes in pain responding and inflammation. In September 2008, Dr Roche was appointed Lecturer in Physiology at NUI Galway. 

Research Interests

Dr Roches' research interests include:

    The role of the cannabinoid system in regulating of neuroinflammation and immune function
    Neural substrates underpinning stress, depression and pain
    Neurobiology underlying autism spectrum disorders

To this end, the Roche Lab employs a whole systems approach to addressing research questions in the aforementioned areas. A wide range of in vivo, ex vivo and in vitro methodologies are utilized to examine the role of a number of neurotransmitter systems including monoamines, endocannabinoids and neuropeptides, neuroendocrine and immune processes in physiological and behavioural responses. 

Peer Reviewed Journals

  Year Publication
(2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'
Henry, RJ,Kerr, DM,Finn, DP,Roche, M (2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :167-180 [DOI] [Details]
(2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'
Bree, D,Moriarty, O,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'. Cns Neuroscience & Therapeutics, 22 :146-153 [DOI] [Details]
(2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'
Jennings, EM,Okine, BN,Olango, WM,Roche, M,Finn, DP (2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :181-189 [DOI] [Details]
(2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'
Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'. Research In Autism Spectrum Disorders, [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree, D,Moriarty, O,Mahony, CM,Morris, B,Bannerton, K,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, 16 :421-435 [DOI] [Details]
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'. International Review Of Neurobiology, 125 [DOI] [Details]
(2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'
Fitzgibbon M. Finn DP, Roche M (2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'. International Journal Of Neuropsychopharmacology, [Details]
(2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'
Burke, NN,Finn, DP,Roche, M (2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'. Behavioural Brain Research, 278 :193-201 [DOI] [Details]
(2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'
Burke, NN,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'. Brain Behavior And Immunity, 42 :147-156 [DOI] [Details]
(2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'
Henry RJ, Kerr DM, Finn DP, Roche M (2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'. Journal Of Neuroimmunology, [DOI] [Details]
(2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'
Okine, BN,Rea, K,Olango, WM,Price, J,Herdman, S,Madasu, MK,Roche, M,Finn, DP (2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'. British Journal Of Pharmacology, 171 :1462-1471 [DOI] [Details]
(2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'
Rea, K,Ford, GK,Olango, WM,Harhen, B,Roche, M,Finn, DP (2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'. European Journal Of Neuroscience, 39 :435-443 [DOI] [Details]
(2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'
Burke, NN,Llorente, R,Marco, EM,Tong, K,Finn, DP,Viveros, MP,Roche, M (2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'. Journal Of Pain, 14 :1173-1184 [DOI] [Details]
(2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'
Kerr, DM,Harhen, B,Okine, BN,Egan, LJ,Finn, DP,Roche, M (2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 :808-819 [DOI] [Details]
(2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'
Burke, NN,Geoghegan, E,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 12 :705-713 [DOI] [Details]
(2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'
Kerr, DM,Downey, L,Conboy, M,Finn, DP,Roche, M (2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'. Behavioural Brain Research, 249 :124-132 [DOI] [Details]
(2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'
Butler, RK,Ford, GK,Hogan, M,Roche, M,Doyle, KM,Kelly, JP,Kendall, DA,Chapman, V,Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91 [DOI] [Details]
(2011) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor'
Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Finn DP and Roche M (2011) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor'. Neuroscience, [DOI] [ARAN Link] [Details]
(2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'
Rea, K,Olango, WM,Okine, BN,Madasu, MK,McGuire, IC,Coyle, K,Harhen, B,Roche, M,Finn, DP (2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'. Pain, 155 :69-79 [DOI] [Details]
(2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'
Olango, WM,Geranton, SM,Roche, M,Hunt, SP,Finn, DP (2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'. European Journal Of Pain, 18 :182-191 [DOI] [Details]
(2014) 'Stress-induced hyperalgesia'
Jennings EM, Okine BN, Roche M, Finn DP (2014) 'Stress-induced hyperalgesia'. Progress in neurobiology, 121C :1-18 [DOI] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, K,Olango, WM,Harhen, B,Kerr, DM,Galligan, R,Fitzgerald, S,Moore, M,Roche, M,Finn, DP (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 :576-585 [DOI] [Details]
(2013) 'Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'
Kerr DM, Harhen B, Egan LJ, Finn DP, Roche M (2013) 'Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 (4):808-819 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [ARAN Link] [Details]
(2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'
Olango, WM,Roche, M,Ford, GK,Harhen, B,Finn, DP (2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'. British Journal Of Pharmacology, 165 :2549-2560 [DOI] [Details]
(2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'
Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 (0):91-98 [DOI] [ARAN Link] [Details]
(2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'
Moriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8 [DOI] [ARAN Link] [Details]
(2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'
Rea, K,Roche, M,Finn, DP (2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'. Journal Of Pain, 12 :712-721 [DOI] [ARAN Link] [Details]
(2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'
Burke, NN,Hayes, E,Calpin, P,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'. Neuroscience, 171 (0):1300-1313 [DOI] [ARAN Link] [Details]
(2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'
Roche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals (Invited Review), 3 (0):2517-2553 [DOI] [ARAN Link] [Details]
(2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'
Roche, M,Johnston, P,Mhuircheartaigh, ON,Olango, WM,Mackie, K,Finn, DP (2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'. European Journal Of Pain, 14 :487-495 [DOI] [Details]
(2009) '6-iodonordihydrocapsaicin'
Roche M, Finn DP (2009) '6-iodonordihydrocapsaicin'. Xpharm, 0 (0):0-0 [DOI] [ARAN Link] [Details]
(2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'
Smith, KL,Roche, M,Jessop, DS,Finn, DP (2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'. European Neuropsychopharmacology, 19 :371-380 [DOI] [Details]
(2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'
Roche M, Shanahan E, Harkin A, Kelly JP (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacological Reports, 60 (0):404-408 [DOI] [Details]
(2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'
Roche M, Kelly JP, O'Driscoll M, Finn DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 (2):263-271 [DOI] [Details]
(2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'
Roche, M., Harkin, A., Kelly, J. P. (2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'. Neuropsychopharmacology, 32 (6):1312-1320 [ARAN Link] [Details]
(2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'
Rea K, Roche M, Finn DP (2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'. British Journal Of Pharmacology, 152 (2):267-286 [DOI] [Details]
(2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'
Roche M, O’Connor E, Diskin C, Finn DP. (2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'. European Journal Of Neuroscience, 26 (9):2643-2653 [DOI] [Details]
(2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'
Roche M, Diamond M, Kelly JP, Finn DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 (1-2):57-67 [DOI] [Details]
(2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'
Zueger, A,Urani, A,Chourbaji, S,Zacher, C,Roche, M,Harkin, A,Gass, P (2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'. Neuroscience Letters, 374 :142-146 [DOI] [Details]
(2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'
Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997 [Details]

Book Chapters

  Year Publication
(2015) 'Neuroinflammatory mechanisms linking Pain and Depression'
Burke N.N., Finn DP, Roche M (2015) 'Neuroinflammatory mechanisms linking Pain and Depression' In: Pain in Psychiatric Disorders: Mod Trends Pharmacopsychiatry. Switzerland: Karger. [Details]
(2015) 'Supraspinal TRPV1 in pain and psychiatric disorders'
Madasu M, Roche M, Finn DP (2015) 'Supraspinal TRPV1 in pain and psychiatric disorders' In: Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Switzerland: Karger. [Details]
(2011) 'The Olfactory Bulbectomised Mouse'
Roche M (2011) 'The Olfactory Bulbectomised Mouse' In: In Mood and Anxiety Related Phenotypes in Mice. USA: Humana Press. [ARAN Link] [Details]

Other Journals

  Year Publication
(2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'
Kerr DM, Henry R, Roche M (2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation' Anatomy and Physiology, 4:e130 . [Details]

Employment

  Employer Position From / To
NUI Galway Lecturer in Physiology (above the bar) 01-MAY-12 / 05-JUL-13
Physiology, NUI Galway Lecturer (below the bar) 01-SEP-08 / 01-MAY-12
Pharmacology and Therapeutics, NUI Galway Post Doctoral researcher 01-SEP-05 / 01-SEP-08
Pharmacology and Therapeutics, NUI Galway Contract Lecturer 01-SEP-04 / 01-SEP-05
Children's Hospital of Philadelphia, USA Research Assistant 18-JAN-01 / 18-DEC-01

Education

  Year Institution Qualification Subject
2015 National Univeristy of Ireland Galway POSTGRAD CERT OF EDUCATION Teaching and Learning
2005 National University of Ireland, Galway PhD Pharmacology
2001 National University of Ireland, Galway MASTERS OF SCIENCE Neuropharmacology
1999 National University of Ireland, Galway BACHELOR OF SCIENCE Physiology

Professional Associations

  Association Function From / To
Royal Academy of Medicine in Ireland, Biomedical Sciences Section Council Member 01-JUL-11 /
Neuroscience Ireland Council member 05-JAN-15 /
Irish Pain Research Network Council member 26-SEP-15 /
Irish Pain Society Council Member 01-JAN-14 /

Community Engagement

  Title Type From / To
Outreach Involved in NUI Galway undergraduate and postgraduate open days, providing information regarding studying Physiology, Science and Biomedical Science /
Outreach Public outreach at Brain Awareness Week and Science Festival /
Outreach Involved in representing the neuroscience research interests at NUI Galway to delegations from pharmaceutical and biomedical companies /

Teaching Interests

I currently supervise a team of 7 PhD students (3 as primary supervisor), and co-supervise/mentor a further 2 postdoctoral researchers and 2 research assistants. To date I have sucessfully supervised 7 PhD and 1MSc research student to completion (4 PhD students as primary supervisor).

I am the overall year coordinator for 3rd year Physiology (B.Sc. and B.Sc. Biomedical Science).

Module coordinator for Neurophysiology (SI311); Endocrinology (SI312/SI3102); Advance Neurophysiology (SI422)

I use a multitude of teaching methadologies and formats from lectures and seminars, practicals and lab based projects, small group teaching, flipped classroom teaching, poster and oral presentations and case studies in my teaching.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2014 Dara Bree  PhD Y
2015 Rebecca Henry PhD Y
2013 Nikita Burke PhD Y
2015 Fiona Mc Gowan N
2015 Marie Fitzgibbon PhD Y
2014 Daniel Kerr PhD Y
2015 Elaine Jennings PhD N
2011 Werede Olango PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Manish Madasu Doctorate - Structured PhD (Science) Co-supervisor (1)
Lisa Flannery Doctorate - Structured Ph.D (Medicine) Supervisor
Louise Corcoran Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Marykate Killilea Doctorate - Structured Ph.D (Medicine) Supervisor

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2009-present Biological Sciences III NU306 Lectures on physiology of the endocrine and central nervous systems - 3rd yr Nursing students
2008-present The Cenrtral Nervous System MD224 Physiological functions of the brain and spinal cord - 2nd year medical students
2015-present Case-based Physiology SI4101 Integrative case-studies on pathophysiological conditions - 4th year Physiology Science students
2015-present Pathophysiology SI432 Lecture series on pathophysiology of CNS disorders - 4th yr Physiology Science students
2008-present Research Project SI435 Supervise final year BSc and Biomedical science research projects - 4th yr Physiology Science students
2008-present Endocrinology SI312/SI3102 Physiological functions of hormones - 3rd year Science students and 2nd year podiatry students
2008-present Advanced Neurophysiology SI422 Pathophysiology underlying neurological, psychiatric and neurodegenerative disorders
2008-present Neurophysiology SI311/SI209 Understanding the physiologial action of neurons, glia and the physiological processes underlying movement, sensation, hearing, vision, emotion, speech and language - 3rd year Sceince students and 2nd year Speech and Language & ocupational Therapty students
2009-2015 Advanced Research Methods SI442

Internal Collaborators

  Name Description of Collaboration
Prof David Finn
Dr Beth Mallard
Prof Antony Wheatley
Prof Sanbing Shen
Prof John Kelly

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Dan Dever Alkermes Ltd U.S.A.
Dan Broom Covidien PLC U.S.A.
Dr Olive Healy Trinity College Dublin IRELAND
Maria Paz Viveros University of Madrid SPAIN
Prof Stephan Hunt University College London UNITED KINGDOM
Francisco Molino-Holgado University of Roehampton, London UNITED KINGDOM