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Natural Sciences
Prof Corrado Santocanale
Ph.D
Contact Details
Centre for Chromosome Biology (CCB)
Professor
SCHOOL OF NATURAL SCIENCES
NUI GALWAY
T: Ext. 5174
E: corrado.santocanale@nuigalway.ie
SCHOOL OF NATURAL SCIENCES
NUI GALWAY
T: Ext. 5174
E: corrado.santocanale@nuigalway.ie

Biography
Research Interests
Research Projects
Project | Start Date | End Date | |
---|---|---|---|
Cellular responses to ATP competitive CDC7 kinase inhibitors | 01-FEB-16 | 31-JAN-19 | |
CDC7 REGULATION OF CLASPIN STABILITY AND ITS EFFECT ON CELL CYCLE CHECKPOINT FUNCTION C SANTOCANALE | 01-APR-13 | 31-MAR-17 | |
CDC7 AND CLASPIN IN THE REGULATION OF DNA REPLICATION IN BREAST CANCER CELLS BREAST CANCER CAMPAIGN CORRADO SANTOCANALE | 01-NOV-12 | 31-JAN-16 | |
GUAN NAN WANG IRCSET EMPOWER POSTDOC CORRADO SANTOCANALE | 01-JUL-12 | 19-OCT-15 | |
ESI HEA PRTLI5 MMI CTRSP EDEL MCGARRY | 01-MAR-11 | 30-SEP-16 | |
EHA ASH RESEARCH EXCH AWRD MARK COYNE | 01-JUL-10 | 30-NOV-12 | |
UNDERSTAND EXPLOIT MOLECULAR DNA 08/IN.1/B2064 - C SANTOCANALE | 01-SEP-09 | 31-MAR-16 | |
REGULATION BY MICRORNAS AND ITS IMPACT IN CANCER | 01-OCT-08 | 30-SEP-12 | |
SFI CDC7 KINASE IN CANCER CELLS EXPOSED TO S-PHASE | 01-SEP-08 | 31-AUG-11 |
Peer Reviewed Journals
Year | Publication | |
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(2016) | 'Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint'
O'Connor A, Maffini S;Rainey MD;Kaczmarczyk A;Gaboriau D;Musacchio A;Santocanale C (2016) 'Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint'. Biology Open, 5 (1):11-19 [DOI] [ARAN Link] [Details] |
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(2016) | 'The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase'
McGarry E;Gaboriau D;Rainey MD;Restuccia U;Bachi A;Santocanale C; (2016) 'The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase'. Cancer Research, 76 (8) [DOI] [Details] |
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(2016) | 'DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach'
Wu KZ;Wang GN;Fitzgerald J;Quachthithu H;Rainey MD;Cattaneo A;Bachi A;Santocanale C; (2016) 'DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach'. Nucleic Acids Research, [DOI] [Details] |
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(2015) | 'Molecular targets for novel drug development in pancreatic cancer'
Eimear O’ Reilly, Corrado Santocanale, Eva Szegezdi (2015) 'Molecular targets for novel drug development in pancreatic cancer'. Annals on Cancer Research, 2 (3) [Details] |
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(2015) | 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'
Lo Re D, Zhou Y;Mucha J;Jones LF;Leahy L;Santocanale C;Krol M;Murphy PV (2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'. Chemistry (Weinheim an der Bergstrasse, Germany), [DOI] [ARAN Link] [Details] |
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(2014) | 'A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response'
FitzGerald, J,Murillo, LS,O'Brien, G,O'Connell, E,O'Connor, A,Wu, K,Wang, GN,Rainey, MD,Natoni, A,Healy, S,O'Dwyer, M,Santocanale, C (2014) 'A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response'. Plos One, 9 [DOI] [Details] |
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(2013) | 'Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage'
Broderick, R,Rainey, MD,Santocanale, C,Nasheuer, HP (2013) 'Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage'. Febs Journal, 280 :4888-4902 [DOI] [Details] |
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(2013) | 'MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells'
Barkley, LR,Santocanale, C (2013) 'MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells'. Oncogenesis, 2 [DOI] [Details] |
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(2013) | 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'
Rainey, MD,Harhen, B,Wang, GN,Murphy, PV,Santocanale, C (2013) 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'. Cell Cycle, 12 :1560-1568 [DOI] [Details] |
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(2013) | 'Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models'
Natoni A, Coyne MR, Jacobsen A, Rainey MD, O'Brien G, Healy S, Montagnoli A, Moll J, O'Dwyer M, Santocanale C (2013) 'Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models'. Cancers, 5 (3):901-918 [DOI] [Details] |
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(2012) | 'Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation'
Martin, L., Rainey, M., Santocanale, C., Gardner, L.B. (2012) 'Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation'. Oncogene, [Details] |
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(2011) | 'Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation'
Napolitano, C,Natoni, A,Santocanale, C,Evensen, L,Lorens, JB,Murphy, PV (2011) 'Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation'. Bioorganic & Medicinal Chemistry Letters, 21 :1167-1170 [DOI] [Details] |
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(2011) | 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'
Natoni, A,Murillo, LS,Kliszczak, AE,Catherwood, MA,Montagnoli, A,Samali, A,O'Dwyer, M,Santocanale, C (2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'. Molecular Cancer Therapeutics, 10 :1624-1634 [DOI] [ARAN Link] [Details] |
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(2011) | 'DNA mediated chromatin pull-down for the study of chromatin replication'
Kliszczak, AE,Rainey, MD,Harhen, B,Boisvert, FM,Santocanale, C (2011) 'DNA mediated chromatin pull-down for the study of chromatin replication'. Scientific Reports, 1 [DOI] [ARAN Link] [Details] |
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(2011) | 'The Cell Cycle Regulator Phosphorylated Retinoblastoma Protein Is Associated With Tau Pathology in Several Tauopathies'
Stone, JG,Siedlak, SL,Tabaton, M,Hirano, A,Castellani, RJ,Santocanale, C,Perry, G,Smith, MA,Zhu, XW,Lee, HG (2011) 'The Cell Cycle Regulator Phosphorylated Retinoblastoma Protein Is Associated With Tau Pathology in Several Tauopathies'. Journal Of Neuropathology And Experimental Neurology, 70 :578-587 [DOI] [Details] |
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(2010) | 'Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding'
Menichincheri M, Albanese C, Alli C, Ballinari D, Bargiotti A, Caldarelli M, Ciavolella A, Cirla A, Colombo M, Colotta F, Croci V, D'Alessio R, D'Anello M, Ermoli A, Fiorentini F, Forte B, Galvani A, Giordano P, Isacchi A, Martina K, Molinari A, Moll JK, Montagnoli A, Orsini P, Orzi F, Pesenti E, Pillan A, Roletto F, Scolaro A, Tatò M, Tibolla M, Valsasina B, Varasi M, Vianello P, Volpi D, Santocanale C, Vanotti E (2010) 'Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding'. Journal Of Medicinal Chemistry, 53 (20):7296-7315 [DOI] [Details] |
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(2010) | 'Cdc7 kinase - a new target for drug development'
Swords R, Mahalingam D, O'Dwyer M, Santocanale C, Kelly K, Carew J, Giles F (2010) 'Cdc7 kinase - a new target for drug development'. European Journal Of Cancer, 46 (1):33-40 [DOI] [Details] |
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(2008) | 'Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships'
Vanotti E, Amici R, Bargiotti A, Berthelsen J, Bosotti R, Ciavolella A, Cirla A, Cristiani C, D'Alessio R, Forte B, Isacchi A, Martina K, Menichincheri M, Molinari A, Montagnoli A, Orsini P, Pillan A, Roletto F, Scolaro A, Tibolla M, Valsasina B, Varasi M, Volpi D, Santocanale C (2008) 'Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships'. Journal Of Medicinal Chemistry, 51 (3):487-501 [DOI] [Details] |
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(2007) | 'Cdc7 is an active kinase in human cancer cells undergoing replication stress'
Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C (2007) 'Cdc7 is an active kinase in human cancer cells undergoing replication stress'. Journal Of Biological Chemistry, 282 (1):208-215 [DOI] [Details] |
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(2006) | 'Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases'
Montagnoli A, Valsasina B, Brotherton D, Troiani S, Rainoldi S, Tenca P, Molinari A, Santocanale C (2006) 'Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases'. Journal Of Biological Chemistry, 281 (15):10281-10290 [DOI] [Details] |
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(2004) | 'Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells'
Montagnoli A, Tenca P, Sola F, Carpani D, Brotherton D, Albanese C, Santocanale C (2004) 'Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells'. Cancer Research, 64 (19):7110-7116 [DOI] [Details] |
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(2002) | 'Drf1, a novel regulatory subunit for human Cdc7 kinase'
Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C (2002) 'Drf1, a novel regulatory subunit for human Cdc7 kinase'. Embo Journal, 21 (12):3171-3181 [DOI] [Details] |
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(2000) | 'Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast'
Diffley JF, Bousset K, Labib K, Noton EA, Santocanale C, Tercero JA (2000) 'Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast'. Cold Spring Harb Symp Quant Biol, 65 :333-342 [Details] |
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(1998) | 'A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication'
Santocanale C, Diffley JF (1998) 'A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication'. Nature, 395 (6702):615-618 [DOI] [Details] |
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(1996) | 'An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast'
Cocker JH, Piatti S, Santocanale C, Nasmyth K and Diffley JF. (1996) 'An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast'. Nature, 379 :180-182 [Details] |
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(1993) | 'Purification and characterization of a new DNA polymerase from budding yeast Saccharomyces cerevisiae. A probable homolog of mammalian DNA polymerase beta'
Shimizu K, Santocanale C, Ropp PA, Longhese MP, Plevani P, Lucchini G, Sugino A (1993) 'Purification and characterization of a new DNA polymerase from budding yeast Saccharomyces cerevisiae. A probable homolog of mammalian DNA polymerase beta'. Journal Of Biological Chemistry, 268 (36):27148-27153 [Details] |
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(1992) | 'Overproduction and functional analysis of DNA primase subunits from yeast and mouse'
Santocanale C, Locati F, Muzi Falconi M, Piseri A, Tseng B, Lucchini G and Plevani P. (1992) 'Overproduction and functional analysis of DNA primase subunits from yeast and mouse'. Gene, 113 :199-205 [Details] |
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(1991) | 'Mutations in conserved yeast DNA primase domains impair DNA replication in vivo'
Francesconi S, Longhese MP, Piseri A, Santocanale C, Lucchini G, Plevani P (1991) 'Mutations in conserved yeast DNA primase domains impair DNA replication in vivo'. Proc Natl Acad Sci U S A, 88 (9):3877-3881 [Details] |
Book Chapters
Year | Publication | |
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(2013) | 'A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization'
Natoni A, O'Dwyer M, Santocanale C (2013) 'A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization' In: [DOI] [Details] |
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(2000) | 'Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast'
Diffley JF, Bousset K, Labib K, Noton EA, Santocanale C and Tercero JA. (2000) 'Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast' In: Cold Spring Harbor symposia on quantitative biology. USA: Cold Spring Harbor press. [Details] |
Conference Publications
Year | Publication | |
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(2014) | Irish Association for Cancer Research
Fitzgerald, J; Murillo, L; O’Brien, G; O’Connell, E; O’Connor, A; Wu, K; Wang, GN; Rainey, MD; Natoni, A; Healy, S; O’Dwyer, M; Santocanale, C (2014) A high through put screen identifies Ryuvidine as a modulator of Cdc7 dependent phosphorylation of MCM2 and an inducer of the DNA damage response Irish Association for Cancer Research [Details] |
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(2013) | Irish Association for Cancer Research
Murillo, L; Natoni, A; O’Connell, E; Fitzgerald, J; O’Dwyer, M; Santocanale, C (2013) Development of a High-Throughput Screening assay for the identification of compounds affecting Cdc7 dependent MCM helicase phosphorylation Irish Association for Cancer Research [Details] |
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(2009) | Increased Activity of the S Phase Kinase Cdc7 Is Associated with Poor Outcome in Diffuse Large B Cell Lymphoma (DLBCL)
Krawczyk, J,Egan, C,Mulvihill, M,Webber, M,Murillo, L,Ingoldsby, H,Santocanale, C,Callagy, G,O'Dwyer, MC (2009) Increased Activity of the S Phase Kinase Cdc7 Is Associated with Poor Outcome in Diffuse Large B Cell Lymphoma (DLBCL) , pp.760-760 [Details] |
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(2009) | PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL
Natoni, A,Hayat, A,Montagnoli, A,Callagy, G,Samali, A,Santocanale, C,O'Dwyer, MC (2009) BLOOD PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL , pp.934-934 [Details] |
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(2009) | ASH annual meeting 2009
Coyne, MRE; Naughton, S; Hayden, PJ; Montagnoli, A; O'Dwyer, ME; Santocanale, C (2009) Targeting Cdc7 Kinase in Multiple Myeloma . In: Source: BLOOD eds. ASH annual meeting 2009 , pp.22 1479-1480 [Details] |
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(2008) | Discovery and characterization of a new potent orally available CdC7 inhibitor with anti-tumor activity
Montagnoli, A,Vanotti, E,Rainoldi, S,Marchesi, V,Ciavolella, A,Croci, V,Patton, V,Albanese, C,Santocanale, C,Moll, J (2008) EJC SUPPLEMENTS Discovery and characterization of a new potent orally available CdC7 inhibitor with anti-tumor activity , pp.116-116 [Details] |
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(2007) | Cdc7 kinase inhibitors: 7-Substituted pyrrolopyridinones as potent and orally active antitumor agents
Bargiotti, A,Berthelsen, J,Bossi, R,Ciavolella, A,Cirla, A,Cristiani, C,Croci, V,D'Alessio, R,Forte, B,Martina, K,Molinari, A,Montagnoli, A,Orsini, P,Orzi, F,Pezzetta, D,Pillan, A,Poggesi, I,Roletto, F,Santocanale, C,Scolaro, A,Tibolla, M,Valsasina, B,Volpi, D,Vanotti, E (2007) MOLECULAR CANCER THERAPEUTICS Cdc7 kinase inhibitors: 7-Substituted pyrrolopyridinones as potent and orally active antitumor agents , pp.3409-3409 [Details] |
Abstract
Year | Publication | |
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(2010) | Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells.
Santocanale, A,Natoni, A,Murillo, L,Catherwood, M,Montagnoli, A,Samali, A,O'Dwyer, M (2010) Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells. Abstract [Details] |
Meeting
Year | Publication | |
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(2009) | Targeting Cdc7 Kinase in Multiple Myeloma.
Coyne, MRE,Naughton, S,Hayden, PJ,Montagnoli, A,O'Dwyer, ME,Santocanale, C (2009) Targeting Cdc7 Kinase in Multiple Myeloma. Meeting [Details] |
Teaching Interests
Recent Postgraduate Students
Graduation | Name | Degree | Primary Supervisor | |
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2012 | Anna Kliszczak | PhD | Y | |
2012 | Raffaella D'Auria | Msc | Y | |
2015 | Kevin Wu | PhD | Y | |
2014 | Mark Coyne | PhD | Y | |
2016 | Edel McGarry | PhD | Y | |
2015 | Ashton Scully | Msc | Y |
Current Postgraduate Students (Research)
Student | Degree Type | Type | |
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Aisling O Connor | Doctorate - Structured Ph.D (Medicine) | Supervisor | |
Huong Quachthithu | Doctorate - Structured Ph.D (Medicine) | Supervisor | |
Rachel O Dea | Doctorate - Structured PhD (Science) | Supervisor |
Internal Collaborators
Name | Description of Collaboration | |
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Internal Collaborators |
External Collaborators
Name | Organisation / Institute | Country | Description of Collaboration | |
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External Collaborators |