Dr Eva Szegezdi

M.Sc., Ph.D.

Contact Details

Lecturer (Fixed Term)
Biochemistry
School of Natural Sciences
Bioresearch Building
NUI

T: Ext. 5037
E: eva.szegezdi@nuigalway.ie
 
researcher

Biography

Affiliation: Lecturer in Biochemistry, NUI, Galway, Head of the Blood Cancer Biobank in Ireland, Principal investigator of the Cancer Niche Laboratory.  
Career information Dr. Szegezdi received her PhD in medical science in 2000 studying cell death signalling at the University of Debrecen, Hungary. She then joined the Cell Stress and Apoptosis Research laboratory led by Prof. Afshin Samali at the National University of Ireland, Galway in 2001 to study stress-induced cell death in heart and pancreatic cells. In 2010 she established her own research group as a Science Foundation Ireland Starting Investigator (SIRG) and an Irish Cancer Society Research Fellow focusing on how the tissues surrounding cancer cells protect the tumour from chemotherapeutics. She took up a university lecturer position in the Discipline of Biochemistry, National University of Ireland, Galway in 2011 where she is now a lecturer, the director of the Masters degree programme on cancer research and head of the Cancer Niche Research Laboratory and a principal investigator in the recently established Blood Cancer Network Ireland funded by SFI and the Irish Cancer Society.
Research and Clinical Interests: Current projects in her laboratory focus on the molecular wiring of cancer cells to predict how tumour cells respond to chemotherapeutics. A particularly interest of the laboratory is to understand the communication between the leukemia cells and the bone marrow tissue where leukemia cells reside in and how the bone marrow tissue makes the leukemic cells resistant to therapeutic drugs.

Research Interests

Mechanism of signal transduction in order to understand the driving forces of disease progression and to identify targets for therapy.

Identified that the pro-inflammatory cytokines interleukin-1b and interferon g act in synergy to induce beta-cell death and thus contribute to type I diabetes. Induction of nitric oxide synthase is necessary and sufficient to cause pancreatic beta cell apoptosis. Current in vivo studies assess the potential of IFNg neutralization to revert the progression of type I diabetes and promote pancreas recovery.

The potential of adult MSCs to repair ischemic heart damage was studied. The contribution of the components of ischemic conditions (hypoxia, nutrient deprivation, oxygen deprivation, inhibition of glues metabolism) to loss of cardiac muscle contractility and cell death was determined. Found that MSCs well tolerate the conditions which are damaging to cardiomyocyte function and survival. MSCs are able to retain functionality during prolonged ischemia by surviving on glycolytic energy production. Active glycolysis on the other hand provides an essential survival factor in MSCs and inhibition of glycolysis triggers rapid MSC death.

Regulation of apoptotic pathways in cancer cells and to the engineering of death ligands (TNF family of cytokines) for selective death receptor activation or receptor neutralization.

First demonstration that high affinity, receptor-selective variants of the death ligand, TRAIL, generated by computational design are more efficient death receptors activators and inducers of tumour cell death than wild type TRAIL. Found that the apoptosis-inducing potency of TRAIL is limited by its promiscuity, i.e. its ability to bind to four receptors due to formation of inactive heteromeric receptor complexes and fast kinetics of receptor activation is a key element in induction of apoptosis. Identified point mutations in TRAIL that provide receptor selectivity and thus enhance anti-tumour efficacy.

Current studies aim to develop a so called ratiometric analysis of protein expression. The working hypothesis is that rather than the absolute amount of a given protein, its amount relative to other proteins playing a role in a given biological process (i.e. the expression ratio of proteins) determines the biological response of a cell to any given stimulus.

Research Projects

  Project Start Date End Date
Development of antagonistic cytokine variants for treatment of type I diabetes 01-DEC-08 30-NOV-09
Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis 01-DEC-09 30-NOV-12
Novel ratiometric approach to identify decisive molecular interactions of the TRAIL apoptotic machinery 01-OCT-09 30-SEP-13

Peer Reviewed Journals

  Year Publication
(2016) 'Decoy receptors block TRAIL sensitivity at supra-cellular level: the role of stromal cells in controlling tumour TRAIL-sensitivity'
O'Leary L, van der Sloot A, Serrano L, Reis C, Cool R, Quax WJ, Deegan S, Murillo L, Thompson K, de Sampaio P, Ryan AE, Singh Dhami SP, Murphy G, Szegezdi E (2016) 'Decoy receptors block TRAIL sensitivity at supra-cellular level: the role of stromal cells in controlling tumour TRAIL-sensitivity'. Oncogene, 35 (10):1261-1270 [DOI] [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [Details]
(2015) 'Molecular targets for novel drug development in pancreatic cancer'
Eimear O’ Reilly, Corrado Santocanale, Eva Szegezdi (2015) 'Molecular targets for novel drug development in pancreatic cancer'. Annals on Cancer Research, 2 (3) [Details]
(2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'
Séverine Cruet-Hennequart; Tanja Paavilainen; Michael O’Dwyer; Réka Tóth; Michael P Carty; Afshin Samali; Eva Szegezdi (2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'. Journal of Leukemia, 4 [DOI] [Details]
(2014) 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'
Paul O’Reilly, Csaba Ortutay, Grainne Gernon, Enda O’Connell, Cathal Seoighe, Susan Boyce, Luis Serrano, Eva Szegezdi (2014) 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'. BMC Genomics, 15 [DOI] [Details]
(2014) 'The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia Initiating cells'
Denis V. Baev, Janusz Krawczyk, Michael O’Dwyer, Eva Szegezdi (2014) 'The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia Initiating cells'. Leukemia research, 3 :79-82 [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk, M,Halpin-McCormick, A,Sessler, T,Samali, A,Szegezdi, E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell Death & Disease, 4 [DOI] [ARAN Link] [Details]
(2013) 'Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines'
Leanza L, O' Reilly P, Doyle A, Venturini E, Zoratti M, Szegezdi E, Szabo I (2013) 'Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines'. Current pharmaceutical design, [Details]
(2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'
Sessler T, Healy S, Samali A, Szegezdi E (2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'. Pharmacology & therapeutics, [DOI] [Details]
(2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'
Szegezdi, E,van der Sloot, AM,Mahalingam, D,O'Leary, L,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,de Jong, S,Samali, A,Serrano, L (2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'. Molecular & Cellular Proteomics, 11 [DOI] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta S, Giricz Z, Natoni A, Donnelly N, Deegan S, Szegezdi E, Samali A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 (22):4023-4030 [DOI] [Details]
(2011) 'Targeting Trail Towards the Clinic'
Mahalingam, Devalingam,N.A.M. Oldenhuis, Corina,Szegezdi, Eva,J. Giles, Francis,G.E. de Vries, Elisabeth,de Jong, Steven,T. Nawrocki, Steffan (2011) 'Targeting Trail Towards the Clinic'. Current Drug Targets, 12 (1414):2079-2090 [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'
van Dijk M, Murphy E, Morrell M , Knapper S , O'Dwyer M, Samali A, Eva Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'. Cancers, 3 :1329-1350 [ARAN Link] [Details]
(2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'
Szegezdi, E,Reis, CR,van der Sloot, AM,Natoni, A,O'Reilly, A,Reeve, J,Cool, RH,O'Dwyer, M,Knapper, S,Serrano, L,Quax, WJ,Samali, A (2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'. Journal Of Cellular And Molecular Medicine, 15 :2216-2231 [DOI] [Details]
(2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'
Mahalingam, D,Natoni, A,Keane, M,Samali, A,Szegezdi, E (2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'. British Journal Of Cancer, 102 :754-764 [DOI] [Details]
(2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'
Reis, CR,van der Sloot, AM,Natoni, A,Szegezdi, E,Setroikromo, R,Meijer, M,Sjollema, K,Stricher, F,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'. Cell Death & Disease, 1 [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'
Gupta, S., Cuffe, L., Szegezdi, E., Logue, S., Neary, C., Healy, S., et al. (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'. Int J Cell Biol, 170215 [ARAN Link] [Details]
(2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'
Vrielink, J,Heins, MS,Setroikromo, R,Szegezdi, E,Mullally, MM,Samali, A,Quax, WJ (2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'. Febs Journal, 277 :1653-1665 [DOI] [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A. (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology: Cell Physiology, [ARAN Link] [Details]
(2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'
Mahalingam, D,Keane, M,Pirianov, G,Mehmet, H,Samali, A,Szegezdi, E (2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'. British Journal Of Cancer, 100 :1415-1424 [DOI] [Details]
(2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'. Biochemistry, 48 :2180-2191 [DOI] [Details]
(2009) 'Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?'
Plantivaux, A.,Szegezdi, E.,Samali, A.,Egan, L. (2009) 'Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?'. Annals N.Y. Acad. Sci, 1171 :38-49 [Details]
(2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'
Gupta, S.,Kass, G. E. N.,Szegezdi, E.,Joseph, B. (2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'. Journal Of Cellular And Molecular Medicine, 13 (66):1004-1033 [Details]
(2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'
Mahalingam, D.,Szegezdi, E.,Keane, M.,de Jong, S.,Samali, A. (2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'. Cancer Treatment Reviews, 35 (33):280-288 [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'
Szegezdi, E.,Reed Herbert, K.,Kavanagh, E. T.,Samali, A.,Gorman, A. M. (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A6A):2482-2496 [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO dependent, mitochondria-mediated and inhibited by bcl-xl'
Holohan, C., Szegezdi, E., Ritter, T., O'Brien, T., Samali, A. (2008) 'Cytokine-induced beta-cell apoptosis is NO dependent, mitochondria-mediated and inhibited by bcl-xl'. J. Cell Mol Med, 12 (2):591-606 [DOI] [Details]
(2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'
Tur, V,van der Sloot, AM,Reis, CR,Szegezdi, E,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'. Journal Of Biological Chemistry, 283 :20560-20568 [DOI] [Details]
(2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'
Mylotte, LA,Duffy, AM,Murphy, M,O'Brien, T,Samali, A,Barry, F,Szegezdi, E (2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'. Stem Cells and Development, 26 :1325-1336 [DOI] [Details]
(2008) 'Structure based design of a DR4 selective TRAIL variant'
Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Serrano L Samali A and Quax W (2008) 'Structure based design of a DR4 selective TRAIL variant'. Journal Of Biological Chemistry, 283 :20560-20568 [Details]
(2008) 'Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development'
Kiss, I.,Ruhl, R.,Szegezdi, E.,Fritzsche, B.,Toth, B.,Pongracz, J.,Perlmann, T.,Fesus, L.,Szondy, Z. (2008) 'Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development'. European Journal of Immunology, 38 (11):147-155 [Details]
(2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'
Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'
Reeve, JLV,Szegezdi, E,Logue, SE,Chonghaile, TN,O'Brien, T,Ritter, T,Samali, A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'. Journal Of Cellular And Molecular Medicine, 11 :509-520 [DOI] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'
Szegezdi, E,Cahill, S,Meyer, M,O'Dwyer, M,Samali, A (2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'. British Journal Of Cancer, 94 :398-406 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi, E.,Logue, S. E.,Gorman, A. M.,Samali, A. (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (99):880-885 [Details]
(2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'
Van der Sloot, AM,Tur, V,Szegezdi, E,Mullally, MM,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 103 :8634-8639 [DOI] [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi, E,Duffy, A,O'Mahoney, ME,Logue, SE,Mylotte, LA,O'Brien, T,Samali, A (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 :1406-1411 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochemical And Biophysical Research Communications, 327 :801-810 [Details]
(2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'
Concannon, CG,FitzGerald, U,Holmberg, CI,Szegezdi, E,Sistonen, L,Samali, A (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'. Cell Stress & Chaperones, 10 :59-65 [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2004) 'TGase2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity'
Szondy, Z.,Sarang, Z.,Molnar, P.,Nemeth, T.,Piacentini, M.,Mastroberardino, P. G.,Falasca, L.,Aeschlimann, D.,Kovacs, J.,Kiss, I.,Szegezdi, E.,Lakos, G.,Rajnavolgyi, E.,Melino, G.,Fesus, L. (2004) 'TGase2 is required for proper phagocytosis of apoptotic cells and to prevent autoimmunity'. Tissue Antigens, 64 (44):342-343 [Details]
(2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'
Szegezdi, E.,Fitzgerald, U.,Samali, A. (2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'. Annals N.Y. Acad. Sci, 1010 :186-194 [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney, M. E.,Logue, S.,Szegezdi, E.,Stenson-Cox, C.,Fitzgerald, U.,Samali, A. (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Annals N.Y. Acad. Sci, 1010 :728-732 [Details]
(2001) 'Cell death in HIV pathogenesis and its modulation by retinoids'
Szondy, Z.,Toth, R.,Szegezdi, E.,Reichert, U.,Ancian, P.,Fesus, L. (2001) 'Cell death in HIV pathogenesis and its modulation by retinoids'. Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways, 946 :95-107 [Details]
(2001) 'Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells'
Toth, R.,Szegezdi, E.,Reichert, U.,Bernardon, J. M.,Michel, S.,Ancian, P.,Kis-Toth, K.,Macsari, Z.,Fesus, L.,Szondy, Z. (2001) 'Activation-induced apoptosis and cell surface expression of Fas (CD95) ligand are reciprocally regulated by retinoic acid receptor alpha and gamma and involve nur77 in T cells'. European Journal of Immunology, 31 (55):1382-1391 [Details]
(2000) 'Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter'
Szegezdi, E.,Szondy, Z.,Nagy, L.,Nemes, Z.,Friis, R. R.,Davies, P. J. A.,Fesus, L. (2000) 'Apoptosis-linked in vivo regulation of the tissue transglutaminase gene promoter'. Cell Death and Differentiation, 7 (1212):1225-1233 [Details]

Book Chapters

  Year Publication
(2011) 'Cytokine-induced b-cell stress and death in type 1 diabetes mellitus'
Vincenz, L; Szegezdi, E; Jäger, R; Holohan, C; O’Brien, T; Samali, A (2011) 'Cytokine-induced b-cell stress and death in type 1 diabetes mellitus' In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments. Croatia: Intech. [Details]

Conference Publications

  Year Publication
(2014) Irish Association for Cancer Research
O'Reilly, P; O'Connell, E; Gernon, G; Szegezdi, E. (2014) Panel of 25 co-acting genes identified as a powerful predictor of TRAIL sensitivity Irish Association for Cancer Research [Details]
(2011) Advances in Tnf Family Research
Quax, W. J.,Reis, C. R.,van der Sloot, A. M.,Tur, V.,Szegezdi, E.,Natoni, A.,Cool, R. H.,Samali, A.,Serrano, L. (2011) Designed Receptor Specific Rhtrail Variants Enhance Induction of Apoptosis in Cancer Cells Advances in Tnf Family Research , pp.726-727 [Details]
(2011) Advances in Tnf Family Research
Reis, C. R.,van der Sloot, A. M.,Szegezdi, E.,Natoni, A.,Tur, V.,Cool, R. H.,Samali, A.,Serrano, L.,Quax, W. J. (2011) Enhancement of Antitumor Properties of Rhtrail by Affinity Increase toward Its Death Receptors Advances in Tnf Family Research , pp.807-808 [Details]
(2011) Advances in Tnf Family Research
van der Sloot, A. M.,Szegezdi, E.,Reis, C. R.,Tur, V.,Quax, W. J.,Samali, A.,Serrano, L. (2011) Computational Design of Receptor Selective Trail Variants Advances in Tnf Family Research , pp.809-809 [Details]
(2011) Advances in Tnf Family Research
van Dijk, M.,Pronai, I.,Somali, A.,Szegezdi, E. (2011) Trail Resistance in Non-Transformed Cells Is Provided by Multiple Factors Advances in Tnf Family Research , pp.821-821 [Details]
(2010) American Society of Hematology Meeting Abstract
Morrell, R. C.,Szegezdi, E.,Halpin-McCormick, A.,Cawley, K.,Samali, A.,O'Dwyer, M. (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia American Society of Hematology Meeting Abstract , pp.768-768 [Details]
(2009) AMER SOC CLINICAL ONCOLOGY Meeting Abstract
Mahalingam, D.,Medina, E.,Swords, R. T.,Kelly, K. R.,Carew, J. S.,Robbert, C. H.,Szegezdi, E.,Francis, G. J.,de Jong, S.,Nawrocki, S. T. (2009) Effect of sunitinib on TRAIL-induced apoptosis in preclinical colon cancer models AMER SOC CLINICAL ONCOLOGY Meeting Abstract [Details]
(2009) Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L (2009) NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance? , pp.38-49 [DOI] [Details]
(2008) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
Plantivaux A, Szegezdi E, Samali A, Egan LJ. (2008) TRAIL resistance in colon cancer cells: is NF-?B involved? APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [Details]
(2007) Proceedings Of The American Association For Cancer Research. Annual Meeting
Szegezdi E, Mahalingam D, Van der Sloot A, Quax W, Keane M, Samali A (2007) Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells Proceedings Of The American Association For Cancer Research. Annual Meeting [Details]
(2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
SZEGEZDI, E et al. (2003) Caspase-12 and ER-stress-mediated apoptosis - The story so far APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS , pp.186-194 [Details]
(2003) American Society of Hematology. Meeting Abstract
Cahill, S.,Szegezdi, E.,Samali, A.,O'Dwyer, M. (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis American Society of Hematology. Meeting Abstract [Details]
(2003) Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes
O'Mahoney, ME,Logue, S,Szegezdi, E,Stenson-Cox, C,Fitzgerald, U,Samali, A (2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes , pp.728-732 [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2009 Irish Cancer Society Research Fellowship - Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis. Irish Cancer Society
2009 Starting Investigator Research Grant Award Science Foundation Ireland

Professional Associations

  Association Function From / To
Irish Association for Cancer Research member 01-MAR-07 /
European Association for Cancer Research member 01-JUN-14 /
Biochemical Society member 01-JUL-05 /

Employment

  Employer Position From / To
University of Debrecen, Hungary Postdoctoral researcher 01-DEC-00 / 30-SEP-02
National University of Ireland, Galway postdoctoral researcher 01-OCT-02 / 05-SEP-11
National University of Ireland, Galway Lecturer 06-SEP-11 /

Education

  Year Institution Qualification Subject
2000 University of Debrecen, Hungary PhD Medical Science
1996 University of Debrecen, Hungary Msc Biochemistry and Molecular Biology

Languages

  Language
English
Hungarian

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester 2, 2011 - today Metabolism and Nutrition MD140
Semester 1, 2015-today Biomolecules, Metabolism and Energy MD138

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Prof. Michael O’Dwyer (Professor of Haematology, UCHG), Prof. Paul Murphy (Head of Chemistry)Prof. Cathal Seoighe (Stokes Professor of Mathematics, Department of Mathematics),Dr. Dimitrios Zeugolis, Principal investigator, Network of Excellence for Functional Biomaterials) Prof. Afshin Samali (Head of ER Stress Research Group;  Discipline of Biochemistry), Prof. Corrado Santocanale (Chair in Molecular Medicine, NCBES, CCB)Dr. Adrienne Gorman (Head of Cell Death and Cell Survival group; Discipline of Biochemistry)

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Dr. Guillermo Montoya (Head of Macromolecular Crystallography Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain); Prof. Luis Serrano (Head of Systems Biology Unit, Centre for Genomic regulation (CRG), Barcelona, Spain);Dr. Steven Knapper, (professor of hematology, University of Cardiff, UK)Dr. Ildiko Szabo, (Department of Biology, University of Padova, Italy), Daniella Zisterer, (School of Biochemistry & Immunology, Trinity College Dublin)Almer van der Sloot (senior researcher, Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Canada)Csaba Ortutay (CEO, Hiducator Ltd, bioinformatics online training, Tampere, Finland)