Dr Andrew Daly

B.A., B.A.I, Ph.D

Contact Details

Lecturer Above The Bar
E: andrew.daly@universityofgalway.ie
 
researcher
 

Biography

Dr Daly is an Assistant Professor in Biomedical Engineering at the University of Galway. His research focuses on bioprinting tissue and organ models with advanced physiological structure and function. In particular, this work focuses on developing bioprinting technologies inspired by organogenesis.

Dr Daly was awarded a PhD in Mechanical Engineering from Trinity College Dublin in 2018, where he developed bioprinted implants for joint resurfacing. For this work, he was awarded the Engineer's Ireland Biomedical Engineering Research Medal in 2018. Following this, he moved to the Department of Bioengineering at the University of Pennsylvania for his postdoctoral training. In 2020, he was awarded an American Heart Association Postdoctoral Fellowship to develop bioprinted cardiac disease models for screening of miRNA therapeutics. In January 2021, he started his research group at the University of Galway and in 2022 he was awarded a European Research Council Starting Grant.

Dr Daly's research is highly cited and has been published in the top journals in the field, including Nature Communications, Nature Reviews Materials, Cell, Biomaterials, Advanced Science, Acta Biomaterialia, Advanced Healthcare Materials, and Biofabrication. To date, he has has received over 1.8 million euro in research funding.

Link to publications
https://scholar.google.com/citations?user=6aab09cAAAAJ&hl=en

Link to personal research webpage
https://www.biofabrication.ie/

Research Career:
2021 - present: Assistant Professor in Biomedical Engineering, College of Science and Engineering, NUI Galway

2021 - present: Funded Investigator at CÚRAM - Science Foundation Ireland Research Centre for Medical Devices  

2018 - 2021: American Heart Association Postdoctoral Fellow, University of Pennsylvania, Philadelphia, USA

2013 - 2017: PhD in Biomedical Engineering, Trinity Centre for Bioengineering, Trinity College Dublin, Ireland

Research Interests

Research Overview
Our work focuses on developing enabling technologies for organ bioprinting. In particular, we create developmentally inspired bioprinting approaches leveraging embryonic processes such as stem cell condensation and tissue fusion. We are currently developing dynamic hydrogels that can program and scale these fundamental behaviours to engineer organs with advanced structural and functional properties.  

Example publications
Bioprinted Tissue Models
https://www.nature.com/articles/s41467-021-21029-2
https://www.sciencedirect.com/science/article/abs/pii/S009286742031624X

Granular Hydrogels
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801076
https://www.nature.com/articles/s41578-019-0148-6
https://www.sciencedirect.com/science/article/abs/pii/S1742706120306383

Cartilage and Bone Bioprinting
https://www.sciencedirect.com/science/article/abs/pii/S0142961218308639
https://iopscience.iop.org/article/10.1088/1758-5090/8/4/045002/meta
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600182
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201700298
https://www.sciencedirect.com/science/article/abs/pii/S0142961218300772

Research Projects

  Project Start Date End Date
ERC Starting Grant - morphoPRINT 01-MAY-23 30-APR-28
Science Foundation Ireland Future Digital Challenge - aiPRINT 01-JAN-23 30-DEC-24

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Juhi Chakraborty ERC Starting Grant Postdoctoral Researcher
Dr Daniel Kelly Science Foundation Ireland Future Digital Challenge - aiPRINT Postdoctoral Researcher
Dr Rashmi Ramakrishnan CÚRAM Industry co-fund Postdoctoral Researcher
Dr Vasileios (Vasilis) Sergis Science Foundation Ireland Future Digital Challenge - aiPRINT Postdoctoral Researcher

Peer Reviewed Journals

  Year Publication
(2024) 'Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue'
Nikolas Di Caprio, Matthew D. Davidson, Andrew C. Daly, Jason A. Burdick (2024) 'Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue'. Advanced Materials, [DOI] [Details]
(2023) 'High resolution lithography 3D bioprinting'
Andrew C. Daly, Khoon S. Lim (2023) 'High resolution lithography 3D bioprinting'. Trends In Biotechnology, [Details]
(2023) 'Granular Hydrogels in Biofabrication: Recent Advances and Future Perspectives'
Andrew C. Daly (2023) 'Granular Hydrogels in Biofabrication: Recent Advances and Future Perspectives'. Advanced Healthcare Materials, [Details]
(2021) 'Bioprinting for the Biologist'
Daly, Andrew C.,Prendergast, Margaret E.,Hughes, Alex J.,Burdick, Jason A. (2021) 'Bioprinting for the Biologist'. Cell, 184 (1):18-32 [Details]
(2021) '3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels'
Daly, Andrew., Davidson, Matthew. D., Burdick, Jason.A. (2021) '3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels'. Nature Communications, [Details]
(2021) 'Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications'
Mendes, Bárbara B.,Daly, Andrew C.,Reis, Rui L.,Domingues, Rui M.A.,Gomes, Manuela E.,Burdick, Jason A. (2021) 'Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications'. Acta Biomaterialia, 119 :101-113 [Details]
(2020) 'Hydrogel microparticles for biomedical applications'
Daly, Andrew C.,Riley, Lindsay,Segura, Tatiana,Burdick, Jason A. (2020) 'Hydrogel microparticles for biomedical applications'. Nature Reviews Materials, 5 (1):20-43 [Details]
(2020) 'The bioprinting roadmap'
Sun, Wei,Starly, Binil,Daly, Andrew C,Burdick, Jason A,Groll, Jürgen,Skeldon, Gregor,Shu, Wenmiao,Sakai, Yasuyuki,Shinohara, Marie,Nishikawa, Masaki,Jang, Jinah,Cho, Dong-Woo,Nie, Minghao,Takeuchi, Shoji,Ostrovidov, Serge,Khademhosseini, Ali,Kamm, Roger D,Mironov, Vladimir,Moroni, Lorenzo,Ozbolat, Ibrahim T (2020) 'The bioprinting roadmap'. Biofabrication, 12 (2) [Details]
(2019) 'Jammed Microgel Inks for 3D Printing Applications'
Highley, Christopher B.,Song, Kwang Hoon,Daly, Andrew C.,Burdick, Jason A. (2019) 'Jammed Microgel Inks for 3D Printing Applications'. Advanced Science, 6 (1) [Details]
(2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'
Sathy, Binulal N.,Daly, Andrew,Gonzalez-Fernandez, Tomas,Olvera, Dinorath,Cunniffe, Grainne,McCarthy, Helen O.,Dunne, Nicholas,Jeon, Oju,Alsberg, Eben,Donahue, Tammy L. Haut,Kelly, Daniel J. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, 88 :314-324 [Details]
(2019) 'Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers'
Daly, Andrew C.,Kelly, Daniel J. (2019) 'Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers'. Biomaterials, 197 :194-206 [Details]
(2018) 'Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions'
Daly, Andrew C,Sathy, Binulal N,Kelly, Daniel J (2018) 'Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions'. Journal of Tissue Engineering, 9 [Details]
(2018) '3D printed microchannel networks to direct vascularisation during endochondral bone repair'
Daly, Andrew C.,Pitacco, Pierluca,Nulty, Jessica,Cunniffe, Gráinne M.,Kelly, Daniel J. (2018) '3D printed microchannel networks to direct vascularisation during endochondral bone repair'. Biomaterials, 162 :34-46 [Details]
(2017) 'Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering'
Cunniffe, Gráinne M.,Gonzalez-Fernandez, Tomas,Daly, Andrew,Sathy, Binulal N.,Jeon, Oju,Alsberg, Eben,Kelly, Daniel J. (2017) 'Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering'. Tissue Engineering Part A, 23 (17-18):891-900 [Details]
(2017) '3D Bioprinting for Cartilage and Osteochondral Tissue Engineering'
Daly, Andrew C.,Freeman, Fiona E.,Gonzalez-Fernandez, Tomas,Critchley, Susan E.,Nulty, Jessica,Kelly, Daniel J. (2017) '3D Bioprinting for Cartilage and Osteochondral Tissue Engineering'. Advanced Healthcare Materials, 6 (22) [Details]
(2016) '3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering'
Daly, Andrew C.,Cunniffe, Gráinne M.,Sathy, Binulal N.,Jeon, Oju,Alsberg, Eben,Kelly, Daniel J. (2016) '3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering'. Advanced Healthcare Materials, 5 (18):2353-2362 [Details]
(2016) 'A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage'
Daly, Andrew C,Critchley, Susan E,Rencsok, Emily M,Kelly, Daniel J (2016) 'A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage'. Biofabrication, 8 (4) [Details]
(2014) 'Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-β3 supplementation and oxygen culture conditions'
Guillaume, Olivier,Daly, Andrew,Lennon, Kerri,Gansau, Jennifer,Buckley, Shane F.,Buckley, Conor T. (2014) 'Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-β3 supplementation and oxygen culture conditions'. Acta Biomaterialia, 10 (5):1985-1995 [Details]

Other Journals

  Year Publication
(2022) 'Bioprinting in granular support hydrogels - characterizing the role of particle morphology and packing density'
Graham Britchfield, Andrew C. Daly (2022) 'Bioprinting in granular support hydrogels - characterizing the role of particle morphology and packing density' bioRxiv, . [DOI] [Details]
(2022) 'An interdisciplinary framework for the characterization of extracellular matrix-hydrogels for biomedical applications'
Sergio Martin-Saldaña, Mansoor Al Waeel, Amir M Alsharabasy, Andrew Daly, Abhay Pandit (2022) 'An interdisciplinary framework for the characterization of extracellular matrix-hydrogels for biomedical applications' Matter, . [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2023 European Research Council Starting Grant European Research Council
2019 American Heart Association Postdoctoral Fellowship American Heart Association
2019 STAR Abstract Award, Society for Biomaterials Society for Biomaterials
2019 Biofabrication Journal Outstanding Reviewer Award Biofabrication Journal
2017 Article "A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage¿ chosen as part of Biofabrication Journal "Highlights of 2016" Biofabrication Journal
2017 Engineer's Ireland Biomedical Engineering Research Medal Engineers Ireland

Professional Associations

  Association Function From / To
Society for Biomaterials Member 01-MAR-19 / 01-FEB-21
International Society for Biofabrication Early Career Researcher Committee Chair 01-MAY-20 / 01-FEB-21

Teaching Interests

Biomaterials, Hydrogels, Bioprinting, Additive Manufacturing, Cell material interactions, Mechanobiology

Current Postgraduate Students (Research)

  Student Degree Type Type
Sogol Kianersi Doctorate - Structured Ph.D (Engineering) Supervisor
Ankita Pramanick Doctorate - Structured Ph.D (Engineering) Supervisor
Hannah Aris Doctorate - Structured Ph.D (Engineering) Co-supervisor (2)

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester 2 Fundamentals of Engineering EI140
Semester 2 Introduction to Biomaterials BME200
Semester 1 Principles of Biomaterials BME328
Semester 2 Mechanobiology BME5101