Professor Laoise McNamara

B.ENG, Ph.D, DIP STAT

Contact Details

Personal Professor
Biomedical Engineering
ENG-3038
New Engineering Building
NUI Galway

T: Ext. 2251
E: laoise.mcnamara@nuigalway.ie
Science Foundation Ireland Lecturer In Biomedical Engineering (Biomechanics)
Mechanical & Biomedical Engineering
3038
College of Engineering and Informatics
National University of Ireland
Galway

T: 35391492251
E: Laoise.McNamara@nuigalway.ie
W: LinkedIn
 
researcher

Biography

Research Career:
 
2016- present: Personal Professor in Biomedical Engineering

2014- 2016: Lecturer in Biomedical Engineering, College of Engineering and Informatics, NUI Galway

2009- 2014: SFI Stokes Lecturer: College of Engineering and Informatics, NUI Galway

2007- 2009: Lecturer: School of Engineering Sciences, University of Southampton, UK

2005- 2007: Lecturer (Fixed term): Dept of Mechanical and Biomedical Engineering, NUI Galway

2004- 2005: Postdoctoral Researcher: Mount Sinai School of Medicine, New York, USA

Dr. Laoise McNamara was recruited to the Department of Mechanical and Biomedical Engineering at NUI Galway through the Science Foundation Ireland Stokes Lectureship program in 2009. She holds a PhD in Biomedical Engineering from Trinity College Dublin, Ireland and a first class honours degree in Mechanical Engineering from the National University of Ireland, Galway. Following her PhD she completed a postdoctoral fellowship in bone cell biology at the Department of Orthopaedic Research at Mount Sinai School of Medicine, New York. Upon completing this research she was appointed to a fixed-term lectureship in Biomedical Engineering at the National University of Ireland, Galway. From 2007-2009 she was a lecturer in Mechanobiology and Musculoskeletal Biomechanics at the University of Southampton in the United Kingdom before taking up her current position.
 
Dr. McNamara's research group consists of eight PhD students and three postdoctoral fellows. She has been awarded funding by the European Research Council, under the Starting Independant Research Grant Program 2010, the Health Research Board Ireland and Science Foundation Ireland. She lectures and co-ordinates courses on the Introduction to Biomedical Engineering, Biomechanics, Medical Implant and Device Design for Biomedical Engineering Undergraduate Degree Program.
 
Dr. McNamara has developed an exceptional research track record in her field, as is evident from international awards and peer-reviewed publications. Her PhD research was internationally recognized with a first prize for a student paper at the European Society of Biomechanics conference in 2002. Her research was awarded a New Investigator Research Award at the Orthopaedic Research Society, 2006 and the American Society for Bone and Mineral Research (ASBMR) Harold B. Frost Young Investigator Award in 2005. In addition her research findings were published in the major international multidisciplinary peer-reviewed journals and her research achievements have been recognized through invited presentations at international conferences and schools. She has served on the awards and program committee for the European Society of Biomechanics and as an international reviewer for the Royal Academy of Engineering (UK) to act to evaluate funding applications. She written book chapters, review articles and is a reviewer for many peer-reviewed journals in her field.

Research Interests

The primary objective of the research in Dr. McNamara's group is to delineate the normal mechanosensory and signalling mechanisms of bone cells. The secondary objective is to determine whether bone tissue mechanics or mechanobiology are impaired during osteoporosis. The final objective is to develop in vitro approaches that can enhance bone tissue regeneration and thereby advance treatment of bone pathologies. The research expertise in Dr. McNamara's group incorporates experimental and computational techniques including micromechanical testing, finite element modelling and theoretical mechano-regulation theories. In addition her group uses in vitro cell culture, advanced microscopy and immunohistochemistry techniques to characterise bone cell biology. Using such methods we focus on:

  • Mechanical properties of bone tissue during osteoporosis
  • Bone mineral composition during osteoporosis
  • Identifying the noncollagenous components of bone tissue during disease
  • Identifying bone cell mechanotransduction machinery in vivo and in vitro
  • Characterising bone cell responses to their mechanical environment in vitro
  • Bone mechanobiology during disease 
  • Developing novel mechanobiology-based approaches to bone tissue regeneration.
 
In addition to these studies Dr. McNamara has research collaborations with Stryker Instruments and Medtronic Vascular. Studies with Stryker Instruments aim to advance understanding of the mechanical and thermal properties of bone and cutting tool materials during surgical cutting procedures. Studies with Medtronic Vascular aim to advance understanding of transcatheter bioprostheses using experimental approaches and computational modelling

Peer Reviewed Journals

  Year Publication
(2016) 'An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants'
Birmingham, E,Niebur, GL,McNamara, LM,McHugh, PE (2016) 'An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants'. Annals Of Biomedical Engineering, 44 :1191-1203 [DOI] [Details]
(2016) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'
Freeman, FE,Haugh, MG,McNamara, LM (2016) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'. Journal Of Tissue Engineering And Regenerative Medicine, 10 :250-262 [DOI] [Details]
(2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'
Zhao, FH,Vaughan, TJ,McNamara, LM (2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'. Biomechanics And Modeling In Mechanobiology, 15 :561-577 [DOI] [Details]
(2016) 'Bone mechanical properties and changes with osteoporosis'
Osterhoff, G,Morgan, EF,Shefelbine, SJ,Karim, L,McNamara, LM,Augat, P (2016) 'Bone mechanical properties and changes with osteoporosis'. Injury-International Journal Of The Care Of The Injured, 47 :11-20 [Details]
(2015) 'The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response'
Metzger, TA,Kreipke, TC,Vaughan, TJ,McNamara, LM,Niebur, GL (2015) 'The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 137 [DOI] [Details]
(2015) 'Differential beta(3) and beta(1) Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats'
Voisin, M,Mcnamara, LM (2015) 'Differential beta(3) and beta(1) Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats'. Anatomical Record-Advances In Integrative Anatomy And Evolutionary Biology, 298 :1548-1559 [DOI] [Details]
(2015) 'Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo'
Freeman, FE,Allen, AB,Stevens, HY,Guldberg, RE,McNamara, LM (2015) 'Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo'. Stem Cell Research & Therapy, 6 [DOI] [Details]
(2015) 'Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis'
Verbruggen, SW,Mc Garrigle, MJ,Haugh, MG,Voisin, MC,McNamara, LM (2015) 'Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis'. Biophysical journal, 108 :1587-1598 [DOI] [Details]
(2015) 'An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation'
Freeman, FE,Haugh, MG,McNamara, LM (2015) 'An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation'. Tissue Engineering Part A, 21 :1320-1332 [DOI] [Details]
(2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'
Birmingham, E,Kreipke, TC,Dolan, EB,Coughlin, TR,Owens, P,McNamara, LM,Niebur, GL,McHugh, PE (2015) 'Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants'. Annals Of Biomedical Engineering, 43 :1036-1050 [DOI] [Details]
(2015) 'Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'
Zhao, FH,Vaughan, TJ,Mcnamara, LM (2015) 'Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold'. Biomechanics And Modeling In Mechanobiology, 14 :231-243 [DOI] [Details]
(2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'
Dolan, EB,Haugh, MG,Voisin, MC,Tallon, D,McNamara, LM (2015) 'Thermally Induced Osteocyte Damage Initiates a Remodelling Signaling Cascade'. Plos One, 10 [DOI] [Details]
(2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia'
Vaughan, TJ,Mullen, CA,Verbruggen, SW,McNamara, LM (2015) 'Bone cell mechanosensation of fluid flow stimulation: a fluid-structure interaction model characterising the role integrin attachments and primary cilia'. Biomechanics And Modeling In Mechanobiology, 14 :703-718 [DOI] [Details]
(2015) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'
Birmingham, E., Kreipke, T.C., Dolan, E.C., Coughlin, T.R., Owens, P., McNamara, L.M., Niebur, G.l., McHugh, P.E. (2015) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'. Annals Of Biomedical Engineering, 43 (4):1036-1050 [Details]
(2015) 'An experimental and computational investigation of bone formation in mechanically loaded trabecular bone explants'
Birmingham, E., Niebur, G.L., McNamara, L.M. and McHugh, P.E. (2015) 'An experimental and computational investigation of bone formation in mechanically loaded trabecular bone explants'. Annals Of Biomedical Engineering, [DOI] [Details]
(2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'
Mullen, CA,Vaughan, TJ,Billiar, KL,McNamara, LM (2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'. Biophysical journal, 108 :1604-1612 [DOI] [Details]
(2015) 'Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow'
Coughlin, TR,Voisin, M,Schaffler, MB,Niebur, GL,McNamara, LM (2015) 'Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow'. Calcified Tissue International, 96 :65-72 [DOI] [Details]
(2015) 'The role of integrin alpha(v)beta(3) in osteocyte mechanotransduction'
Haugh, MG,Vaughan, TJ,McNamara, LM (2015) 'The role of integrin alpha(v)beta(3) in osteocyte mechanotransduction'. Journal Of The Mechanical Behavior Of Biomedical Materials, 42 :67-75 [DOI] [Details]
(2015) 'Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement'
Gunning, PS,Saikrishnan, N,Yoganathan, AP,McNamara, LM (2015) 'Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement'. Journal Of The Royal Society Interface, 12 [DOI] [Details]
(2015) 'Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells During Osteoporosis'
Vaughan, TJ,Voisin, M,Niebur, GL,McNamara, LM (2015) 'Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells During Osteoporosis'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 137 [DOI] [Details]
(2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'
Brennan, MA,Haugh, MG,O'Brien, FJ,McNamara, LM (2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'. Hormone and Metabolic Research, 46 :537-545 [DOI] [Details]
(2014) 'Cell morphology and focal adhesion location alters internal cell stress'
Mullen, CA,Vaughan, TJ,Voisin, MC,Brennan, MA,Layrolle, P,McNamara, LM (2014) 'Cell morphology and focal adhesion location alters internal cell stress'. Journal Of The Royal Society Interface, 11 [DOI] [Details]
(2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'
Brennan, MA,Gleeson, JP,O'Brien, EJ,McNamara, LM (2014) 'Effects of ageing, prolonged estrogen deficiency and zoledronate on bone tissue mineral distribution'. Journal Of The Mechanical Behavior Of Biomedical Materials, 29 :161-170 [DOI] [Details]
(2014) 'Simulation of Self Expanding Transcatheter Aortic Valve in a Realistic Aortic Root: Implications of Deployment Geometry on Leaflet Deformation'
Gunning, PS,Vaughan, TJ,McNamara, LM (2014) 'Simulation of Self Expanding Transcatheter Aortic Valve in a Realistic Aortic Root: Implications of Deployment Geometry on Leaflet Deformation'. Annals Of Biomedical Engineering, 42 :1989-2001 [DOI] [Details]
(2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'
McNamara, LM (2014) 'Multidisciplinary research into bonemechanobiology during normal physiology and the bone disease osteoporosis'. Osteoporosis International, 25 [Details]
(2014) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'
Birmingham, E., Kreipke, T.C., Dolan, E.C., Coughlin, T.R., Owens, P., McNamara, L.M., Niebur, G.L. and McHugh, P.E. (2014) 'Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants'. Annals Of Biomedical Engineering, 43 (4):1036-1050 [Details]
(2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'
Gunning, PS,Saikrishnan, N,McNamara, LM,Yoganathan, AP (2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'. Annals Of Biomedical Engineering, 42 :1195-1206 [DOI] [Details]
(2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'
MA Brennan, MG Haugh, FJ O'Brien, LM McNamara (2014) 'Estrogen Withdrawal from Osteoblasts and Osteocytes Causes Increased Mineralization and Apoptosis'. Hormone and Metabolic Research, [DOI] [Details]
(2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomechanics And Modeling In Mechanobiology, 13 :85-97 [DOI] [Details]
(2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'
PS Gunning, N Saikrishnan, LM McNamara, AP Yoganathan (2014) 'An In Vitro Evaluation of the Impact of Eccentric Deployment on Transcatheter Aortic Valve Hemodynamics'. Annals Of Biomedical Engineering, 42 (6):1195-1206 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB,Vaughan, TJ,Niebur, GL,Casey, C,Tallon, D,McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'
Mullen, C.A., Haugh, M.G., Schaffler, M.B., Majeska, R.J., McNamara, L.M. (2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'. Journal Of Mechanical Behavior Of Biomedical Materials, [Details]
(2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen SW, Vaughan TJ, McNamara LM (2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomech Model Mechanobiol, [DOI] [Details]
(2013) 'Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques'
Birmingham, E., Grogan, J.A., Niebur, G.L., McNamara, L.M., McHugh, P.E. (2013) 'Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques'. Annals Of Biomedical Engineering, 41 (4):814-826 [DOI] [Details]
(2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan, TJ,Verbruggen, SW,McNamara, LM (2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International Journal For Numerical Methods In Biomedical Engineering, 29 :1361-1372 [DOI] [Details]
(2013) 'Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques'
Birmingham, E,Grogan, JA,Niebur, GL,McNamara, LM,McHugh, PE (2013) 'Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques'. Annals Of Biomedical Engineering, 41 :814-826 [DOI] [Details]
(2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'
Mullen, CA,Haugh, MG,Schaffler, MB,Majeska, RJ,McNamara, LM (2013) 'Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation'. Journal Of The Mechanical Behavior Of Biomedical Materials, 28 :183-194 [DOI] [Details]
(2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ,Haugh, MG,McNamara, LM (2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal Of The Royal Society Interface, 10 [DOI] [Details]
(2013) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'
Freeman FE, Haugh MG, McNamara LM. (2013) 'Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy'. Journal Of Tissue Engineering And Regenerative Medicine, [DOI] [Details]
(2013) '2. Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan TJ, Verbruggen SW, McNamara LM. (2013) '2. Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International Journal For Numerical Methods In Engineering, [DOI] [Details]
(2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'
Brennan, O,Kuliwaba, JS,Lee, TC,Parkinson, IH,Fazzalari, NL,McNamara, LM,O'Brien, FJ (2012) 'Temporal Changes in Bone Composition, Architecture, and Strength Following Estrogen Deficiency in Osteoporosis'. Calcified Tissue International, 91 :440-449 [DOI] [Details]
(2012) 'Osteogenesic differentiation of medenchymal stem cells is regulated by Osteocyte and Osteoblast cells in a simplified bone niche'
Birmingham, E., Niebur, G., McHugh, P.E., Shaw, G., Barry, F.P., McNamara, L.M. (2012) 'Osteogenesic differentiation of medenchymal stem cells is regulated by Osteocyte and Osteoblast cells in a simplified bone niche'. European Cells And Materials, 23 :13-27 [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, TJ,McCarthy, CT,McNamara, LM (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal Of The Mechanical Behavior Of Biomedical Materials, 12 :50-62 [DOI] [Details]
(2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'
Dolan, EB,Haugh, MG,Tallon, D,Casey, C,McNamara, LM (2012) 'Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting'. Journal Of The Royal Society Interface, 9 :3503-3513 [DOI] [Details]
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal Of The Royal Society Interface, 9 :2735-2744 [DOI] [Details]
(2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'
Birmingham, E,Niebur, GL,McHugh, PE,Shaw, G,Barry, FP,McNamara, LM (2012) 'OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE'. European Cells & Materials, 23 :13-27 [Details]
(2012) 'Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro'
Brennan O, O'Brien FJ, McNamara LM. (2012) 'Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro'. Hormone and Metabolic Research, 44 (2) [Details]
(2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'
Brennan, MA,Gleeson, JP,Browne, M,O'Brien, FJ,Thurner, PJ,McNamara, LM (2011) 'SITE SPECIFIC INCREASE IN HETEROGENEITY OF TRABECULAR BONE TISSUE MINERAL DURING OESTROGEN DEFICIENCY'. European Cells & Materials, 21 [Details]
(2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'
Brennan, O,Kennedy, OD,Lee, TC,Rackard, SM,O'Brien, FJ,McNamara, LM (2011) 'The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis'. Journal Of Biomechanics, 44 :386-390 [DOI] [Details]
(2010) 'Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures'
McNamara, L.M. (2010) 'Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures'. Jourmal of the Royal Society Interface, 7 (44):353-372 [Details]
(2009) 'Attachment of osteocyte cell processes to the bone matrix'
McNamara, L.M., Majeska, R.J., Weinbaum, S., Friedrich, V., Schaffler, M.B. (2009) 'Attachment of osteocyte cell processes to the bone matrix'. Anatomical Record, [Details]
(2008) 'Strain amplification and integrin based signalling in osteocytes'
Wang, Y., McNamara, L.M., Schaffler, M.B., Weinbaum, S. (2008) 'Strain amplification and integrin based signalling in osteocytes'. Journal of Musculoskeletal and Neuronal Interactions, 8 (4):332-334 [Details]
(2008) 'Loss of trabeculae in osteoporotic cancellous bone by biomechanical means'
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2008) 'Loss of trabeculae in osteoporotic cancellous bone by biomechanical means'. Journal of the Royal Society Interface, 5 (5):1243-1253 [Details]
(2007) 'Bone remodelling algorithms incorporating both strain and microdamage stimuli'
McNamara, L. M. & Prendergast, P. J. (2007) 'Bone remodelling algorithms incorporating both strain and microdamage stimuli'. Journal of Biomechanics, 40 (6):1381-1391 [Details]
(2007) 'The effect of patient-specific bone remodeling rates on remodelling/repair in trabecular bone'
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2007) 'The effect of patient-specific bone remodeling rates on remodelling/repair in trabecular bone'. III International congress on Computational Bioengineering, [Details]
(2007) 'Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes'
Wang, Y., McNamara, L.M., Schaffler, M.B. Weinbaum, S.A. (2007) 'Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes'. Proceedings of the National Academy of Sciences, 10 (40):15941-15946 [Details]
(2006) 'Stress-concentrating effect of resorption lacunae in trabecular bone'
McNamara, L.M., Van der Linden, J.C., Weinans, H., Prendergast, P.J. (2006) 'Stress-concentrating effect of resorption lacunae in trabecular bone'. Journal Of Biomechanics, 39 (4):734-741 [Details]
(2006) 'Strength of cancellous bone trabecular tissue from normal, ovarectomized and drug-treated rats over the course of ageing'
McNamara, L.M., Lyons, C.G., Ederveen, A.H., Weinans, H., Price, C.J., Schaffler, M.B., Prendergast, P.J. (2006) 'Strength of cancellous bone trabecular tissue from normal, ovarectomized and drug-treated rats over the course of ageing'. BONE, 39 (2):392-400 [Details]
(2005) 'Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis'
McNamara, L.M., Prendergast, P.J. (2005) 'Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis'. European Journal of Morphology, 42 (01-Feb):99-109 [Details]
(2005) 'Bone tissue material properties are altered during Osteoporosis'
McNamara, L. M., Prendergast, P. J. and Schaffler, M. B. (2005) 'Bone tissue material properties are altered during Osteoporosis'. Journal of Musculoskeletal and Neuronal Interactions, 5 (4):342-343 [Details]

Book Chapters

  Year Publication
(2011) 'Bone as a Material'
McNamara, L.M. (2011) 'Bone as a Material' In: Comprehensive Biomaterials. Amsterdam: Elsevier. [Details]
(2008) 'Bones of Contention'
McNamara, L.M. (2008) 'Bones of Contention' In: Perspectives in Design and Bioengeineering. [Details]
(2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation'
Lee, T.C., McHugh, P.E., O'Brien, F.J., O'Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahony, N.J., Harrison, N., Lohfield, S., Brennan, O., Gleeson, J., Hazenberg, J.G., Mullins, L., Tyndyk, M., McNamara, L.M., O'Kelly, K. (2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation' In: Topics in Bio-Mechanical Engineering. [Details]
(2004) 'Topics in Biomechanical Engineering'
Lee, T.C., McHugh, P.E., O’Brien, F.J., O’Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahoney, N.J., Harrison, N., Lohfeld, S., Brennan, O., Hazenberg J.G., Mullins, L., Tyndyk, M., McNamara, L.M. O’ Kelly, K. and Prendergast, P.J. (2004) 'Topics in Biomechanical Engineering' In: Bone for life: osteoporosis, bone remodelling and computer simulation. Dublin & Galway: TCBE & NCBES. [Details]

Conference Publications

  Year Publication
(2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW
Vaughan, TJ,Haugh, MG,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW [Details]
(2014) PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE
Coughlin, TR,Haugh, M,Voisin, M,Birmingham, E,McNamara, LM,Niebur, GL, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE [Details]
(2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION
Dolan, EB,Vaughan, TJ,Niebur, GL,Tallon, D,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION [Details]
(2014) HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY
Gunning, PS,Saikrishnan, N,Yoganathan, AP,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY [Details]
(2012) THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS
Haugh, MG,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS , pp.677-678 [Details]
(2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT
Gunning, PS,Harewood, FJ,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT , pp.1043-1044 [Details]
(2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT
Verbruggen, SW,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT , pp.517-518 [Details]

Abstract

  Year Publication
(2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells.
Virjula, S,Zhao, F,Leivo, J,Vanhatupa, S,Honkala, A,Viehrig, M,Kreutzer, J,McNamara, LM,Kallio, P,Miettinen, S (2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells. Abstract [Details]
(2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage.
Haugh, MG,Vaughan, TJ,McNamara, LM,O'Brien, FJ,Heilshorn, SC (2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage. Abstract [Details]
(2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation.
Mc Garrigle, MJ,Mullen, CA,Owens, P,Voisin, MC,McNamara, LM (2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation. Abstract [Details]
(2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model.
Freeman, FE,Allen, AB,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model. Abstract [Details]
(2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors.
Freeman, FE,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors. Abstract [Details]

Conference Paper

  Year Publication
(2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics.
Birmingham, E., Niebur, G., McNamara, L., McHugh, P. (2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society.
Brennan, O., Kuliwaba, J.S., Mahony, N.J., Parkinson, I.H., Fazzalari, N.L., McNamara, L.M., O'Brien, F.J. (2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, Thurner, P J, McNamara, LM (2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society.
Mullen, C., McNamara, L.M. (2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society. Granada, Spain: Conference Paper [Details]
(2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society.
Brennan, O., Kennedy, O.D., Lee T.C., Rackard, S.M., O'Brien, F.J., McNamara, L.M. (2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society. New Orleans, USA: Conference Paper [Details]
(2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society.
Birmingham E., Niebur G., McHugh P., McNamara L. (2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics.
Gunning, P., O'Keeffe L., McNamara, L.M. (2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, J, Thurner, P, J, McNamara, L (2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics.
Verbruggen, S., McNamara, L.M. (2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics.
Birmingham E., McNamara L., Niebur G., McHugh P.E. (2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics. Edinburgh: Conference Paper [Details]
(2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society.
McNamara, L.M., Brennan, M., Brennan, O. (2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society. Las Vegas, Nevada, USA: Conference Paper [Details]
(2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society.
McNamara, L.M., O'Brien F.J., Gillespie, C. (2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society.
Fritton, J.C., Chinitz, N., Berman, D., McNamara, L.M., Choi, B.G., Badimon, J.J., Schaffler, M.B. (2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society.
Wang, Y., Weinbaum, S., McNamara, L.M., Schaffler, M.B. (2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting.
Wang, Y., McNamara, L.M., Schaffler, M.B., Weinbaum, S. (2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting. Conference Paper [Details]
(2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society.
McNamara, LM, Majeska, RJ, Weinbaum, S, Friedrich, V, Schaffler, MB (2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society. Conference Paper [Details]
(2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Lyons, C.G., Ederveen, A.H., Weinans, H., Price, C.J., Schaffler, M.B., Prendergast, P.J. (2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics. Conference Paper [Details]
(2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Herman, B.C., Majeska, R.J., Schaffler, M.B. (2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society.
McNamara, L.M., Prendergast, L.M. (2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society. Washington: Conference Paper [Details]
(2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop.
McNamara, L.M., Prendergast, P.J., Schaffler, M.B (2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop. Sun Valley, Idaho, USA: Conference Paper [Details]
(2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society.
McNamara, L.M., Prendergast, P.J., Lyons, C.G., Ederveen, A.G.H., Weinans, H. (2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics.
McNamara, L.M., Prendergast, P.J. (2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics. Hertogenbosch: Conference Paper [Details]
(2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA.
Prendergast, PJ, McNamara, LM, Kelly, DJ, Lacroix, D (2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA. Conference Paper [Details]
(2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics.
McNamara, L.M., Prendergast, P.J., O' Kelly, K., Lyons, G. (2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics. Calgary, Canada: Conference Paper [Details]
(2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics.
McNamara, L.M., Van der Linden, J.C., Weinans, H., Prendergast, P.J. (2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics. Conference Paper [Details]

Correction

  Year Publication
(2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012).
Brennan, O,O'Brien, FJ,McNamara, LM (2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012). Correction [Details]

Meeting

  Year Publication
(2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES.
Gunning, P,Saikrishnan, N,Yoganathan, A,McNamara, LM (2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES. Meeting [Details]

Reviews

  Year Publication
(2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures.
McNamara, LM (2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. Reviews [DOI] [Details]

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Professor Frank Barry, National Centre for Biomedical Engineering SciencesProfessor Peter McHugh, Mechanical and Biomedical EngineeringDr. Patrick McGarry, Mechanical and Biomedical Engineering

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Professor Glen Niebur, University of Notre Dame, USAProfressor Ajit Yoganathan, Georgia Tech University, USAProfessor Richard Oreffo, University of Southampton, United KingdomDr. Philipp Thurner, University of Southampton, United KingdomDr. Martin Browne, University of Southampton, United KingdomProfessor Fergal O'Brien, Royal College of Surgeons in Ireland