Professor Laoise McNamara

B.ENG, Ph.D, DIP STAT

 
researcher
 

Biography

Research Career:
 
2016- present: Personal Professor in Biomedical Engineering

2014- 2016: Lecturer in Biomedical Engineering, College of Engineering and Informatics, NUI Galway

2009- 2014: SFI Stokes Lecturer: College of Engineering and Informatics, NUI Galway

2007- 2009: Lecturer: School of Engineering Sciences, University of Southampton, UK

2005- 2007: Lecturer (Fixed term): Dept of Mechanical and Biomedical Engineering, NUI Galway

2004- 2005: Postdoctoral Researcher: Mount Sinai School of Medicine, New York, USA

Professor Laoise McNamara is a Personal Professor in Biomedical Engineering at the National University of Ireland, Galway. She established the Mechanobiology and Medical Device Research group at NUI Galway in 2009, which is currently comprised of 14 researchers. The MMDRG research group (www.mechanobiology.ie) use multidisciplinary approaches to understand mechanobiology and how this process contributes to bone development and osteoporosis. They have developed novel multiphysics and multiscale computational modelling techniques and have applied these methods to derive an understanding of the mechanical stimuli that bone cells experience in vivo in healthy and osteoporotic bone tissue. Her research group have uncovered changes in bone mechanobiology during osteoporosis. Her research has been applied to understand the role of mechanical stimulation in bone regeneration and she develops in vitro tissue regeneration strategies that exploit mechanobiological responses to overcome challenges in the field of bone tissue engineering. Professor McNamara’s research is informing the generation of novel therapeutic approaches for osteoporosis. Professor McNamara collaborates with Stryker, Boston Scientific and Medtronic applying her expertise in computational and experimental biomechanics to the pre-clinical assessment of surgical and minimally invasive medical devices. Professor McNamara was awarded an Irish Research Council (IRC) Laureate Award in 2018, the SFI Investigators Grant in 2015 and a European Research Council Starting Independent Researcher Award in 2011 along with various other Health Research Board, SFI and Irish Research Council funding. She has been awarded the ‘Bone and Joint Decade’ New Investigator Award by the Orthopaedic Research Society, and the Harold B. Frost Young Investigator Award by the American Society for Bone and Mineral Research (ASBMR). She has published more than 70 research articles in various high Impact Factor journals; PNAS, European Cells and Materials, the Journal of the Royal Society Interface, Bone, Tissue Engineering Part A and the Biophysical Journal, among many others. She is a reviewer for over 20 peer-reviewed international journals. She has also acted as a Royal Academy of Engineering (UK) reviewer for the Irish Research Council for Science and Engineering Technology (IRCSET) Postdoctoral Fellowships scheme. Professor McNamara a member of the Executive board and Platform Lead for the Science Foundation Ireland (SFI) funded Centre for Research in Medical Devices (CURAM) and is the Vice Dean for Recruitment and Internationalisation in the College of Engineering and Informatics at NUI Galway.

Research Interests

The primary objective of the research in Professor McNamara's group is to delineate the normal mechanosensory and signalling mechanisms of bone cells. The secondary objective is to determine whether bone tissue mechanics or mechanobiology are impaired during osteoporosis. The final objective is to develop in vitro approaches that can enhance bone tissue regeneration and thereby advance treatment of bone pathologies. The research expertise in Professor McNamara's group incorporates experimental and computational techniques including micromechanical testing, finite element modelling and theoretical mechano-regulation theories. In addition her group uses in vitro cell culture, advanced microscopy and immunohistochemistry techniques to characterise bone cell biology. Using such methods we focus on:

  • Mechanical properties of bone tissue during osteoporosis
  • Bone mineral composition during osteoporosis
  • Identifying the noncollagenous components of bone tissue during disease
  • Identifying bone cell mechanotransduction machinery in vivo and in vitro
  • Characterising bone cell responses to their mechanical environment in vitro
  • Bone mechanobiology during disease 
  • Developing novel mechanobiology-based approaches to bone tissue regeneration.
 
In addition to these studies Professor McNamara has research collaborations with Stryker Instruments and Boston Scientific. Studies with Stryker Instruments aim to advance understanding of the mechanical and thermal properties of bone and cutting tool materials during surgical cutting procedures. Studies with Boston Scientific aim to advance understanding of transcatheter bioprostheses using experimental approaches and computational modelling

Research Projects

  Project Start Date End Date
IRC Laureate - Mechanobiological model systems for bone metastases mimetics 01-SEP-18 31-AUG-22

Book Chapters

  Year Publication
(2011) 'Bone as a Material'
McNamara, L.M. (2011) 'Bone as a Material' In: Comprehensive Biomaterials. Amsterdam: Elsevier. [Details]
(2008) 'Bones of Contention'
McNamara, L.M. (2008) 'Bones of Contention' In: Perspectives in Design and Bioengeineering. [Details]
(2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation'
Lee, T.C., McHugh, P.E., O'Brien, F.J., O'Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahony, N.J., Harrison, N., Lohfield, S., Brennan, O., Gleeson, J., Hazenberg, J.G., Mullins, L., Tyndyk, M., McNamara, L.M., O'Kelly, K. (2004) 'Bone for Life: Osteoporosis, Bone Remodelling and Computer Simulation' In: Topics in Bio-Mechanical Engineering. [Details]
(2004) 'Topics in Biomechanical Engineering'
Lee, T.C., McHugh, P.E., O’Brien, F.J., O’Mahoney, D., Taylor, D., Bruzzi, M., Rackard, S.M., Kennedy, O.D., Mahoney, N.J., Harrison, N., Lohfeld, S., Brennan, O., Hazenberg J.G., Mullins, L., Tyndyk, M., McNamara, L.M. O’ Kelly, K. and Prendergast, P.J. (2004) 'Topics in Biomechanical Engineering' In: Bone for life: osteoporosis, bone remodelling and computer simulation. Dublin & Galway: TCBE & NCBES. [Details]

Conference Publications

  Year Publication
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Verbruggen, SW;Vaughan, TJ;McNamara, LM (2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.517-518 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Gunning, PS;Harewood, FJ;Vaughan, TJ;McNamara, LM (2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.1043-1044 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Haugh, MG;McNamara, LM (2012) THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.677-678 [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B
Coughlin, TR;Haugh, M;Voisin, M;Birmingham, E;McNamara, LM;Niebur, GL (2014) PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A
Vaughan, TJ;Haugh, MG;McNamara, LM (2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B
Dolan, EB;Vaughan, TJ;Niebur, GL;Tallon, D;McNamara, LM (2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A
Gunning, PS;Saikrishnan, N;Yoganathan, AP;McNamara, LM (2014) HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A [Details]
(2011) 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M. (2011) An investigation into the microenvironment of the stem cell niche 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA [Details]
(2012) Proceedings of Orthopaedic Research Society Annual Meeting, San Francisco, CA, USA
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M. (2012) The Synergistic Effect of Osteocytes and Osteoblasts on the Osteogenic Differentiation of MSCs Proceedings of Orthopaedic Research Society Annual Meeting, San Francisco, CA, USA [Details]
(2012) Proceedings of the Annual Symposium on Computational Methods in Orthopaedic Biomechanics (Pre-ORS), Berkeley, CA, USA
Birmingham, E., Niebur, G.L., McNamara, L.M. and McHugh, P.E. (2012) Computational Modelling of Trabecular Bone Marrow Proceedings of the Annual Symposium on Computational Methods in Orthopaedic Biomechanics (Pre-ORS), Berkeley, CA, USA [Details]
(2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW
Vaughan, TJ,Haugh, MG,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW [Details]
(2014) PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE
Coughlin, TR,Haugh, M,Voisin, M,Birmingham, E,McNamara, LM,Niebur, GL, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B PRIMARY CILIA KNOCKDOWN REDUCES THE NUMBER OF STROMAL CELLS IN THREE DIMENSIONAL EX VIVO CULTURE [Details]
(2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION
Dolan, EB,Vaughan, TJ,Niebur, GL,Tallon, D,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION [Details]
(2014) HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY
Gunning, PS,Saikrishnan, N,Yoganathan, AP,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A HEMODYNAMIC AND STRUCTURAL IMPLICATIONS OF ASYMMETRIC DEPLOYMENT OF TRANSCATHETER AORTIC VALVES - AN IN VITRO STUDY [Details]
(2012) THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS
Haugh, MG,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B THE ROLE OF INTEGRINS IN OSTEOCYTE RESPONSE TO MECHANICAL STIMULUS , pp.677-678 [Details]
(2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT
Gunning, PS,Harewood, FJ,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT , pp.1043-1044 [Details]
(2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT
Verbruggen, SW,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT , pp.517-518 [Details]

Conference Contributions

  Year Publication
(2011) 2nd Proceedings of the Orthopaedic Research Society Annual Meeting,
Birmingham, E., Niebur, G.L., McHugh, P.E. and McNamara, L.M (2011) An investigation into the microenvironment of the stem cell niche. [Oral Presentation], 2nd Proceedings of the Orthopaedic Research Society Annual Meeting, Long Beach, CA, USA , 01-JAN-11 - 01-JAN-11. [Details]

Abstract

  Year Publication
(2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells.
Virjula, S,Zhao, F,Leivo, J,Vanhatupa, S,Honkala, A,Viehrig, M,Kreutzer, J,McNamara, LM,Kallio, P,Miettinen, S (2015) The Effect of Stretching on the Osteogenic Differentiation and Mechanical Properties of Human Adipose Stem Cells. Abstract [Details]
(2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage.
Haugh, MG,Vaughan, TJ,McNamara, LM,O'Brien, FJ,Heilshorn, SC (2015) An Experimental and Computational Investigation of 3D Matrix Mechanics in Directing Stem Cell Lineage. Abstract [Details]
(2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation.
Mc Garrigle, MJ,Mullen, CA,Owens, P,Voisin, MC,McNamara, LM (2015) Osteoblast-Osteocyte Differentiation within a Three Dimensional Matrix is Determined by Matrix Stiffness and Intercellular Separation. Abstract [Details]
(2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model.
Freeman, FE,Allen, AB,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Investigation of the In Vivo Vascularisation And Mineralisation Potentials of Endochondrally Primed Cellular Aggregates in a Rat Subcutaneous Delivery Model. Abstract [Details]
(2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors.
Freeman, FE,Owens, P,Stevens, HY,Guldberg, RE,McNamara, LM (2015) Endochondrally Priming of Human MSCs In Vitro Enhances their Mineralisation Potential without the Addition of Osteogenic Growth Factors. Abstract [Details]

Conference Paper

  Year Publication
(2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics.
Birmingham, E., Niebur, G., McNamara, L., McHugh, P. (2011) Computational Modelling of Trabecular Bone Marrow. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society.
Brennan, O., Kuliwaba, J.S., Mahony, N.J., Parkinson, I.H., Fazzalari, N.L., McNamara, L.M., O'Brien, F.J. (2011) Bone Mineral and Matrix Composition s Altered Prior to Significant Architectural Changes in Osteoporosis. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, Thurner, P J, McNamara, LM (2011) Estrogen deficiency increased heterogeneity of bone tissue is anatomically regional dependent . Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society.
Mullen, C., McNamara, L.M. (2011) Experimental and Computational Investigation into Osteocyte Differentiation. European Chapter of the Tissue Engineering and Regenerative Medicine International Society. Granada, Spain: Conference Paper [Details]
(2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society.
Brennan, O., Kennedy, O.D., Lee T.C., Rackard, S.M., O'Brien, F.J., McNamara, L.M. (2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Trans 56th Orthopaedic Research Society. New Orleans, USA: Conference Paper [Details]
(2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society.
Birmingham E., Niebur G., McHugh P., McNamara L. (2011) An investigation into the microenvironment of the stem cell niche. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics.
Gunning, P., O'Keeffe L., McNamara, L.M. (2011) Computational analysis of transcatheter bioprosthetic valve design. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society.
Brennan, M, Browne, M, O'Brien, F, J, Thurner, P, J, McNamara, L (2011) Site Specific Increase in Heterogeneity of Bone Tissue Mineral during Estrogen Deficiency. Trans 57th Orthopaedic Research Society. Long Beach, California, USA: Conference Paper [Details]
(2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics.
Verbruggen, S., McNamara, L.M. (2011) Multi-Scale Computational Modelling of Physiological Loading on Bone Cells. International workshop on Computational Mechanics. Limerick, Ireland: Conference Paper [Details]
(2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics.
Birmingham E., McNamara L., Niebur G., McHugh P.E. (2010) Understanding the biomechanical microenvironment of the stem cell niche in bone. Proceedings of the 17th Congress of the European Society of Biomechanics. Edinburgh: Conference Paper [Details]
(2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society.
McNamara, L.M., Brennan, M., Brennan, O. (2009) Estrogen deficiency alters mineral production by osteoblastic cells in vitro. Trans 55th Orthopaedic Research Society. Las Vegas, Nevada, USA: Conference Paper [Details]
(2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society.
McNamara, L.M., O'Brien F.J., Gillespie, C. (2008) Site-specific differences in bone mineral content from normal and ovariectomized bone. Trans 54th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society.
Fritton, J.C., Chinitz, N., Berman, D., McNamara, L.M., Choi, B.G., Badimon, J.J., Schaffler, M.B. (2007) Atherogenic treatment impairs age-related cortical bone adaptation in female rabbits. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society.
Wang, Y., Weinbaum, S., McNamara, L.M., Schaffler, M.B. (2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2007) 3D simulation of damage repair along a single trabecular strut. Trans 53rd Orthopaedic Research Society. San Diego: Conference Paper [Details]
(2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting.
Wang, Y., McNamara, L.M., Schaffler, M.B., Weinbaum, S. (2006) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Biomedical Engineering Society Fall Meeting. Conference Paper [Details]
(2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society.
McNamara, LM, Majeska, RJ, Weinbaum, S, Friedrich, V, Schaffler, MB (2006) Attachment of osteocyte cell processes to bone matrix, New Investigator Research Award. Trans 52nd Orthopaedic Research Society. Conference Paper [Details]
(2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Lyons, C.G., Ederveen, A.H., Weinans, H., Price, C.J., Schaffler, M.B., Prendergast, P.J. (2006) Changes in bone tissue material properties during osteoporosis and anti-resorptive drug treatment are coupled to changes in mineral content. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics.
Mulvihill, B.M., McNamara, L.M., Prendergast, P.J. (2006) 3D Simulation of Damage Repair along a Single Trabecular Strut. Proceedings of the 5th World Congress of Biomechanics. Conference Paper [Details]
(2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society.
McNamara, L.M., Herman, B.C., Majeska, R.J., Schaffler, M.B. (2006) Development of osteocytic phenotype in vitro depends on extracellular matrix composition. Trans 52nd Orthopaedic Research Society. Chicago: Conference Paper [Details]
(2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society.
McNamara, L.M., Prendergast, L.M. (2005) Trabecular perforation during osteoporosis may begin with a chance in bone tissue elastic behavior. Trans 51st Orthopaedic Research Society. Washington: Conference Paper [Details]
(2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop.
McNamara, L.M., Prendergast, P.J., Schaffler, M.B (2005) Bone tissue material properties are altered during osteoporosis, American Society for Bone and Mineral Research Harold B. Frost Young Investigator Award. Proc 35th Sun Valley Skeletal Tissue Biology Workshop. Sun Valley, Idaho, USA: Conference Paper [Details]
(2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society.
McNamara, L.M., Prendergast, P.J., Lyons, C.G., Ederveen, A.G.H., Weinans, H. (2004) Strength of single rat trabeculae in normal, ovariectomized and drug treated bone during ageing. Trans 50th Orthopaedic Research Society. San Francisco, California: Conference Paper [Details]
(2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics.
McNamara, L.M., Prendergast, P.J. (2004) Can BMU activity be predicted using a mechano-regulatory rule combining strain and microdamage. Proc 14th European Society of Biomechanics. Hertogenbosch: Conference Paper [Details]
(2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA.
Prendergast, PJ, McNamara, LM, Kelly, DJ, Lacroix, D (2002) Finite Element Analysis and Bone Remodeling. Proc 4th Bone Fluid Flow Meeting, STEGA. Conference Paper [Details]
(2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics.
McNamara, L.M., Prendergast, P.J., O' Kelly, K., Lyons, G. (2002) Micro-tensile testing of individual bone trabeculae from Normal, Ageing and Ovarectomized Bones. Proc 4th World Congress of Biomechanics. Calgary, Canada: Conference Paper [Details]
(2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics.
McNamara, L.M., Van der Linden, J.C., Weinans, H., Prendergast, P.J. (2002) High stresses occur in bone trabeculae under low loads! A study using micro-serial sectioning techniques and finite element analysis. Proc 13th European Society of Biomechanics, ACTA of Bioengineering and Biomechanics. Conference Paper [Details]

Correction

  Year Publication
(2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012).
Brennan, O,O'Brien, FJ,McNamara, LM (2012) Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro (vol 44, pg 47, 2012). Correction [Details]

Meeting

  Year Publication
(2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES.
Gunning, P,Saikrishnan, N,Yoganathan, A,McNamara, LM (2013) A COMPUTATIONAL MODEL FOR PREOPERATIVE EVALUATION OF ASYMMETRIC DEPLOYED TRANSCATHETER AORTIC VALVES. Meeting [Details]

Reviews

  Year Publication
(2019) Integrins in Osteocyte Biology and Mechanotransduction.
Geoghegan, IP;Hoey, DA;McNamara, LM (2019) Integrins in Osteocyte Biology and Mechanotransduction. NEW YORK: Reviews [DOI] [Details]
(2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures.
McNamara, LM (2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. LONDON: Reviews [DOI] [Details]
(2016) Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template.
Freeman, FE;Stevens, HY;Owens, P;Guldberg, RE;McNamara, LM (2016) Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template. NEW ROCHELLE: Reviews [DOI] [Details]
(2017) Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration.
Freeman, FE;McNamara, LM (2017) Endochondral Priming: A Developmental Engineering Strategy for Bone Tissue Regeneration. NEW ROCHELLE: Reviews [DOI] [Details]
(2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures.
McNamara, LM (2010) Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures. Reviews [DOI] [Details]

Teaching Interests

Medical Implant and Device Design (ME421)
Biomechanics (ME416)
Introduction to Biomedical Engineering (ME218)

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Professor Frank Barry, National Centre for Biomedical Engineering SciencesProfessor Peter McHugh, Mechanical and Biomedical EngineeringDr. Patrick McGarry, Mechanical and Biomedical Engineering

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Professor Glen Niebur, University of Notre Dame, USAProfressor Ajit Yoganathan, Georgia Tech University, USAProfessor Richard Oreffo, University of Southampton, United KingdomDr. Philipp Thurner, University of Southampton, United KingdomDr. Martin Browne, University of Southampton, United KingdomProfessor Fergal O'Brien, Royal College of Surgeons in Ireland