Prof. Nicholas Allen

BSc, MB BCh BAO, MRCPI, MD, HDip, MSc,

 
researcher
 

Biography

  • Consultant Paediatrician & Paediatric Neurologist, Galway University Hospital, Ireland.
  • Established Professor of Paediatrics, NUI Galway. 
  • Undergraduate Medical studies at NUI Galway. 
  • Intercalated-research BSc. physiology NUI Galway.
  • Completed Internship, Basic Specialist Training and Higher Specialist Training in Paediatrics in Ireland (general paediatrics, oncology, neonatology, nephrology, endocrinology, and paediatric neurology)
  • Completed further paediatric neurology sub-specialisation as part of the SpR programme.
  • Completed Clinical and Research Fellowships in Paediatric Neurology and Epilepsy (Temple St. Children’s University Hospital, Dublin and Great Ormond St. Children’s Hospital, London) and Neuromuscular Disorders at the Evelina Children’s Hospital, Guys & St. Thomas Trust, London.
  • Interested in Clinical Education: 
    • Master’s Degree in Clinical Education
    • Previous 1 year post as Specialist Clinical Tutor in Paediatrics (University College Dublin)
    • Chair of Paediatrics, NUI Galway (active in delivery of undergraduate programme).
  • Research
    • Completed Research M.D. thesis in basic science.
    • Later research interests in paediatric neurology, epilepsy, neurogenetics, general paediatrics and medical education. 
    • Current Research:
      • Clinical Paediatric Neurology, Epilepsy, Paediatrics
      • Pluripotent Stem Cell Models of Genetic Epilepsy in Collaboration with Prof. Sanbing Shen, NUI Galway and other collaborators nationally and internationally.

Research Projects

  Project Start Date End Date
IRC ENTERPRISE PARTNERSHIP SCHEME (POSTGRADUATE) 2019 - Rachel Stewart - Modelling epilepsy using pluripotent stem cells-derived 3D organoids. 01-MAR-19 28-FEB-23
RPAC 17-18 SEVERE EPILEPSY: HUMAN STEM CELL MODELLING 21-AUG-18 20-AUG-22
Rescuing cardiac and neuronal ion channelopathy phenotypes through applied genome editing technologies 15-JUN-18 31-DEC-22

Peer Reviewed Journals

  Year Publication
(2020) 'A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability'
Benson, KA;White, M;Allen, NM;Byrne, S;Carton, R;Comerford, E;Costello, D;Doherty, C;Dunleavey, B;El-Naggar, H;Gangadharan, N;Heavin, S;Kearney, H;Lench, NJ;Lynch, J;McCormack, M;O'Regan, M;Podesta, K;Power, K;Rogers, AS;Steward, CA;Sweeney, B;Webb, D;Fitzsimons, M;Greally, M;Delanty, N;Cavalleri, GL (2020) 'A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability'. European Journal Of Human Genetics, [DOI] [Details]
(2020) 'Acute Necrotizing Encephalopathy (ANE) Triggered by Influenza'
Julia C. Morrison, Rebecca Finnegan, Aoife Cleary, Eilish Twomey, Nicholas M. Allen​ (2020) 'Acute Necrotizing Encephalopathy (ANE) Triggered by Influenza'. American Journal Of Neuroradiology, [Details]
(2020) 'Identification of a novel cystic fibrosis mutation in three patients of South Asian descent'
Semple, A;Clark, T;Allen, NM;Krishnananthan, T;Nwokoro, C;Girodon, E;Porzio, M;Herzig, M (2020) 'Identification of a novel cystic fibrosis mutation in three patients of South Asian descent'. The Clinical Respiratory Journal, 14 :586-588 [DOI] [Details]
(2020) 'Generation of three induced pluripotent stem cell (iPSC) lines from a patient with developmental epileptic encephalopathy due to the pathogenic KCNA2 variant c.869T>G; p.Leu290Arg (NUIGi052-A, NUIGi052-B, NUIGi052-C)'
Arbini A;Gilmore J;King MD;Gorman KM;Krawczyk J;McInerney V;O'Brien T;Shen S;Allen NM; (2020) 'Generation of three induced pluripotent stem cell (iPSC) lines from a patient with developmental epileptic encephalopathy due to the pathogenic KCNA2 variant c.869T>G; p.Leu290Arg (NUIGi052-A, NUIGi052-B, NUIGi052-C)'. Stem Cell Research, 46 [DOI] [Details]
(2020) 'Catatonia as a feature of down syndrome: An under-recognised entity?'
Lyons, A,Allen, NM,Flanagan, O,Cahalane, D (2020) 'Catatonia as a feature of down syndrome: An under-recognised entity?'. European Journal Of Paediatric Neurology, 25 :187-190 [DOI] [Details]
(2020) 'Derivation of two iPSC lines from a sporadic ASD patient (NUIGi033-A) and a paternal control (NUIGi034-A)'
de la Cruz BM;Ding Y;McInerney V;Krawczyk J;Lu Y;Yang G;Qian X;Li W;Howard L;Allen NM;O'Brien T;Gallagher L;Shen S; (2020) 'Derivation of two iPSC lines from a sporadic ASD patient (NUIGi033-A) and a paternal control (NUIGi034-A)'. Stem Cell Research, 44 [DOI] [Details]
(2020) 'Genetic potassium channel-associated epilepsies: Clinical review of the Kv family'
Allen NM;Weckhuysen S;Gorman K;King MD;Lerche H; (2020) 'Genetic potassium channel-associated epilepsies: Clinical review of the Kv family'. European Journal Of Paediatric Neurology, 24 [DOI] [Details]
(2020) 'Catatonia as a feature of down syndrome: An under-recognised entity?'
Lyons A;Allen NM;Flanagan O;Cahalane D; (2020) 'Catatonia as a feature of down syndrome: An under-recognised entity?'. European Journal Of Paediatric Neurology, 25 [DOI] [Details]
(2019) 'Journal club: old tricks and fresh approaches'
McGlacken-Byrne SM;O'Rahelly M;Cantillon P;Allen NM; (2019) 'Journal club: old tricks and fresh approaches'. Archives Of Disease In Childhood-Education And Practice Edition, [DOI] [Details]
(2018) 'Cost of exome sequencing in epileptic encephalopathy: is it 'worth it'?'
Forman, E. B.,Gorman, K. M.,Conroy, J.,Arthur, N.,Grant, C.,Ennis, S.,Allen, N. M.,Lynch, S. A.,King, M. D. (2018) 'Cost of exome sequencing in epileptic encephalopathy: is it 'worth it'?'. Arch Dis ChildArch Dis Child, 103 (33) [Details]
(2018) 'Rethinking status dystonicus: A welcome start to a challenging problem'
Lumsden, D. E.,Allen, N. M. (2018) 'Rethinking status dystonicus: A welcome start to a challenging problem'. Mov DisordMov Disord, 33 (22) [Details]
(2018) 'Interferonopathies in laboratory-negative suspected congenital infection'
Forman, E. B.,King, M. D.,Allen, N. M. (2018) 'Interferonopathies in laboratory-negative suspected congenital infection'. Lancet Infect DisLancet Infect Dis, 18 (11) [Details]
(2018) 'Unusual Presentations of Dystrophinopathies in Childhood'
Allen, NM,Ewer, A,Nakou, V,Konstantoulaki, E,Wraige, E,Gowda, V,Jungbluth, H (2018) 'Unusual Presentations of Dystrophinopathies in Childhood'. Pediatrics, 141 :510-514 [DOI] [Details]
(2018) 'Neck-Tongue Syndrome: An Underrecognized Childhood Onset Cephalalgia'
Allen, NM,Dafsari, HS,Wraige, E,Jungbluth, H (2018) 'Neck-Tongue Syndrome: An Underrecognized Childhood Onset Cephalalgia'. Journal of child neurology, 33 :347-350 [DOI] [Details]
(2018) 'Status dystonicus due to missense variant in ARX: Diagnosis and management'
Gorman, KM,Cary, H,Gaffney, L,Forman, E,Waldron, D,Al-Delami, F,Lynch, BJ,King, MD,Allen, NM (2018) 'Status dystonicus due to missense variant in ARX: Diagnosis and management'. European Journal Of Paediatric Neurology, 22 :862-865 [DOI] [Details]
(2017) '2015-2016 Influenza Season in an Irish Regional Paediatric Unit: Importance of Influenza Vaccination Highlighted'
Ryan, G.,Cleary, A.,Keady, D.,Allen, N. M.,Moylett, E. (2017) '2015-2016 Influenza Season in an Irish Regional Paediatric Unit: Importance of Influenza Vaccination Highlighted'. Ir Med J, 110 (77) [Details]
(2017) 'Status dystonicus in childhood'
Lumsden, DE;King, MD;Allen, NM (2017) 'Status dystonicus in childhood'. Current opinion in pediatrics, 29 :674-682 [DOI] [Details]
(2017) 'Activated Platelets Induce Endothelial Cell Activation via an Interleukin-1beta Pathway in Systemic Lupus Erythematosus'
Nhek, S.,Clancy, R.,Lee, K. A.,Allen, N. M.,Barrett, T. J.,Marcantoni, E.,Nwaukoni, J.,Rasmussen, S.,Rubin, M.,Newman, J. D.,Buyon, J. P.,Berger, J. S. (2017) 'Activated Platelets Induce Endothelial Cell Activation via an Interleukin-1beta Pathway in Systemic Lupus Erythematosus'. Arterioscler Thromb Vasc BiolArterioscler Thromb Vasc Biol, 37 (44):707-716 [Details]
(2017) 'Novel COL4A2 variant in a large pedigree: Consequences and dilemmas'
McGovern, M.,Flanagan, O.,Lynch, B.,Lynch, S. A.,Allen, N. M. (2017) 'Novel COL4A2 variant in a large pedigree: Consequences and dilemmas'. Clin GenetClin Genet, 92 (44):447-448 [Details]
(2017) 'Clinical spectrum and genotype-phenotype associations of KCNA2-related encephalopathies'
Masnada, S.,Hedrich, U. B. S.,Gardella, E.,Schubert, J.,Kaiwar, C.,Klee, E. W.,Lanpher, B. C.,Gavrilova, R. H.,Synofzik, M.,Bast, T.,Gorman, K.,King, M. D.,Allen, N. M.,Conroy, J.,Ben Zeev, B.,Tzadok, M.,Korff, C.,Dubois, F.,Ramsey, K.,Narayanan, V.,Serratosa, J. M.,Giraldez, B. G.,Helbig, I.,Marsh, E.,O'Brien, M.,Bergqvist, C. A.,Binelli, A.,Porter, B.,Zaeyen, E.,Horovitz, D. D.,Wolff, M.,Marjanovic, D.,Caglayan, H. S.,Arslan, M.,Pena, S. D. J.,Sisodiya, S. M.,Balestrini, S.,Syrbe, S.,Veggiotti, P.,Lemke, J. R.,Moller, R. S.,Lerche, H.,Rubboli, G. (2017) 'Clinical spectrum and genotype-phenotype associations of KCNA2-related encephalopathies'. BrainBrain, 140 (99):2337-2354 [Details]
(2017) 'Novel SMC1A variant and epilepsy of infancy with migrating focal seizures: Expansion of the phenotype'
Gorman, K. M.,Forman, E.,Conroy, J.,Allen, N. M.,Shahwan, A.,Lynch, S. A.,Ennis, S.,King, M. D. (2017) 'Novel SMC1A variant and epilepsy of infancy with migrating focal seizures: Expansion of the phenotype'. EpilepsiaEpilepsia, 58 (77):1301-1302 [Details]
(2016) 'Lyme Neuroborreliosis: A Potentially Preventable Cause of Stroke'
Allen, N. M.,Jungbluth, H. (2016) 'Lyme Neuroborreliosis: A Potentially Preventable Cause of Stroke'. J PediatrJ Pediatr, 170 [Details]
(2016) 'NAPB - a novel SNARE-associated protein for early-onset epileptic encephalopathy'
Conroy, J.,Allen, N. M.,Gorman, K. M.,Shahwan, A.,Ennis, S.,Lynch, S. A.,King, M. D. (2016) 'NAPB - a novel SNARE-associated protein for early-onset epileptic encephalopathy'. Clin GenetClin Genet, 89 (22) [Details]
(2016) 'Unexplained early onset epileptic encephalopathy: Exome screening and phenotype expansion'
Allen, N. M.,Conroy, J.,Shahwan, A.,Lynch, B.,Correa, R. G.,Pena, S. D.,McCreary, D.,Magalhaes, T. R.,Ennis, S.,Lynch, S. A.,King, M. D. (2016) 'Unexplained early onset epileptic encephalopathy: Exome screening and phenotype expansion'. EpilepsiaEpilepsia, 57 (11) [Details]
(2016) 'Salbutamol-responsive fetal acetylcholine receptor inactivation syndrome'
Allen, N. M.,Hacohen, Y.,Palace, J.,Beeson, D.,Vincent, A.,Jungbluth, H. (2016) 'Salbutamol-responsive fetal acetylcholine receptor inactivation syndrome'. NeurologyNeurology, 86 (77):692-4 [Details]
(2016) 'Novel European SLC1A4 variant: infantile spasms and population ancestry analysis'
Conroy, J,Allen, NM,Gorman, K,O'Halloran, E,Shahwan, A,Lynch, B,Lynch, SA,Ennis, S,King, MD (2016) 'Novel European SLC1A4 variant: infantile spasms and population ancestry analysis'. Journal Of Human Genetics, 61 :761-764 [DOI] [Details]
(2016) 'Atypical benign partial epilepsy of childhood with acquired neurocognitive, lexical semantic, and autistic spectrum disorder'
Allen, NM,Conroy, J,Deonna, T,McCreary, D,McGettigan, P,Madigan, C,Carter, I,Ennis, S,Lynch, SA,Shahwan, A,King, MD (2016) 'Atypical benign partial epilepsy of childhood with acquired neurocognitive, lexical semantic, and autistic spectrum disorder'. Epilepsy & Behavior Case Reports, 6 :42-48 [DOI] [Details]
(2015) 'Clinical Reasoning: Juvenile neurocognitive decline: A snaky diagnosis'
Allen, N. M.,Shahwan, A.,Madigan, C.,Nestor, T.,King, M. D. (2015) 'Clinical Reasoning: Juvenile neurocognitive decline: A snaky diagnosis'. NeurologyNeurology, 85 (2222) [Details]
(2015) 'Chromosomal microarray in unexplained severe early onset epilepsy - A single centre cohort'
Allen, N. M.,Conroy, J.,Shahwan, A.,Ennis, S.,Lynch, B.,Lynch, S. A.,King, M. D. (2015) 'Chromosomal microarray in unexplained severe early onset epilepsy - A single centre cohort'. Eur J Paediatr NeurolEur J Paediatr Neurol, 19 (44):390-4 [Details]
(2015) 'Sydenham's chorea: not gone but perhaps forgotten'
Crealey, M.,Allen, N. M.,Webb, D.,Bouldin, A.,Mc Sweeney, N.,Peake, D.,Tirupathi, S.,Butler, K.,King, M. D. (2015) 'Sydenham's chorea: not gone but perhaps forgotten'. Arch Dis ChildArch Dis Child, 100 (1212):1160-2 [Details]
(2015) 'The Bhutani Nomogram Reduces Incidence of Severe Hyperbilirubinaemia in Term and Near Term Infants'
O'Reilly, P.,Walsh, O.,Allen, N. M.,Corcoran, J. D. (2015) 'The Bhutani Nomogram Reduces Incidence of Severe Hyperbilirubinaemia in Term and Near Term Infants'. Ir Med JIr Med J, 108 (66):181-2 [Details]
(2014) 'The variable phenotypes of KCNQ-related epilepsy'
Allen, N. M.,Mannion, M.,Conroy, J.,Lynch, S. A.,Shahwan, A.,Lynch, B.,King, M. D. (2014) 'The variable phenotypes of KCNQ-related epilepsy'. EpilepsiaEpilepsia, 55 (99) [Details]
(2014) 'Status dystonicus: a practice guide'
Allen, N. M.,Lin, J. P.,Lynch, T.,King, M. D. (2014) 'Status dystonicus: a practice guide'. Dev Med Child NeurolDev Med Child Neurol, 56 (22):105-12 [Details]
(2014) 'Excellent outcome with de novo 15q13.3 microdeletion causing infantile spasms--a further patient'
Allen, N. M.,Conroy, J.,Shahwan, A.,Ennis, S.,Lynch, B.,Lynch, S. A.,King, M. D. (2014) 'Excellent outcome with de novo 15q13.3 microdeletion causing infantile spasms--a further patient'. Am J Med Genet AAm J Med Genet A, 164a (77):1863-6 [Details]
(2014) 'Explosive onset non-epileptic jerks and profound hypotonia in an infant with Alpers-Huttenlocher syndrome'
Allen, N. M.,Winter, T.,Shahwan, A.,King, M. D. (2014) 'Explosive onset non-epileptic jerks and profound hypotonia in an infant with Alpers-Huttenlocher syndrome'. SeizureSeizure, 23 (33):237-9 [Details]
(2014) 'De Novo Interstitial Deletion 2q14.1q22.1: Is There a Recognizable Phenotype?'
Greally, MT,Robinson, E,Allen, NM,O'Donovan, D,Crolla, JA (2014) 'De Novo Interstitial Deletion 2q14.1q22.1: Is There a Recognizable Phenotype?'. American Journal Of Medical Genetics Part A, 164 :3194-3202 [DOI] [Details]
(2013) 'Not all twitching is epileptic! Hand myoclonus in a boy with spinal cord tumor'
Allen, N. M.,Moran, M. M.,King, M. D. (2013) 'Not all twitching is epileptic! Hand myoclonus in a boy with spinal cord tumor'. J PediatrJ Pediatr, 162 (22):431-4310 [Details]
(2012) 'Limbic encephalitis in a boy with N-methyl-D-aspartate receptor antibodies'
Allen, N. M.,Lynch, B.,Twomey, E. (2012) 'Limbic encephalitis in a boy with N-methyl-D-aspartate receptor antibodies'. J PediatrJ Pediatr, 160 (66) [Details]
(2012) 'Excessive blinking and ataxia in a child with occult neuroblastoma and voltage-gated potassium channel antibodies'
Allen, N. M.,McKeon, A.,O'Rourke, D. J.,O'Meara, A.,King, M. D. (2012) 'Excessive blinking and ataxia in a child with occult neuroblastoma and voltage-gated potassium channel antibodies'. PediatricsPediatrics, 129 (55) [Details]
(2012) 'Variant late-infantile neuronal ceroid lipofuscinosis due to a novel heterozygous CLN8 mutation and de novo 8p23.3 deletion'
Allen, N. M.,O'HIci, B.,Anderson, G.,Nestor, T.,Lynch, S. A.,King, M. D. (2012) 'Variant late-infantile neuronal ceroid lipofuscinosis due to a novel heterozygous CLN8 mutation and de novo 8p23.3 deletion'. Clin GenetClin Genet, 81 (66):602-4 [Details]
(2011) 'Neonatal therapeutic hypothermia: practice and opinions in the Republic of Ireland'
Allen, NM,Foran, A,O'Donovan, DJ (2011) 'Neonatal therapeutic hypothermia: practice and opinions in the Republic of Ireland'. Archives Of Disease In Childhood-Fetal And Neonatal Edition, 96 :233-233 [DOI] [Details]
(2011) 'Idiopathic Ventricular Tachycardia in a Newborn: Immediate Response to Lidocaine'
Allen, NM,Azam, M,Dunne, KP,Walsh, KP (2011) 'Idiopathic Ventricular Tachycardia in a Newborn: Immediate Response to Lidocaine'. Pediatric Cardiology, 32 :706-707 [DOI] [Details]
(2011) 'Is neonatal group B streptococcal infection preventable?'
Azam, M.,Allen, N. M.,O'Donovan, D.,Moylett, E. (2011) 'Is neonatal group B streptococcal infection preventable?'. Ir Med J, 104 (55):149-51 [Details]
(2011) 'Stiff neonate with mitochondrial DNA depletion and secondary neurotransmitter defects'
Moran, M. M.,Allen, N. M.,Treacy, E. P.,King, M. D. (2011) 'Stiff neonate with mitochondrial DNA depletion and secondary neurotransmitter defects'. Pediatr NeurolPediatr Neurol, 45 (66):403-5 [Details]
(2011) 'Transcutaneous bilirubin - comparing the accuracy of BiliChek (R) and JM 103 (R) in a regional postnatal unit'
Qualter, YM,Allen, NM,Corcoran, JD,O'Donovan, DJ (2011) 'Transcutaneous bilirubin - comparing the accuracy of BiliChek (R) and JM 103 (R) in a regional postnatal unit'. Journal Of Maternal-Fetal & Neonatal Medicine, 24 :267-270 [DOI] [Details]
(2010) 'Images in neonatal medicine. Benign tonic downgaze of infancy'
Allen, N. M.,Tibussek, D.,Borusiak, P.,King, M. D. (2010) 'Images in neonatal medicine. Benign tonic downgaze of infancy'. Arch Dis Child Fetal Neonatal EdArch Dis Child Fetal Neonatal Ed, 95 (55) [Details]
(2010) 'Initial assessment of jaundice in otherwise healthy infants--a comparison of methods in two postnatal units'
Allen, N. M.,O'Donnell, S. M.,White, M. J.,Corcoran, J. D. (2010) 'Initial assessment of jaundice in otherwise healthy infants--a comparison of methods in two postnatal units'. Ir Med JIr Med J, 103 (1010):310-3 [Details]
(2010) 'Traumatic delivery, diaphragmatic paresis, and dextrocardia'
Allen, N. M.,Clarke, T.,Ryan, S. P.,Farombi-Oghuvbu, I. (2010) 'Traumatic delivery, diaphragmatic paresis, and dextrocardia'. J PediatrJ Pediatr, 156 (66) [Details]
(2009) 'Severe hyperbilirubinaemia and kernicterus: more caution is needed in newborn jaundice surveillance'
Allen, N. M.,Mohammad, F.,Foran, A.,Corcoran, D.,Clarke, T. (2009) 'Severe hyperbilirubinaemia and kernicterus: more caution is needed in newborn jaundice surveillance'. Ir Med JIr Med J, 102 (77):228-9 [Details]
(2007) 'Foam eater'
Allen, NM;O'Donovan, DJ (2007) 'Foam eater'. Journal Of Pediatrics, 151 :710-710 [DOI] [Details]
(2007) 'Expression and function of protease-activated receptor 4 in human myometrium'
Allen NM, O'Brien M, Friel AM, Smith TJ, Morrison JJ (2007) 'Expression and function of protease-activated receptor 4 in human myometrium'. American Journal Of Obstetrics And Gynecology, 196 (2):1690-1696 [DOI] [Details]
(2005) 'Screening for haemoglobinopathy--a comparison of two methods in an Irish maternity unit'
Allen NM, Ni Riain M, Murray M, Hession M. (2005) 'Screening for haemoglobinopathy--a comparison of two methods in an Irish maternity unit'. Ir Med J, 98 (9):276-278 [Details]
(2004) 'Thrombin and PAR-1 agonism: Effects on human uterine contractility in vitro'
O'Sullivan, C. J., Allen, N. M., O'Loughlin, A. J., Friel, A. M. & Morrison, J. J. (2004) 'Thrombin and PAR-1 agonism: Effects on human uterine contractility in vitro'. American Journal of Obstetrics & Gynaecology, 190 :1098-1105 [Details]
(2004) 'Thrombin and PAR1-activating peptide: effects on human uterine contractility in vitro'
O'Sullivan CJ, Allen NM, O'Loughlin AJ, Friel AM, Morrison JJ (2004) 'Thrombin and PAR1-activating peptide: effects on human uterine contractility in vitro'. American Journal Of Obstetrics And Gynecology, 190 (4):1098-1105 [DOI] [Details]
(2004) 'PAR-4 modulation and thrombin in human pregnant myometrium'
Allen, NM,Friel, AM,Morrison, JJ (2004) 'PAR-4 modulation and thrombin in human pregnant myometrium'. American Journal Of Obstetrics & Gynaecology, :322-323 [Details]

Current Postgraduate Students (Research)

  Student Degree Type Type
Rachel Stewart Doctorate - Structured Ph.D (Medicine) Supervisor
Alessia Arbini Doctorate - Structured Ph.D (Medicine) Supervisor