Dr Michelle Roche

BSc., MSc., PhD.

Contact Details

Senior Lecturer
Physiology
Rm2010 Human Biology Building
University of Galway
University Road
T: Ext. 5427
E: michelle.roche@nuigalway.ie
 
researcher
 

Biography

Dr Roche is an Associate Professor and Neuroscientist in Physiology at the University of Galway. Her research focuses on enhancing understanding of the neurobiology underlying autism, affective disorders, pain and their interactions with the aim to identify novel therapeutic targets for these conditions. She has a particular interest in the role of neuroimmune, endocannabinoid and opioid systems in these disorders.

Dr Roche is the 
Director of the Galway Neuroscience Centre and Co-Director of the Centre for Pain Research at the University of Galway. She is President of the Irish Pain Society and former governing council member and communication officer of Neuroscience Ireland.
Dr Roche is member of the Scientific Advisory Panel and Workshop Committee of the European College of Neuropsychopharmacology (ECNP). She is also Editorial Board member of several international scientific journals including Neuropharmacology, Molecules, Frontiers in Pain Research and Neuronal Signalling.

Research Interests

Research Interests and Projects:

Pain-Depression interactions and co-morbidity: Despite depressed patients being twice as likely to experience chronic pain, the neurobiology underlying this co-morbidity remains to be elucidated. Our lab have worked in this research area for the past 15 years, examining how and why pain responding is altered in stress, anxious and depressed states. We have identified the endocannabinoid and opioid systems, and specific neuroimmune pathways, as key players in this interaction and as such may provide novel therapeutic targets for this co-morbidity. We are particularly interested in sex differences, to determine if similar mechanisms may be responsible and viable therapeutic targets for both sexes.

Current projects in this area include the EU funded MSCA European Joint Doctoral Programme: HaPpY. Here 15 PhD students across the EU (5 of which will be based at the University of Galway) will work to 
break the vicious cycle linking chronic pain and mood disorders
https://happyejd.com/

Mechanisms underlying altered behavioural responding associated with autism. Our research in this field has identified the endocannabinoid and opioid systems as key players in mediating and modulating behaviours known to be altered in individuals with neurodevelopmental disorders such as autism.  We have demonstrated that modulation of these systems can alter specific behaviours in preclinical models which supports ongoing clinical research in the field. Ongoing research in the Roche lab is examining the mechanism by which these effects occur and potential sex differences with an aim to identify new therapeutic targets. 

Endocannabinoid regulation of neuroimmune function:
Cannabinoids are were known to modulate inflammatory responses. Data from our lab has demonstrated a distinct and separate role and mechanism for the two main endocannabinoids on acute inflammatory and behavioural responses to bacterial and viral infection. This research has provided valuable insight into the neuro-immuno-modulatory effects of cannabinoids and their potential as a novel therapeutic approach for acute neuroinflammatory conditions.


Development and characterization of a novel preclinical models of pain. There is a growing recognition of the need for more translationally valid and relevant models that will better predict clinical efficacy of novel therapeutics. As such we have developed and validated a wide range novel preclinical models to aid in addressing these research questions.


Peer Reviewed Journals

  Year Publication
(2022) 'Effects of Intra-BLA Administration of PPAR Antagonists on Formalin-Evoked Nociceptive Behaviour, Fear-Conditioned Analgesia, and Conditioned Fear in the Presence or Absence of Nociceptive Tone in Rats'
Gaspar JC, Okine BN, Dinneen D, Roche M, Finn DP (2022) 'Effects of Intra-BLA Administration of PPAR Antagonists on Formalin-Evoked Nociceptive Behaviour, Fear-Conditioned Analgesia, and Conditioned Fear in the Presence or Absence of Nociceptive Tone in Rats'. Molecules (Basel, Switzerland), 27 (6) [Details]
(2021) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'
Ferdousi MI, Calcagno P, Clarke M, Aggarwal S, Sanchez C, Smith KL, Eyerman DJ, Kelly JP, Roche M, Finn DP. (2021) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'. Journal Of Pain, 162 (2):405-420 [DOI] [Details]
(2021) 'Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls'
Hughes EM, Calcagno P, Sanchez C, Smith K, Kelly JP, Finn DP, Roche M. (2021) 'Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls'. Brain Research Bulletin, 174 (1):260-267 [Details]
(2021) 'Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls'
Hughes EM, Calcagno P, Sanchez C, Smith K, Kelly JP, Finn DP, Roche M (2021) 'Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls'. Brain Research Bulletin, (174):260-267 [DOI] [Details]
(2021) 'Increasing Endocannabinoid Tone Alters Anxiety-Like and Stress Coping Behaviour in Female Rats Prenatally Exposed to Valproic Acid'
Thornton AM, Humphrey RM, Kerr DM, Finn DP, Roche M (2021) 'Increasing Endocannabinoid Tone Alters Anxiety-Like and Stress Coping Behaviour in Female Rats Prenatally Exposed to Valproic Acid'. Molecules (Basel, Switzerland), 26 (12):3720-3725 [DOI] [Details]
(2021) 'N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPAR¿'
Flannery LE, Kerr DM, Hughes EM, Kelly C, Costello J, Thornton AM, Humphrey RM, Finn DP, Roche M. (2021) 'N-acylethanolamine regulation of TLR3-induced hyperthermia and neuroinflammatory gene expression: A role for PPAR¿'. Journal Of Neuroimmunology, 358 (1):577654-577660 [DOI] [Details]
(2021) 'Sexually Dimorphic Expression of Fear-conditioned Analgesia in Rats and Associated Alterations in the Endocannabinoid System in the Periaqueductal Grey'
Llorente-Berzal A, McGowan F, Gaspar JC, Rea K, Roche M, Finn DP (2021) 'Sexually Dimorphic Expression of Fear-conditioned Analgesia in Rats and Associated Alterations in the Endocannabinoid System in the Periaqueductal Grey'. Neuroscience, 1 (480):117-130 [DOI] [Details]
(2021) 'Exploring Parental Responses to Pre-schoolers' Everyday Pain Experiences Through Electronic Diary and Ecological Momentary Assessment Methodologies'
O'Sullivan G, McGuire B, Roche M, Caes L (2021) 'Exploring Parental Responses to Pre-schoolers' Everyday Pain Experiences Through Electronic Diary and Ecological Momentary Assessment Methodologies'. Frontiers in psychology, [Details]
(2021) 'Where do children learn about pain? The role of caregiver responses to preschoolers' pain experience within natural settings'
O'Sullivan G;McGuire BE;Roche M;Caes L; (2021) 'Where do children learn about pain? The role of caregiver responses to preschoolers' pain experience within natural settings'. Pain, 162 (5) [DOI] [Details]
(2021) 'Pharmacological Blockade of PPAR¿ Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats'
Gaspar JC;Healy C;Ferdousi MI;Roche M;Finn DP; (2021) 'Pharmacological Blockade of PPAR¿ Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats'. Biomedicines, 9 (6):610-615 [DOI] [ARAN Link] [Details]
(2020) 'Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults'
Caes L;Roche M; (2020) 'Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults'. Annals Of Palliative Medicine, 9 (4) [DOI] [ARAN Link] [Details]
(2020) 'Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System'
Killilea M;Kerr DM;Mallard BM;Roche M;Wheatley AM; (2020) 'Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System'. Molecules (Basel, Switzerland), 25 (17) [DOI] [ARAN Link] [Details]
(2020) 'Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid'
Hughes, EM,Thornton, AM,Kerr, DM,Smith, K,Sanchez, C,Kelly, JP,Finn, DP,Roche, M (2020) 'Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid'. Neuroscience, 444 :9-18 [DOI] [ARAN Link] [Details]
(2020) 'Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats'
Jarrin, S,Pandit, A,Roche, M,Finn, DP (2020) 'Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats'. Frontiers In Behavioral Neuroscience, 14 (1):139-145 [DOI] [ARAN Link] [Details]
(2020) 'Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex'
Okine, BN,Mc Laughlin, G,Gaspar, JC,Harhen, B,Roche, M,Finn, DP (2020) 'Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex'. Neuroscience, 443 (1):19-29 [DOI] [ARAN Link] [Details]
(2020) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'
Ferdousi MI;Calcagno P;Clarke M;Aggarwal S;Sanchez C;Smith KL;Eyerman DJ;Kelly JP;Roche M;Finn DP; (2020) 'Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state'. Pain, [DOI] [ARAN Link] [Details]
(2020) 'Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats'
O'Sullivan, G,Humphrey, RM,Thornton, AM,Kerr, DM,McGuire, BE,Caes, L,Roche, M (2020) 'Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats'. Behavioural Brain Research, 392 [DOI] [ARAN Link] [Details]
(2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'
Hughes EM;Calcagno P;Clarke M;Sanchez C;Smith K;Kelly JP;Finn DP;Roche M; (2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'. Brain Research, doi: 10.1016/j.brainres.2020.146675 [DOI] [ARAN Link] [Details]
(2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'
Corcoran L;Mattimoe D;Roche M;Finn DP; (2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'. British Journal Of Pharmacology, doi: 10.1111/bph.14976 [DOI] [ARAN Link] [Details]
(2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'
Rea, K,McGowan, F,Corcoran, L,Roche, M,Finn, DP (2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'. British Journal Of Pharmacology, 176 :1492-1505 [DOI] [ARAN Link] [Details]
(2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'
Burke NN, Li Y, Deaver DR, Finn DP, Roche M, Eyerman DJ, Sanchez C, Kelly JP. (2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'. Journal Of Psychopharmacology, [ARAN Link] [Details]
(2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'
Fitzgibbon, M,Kerr, DM,Henry, RJ,Finn, DP,Roche, M (2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'. Brain Behavior And Immunity, 82 :372-381 [DOI] [ARAN Link] [Details]
(2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'
O'Sullivan G;McGuire B;Roche M;Caes L; (2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'. Psychology & Health, doi: 10.1080/08870446.2019.1707830 [DOI] [ARAN Link] [Details]
(2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'
Burke, NN,Ferdousi, M,Deaver, DR,Finn, DP,Roche, M,Kelly, JP (2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'. Neuropharmacology, 146 :327-336 [DOI] [ARAN Link] [Details]
(2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'
Burke, NN,Li, Y,Deaver, DR,Finn, DP,Roche, M,Eyerman, DJ,Sanchez, C,Kelly, JP (2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'. Journal Of Psychopharmacology, 33 (12):1620-1627 [DOI] [ARAN Link] [Details]
(2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'
Flannery LE, Henry RJ, Kerr DM, Finn DP, Roche M (2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'. Journal Of Neuroscience Research, 96 (6) [DOI] [Details]
(2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'
Buckley, DA,Jennings, EM,Burke, NN,Roche, M,McInerney, V,Wren, JD,Finn, DP,McHugh, PC (2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'. Molecular Neurobiology, 55 :2420-2430 [DOI] [ARAN Link] [Details]
(2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'
Flannery, LE,Kerr, DM,Finn, DP,Roche, M (2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'. Behavioural Brain Research, 353 :11-20 [DOI] [ARAN Link] [Details]
(2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'
Liu, M,Fitzgibbon, M,Wang, YQ,Reilly, J,Qian, XH,O'Brien, T,Clapcote, S,Shen, SB,Roche, M (2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'. Translational Psychiatry, 8 [DOI] [ARAN Link] [Details]
(2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'
Okine, BN;Gaspar, JC;Madasu, MK;Olango, WM;Harhen, B;Roche, M;Finn, DP (2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'. Brain Research, 1657 :185-192 [DOI] [ARAN Link] [Details]
(2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke, NN;Finn, DP;McGuire, BE;Roche, M (2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. J Neurosci Res, 95 (6):1257-1270 [DOI] [ARAN Link] [Details]
(2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'
Henry, RJ,Kerr, DM,Flannery, LE,Killilea, M,Hughes, EM,Corcoran, L,Finn, DP,Roche, M (2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'. Brain Behavior And Immunity, 62 :318-331 [DOI] [ARAN Link] [Details]
(2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'
Jennings, EM,Okine, BN,Olango, WM,Roche, M,Finn, DP (2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :181-189 [DOI] [ARAN Link] [Details]
(2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'
Dyall, SC,Mandhair, HK,Fincham, REA,Kerr, DM,Roche, M,Molina-Holgado, F (2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'. Neuropharmacology, 107 :387-395 [DOI] [ARAN Link] [Details]
(2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'
Burke, NN,Coppinger, J,Deaver, DR,Roche, M,Finn, DP,Kelly, J (2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'. Physiology & Behavior, 167 :28-34 [DOI] [ARAN Link] [Details]
(2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'
Kerr, DM; Gilmartin, A; Roche, M; (2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'. Pharmacological Research, 113 (Pt A):228-235 [DOI] [ARAN Link] [Details]
(2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke NN;Finn DP;McGuire BE;Roche M; (2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. Journal Of Neuroscience Research, 95 (6):1257-1270 [DOI] [ARAN Link] [Details]
(2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'
Okine, BN;Madasu, MK;McGowan, F;Prendergast, C;Gaspar, JC;Harhen, B;Roche, M;Finn, DP (2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'. Pain, 157 :2687-2696 [DOI] [ARAN Link] [Details]
(2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'
Bree, D,Moriarty, O,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'. Cns Neuroscience & Therapeutics, 22 :146-153 [DOI] [ARAN Link] [Details]
(2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'
Moriarty, O,Gorman, CL,McGowan, F,Ford, GK,Roche, M,Thompson, K,Dockery, P,McGuire, BE,Finn, DP (2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'. Scandinavian Journal Of Pain, 10 :61-73 [DOI] [ARAN Link] [Details]
(2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'
Henry, RJ,Kerr, DM,Finn, DP,Roche, M (2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :167-180 [DOI] [ARAN Link] [Details]
(2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'
Madasu MK;Okine BN;Olango WM;Rea K;Lenihan R;Roche M;Finn DP; (2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'. Pharmacological Research, 113 (Pt A):44-54 [DOI] [ARAN Link] [Details]
(2016) '6-iodonordihydrocapsaicin'
Roche M (2016) '6-iodonordihydrocapsaicin'. Reference Module in Biomedical Sciences, doi.org/10.1016/B978-0-12-801238-3.99373-5 [DOI] [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree D, Moriarty O, O'Mahony CM, Morris B, Bannerton K, Broom DC, Kelly JP, Roche M, Finn DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree, D,Moriarty, O,Mahony, CM,Morris, B,Bannerton, K,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, 16 :421-435 [DOI] [ARAN Link] [Details]
(2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'
Fitzgibbon, M; Finn, DP; Roche, M (2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'. International Journal Of Neuropsychopharmacology, 5:19 (3) [ARAN Link] [Details]
(2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'
Burke, NN,Finn, DP,Roche, M (2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'. Behavioural Brain Research, 278 :193-201 [DOI] [ARAN Link] [Details]
(2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'
Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'. Research In Autism Spectrum Disorders, 10 :78-92 [Details]
(2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'
Rea, K,Olango, WM,Okine, BN,Madasu, MK,McGuire, IC,Coyle, K,Harhen, B,Roche, M,Finn, DP (2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'. Pain, 155 :69-79 [DOI] [Details]
(2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'
Olango, WM,Geranton, SM,Roche, M,Hunt, SP,Finn, DP (2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'. European Journal Of Pain, 18 :182-191 [DOI] [Details]
(2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'
Henry RJ, Kerr DM, Finn DP, Roche M (2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'. Journal Of Neuroimmunology, 276 (1-2):126-134 [DOI] [Details]
(2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'
Okine, BN,Rea, K,Olango, WM,Price, J,Herdman, S,Madasu, MK,Roche, M,Finn, DP (2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'. British Journal Of Pharmacology, 171 :1462-1471 [DOI] [ARAN Link] [Details]
(2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'
Burke, NN,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'. Brain Behavior And Immunity, 42 :147-156 [DOI] [ARAN Link] [Details]
(2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'
Okine BN, Rea K, Olango WM, Price J, Roche M, Finn DP (2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'. British J Pharmacology, [ARAN Link] [Details]
(2014) 'Stress-induced hyperalgesia'
Jennings EM, Okine BN, Roche M, Finn DP (2014) 'Stress-induced hyperalgesia'. Progress In Neurobiology, 64 :1-18 [DOI] [Details]
(2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'
Rea, K,Ford, GK,Olango, WM,Harhen, B,Roche, M,Finn, DP (2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'. European Journal Of Neuroscience, 39 :435-443 [DOI] [Details]
(2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'
Kerr DM, Henry R, Roche M (2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'. Anatomy and Physiology, 4 (e) [ARAN Link] [Details]
(2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'
Kerr, DM,Downey, L,Conboy, M,Finn, DP,Roche, M (2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'. Behavioural Brain Research, 249 :124-132 [DOI] [Details]
(2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'
Kerr, DM,Harhen, B,Okine, BN,Egan, LJ,Finn, DP,Roche, M (2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 :808-819 [DOI] [Details]
(2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'
Burke, NN,Geoghegan, E,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 12 :705-713 [DOI] [ARAN Link] [Details]
(2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'
Burke, NN,Llorente, R,Marco, EM,Tong, K,Finn, DP,Viveros, MP,Roche, M (2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'. Journal Of Pain, 14 :1173-1184 [DOI] [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, Kieran and Olango, Weredeselam M and Harhen, Brendan and Kerr, Daniel M and Galligan, Rachel and Fitzgerald, Sean and Moore, Maeve and Roche, Michelle and Finn, David P (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 (4):576-585 [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, K,Olango, WM,Harhen, B,Kerr, DM,Galligan, R,Fitzgerald, S,Moore, M,Roche, M,Finn, DP (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 :576-585 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [ARAN Link] [Details]
(2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'
Moriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8 [DOI] [ARAN Link] [Details]
(2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'
Moriarty O, Roche, M, McGuire BE, Finn DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. J Neurosci Methods, 204 (1):1-8 [Details]
(2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'
Olango, WM,Roche, M,Ford, GK,Harhen, B,Finn, DP (2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'. British Journal Of Pharmacology, 165 :2549-2560 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr, DM;Burke, NN;Ford, GK;Connor, TJ;Harhen, B;Egan, LJ;Finn, DP;Roche, M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [DOI] [Details]
(2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'
Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 (0):91-98 [DOI] [ARAN Link] [Details]
(2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'
Butler, RK,Ford, GK,Hogan, M,Roche, M,Doyle, KM,Kelly, JP,Kendall, DA,Chapman, V,Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91 [DOI] [ARAN Link] [Details]
(2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'
Rea, K,Roche, M,Finn, DP (2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'. Journal Of Pain, 12 :712-721 [DOI] [ARAN Link] [Details]
(2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'
Burke, NN,Hayes, E,Calpin, P,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'. Neuroscience, 171 (0):1300-1313 [DOI] [ARAN Link] [Details]
(2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'
Roche, M,Johnston, P,Mhuircheartaigh, ON,Olango, WM,Mackie, K,Finn, DP (2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'. European Journal Of Pain, 14 :487-495 [DOI] [Details]
(2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'
Roche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals, :2517-2553 [DOI] [ARAN Link] [Details]
(2009) '6-iodonordihydrocapsaicin'
Roche M, Finn DP (2009) '6-iodonordihydrocapsaicin'. Xpharm; Executive Eds: Sj Enna And Db Bylund; Publisher, Elsevier, Inc., New York, :0-0 [DOI] [ARAN Link] [Details]
(2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'
Smith, KL,Roche, M,Jessop, DS,Finn, DP (2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'. European Neuropsychopharmacology, 19 :371-380 [DOI] [Details]
(2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'
Roche M, Shanahan E, Harkin A, Kelly JP (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacological Reports, 60 (0):404-408 [DOI] [Details]
(2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'
Roche M, Kelly JP, O'Driscoll M, Finn DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 (2):263-271 [DOI] [Details]
(2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'
Rea K, Roche M, Finn DP (2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'. British Journal Of Pharmacology, 152 (5):633-648 [DOI] [Details]
(2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'
Roche M, O’Connor E, Diskin C, Finn DP. (2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'. European Journal Of Neuroscience, 26 (9):2643-2653 [DOI] [Details]
(2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'
Roche, M., Harkin, A., Kelly, J. P. (2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'. Neuropsychopharmacology, 32 (6):1312-1320 [ARAN Link] [Details]
(2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'
Roche M, Diamond M, Kelly JP, Finn DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 (1-2):57-67 [DOI] [Details]
(2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'
Zueger, A,Urani, A,Chourbaji, S,Zacher, C,Roche, M,Harkin, A,Gass, P (2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'. Neuroscience Letters, 374 :142-146 [DOI] [Details]
(2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'
Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997 [ARAN Link] [Details]

Book Chapters

  Year Publication
(2022) 'The olfactory bulbectomized rodent remains a valuable preclinical model of depression and antidepressant activity'
Roche M, Kelly JP (2022) 'The olfactory bulbectomized rodent remains a valuable preclinical model of depression and antidepressant activity' In: Psychiatric Vulnerability, Mood, and Anxiety Disorders. New York, NY: Humana. [Details]
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran. L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress' In: International Review of Neurobiology, Endocannabinoids. US: Elsevier Inc. [ARAN Link] [Details]
(2015) 'Supraspinal TRPV1 in pain and psychiatric disorders'
Madasu M, Roche M, Finn DP (2015) 'Supraspinal TRPV1 in pain and psychiatric disorders' In: Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2015) 'Neuroinflammatory mechanisms linking Pain and Depression'
Burke N.N., Finn DP, Roche M (2015) 'Neuroinflammatory mechanisms linking Pain and Depression' In: Pain in Psychiatric Disorders: Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2011) 'The Olfactory Bulbectomised Mouse'
Roche M (2011) 'The Olfactory Bulbectomised Mouse' In: In Mood and Anxiety Related Phenotypes in Mice. :267-286 USA: Humana Press. [ARAN Link] [Details]

Conference Publications

  Year Publication
(2014) 24th Annual Symposium of the International Cannabinoid Research Society
Madasu MK, Okine BN, Olango WM, Roche M and Finn DP (2014) Differential effects of pharmacological modulation of Trpv1 in the lateral periaqueductal grey on formalin-evoked nociceptive behaviour in Sprague-Dawley and Wistar-Kyoto rats 24th Annual Symposium of the International Cannabinoid Research Society Lago Maggiore, Italy, , 28-JUN-14 - 03-JUL-14 , pp.1-32 [Details]
(2015) Neuroscience Ireland Annual Meeting 2015
Flannery L, Henry R, Kerr DM, Finn DP, Roche M (2015) TLR3-induced inflammatory responses in the hypothalamus are attenuated following FAAH, but not MAGL, inhibition; an effect independent of sex Neuroscience Ireland Annual Meeting 2015 [Details]
(2015) The Cannabinoid Conference 2015
Corcoran L, Rea K, Roche M, Finn DP (2015) The endocannabinoid system in the anterior cingulate cortex plays a role in the termination of FCA in rats The Cannabinoid Conference 2015 Sestri, Italy, [Details]
(2016) Irish Pain Society Annual Scientific Meeting
Ferdousi M, Burke NN, Clarke M, Deaver DR, Roche M, Kelly JP, Finn DP (2016) Differential expression of opioid receptor genes in brain regions involved in pain and negative affect in Wistar-Kyoto versus Sprague-Dawley rats Irish Pain Society Annual Scientific Meeting Dublin, Ireland, [Details]
(2016) Irish Pain Society 16th Annual Scientific Meeting
Madasu MK, Okine BN, Olango WM, Roche M and Finn DP (2016) Genotype-dependent responsivity to inflammatory pain: a role for TRPV1 in the ventrolateral periaqueductal grey Irish Pain Society 16th Annual Scientific Meeting Dublin, Ireland, , 03-SEP-16 - 03-SEP-16 [Details]
(2016) Neuroscience Ireland Young Neuroscientists Symposium
Jarrin S, Okine BN, Thompson K, Ruane T, Naughton C, Dowd E, Pandit A, Roche M, Finn DP (2016) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour Neuroscience Ireland Young Neuroscientists Symposium Dublin, Ireland, [Details]
(2017) Irish Pain Society 17th Annual Scientific Meeting & 3rd Irish Pain Research Network Symposium
Llorente-Berzal A, McGowan F, Rea K, Roche M, Finn DP (2017) Fear-conditioned analgesia and associated alterations in the endocannabinoid system of the periaqueductal grey exhibit sexual dimorphism in rats Irish Pain Society 17th Annual Scientific Meeting & 3rd Irish Pain Research Network Symposium Galway, Ireland, [Details]
(2017) Irish Pain Society 17th Annual Scientific Meeting & 3rd Irish Pain Research Network Symposium
Power, E, Mannion, O, Taylor, BK, Werner, MU, Roche, M. & Finn, DP (2017) Latent Sensitisation in a Rat Model of Postoperative Pain following Inguinal Hernia Repair ¿ Behavioural, Endocannabinoid and Opioid Characterisation Irish Pain Society 17th Annual Scientific Meeting & 3rd Irish Pain Research Network Symposium Galway, Ireland, [Details]
(2017) Irish Pain Society Annual Meeting
Jarrin S, Pandit A, Roche M, Finn DP (2017) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour Irish Pain Society Annual Meeting Galway, Ireland, [Details]
(2017) 10th Neuroscience Ireland Conference
Gaspar JC, Okine BN, Llorente-Berzal A, Burke O, Dinneen D, Roche M, Finn DP (2017) The effects of pharmacological blockade of PPARs on formalin-evoked nociceptive behaviour, fear conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats 10th Neuroscience Ireland Conference Galway, Ireland, , 28-AUG-17 - 29-AUG-17 [Details]
(2017) Royal Acadamy of Medicine in Ireland (RAMI) Section of Biomedical Sciences Annual Meeting 2017
McHugh KL, Calcagno P, Clarke M, Everman D, Sanchez C, Roche M, Finn DP, Kelly JP (2017) A comparative assessment of single versus paired-housing on behavioural responses in the olfactory bulbectomised (OB) rat model of depression Royal Acadamy of Medicine in Ireland (RAMI) Section of Biomedical Sciences Annual Meeting 2017 Dublin, Ireland, [Details]
(2017) Neuroscience Ireland Annual General Meeting 2017
McHugh KL, Calcagno P, Clarke M, Everman D, Sanchez C, Roche M, Finn DP, Kelly JP (2017) A comparative assessment of single versus paired-housing on behavioural responses in the olfactory bulbectomised (OB) rat model of depression Neuroscience Ireland Annual General Meeting 2017 Galway, Ireland, [Details]
(2017) Neuroscience Ireland
Power, E, Mannion, O, Taylor, BK, Werner, MU, Roche, M. & Finn, DP (2017) Latent Sensitisation in a Rat Model of Postoperative Pain following Inguinal Hernia Repair ¿ Behavioural, Endocannabinoid and Opioid Characterisation Neuroscience Ireland [Details]
(2017) 8th European Workshop on Cannabinoid Research Society
Gaspar JC, Okine BN, Llorente-Berzal A, Burke O, Dinneen D, Roche M, Finn DP (2017) The effects of pharmacological blockade of PPARs on formalin-evoked nociceptive behaviour, fear conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats 8th European Workshop on Cannabinoid Research Society Roehampton, UK, , 31-AUG-17 - 02-SEP-17 [Details]
(2017) 10th Congress of the European Pain Federation, EFIC
Ferdousi M, Calcagno P, Clarke M, Eyermann D, Sanchez C, Kelly JP, Roche M, Finn DP (2017) Evidence for Hyporesponsivity to Morphine in the Wistar-Kyoto Rat Model of Hyperalgesia Associated with Negative Affective State 10th Congress of the European Pain Federation, EFIC Copenhagen, Denmark, , 06-SEP-17 - 09-SEP-17 [Details]
(2017) 10th Neuroscience Ireland Conference
Corcoran L, Rea K, Roche M, Finn DP (2017) Hyperalgesia and impaired expression of fear-conditioned analgesia in the stress- and pain-hyperresponsive Wistar-Kyoto rat strain: A role for anandamide in the infralimbic cortex? 10th Neuroscience Ireland Conference Galway, Ireland, [Details]
(2017) Irish Pain Society Annual Scientific Meeting
Flannery LE, Humphrey R, Kerr DM, Finn DP, Roche M (2017) Endocannabinoid modulation of TLR3-induced neuroinflammation and behavioural alterations in rats Irish Pain Society Annual Scientific Meeting Galway, Ireland, [Details]
(2017) 10th Neuroscience Ireland Conference
Flannery LE, Kerr DM, Finn DP, Roche M (2017) The FAAH substrates OEA and PEA modulate TLR3-induced neuroinflammation and/or fever in rats 10th Neuroscience Ireland Conference Galway, Ireland, , 28-AUG-17 - 29-AUG-17 [Details]
(2017) 10th Neuroscience Ireland Conference
Hughes EM, Flannery LE, Clarke M, Calcagno P, Kerr DM, Eyerman D, Sanchez C, Kelly, JP, Finn DP, Roche M (2017) Altered expression of mRNA encoding opioid peptides and receptors in discrete brain regions of adolescent and adult rats prenatally exposed to valproic acid 10th Neuroscience Ireland Conference Galway, Ireland, [Details]
(2017) 11th Neuroscience Ireland Conference
Harhen B, Fearnhead H, Roche M ,Finn DP (2017) Mass spectrometry assay for leelamine 11th Neuroscience Ireland Conference Galway, Ireland, [Details]
(2017) Photonics Ireland
Jarrin S, Pandit A, Roche M, Finn DP (2017) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour Photonics Ireland Cork, Ireland, , 13-SEP-17 - 15-SEP-17 [Details]
(2017) Neuroscience Ireland Conference 2017
Llorente-Berzal A, McGowan F, Rea K, Roche M, Finn DP (2017) Fear-conditioned analgesia and associated alterations in the endocannabinoid system of the periaqueductal grey exhibit sexual dimorphism in rats Neuroscience Ireland Conference 2017 Galway, Ireland, [Details]
(2017) 8th Annual Scientific Meeting organised by the College of Anaesthetists Faculty of Pain Medicine
Jarrin S, Okine BN, Thompson K, Ruane T, Naughton C, Dowd E, Pandit A, Roche M, Finn DP (2017) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour 8th Annual Scientific Meeting organised by the College of Anaesthetists Faculty of Pain Medicine [Details]
(2017) Irish Pain Society Annual Scientific Meeting
Ferdousi M, Calcagno P, Clarke M, Eyermann D, Sanchez C, Kelly JP, Roche M, Finn DP (2017) Evidence for Hyporesponsivity to Morphine in the Wistar-Kyoto Rat Model of Hyperalgesia Associated with Negative Affective State Irish Pain Society Annual Scientific Meeting Galway, Ireland, [Details]
(2018) International Association for the Study of Pain (IASP) 17th World Congress on Pain
Ferdousi M, Calcagno P, Aggarwal S, Sanchez C, Kelly JP, Roche M, Finn DP (2018) Hyporesponsivity to morphine microinjected into the ventrolateral periaqueductal grey in Wistar-Kyoto versus Sprague-Dawley rats International Association for the Study of Pain (IASP) 17th World Congress on Pain Boston, USA, , 12-SEP-18 - 16-SEP-18 [Details]
(2018) Young Neuroscience Ireland Symposium
Llorente-Berzal A, McGowan F, Rea K, Roche M, Finn DP (2018) Sexually dimorphic expression of fear-conditioned analgesia in rats and associated alterations in the endocannabinoid system in the periaqueductal grey Young Neuroscience Ireland Symposium Dublin, Ireland, [Details]
(2018) Annual Meeting of the Society for Neuroscience
Ferdousi M, Calcagno P, Clarke M, Aggarwal S, Sanchez C, Smith K, Kelly JP, Roche M, Finn DP (2018) Hyporesponsivity to morphine in the Wistar¿Kyoto rat model of hyperalgesia associated with negative affective state Annual Meeting of the Society for Neuroscience San Diego, USA, , 03-NOV-18 - 07-NOV-18 [Details]
(2019) Irish Mass Spectrometry Society Annual Meeting, NIBRT
Harhen B, Fearnhead H, Roche M, Finn DP (2019) Discovery of a series of novel leelamine metabolites in rat tissue using liquid chromatography and tandem mass spectrometry Irish Mass Spectrometry Society Annual Meeting, NIBRT Dublin, Ireland, [Details]
(2019) British Neuroscience Association Festival of Neuroscience
Jarrin S, Pandit A, Roche M, Finn DP (2019) Differential effects of optogenetic modulation of rat anterior cingulate cortical glutamatergic neurons on the affective and sensory components of pain British Neuroscience Association Festival of Neuroscience Dublin, Ireland, [Details]
(2019) British Neuroscience Association Festival of Neuroscience
Harhen B, Llorente-Berzal A, Fearnhead H, Roche M, Finn DP (2019) Discovery of a series of novel leelamine metabolites in rat tissue using liquid chromatography and tandem mass spectrometry British Neuroscience Association Festival of Neuroscience Dublin, Ireland, , 14-APR-19 - 17-APR-19 [Details]
(2020) 12th Federation of European Neuroscience Societies (FENS) Forum
Thornton AM, Hughes EM, Humphrey RM, Kerr DM, Finn DP, Roche M (2020) Increasing anandamide tone attenuates hyperthermia and social cognitive deficits induced following viral infection in female rats prenatally exposed to valproic acid 12th Federation of European Neuroscience Societies (FENS) Forum Virtual, [Details]
(2020) Federation of European Neuroscience Societies (FENS) 2020
Humphrey RM, Finn DP, Roche M (2020) Altered nociceptive responding in a preclinical model of autism is associated with changes in supraspinal opioid receptor expression Federation of European Neuroscience Societies (FENS) 2020 Virtual, [Details]
(2021) European College of Neuropsychopharmacology (ECNP) Workshop for Early Career Scientists
Humphrey RM, Finn DP, Roche M (2021) Altered pain responding in a model of autism associated with changes in endocannabinoid system-related gene expression . In: Eur Neuropsychopharmacol eds. European College of Neuropsychopharmacology (ECNP) Workshop for Early Career Scientists Lisbon, Hybrid, , 02-OCT-21 - 05-OCT-21 [Details]

Education

  Year Institution Qualification Subject
2015 National Univeristy of Ireland Galway POSTGRAD CERT OF EDUCATION Teaching and Learning
2005 National University of Ireland, Galway PhD Pharmacology
2001 National University of Ireland, Galway MASTERS OF SCIENCE Neuropharmacology
1999 National University of Ireland, Galway BACHELOR OF SCIENCE Physiology

Employment

  Employer Position From / To
National University of Ireland Galway Senior Lecturer/Associate Professor 01-OCT-20 /
NUI Galway Lecturer in Physiology (above the bar) 01-MAY-12 / 01-OCT-20
Physiology, NUI Galway Lecturer (below the bar) 01-SEP-08 / 01-MAY-12
Pharmacology and Therapeutics, NUI Galway Post Doctoral researcher 01-SEP-05 / 01-SEP-08
Pharmacology and Therapeutics, NUI Galway Contract Lecturer 01-SEP-04 / 01-SEP-05
Children's Hospital of Philadelphia, USA Research Assistant 18-JAN-01 / 18-DEC-01

Professional Associations

  Association Function From / To
Irish Pain Society President-elect 01-OCT-22 / 01-NOV-23
European Neuropsychopharmacology Society Early Career Workshop Committee member 01-MAR-21 / 01-APR-23
Neuroscience Ireland Communications Officer 01-JAN-19 / 01-JAN-21
European College of Neuropsychopharmacology Scientific Advisory Panel member 01-JAN-17 / 01-JAN-20
European College of Neuropsychopharmacology Member of the scientific programme committee ECNP congress 2019 01-JUN-17 / 31-DEC-19
Irish Pain Society Council Member 01-JAN-14 /
Royal Academy of Medicine in Ireland, Biomedical Sciences Section Council Member 01-JUL-11 /
Irish Pain Research Network Council member 26-SEP-15 /

Committees

  Committee Function From / To
Galway Neuroscience Centre Director 01-JAN-23 / 01-JAN-25
Centre for Pain Research Co-Director 01-DEC-20 /
School of Medicine Athena Swan Committee Chair of Career Development Group 01-JAN-20 /
College of Medicine, Nursing and Health Science Graduate Studies Committee member 14-JAN-16 / 15-JAN-17
College of Science Research Committee Committee Member 01-SEP-11 / 02-MAR-15
Graduate Research Committee (GRC) GRC member for 6 PhD students 01-JAN-09 /

Teaching Interests

The Roche lab is currently comprised of 6 PhD students, one MSc student, 4 undergraduate students and one research assistant. To date, 17 PhD and 3 MSc research students have completed their studies under my supervision. I have also had the privilege to work with and mentor 6 post-doctoral researchers, 8 research assistants and host a number of visiting academics and researchers in my lab. 

In addition to my research, I am also actively engaged in undergraduate and postgraduate teaching to a wide array of students from medical, nursing and health sciences, to science, engineering and psychology.

I am the coordinator for 4th year Physiology (B.Sc. and B.Sc. Biomedical Science) Programme.

I also coordinate several modules primarily in the areas of Neurophysiology (SI311/SI209/SI422) and Endocrinology (SI312/SI3102).

I use a multitude of teaching methodologies and formats from lectures and seminars, practicals and lab based projects, small group teaching, flipped classroom teaching, poster and oral presentations and case studies in my teaching.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2020 Aoife Thornton PhD Y
2020 Sarah Jarrin PhD
2020 Mehnaz Ferdousi PhD
2020 Kelly McHugh PhD
2020 Grace O'Sullivan PhD
2020 Patricia Calcagno
2020 Edel Hughes PhD Y
2019 James Prendergast Msc
2019 Jessica Gaspar PhD
2019 Emer Power PhD
2019 Darragh Mattimoe Msc
2018 Louise Corcoran PhD
2018 MaryKate Killilea PhD
2017 Lisa Flannery PhD Y
2016 Manish Kumar Madasu
2015 Elaine Jennings PhD N
2015 Rebecca Henry PhD Y
2015 Marie Fitzgibbon PhD Y
2015 Fiona Mc Gowan N
2014 Dara Bree  PhD Y
2014 Daniel Kerr PhD Y
2013 Nikita Burke PhD Y
2011 Werede Olango PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Alba Diego Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Ariadni Bella Doctorate - Structured Ph.D (Medicine) Supervisor
Rachel Humphrey Doctorate - Structured Ph.D (Medicine) Supervisor
Brendan Harhen Doctorate - Ph.D. Co-supervisor (1)

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2008-present The Cenrtral Nervous System MD224 Physiological functions of the brain and spinal cord - 2nd year medical students
2015-present Case-based Physiology SI4101 Integrative case-studies on pathophysiological conditions - 4th year Physiology Science students
2008-present Research Project SI435 Supervise final year BSc and Biomedical science research projects - 4th yr Physiology Science students
2008-present Endocrinology SI312/SI3102 Physiological functions of hormones - 3rd year Science students and 2nd year podiatry students
2008-present Advanced Neurophysiology SI422 Pathophysiology underlying neurological, psychiatric and neurodegenerative disorders
2008-present Neurophysiology SI311/SI209 Understanding the physiologial action of neurons, glia and the physiological processes underlying movement, sensation, hearing, vision, emotion, speech and language - 3rd year Sceince students and 2nd year Speech and Language & ocupational Therapty students