Dr Michelle Roche

BSc., MSc., PhD.

 
researcher
 

Biography

Dr Roche graduated in 1999 with a B.Sc. (Hons.) degree in Physiology at NUI Galway following which she undertook an M.Sc. in Neuropharmacology (1999-2001). Her interest in stress-related disorders began during her time as a research assistant in Prof Rita Valentino laboratory in Philadelphia (2001) where she examined the neural circuitry underlying stress-induced changes in the serotonergic system. She subsequently pursued a Ph.D. (2002-2005) characterizing behavioural and physiological responses in models of depression at the Department of Pharmacology, NUI Galway. Following a year as a contract lecturer, Dr Roche undertook a post-doctoral research (2005-2008) position focused on the role of the endocannabinoid system on conditioned stress-induced changes in pain responding and inflammation. In September 2008, Dr Roche was appointed Lecturer in Physiology at NUI Galway. 

Research Interests

Dr Roches research interests include

   The role of the cannabinoid system in regulating of neuroinflammation and immune function
   Neural substrates underpinning stress, depression and pain and their interaction
   Neurobiology underlying autism spectrum disorders

The Roche Lab employs a whole systems approach to addressing research questions in the aforementioned areas. A wide range of in vivo, ex vivo and in vitro methodologies are utilized to examine the role of a number of neurotransmitter systems including monoamines, endocannabinoids and neuropeptides, neuroendocrine and immune processes in physiological and behavioural responses.


Peer Reviewed Journals

  Year Publication
(2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'
Hughes EM;Calcagno P;Clarke M;Sanchez C;Smith K;Kelly JP;Finn DP;Roche M; (2020) 'Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats'. Brain Research, doi: 10.1016/j.brainres.2020.146675 [DOI] [Details]
(2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'
Corcoran L;Mattimoe D;Roche M;Finn DP; (2020) 'Attenuation of fear-conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: potential role for CB2 receptors'. British Journal Of Pharmacology, doi: 10.1111/bph.14976 [DOI] [Details]
(2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'
O'Sullivan G;McGuire B;Roche M;Caes L; (2019) 'Am I being watched? The role of researcher presence on toddlers' behaviour during 'everyday' pain experiences: a pilot study'. Psychology & Health, doi: 10.1080/08870446.2019.1707830 [DOI] [ARAN Link] [Details]
(2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'
Fitzgibbon, M,Kerr, DM,Henry, RJ,Finn, DP,Roche, M (2019) 'Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-alpha mouse model of depression'. Brain Behavior And Immunity, 82 :372-381 [DOI] [ARAN Link] [Details]
(2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'
Rea, K,McGowan, F,Corcoran, L,Roche, M,Finn, DP (2019) 'The prefrontal cortical endocannabinoid system modulates fear-pain interactions in a subregion-specific manner'. British Journal Of Pharmacology, 176 :1492-1505 [DOI] [ARAN Link] [Details]
(2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'
Burke, NN,Ferdousi, M,Deaver, DR,Finn, DP,Roche, M,Kelly, JP (2019) 'Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats'. Neuropharmacology, 146 :327-336 [DOI] [ARAN Link] [Details]
(2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'
Burke, NN,Li, Y,Deaver, DR,Finn, DP,Roche, M,Eyerman, DJ,Sanchez, C,Kelly, JP (2019) 'Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats'. Journal Of Psychopharmacology, [DOI] [ARAN Link] [Details]
(2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'
Flannery LE, Henry RJ, Kerr DM, Finn DP, Roche M (2018) 'FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat; effects independent of sex'. Journal Of Neuroscience Research, 96 (6) [DOI] [Details]
(2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'
Buckley, DA,Jennings, EM,Burke, NN,Roche, M,McInerney, V,Wren, JD,Finn, DP,McHugh, PC (2018) 'The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain'. Molecular Neurobiology, 55 :2420-2430 [DOI] [ARAN Link] [Details]
(2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'
Flannery, LE,Kerr, DM,Finn, DP,Roche, M (2018) 'FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats'. Behavioural Brain Research, 353 :11-20 [DOI] [ARAN Link] [Details]
(2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'
Liu, M,Fitzgibbon, M,Wang, YQ,Reilly, J,Qian, XH,O'Brien, T,Clapcote, S,Shen, SB,Roche, M (2018) 'Ulk4 regulates GABAergic signaling and anxiety-related behavior'. Translational Psychiatry, 8 [DOI] [ARAN Link] [Details]
(2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'
Henry, RJ,Kerr, DM,Flannery, LE,Killilea, M,Hughes, EM,Corcoran, L,Finn, DP,Roche, M (2017) 'Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1'. Brain Behavior And Immunity, 62 :318-331 [DOI] [ARAN Link] [Details]
(2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke, NN;Finn, DP;McGuire, BE;Roche, M (2017) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. J Neurosci Res, 95 (6):1257-1270 [DOI] [Details]
(2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'
Okine, BN;Gaspar, JC;Madasu, MK;Olango, WM;Harhen, B;Roche, M;Finn, DP (2017) 'Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia'. Brain Research, 1657 :185-192 [DOI] [ARAN Link] [Details]
(2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'
Jennings, EM,Okine, BN,Olango, WM,Roche, M,Finn, DP (2016) 'Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :181-189 [DOI] [ARAN Link] [Details]
(2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'
Burke, NN,Coppinger, J,Deaver, DR,Roche, M,Finn, DP,Kelly, J (2016) 'Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat'. Physiology & Behavior, 167 :28-34 [DOI] [ARAN Link] [Details]
(2016) '6-iodonordihydrocapsaicin'
Roche M (2016) '6-iodonordihydrocapsaicin'. Reference Module in Biomedical Sciences, doi.org/10.1016/B978-0-12-801238-3.99373-5 [DOI] [Details]
(2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'
Dyall, SC,Mandhair, HK,Fincham, REA,Kerr, DM,Roche, M,Molina-Holgado, F (2016) 'Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways'. Neuropharmacology, 107 :387-395 [DOI] [Details]
(2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'
Henry, RJ,Kerr, DM,Finn, DP,Roche, M (2016) 'For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders'. Progress In Neuro-Psychopharmacology & Biological Psychiatry, 64 :167-180 [DOI] [ARAN Link] [Details]
(2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'
Okine, BN;Madasu, MK;McGowan, F;Prendergast, C;Gaspar, JC;Harhen, B;Roche, M;Finn, DP (2016) 'N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism'. Pain, 157 :2687-2696 [DOI] [ARAN Link] [Details]
(2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'
Moriarty, O,Gorman, CL,McGowan, F,Ford, GK,Roche, M,Thompson, K,Dockery, P,McGuire, BE,Finn, DP (2016) 'Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain'. Scandinavian Journal Of Pain, 10 :61-73 [DOI] [ARAN Link] [Details]
(2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'
Bree, D,Moriarty, O,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2016) 'Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain'. Cns Neuroscience & Therapeutics, 22 :146-153 [DOI] [ARAN Link] [Details]
(2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'
Burke NN;Finn DP;McGuire BE;Roche M; (2016) 'Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms'. Journal Of Neuroscience Research, 95 (6):1257-1270 [DOI] [ARAN Link] [Details]
(2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'
Kerr, DM; Gilmartin, A; Roche, M; (2016) 'Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid'. Pharmacological Research, 113 (Pt A):228-235 [DOI] [ARAN Link] [Details]
(2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'
Madasu MK;Okine BN;Olango WM;Rea K;Lenihan R;Roche M;Finn DP; (2016) 'Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey'. Pharmacological Research, 113 (Pt A):44-54 [DOI] [ARAN Link] [Details]
(2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'
Fitzgibbon, M; Finn, DP; Roche, M (2015) 'High times for painful blues: the endocannabinoid system in pain-depression comorbidity'. International Journal Of Neuropsychopharmacology, 5:19 (3) [ARAN Link] [Details]
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'. International Review Of Neurobiology, 125 :203-255 [DOI] [ARAN Link] [Details]
(2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'
Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'. Research In Autism Spectrum Disorders, 10 :78-92 [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree, D,Moriarty, O,Mahony, CM,Morris, B,Bannerton, K,Broom, DC,Kelly, JP,Roche, M,Finn, DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, 16 :421-435 [DOI] [ARAN Link] [Details]
(2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'
Bree D, Moriarty O, O'Mahony CM, Morris B, Bannerton K, Broom DC, Kelly JP, Roche M, Finn DP (2015) 'Development and Characterization of a Novel, Anatomically Relevant Rat Model of Acute Postoperative Pain'. Journal Of Pain, [Details]
(2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'
Burke, NN,Finn, DP,Roche, M (2015) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'. Behavioural Brain Research, 278 :193-201 [DOI] [ARAN Link] [Details]
(2014) 'Stress-induced hyperalgesia'
Jennings EM, Okine BN, Roche M, Finn DP (2014) 'Stress-induced hyperalgesia'. Progress In Neurobiology, 64 :1-18 [DOI] [Details]
(2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'
Rea, K,Olango, WM,Okine, BN,Madasu, MK,McGuire, IC,Coyle, K,Harhen, B,Roche, M,Finn, DP (2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'. Pain, 155 :69-79 [DOI] [Details]
(2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'
Olango, WM,Geranton, SM,Roche, M,Hunt, SP,Finn, DP (2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'. European Journal Of Pain, 18 :182-191 [DOI] [Details]
(2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'
Rea, K,Ford, GK,Olango, WM,Harhen, B,Roche, M,Finn, DP (2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'. European Journal Of Neuroscience, 39 :435-443 [DOI] [Details]
(2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'
Okine BN, Rea K, Olango WM, Price J, Roche M, Finn DP (2014) 'A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'. British J Pharmacology, [Details]
(2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'
Burke, NN,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'. Brain Behavior And Immunity, 42 :147-156 [DOI] [ARAN Link] [Details]
(2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'
Okine, BN,Rea, K,Olango, WM,Price, J,Herdman, S,Madasu, MK,Roche, M,Finn, DP (2014) 'A role for PPARa in the medial prefrontal cortex in formalin- evoked nociceptive responding in rats'. British Journal Of Pharmacology, 171 :1462-1471 [DOI] [ARAN Link] [Details]
(2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'
Henry RJ, Kerr DM, Finn DP, Roche M (2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'. Journal Of Neuroimmunology, 276 (1-2):126-134 [DOI] [Details]
(2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'
Burke, NN,Llorente, R,Marco, EM,Tong, K,Finn, DP,Viveros, MP,Roche, M (2013) 'Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury'. Journal Of Pain, 14 :1173-1184 [DOI] [ARAN Link] [Details]
(2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'
Burke, NN,Geoghegan, E,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2013) 'Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 12 :705-713 [DOI] [ARAN Link] [Details]
(2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'
Kerr, DM,Harhen, B,Okine, BN,Egan, LJ,Finn, DP,Roche, M (2013) 'The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 :808-819 [DOI] [Details]
(2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'
Kerr, DM,Downey, L,Conboy, M,Finn, DP,Roche, M (2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'. Behavioural Brain Research, 249 :124-132 [DOI] [Details]
(2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'
Kerr DM, Henry R, Roche M (2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation'. Anatomy and Physiology, 4 (e) [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, Kieran and Olango, Weredeselam M and Harhen, Brendan and Kerr, Daniel M and Galligan, Rachel and Fitzgerald, Sean and Moore, Maeve and Roche, Michelle and Finn, David P (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 (4):576-585 [ARAN Link] [Details]
(2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'
Rea, K,Olango, WM,Harhen, B,Kerr, DM,Galligan, R,Fitzgerald, S,Moore, M,Roche, M,Finn, DP (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 :576-585 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [ARAN Link] [Details]
(2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'
Olango, WM,Roche, M,Ford, GK,Harhen, B,Finn, DP (2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'. British Journal Of Pharmacology, 165 :2549-2560 [DOI] [ARAN Link] [Details]
(2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'
Kerr, DM;Burke, NN;Ford, GK;Connor, TJ;Harhen, B;Egan, LJ;Finn, DP;Roche, M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63 [DOI] [Details]
(2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'
Moriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8 [DOI] [ARAN Link] [Details]
(2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'
Butler, RK,Ford, GK,Hogan, M,Roche, M,Doyle, KM,Kelly, JP,Kendall, DA,Chapman, V,Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91 [DOI] [ARAN Link] [Details]
(2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'
Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 (0):91-98 [DOI] [ARAN Link] [Details]
(2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'
Rea, K,Roche, M,Finn, DP (2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'. Journal Of Pain, 12 :712-721 [DOI] [ARAN Link] [Details]
(2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'
Roche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals, :2517-2553 [DOI] [ARAN Link] [Details]
(2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'
Burke, NN,Hayes, E,Calpin, P,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'. Neuroscience, 171 (0):1300-1313 [DOI] [ARAN Link] [Details]
(2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'
Roche, M,Johnston, P,Mhuircheartaigh, ON,Olango, WM,Mackie, K,Finn, DP (2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'. European Journal Of Pain, 14 :487-495 [DOI] [Details]
(2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'
Smith, KL,Roche, M,Jessop, DS,Finn, DP (2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'. European Neuropsychopharmacology, 19 :371-380 [DOI] [Details]
(2009) '6-iodonordihydrocapsaicin'
Roche M, Finn DP (2009) '6-iodonordihydrocapsaicin'. Xpharm; Executive Eds: Sj Enna And Db Bylund; Publisher, Elsevier, Inc., New York, :0-0 [DOI] [ARAN Link] [Details]
(2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'
Roche M, Shanahan E, Harkin A, Kelly JP (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacological Reports, 60 (0):404-408 [DOI] [Details]
(2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'
Roche M, Kelly JP, O'Driscoll M, Finn DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 (2):263-271 [DOI] [Details]
(2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'
Roche, M., Harkin, A., Kelly, J. P. (2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'. Neuropsychopharmacology, 32 (6):1312-1320 [ARAN Link] [Details]
(2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'
Rea K, Roche M, Finn DP (2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'. British Journal Of Pharmacology, 152 (5):633-648 [DOI] [Details]
(2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'
Roche M, O’Connor E, Diskin C, Finn DP. (2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'. European Journal Of Neuroscience, 26 (9):2643-2653 [DOI] [Details]
(2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'
Roche M, Diamond M, Kelly JP, Finn DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 (1-2):57-67 [DOI] [Details]
(2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'
Zueger, A,Urani, A,Chourbaji, S,Zacher, C,Roche, M,Harkin, A,Gass, P (2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'. Neuroscience Letters, 374 :142-146 [DOI] [Details]
(2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'
Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997 [ARAN Link] [Details]

Book Chapters

  Year Publication
(2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress'
Corcoran. L, Roche M, Finn DP (2015) 'The Role of the Brain's Endocannabinoid System in Pain and Its Modulation by Stress' In: International Review of Neurobiology, Endocannabinoids. US: Elsevier Inc. [ARAN Link] [Details]
(2015) 'Neuroinflammatory mechanisms linking Pain and Depression'
Burke N.N., Finn DP, Roche M (2015) 'Neuroinflammatory mechanisms linking Pain and Depression' In: Pain in Psychiatric Disorders: Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2015) 'Supraspinal TRPV1 in pain and psychiatric disorders'
Madasu M, Roche M, Finn DP (2015) 'Supraspinal TRPV1 in pain and psychiatric disorders' In: Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Switzerland: Karger. [ARAN Link] [Details]
(2011) 'The Olfactory Bulbectomised Mouse'
Roche M (2011) 'The Olfactory Bulbectomised Mouse' In: In Mood and Anxiety Related Phenotypes in Mice. USA: Humana Press. [ARAN Link] [Details]

Conference Publications

  Year Publication
(2019) Children’s Research Network PhD Symposium
O’Sullivan, G., McGuire, B., Roche, M., & Caes, L. (2019) The influence of social context on ‘everyday’ pain experiences in childhood Children’s Research Network PhD Symposium [Details]
(2019) European College of Neuropsychopharmacology (ECNP), 32nd ECNP Congress
McHugh KL, Calcagno P, Ferdousi M, Sanchez C, Roche M, Finn DP, Kelly JP (2019) Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat European College of Neuropsychopharmacology (ECNP), 32nd ECNP Congress [ARAN Link] [Details]
(2019) EFIC Congress
Power E, Mannion O, Coentro J, Roche M, Zeugolis D, Pandit A, & Finn DP (2019) Development and Preclinical Testing of a Prototype Levobupivacaine-Eluting Device for the Treatment of Postoperative Pain following Inguinal Hernia Repair EFIC Congress Valencia, [Details]
(2019) British Neuroscience Association
Thornton AM, Humphrey RM, Kerr DM, Finn DP, Roche M (2019) Effects of pharmacological modulation of the endogenous opioid and cannabinoid systems on affective responding in a rat model of autism British Neuroscience Association [Details]
(2019) 32nd European College of Neuropsychopharmacology (ECNP) Congress
Thornton AM, Hughes EM, Humphrey RM, Kerr DM, Finn DP, Roche M (2019) Impaired social behaviour in valproic acid-exposed rats following viral immune challenge is accompanied by reduced c-fos expression in the hypothalamus 32nd European College of Neuropsychopharmacology (ECNP) Congress [Details]
(2019) British Neuroscience Association
Prendergast, J., Okolo, A., Douglas, A., Shearer, J., Roche, M. and Doyle, K. (2019) Cyclooxygenase-2 Expression in the Brain Following Ischemic Stroke and its Effects on Glial Cells British Neuroscience Association [Details]
(2019) British Neuroscience Association
Hughes E.M., Thornton A.M., Kerr, D.M., Clarke M., Calcagno, P., Sanchez C., Kelly, J.P., Finn, D.P., Roche, M. (2019) Differential effects of morphine on social responding in the VPA model of social impairment British Neuroscience Association [Details]
(2019) European Neuropsychopharmacology
Hughes E.M., Thornton A.M., Humphrey R.M., Kerr, D.M., Aggarwal, S., Sanchez C., Kelly, J.P., Finn, D.P., Roche, M (2019) Pharmacological modulation of kappa- and delta- opioid receptors elicits differential effects on social responding in rats prenatally exposed to VPA or saline European Neuropsychopharmacology [Details]
(2019) 11th Congress of the European Pain Federation
Humphrey RM, Calcagno P, Finn DP, Roche M (2019) Nociceptive responding in the valproic acid animal model of autism and associated changes in neuronal activation 11th Congress of the European Pain Federation [Details]
(2019) British Neuroscience Association
Humphrey RM, Thornton AM, Hughes EM, Kerr DM, Finn DP, Roche M (2019) Altered Thermal and Mechanical Nociceptive Responding Following TLR4, but not TLR3 Activation in the Valproic Acid Rat Model of Autism British Neuroscience Association [Details]
(2019) British Neuroscience Association
Power E, Bourke S, Mannion O, Taylor BK, Werner MU, Roche M & Finn D.P. (2019) Pharmacological and Molecular Characterisation of Latent Sensitisation in a Rat Model of Postoperative Pain following Inguinal Hernia Repair British Neuroscience Association [Details]
(2019) British Neuroscience Association
Mattimoe D, Corcoran L, Finn DP, Roche M (2019) The effects of MAGL inhibition and CB2 receptor antagonism in the anterior cingulate cortex on fear-conditioned analgesia, formalin-evoked nociceptive behaviour and levels of endocannabinoids and neurotransmitter in the rat nucleus accumbens British Neuroscience Association [Details]
(2019) British Neuroscience Association Festival of Neuroscience
Harhen B, Llorente-Berzal A, Fearnhead H, Roche M, Finn DP (2019) Discovery of a series of novel leelamine metabolites in rat tissue using liquid chromatography and tandem mass spectrometry British Neuroscience Association Festival of Neuroscience [Details]
(2019) British Pharmacology Society: Pharmacology 2018
Thornton, AM,Kerr, DM,Finn, DP,Roche, M (2019) Differential effects of monoacylglycerol lipase inhibition on social behavioural responding in saline- and VPA-exposed adolescent rats British Pharmacology Society: Pharmacology 2018 , pp.2978-2978 [Details]
(2019) British Neuroscience Association Festival of Neuroscience
Ferdousi M, Calcagno P, Aggarwal S, Sanchez C, Smith K, Kelly JP, Roche M, Finn DP (2019) Differential effect of kappa opioid receptor modulation in the Wistar-Kyoto rat model of hyperalgesia associated with negative affective state British Neuroscience Association Festival of Neuroscience [Details]
(2019) British Pharmacology Society: Pharmacology 2018
Hughes, EM,Thornton, AM,Kerr, DM,Clarke, M,Calcagno, P,Sanchez, C,Kelly, JP,Finn, DP,Roche, M (2019) Kappa opioid receptor-mediated modulation of social motivation and cognition in adolescent rats prenatally exposed to valproic acid British Pharmacology Society: Pharmacology 2018 , pp.2981-2982 [Details]
(2019) EUROPEAN NEUROPSYCHOPHARMACOLOGY Congress
Ferdousi, M,Calcagno, P,Sanchez, C,Smith, KL,Kelly, JP,Roche, M,Finn, DP (2019) Characterisation of pain-, anxiety- and cognition-related behaviour in the complete Freund's adjuvant model of chronic inflammatory pain in Wistar-Kyoto rats EUROPEAN NEUROPSYCHOPHARMACOLOGY Congress , pp.397-398 [DOI] [Details]
(2019) EUROPEAN NEUROPSYCHOPHARMACOLOGY Congress
Thornton, AM,Hughes, EM,Humphrey, RM,Kerr, DM,Finn, DP,Roche, M (2019) Impaired social behaviour in valproic acid-exposed rats following viral immune challenge is accompanied by reduced c-fos expression in the hypothalamus EUROPEAN NEUROPSYCHOPHARMACOLOGY Congress , pp.161-162 [DOI] [Details]
(2019) European College of Neuropsychopharmacology (ECNP) Workshop for Early Career Scientists in Europe
Thornton AM, Hughes EM, Humphrey RM, Kerr DM, Finn DP, Roche M (2019) Autistic-like symptoms revealed in female rats prenatally exposed to valproic acid following a viral immune challenge European College of Neuropsychopharmacology (ECNP) Workshop for Early Career Scientists in Europe [Details]
(2018) Irish Pain Society 18th Annual Scientific Meeting
Humphrey RM, Finn DP, Roche M (2018) Nociceptive Responding in the Valproic Acid Rat Model of Autism Irish Pain Society 18th Annual Scientific Meeting [Details]
(2018) Differential effects of monoacylglycerol lipase inhibition of social behavioural responding in saline- and VPA-exposed adolescent rats
Thornton AM, Kerr DM, Finn DP, Roche M (2018) British Pharmacological Society Pharmacology Differential effects of monoacylglycerol lipase inhibition of social behavioural responding in saline- and VPA-exposed adolescent rats London, [Details]
(2018) Optogen, the 5th International Workshop on Technologies for Optogenetics and Neurophotonics
Jarrin S, Pandit A, Roche M, Finn DP (2018) Differential effects of optogenetic modulation of rat anterior cingulate cortical glutamatergic neurons on the affective and sensory components of pain Optogen, the 5th International Workshop on Technologies for Optogenetics and Neurophotonics [Details]
(2018) Society for Neuroscience conference
McHugh KL, Doherty H, Calcagno P, Clarke M, Eyerman D, Sanchez C, Roche M, Finn DP, Kelly JP (2018) Evaluation of the 3-chamber sociability test in the olfactory bulbectomized (OB) rat model of depression Society for Neuroscience conference [Details]
(2018) Society of Neuroscience Meeting
Gaspar J, Okine B, Llorente-Berzal A, Dinneen D, Roche M, Finn DP (2018) Differential role of amygdala PPARs in conditioned fear-related behaviour in the presence or absence of nociceptive tone Society of Neuroscience Meeting San Diego (California, USA), , 03-NOV-18 - 07-NOV-18 [Details]
(2018) 11th FENS - Forum of Neuroscience Scientific Meeting
Gaspar JC, Okine BN, Llorente-Berzal A, Dinneen D, Roche M, Finn DP (2018) The effects of pharmacological blockade of PPARs on formalin-evoked nociceptive behaviour, fear conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats 11th FENS - Forum of Neuroscience Scientific Meeting [Details]
(2018) 28th Annual Symposium of the International Cannabinoid Research Society
Corcoran. L, Roche M, Finn DP (2018) Regulation of nociceptive behaviour and fear-conditioned analgesia by 2-AG in the rat medial prefrontal cortex 28th Annual Symposium of the International Cannabinoid Research Society [Details]
(2018) Gordon Research Conference on Optogenetic Approaches to Understanding Neural Circuits and Behavior
Jarrin S, Pandit A, Roche M, Finn DP (2018) The effects of optogenetic modulation of rat anterior cingulate cortical glutamatergic neurons on the affective component of pain Gordon Research Conference on Optogenetic Approaches to Understanding Neural Circuits and Behavior [Details]
(2018) 11th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience
Hughes EM, Thornton AM, Clarke M, Calcagno P, Sanchez C, Kelly JP, Finn DP, Roche M (2018) Kappa opioid receptor-mediated modulation of social motivation and cognition in adolescent rats 11th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience [Details]
(2018) Problems of Drug Dependence 80th Annual Meeting
Cunningham JI, Burke NN, Todtenkopf MS, Finn DP, Roche M, Kelly JP, Sanchez C (2018) Samidorphan attenuates the effects of buprenorphine in rat models evaluating abuse potential Problems of Drug Dependence 80th Annual Meeting San Diego, [Details]
(2017) 10th Congress of the European Pain Federation (EFIC)
Power, E, Mannion, O, Taylor, BK, Werner, MU, Roche, M. & Finn, DP (2017) Latent Sensitisation in a Rat Model of Postoperative Pain following Inguinal Hernia Repair – Behavioural, Endocannabinoid and Opioid Characterisation 10th Congress of the European Pain Federation (EFIC) [Details]
(2017) European Workshop on Cannabinoid Research
Killilea M, Kerr D.M, Mallard B.L, Roche M., Wheatley A.M (2017) Alterations in the hepatic endocannabinoid system in a model of stress-induced exacerbated acute liver injury European Workshop on Cannabinoid Research United Kingdom, [Details]
(2017) 47th European Brain and Behaviour Society Meeting
Hughes EM, Flannery LE, Clarke M, Calcagno P, Kerr DM, Eyerman D, Sanchez C, Kelly, JP, Finn DP, Roche M (2017) Altered expression of mRNA encoding opioid peptides and receptors in discrete brain regions of the valproic acid animal model of social impairment 47th European Brain and Behaviour Society Meeting Bilbao, Spain, [Details]
(2017) European Workshop on Cannabinoid Research
Thornton AM, Finn DP, Molina-Holgado F, Roche M (2017) Cannabinoid receptor antagonism augments the valproic induced attenuation of neural stem cell proliferation, an effect not dependant on IL1β European Workshop on Cannabinoid Research [Details]
(2017) International Liver Congress (EASL) Amsterdam
Killilea, M,Kerr, DM,Mallard, BL,Roche, M,Wheatley, AM (2017) Exacerbated LPS/GalN-induced liver injury in the stress sensitive Wistar Kyoto rat: possible role of the endocannabinoid system International Liver Congress (EASL) Amsterdam , pp.340-340 [Details]
(2017) 27th Annual Symposium of the International Cannabinoid Research Society
Gaspar JC, Okine BN, Llorente-Berzal A, Burke O, Dinneen D, Roche M, Finn DP (2017) The effects of pharmacological blockade of PPARs on formalin-evoked nociceptive behaviour, fear conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats 27th Annual Symposium of the International Cannabinoid Research Society [Details]
(2017) 16th World Pain Congress, Yokohoma, Japan
Madasu MK, Okine BN, Olango WM, Roche M and Finn DP (2017) Genotype-dependent responsivity to inflammatory pain: a role for TRPV1 in the ventrolateral periaqueductal grey 16th World Pain Congress, Yokohoma, Japan Proceedings, [Details]
(2017) Presented at 8th European Workshop on Cannabinoid Research
Flannery LE, Kerr DM, Finn DP, Roche M (2017) Endocannabinoid modulation of TLR3 induced neuroinflammation and behavioural alterations in rats Presented at 8th European Workshop on Cannabinoid Research [Details]
(2017) The Challenge of Chronic Pain Meeting
Ferdousi M, Calcagno P, Clarke M, Eyerman D, Sanchez C, Kelly J, Roche M, Finn DP (2017) Evidence for hyporesponsivity to morphine in the Wistar-Kyoto rat model of hyperalgesia associated with negative affective state The Challenge of Chronic Pain Meeting Proceedings, [Details]
(2017) British Pharmacological Society (BPS) conference, Pharmacology 2017
McHugh KL, Calcagno P, Clarke M, Everman D, Sanchez C, Roche M, Finn DP, Kelly JP (2017) An assessment of single versus paired-housing on social cognition in the 3-chamber sociability test in the olfactory bulbectomized (OB) rat model of depression British Pharmacological Society (BPS) conference, Pharmacology 2017 [Details]
(2017) 10th Congress of the European Federation of IASP Chapters (EFIC)
Jarrin S, Pandit A, Roche M, Finn DP (2017) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour 10th Congress of the European Federation of IASP Chapters (EFIC) [Details]
(2017) European College Neuropsychopharmacology Workshop, March 2017
Flannery LE, Kerr DM, Finn DP, Roche M (2017) Increasing endogenous N-acylethanolamine levels attenuates TLR3-induced neuroinflammation, nociceptive and anxiety-like behaviour in rats European College Neuropsychopharmacology Workshop, March 2017 Eur J Neuropsychopharmacology Vol27 Suppl1, , pp.S12-S13 [Details]
(2017) College of Anesthetists Faculty of Pain Medicine 10th Annual Scientific Meeting
Jarrin SE, Okine BN, Thompson K, Ruane T, Naughton C, Dowd E, Pandit A, Roche M, Finn DP (2017) The effects of optogenetic stimulation of glutamatergic neurons in the rat anterior cingulate cortex on locomotor activity and nociceptive behaviour College of Anesthetists Faculty of Pain Medicine 10th Annual Scientific Meeting [Details]
(2017) Annual Research Day of the Centre for Pain Research
Llorente-Berzal, A; McGowan, F; Rea, F; Belardo, C; Maione, S; Roche, M; Finn, DP (2017) Sexual dimorphism in fear-conditioned analgesia: a role for N-acylethanolamines in the periaqueductal gray? Annual Research Day of the Centre for Pain Research Galway, , 10-MAR-17 [Details]
(2017) College of Anesthetists Faculty of Pain Medicine 10th Annual Scientific Meeting
Power, E., Madasu, M.K., Kelly, J.P., Roche, M., & Finn, D.P. (2017) Characterisation of Affective Responding and the Endocannabinoid System in a Rat Model of Acute Postoperative Pain Following Inguinal Hernia Repair College of Anesthetists Faculty of Pain Medicine 10th Annual Scientific Meeting [Details]
(2017) European College of Neuropsychopharmacology (ECNP), Workshop 2017, Nice, France
Flannery, L,Kerr, DM,Finn, DP,Roche, M (2017) N-acylethanolamines attenuate Toll-like receptor (TLR) 3-induced neuroinflammation, nociceptive and anxiety-like behaviour in rats European College of Neuropsychopharmacology (ECNP), Workshop 2017, Nice, France , pp.12-13 [Details]
(2016) Galway Neuroscience Centre's Research Day
Llorente-Berzal, A; McGowan, F; Rea, K; Belardo, C; Maione, S; Roche, M; Finn, DP (2016) Sexual dimorphism in fear-conditioned analgesia: a role for N-acylethanolamines in the periaqueductal gray? Galway Neuroscience Centre's Research Day Galway, , 02-DEC-16 [Details]
(2016) 17th Congress of the Spanish Society on Cannabinoid Research
Llorente-Berzal, A; McGowan, F; Rea, K; Belardo, C; Maione, S; Roche, M; Finn, DP (2016) Sexual dimorphism in fear-conditioned analgesia: a role for N-acylethanolamines in the periaqueductal gray? 17th Congress of the Spanish Society on Cannabinoid Research Las Palmas de Gran Canaria (Spain), , 24-NOV-16 - 26-NOV-16 [Details]
(2016) Annual Research Day of the Centre for Pain Research
Gaspar, JC; Okine, B; Llorente-Berzal, A; Burke, O; Roche, M; Finn, DP (2016) Investigating the effects of pharmacological blockade of PPAR-alpha and PPAR-beta/delta on formalin-evoked nociceptive behavior, fear-conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats Annual Research Day of the Centre for Pain Research Galway, , 14-MAR-16 [Details]
(2016) Neuroscience Ireland Young Neuroscientists Meeting
Jarrin, S., Okine, B.N., Thompson, K., Ruane, T., Naughton, C., Dowd, E., Pandit, A., Roche, M., Finn, D.P. (2016) Optogenetic Stimulation of Glutamatergic Neurons in the Rat Anterior Cingulate Cortex Neuroscience Ireland Young Neuroscientists Meeting Dublin, [Details]
(2016) EUROPEAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY CONGRESS
Roche, M (2016) Immune factors as biomarkers for stress-related psychiatric and pain disorders EUROPEAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY CONGRESS European Neuropsychopharmacology, , pp.156-157 [Details]
(2016) IRISH JOURNAL OF MEDICAL SCIENCE
Flannery, L,Henry, R,Kerr, DM,Finn, DP,Roche, M (2016) TLR3-Induced Inflammatory Responses in the Rat Hypothalamus are Attenuated Following FAAH, but not MAGL, Inhibition; an Effect Independent of Sex IRISH JOURNAL OF MEDICAL SCIENCE , pp.16-17 [Details]
(2016) British Pharmacological Society conference
McHugh KL, Doherty H, Deaver D, Roche M, Finn DP, Kelly JP (2016) An assessment of social cognition in the olfactory bulbectomized rat model of depression British Pharmacological Society conference Proceedings, [Details]
(2016) Annual Symposium of the International Cannabinoid Research Society
Corcoran. L, Rea. K, Roche M, Finn DP (2016) Impaired Expression Of Fear-Conditioned Analgesia In The Stress- And Pain-Hyperresponsive Wistar-Kyoto Rat Strain Annual Symposium of the International Cannabinoid Research Society Proceedings, , pp.2-9 [Details]
(2016) Associação deos Estudantes Brasileiros no Reino Unido ABEP-UK, London, UK
Gaspar JC, Okine B, Llorente-Berzal A, Burke O, Roche M, Finn DP (2016) Investigating the effects of pharmacological blockade of PPAR- and PPAR- on formalin-evoked nociceptive behaviour, fear-conditioned analgesia and conditioned fear in the presence of nociceptive tone in rats Associação deos Estudantes Brasileiros no Reino Unido ABEP-UK, London, UK [Details]
(2016) Royal Academy of Medical Sciences Biomedical Sciences Annual Meeting
Flannery, L,Henry, R,Kerr, D,Finn, DP,Roche, M (2016) Enhancing Endogenous Anandamide Tone Attenuates the Expresion of TLR3-Induced Inflammatory Mediators in the Rat Spleen, Effects Partially Mediated by CB1 Receptors Royal Academy of Medical Sciences Biomedical Sciences Annual Meeting IRISH JOURNAL OF MEDICAL SCIENCE, , pp.29-30 [Details]
(2016) IRISH JOURNAL OF MEDICAL SCIENCE
Henry, R,Kerr, D,Finn, DP,Roche, M (2016) Central Inhibition of Fatty Acid Amide Hydrolase Attenuates TLR-3 Induced Expression of Interferon-Gamma and Related Genes in the Rat Hippocampus IRISH JOURNAL OF MEDICAL SCIENCE , pp.43-44 [Details]
(2016) European College Neuropsychopharmacology Congress
Okine BN, McLaughlin G, Roche M, Finn DP (2016) Pharmacological blockade of GPR55 in the anterior cingulate cortex reduces formalin-evoked nociceptive behaviour in rats European College Neuropsychopharmacology Congress Eur J Neuropsychopharmacology Volume 26 Supp 2, [Details]
(2015) 36th Annual Conference of the Stress and Anxiety Research Society
Hughes, B. M., Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., Reed, P., & Goodwin, M. S. (2015) Psychophysiological stress responses and challenging behaviour in children with autism spectrum disorder 36th Annual Conference of the Stress and Anxiety Research Society Tel Aviv, Israel. Proceedings, [Details]
(2015) European College Neuropsychopharmacology Congress
Burke, NN,Deaver, DR,Finn, DP,Roche, M,Kelly, JP (2015) Chronic administration of buprenorphine in combination with samidorphan produces antidepressant-like effects in rats without locomotor sensitization European College Neuropsychopharmacology Congress . Eur Neuropsychopharmacol. 2015, Vol 25, Supplement 2, , pp.379-380 [Details]
(2015) British Pharmacology Association Conference July 2015
Burke NN, Deaver DR, Finn DP, Roche M, Kelly JP. (2015) Buprenorphine, alone and in combination with the novel opioid receptor modulator samidorphan, displays antidepressant-like effects in two rat models British Pharmacology Association Conference July 2015 Journal of Psychopharmacology, Issue 29 (8), [Details]
(2015) 9th Neuroscience Ireland Conference, Dublin, September 2015
Corcoran. L, Rea. K, Roche M, Finn DP (2015) The endocannabinoid system in the anterior cingulate cortex plays a role in the termination of FCA in rats 9th Neuroscience Ireland Conference, Dublin, September 2015 Proceedings, [Details]
(2015) International College of Neuropsychopharmacology -Thematic Meeting Dublin, June 2015
Madasu MK, Okine BN, Olango WM, Roche M and Finn DP (2015) Differential effects of pharmacological modulation of Trpv1 in the lateral periaqueductal grey on formalin-evoked nociceptive behaviour in Sprague-Dawley and Wistar-Kyoto rats International College of Neuropsychopharmacology -Thematic Meeting Dublin, June 2015 Proceedings, [Details]
(2015) 7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine
Fitzgibbon M, Henry RJ, Kerr DM, Finn DP, Roche M (2015) Peripheral inhibition of FAAH attenuates formalin-evoked nociceptive responding in a mouse model of IFN-α-induced hyperalgesia 7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine Proceedings, [Details]
(2015) International College of Neuropsychopharmacology (CINP) Thematic Meeting 2015
Fitzgibbon M, Henry RJ, Kerr DM, Finn DP, Roche M (2015) Characterization of the endocannabinoid system in the descending pain pathway in a mouse model of IFN-α-induced hyperalgesia International College of Neuropsychopharmacology (CINP) Thematic Meeting 2015 Int J Neuropsychopharmacol Suppl, [Details]
(2015) International College of Neuropsychopharmacology (CINP) Thematic Meeting 2015
Jennings EM, Olango WM, Rea K, Okine B, McGowan F, Roche M, Finn DP. (2015) Altered CB1 receptor expression and functionality in the lateral Periaqueductal grey of hyperalgesic Wistar-kyoto rats International College of Neuropsychopharmacology (CINP) Thematic Meeting 2015 Int J Neuropsychopharmacol Suppl, [Details]
(2015) International College of Neuropsychopharmacology (CINP) Thematic Meeting
Burke NN, Coppinger J, Deaver D, Roche M, Finn DP, Kelly J (2015) Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat International College of Neuropsychopharmacology (CINP) Thematic Meeting Proceedings, [Details]
(2015) Wellcome Trust conference - The Challenge of Chronic Pain
Burke NN, Finn DP, Roche M (2015) Peripheral nerve injury is associated with sensory hypersensitivity and negative affect in female rats Wellcome Trust conference - The Challenge of Chronic Pain Proceedings, [Details]
(2015) Neuroscience Ireland Conference, September 2015
Killilea M, Farrelly C, Mallard BL, Wheatley AW, Roche M. (2015) WKY rats exhibit a reduced homecage locomotor activity response to chronic restraint stress Neuroscience Ireland Conference, September 2015 Proceedings, [Details]
(2015) British Neuroscience Association, Edinburgh April 2015
Roche M (2015) Endocannabinoid modulation of toll-like receptor (TLR)-induced neuroinflammation British Neuroscience Association, Edinburgh April 2015 Proceedings, [Details]
(2015) British Neuroscience Association, Edinburgh April 2015
Henry R, Kerr D, Finn DP, Roche M (2015) Increasing Fatty acid amide hydolase substrates attenuates TLR4-induced neuroinflammation independent of central cannabinoid receptor activation British Neuroscience Association, Edinburgh April 2015 Proceedings, [Details]
(2015) 9th Annual Autism Conference of the Association for Behavior Analysis International (ABAI). Las Vegas, NV, USA Jan 2015
Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) . Salivary cortisol levels and challenging behavior in children with autism spectrum disorder 9th Annual Autism Conference of the Association for Behavior Analysis International (ABAI). Las Vegas, NV, USA Jan 2015 Proceedings, [Details]
(2019) British Neuroscience Association Festival of Neuroscience
Gaspar JC, Okine BN, Llorente-Berzal A, Dinneen D, Roche M, Finn DP (2019) Differential role of amygdala PPARs in conditioned fear-related behaviour in the presence or absence of nociceptive tone British Neuroscience Association Festival of Neuroscience [Details]
(2015) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Flannery L, Henry R, Kerr DM, Finn DP, Roche M (2015) TLR3-induced inflammatory responses in the hypothalamus are attenuated following FAAH, but not MAGL, inhibition; an effect independent of sex Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, [Details]
(2015) 7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine
Flannery L, Henry R, KerrDM, Finn DP, Roche M (2015) TLR3-induced inflammatory responses in the hypothalamus are attenuated following FAAH, but not MAGL, inhibition; an effect independent of sex 7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine [Details]
(2015) Society for Neuroscience, US 2015
Jennings E.M., Burke N.N., Roche M and Finn DP (2015) Genotype-dependent exacerbation of nerve injury-induced pain, anxiety and depressive behaviour in rats Society for Neuroscience, US 2015 Proceedings, [Details]
(2015) 9th Annual Conference of the Division of Behaviour Analysis
Lydon, S; Healy, O; Roche, M; Henry, R; Mulhern, T; Hughes, BM (2015) Salivary cortisol levels and challenging behavior in children with autism spectrum disorder 9th Annual Conference of the Division of Behaviour Analysis Galway, Ireland, , 01-JUN-15 [Details]
(2015) 25th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Okine BN, McLaughlin G, Roche M, Finn DP (2015) Administration of the selective gpr55 receptor antagonist, cid16020046, into the anterior cingulate cortex reduces formalin-evoked nociceptive behavior in rats 25th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society [Details]
(2014) European College Neuropsychopharmacology Young Scientist Workshop
Fitzgibbon, M,O'Reilly, N,Kerr, DM,Finn, DP,Roche, M (2014) Transient depressive-like behaviour in response to repeated interferon-alpha administration in mice European College Neuropsychopharmacology Young Scientist Workshop European Neuropsychopharmacology Suppl, , pp.37-38 [Details]
(2014) International Behavioural Neuroscience Society (IBNS) conference
Fitzgibbon M, Liu M, Shen S, Roche M (2014) Behavioral characterization of unc-51-like kinase 4 heterozygous (ULK4+/-) mice International Behavioural Neuroscience Society (IBNS) conference [Details]
(2014) European College of Neuropsychopharmacology Congress
Fitzgibbon M, Liu M, Bannon J, Shen S, Roche M (2014) Unc-51-like kinase 4 heterozygous (Ulk4+/-) mice display an anxiogenic-like behavioural phenotype and alterations in the GABAergic system within the amygdala European College of Neuropsychopharmacology Congress European Neuropsychopharmacology Volume 24, Supplement 1, [Details]
(2014) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Flannery L, Henry R, Kerr D, Finn DP, Roche M (2014) Enhancing endogenous anandamide tone attenuates the expression of TLR3-induced inflammatory mediators in the rat spleen, effects partially mediated by CB1 receptors Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, [Details]
(2014) European Behavioural Pharmacology Society Annual Workshop, Brighton, UK
Fitzgibbon M, O’Reilly N, Kerr DM, Finn DP, Roche M. (2014) Enhanced formalin-evoked nociceptive responding in the interferon-alpha induced mouse model of depression European Behavioural Pharmacology Society Annual Workshop, Brighton, UK Proceedings, [Details]
(2014) British Association for Pharmacology summer meeting, Cambridge
Jennings EM, Olango WM, Rea K, Okine B, McGowan F, Roche M, Finn DP. (2014) Altered CB1 receptor signalling in the lateral PAG of Wistar-Kyoto rats is associated with enhanced formalin-evoked nociceptive behaviour compared with Sprague-Dawley rats British Association for Pharmacology summer meeting, Cambridge Journal of Psychopharmacology suppl vol 28, issue 8, [Details]
(2014) Annual Scientific Meeting of the Irish Pain Society, Dublin
Rea K, McGowan F, Roche M, Finn DP (2014) Investigation of interactions between anticipation of reward and nociceptive behaviour in rats Annual Scientific Meeting of the Irish Pain Society, Dublin Proceedings, [Details]
(2014) International Association for the Study of Pain, 15th World Congress on Pain, Buenos Aires, Argentina
Burke NN, Kerr DM, Moriarty O, Finn DP, Roche M. (2014) Chronic minocycline attenuates neuropathic pain behaviour in a rat model of depression: effects associated with increased M2 microglial expression International Association for the Study of Pain, 15th World Congress on Pain, Buenos Aires, Argentina Proceedings, [Details]
(2014) . European College Neuropsychopharmacology Young Scientist Workshop
Fitzgibbon M, O’Reilly N, Kerr DM, Finn DP, Roche M (2014) Transient depressive-like behavior in response to repeated interferon-alpha administration in mice . European College Neuropsychopharmacology Young Scientist Workshop [Details]
(2014) International Association for the Study of Pain 15th World Congress on Pain, Buenos Aires, Argentina
Fitzgibbon M, O’Reilly N, Kerr DM, Finn DP, Roche M. (2014) Enhanced inflammatory pain behaviour in the interferon-alpha induced mouse model of depression International Association for the Study of Pain 15th World Congress on Pain, Buenos Aires, Argentina Proceedings, [Details]
(2014) 24th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Okine BN, Madasu MK, Gowan F, Harhen B, Roche M, Finn DP (2014) Direct administration of n-palmitoylethanolamide into the rat medial prefrontal cortex reduces formalin-evoked nociceptive behaviour via a cb1 receptor-mediated mechanism 24th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society [Details]
(2014) Neuroscience Ireland, Young Neuroscientists Symposium
Killilea M, Flannery L, Kerr DM, Mallard B, Wheatley AM, Roche M (2014) LPS-induced locomotor and inflammatory responding in the stress sensitive WKY rat Neuroscience Ireland, Young Neuroscientists Symposium , pp.45-45 [Details]
(2014) XII International Congress of Neuroimmunology (ISNI)
Henry R, Kerr DM, Finn DP, Roche M (2014) FAAH inhibition modulates TLR3-induced inflammatory responses in the periphery and brain: possible role for CB1 receptors XII International Congress of Neuroimmunology (ISNI) Journal of Neuroimmunology Volume 275, Issue 1-2, [Details]
(2014) European College of Neuropsychopharmacology Congress
Burke, NN,Deaver, DR,Finn, DP,Roche, M,Kelly, JP (2014) The effects of subacute administration of buprenorphine and the novel opioid modulator samidorphan on home-cage locomotor activity in rats European College of Neuropsychopharmacology Congress EUROPEAN NEUROPSYCHOPHARMACOLOGY, , pp.276-277 [Details]
(2014) International Cannabinoid Research Society Symposium, Italy
Henry R, Kerr DM, Finn DP, Roche M (2014) FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus International Cannabinoid Research Society Symposium, Italy 24th Annual Symposium of the International Cannabinoid Research Society, , pp.3-10 [Details]
(2014) European College Neuropsychopharmacology Congress
McGowan, F,Rea, K,Khalid, S,Roche, M,Finn, DP (2014) The endocannabinoid system in the prelimbic cortex mediates fear-conditioned analgesia in rats European College Neuropsychopharmacology Congress European Neuropsychopharmacology Volume 24, Supplement 2, , pp.256-257 [Details]
(2014) European College Neuropsychopharmacology Young Scientist Workshop
Henry, R,Kerr, DM,Finn, DP,Roche, M (2014) N-Acylethanolamines modulate early but not late phase neuroinflammatory responses to TLR-3 activation European College Neuropsychopharmacology Young Scientist Workshop European Neuropsychopharmacology Volume 24, Supplement 1, , pp.11-11 [Details]
(2013) Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting
Okine, B,Olango, WM,Harhen, B,Roche, M,Finn, DP (2013) Characterisation of the endocannabinoid system in the RVM and spinal cord dorsal horn of two rat strains differing in nociceptive responsivity Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting IRISH JOURNAL OF MEDICAL SCIENCE, , pp.120-120 [Details]
(2013) European College of Neuropsychopharmacology Congress
Jennings, EM,Okine, B,Olango, WM,Roche, M,Finn, DP (2013) Swim-stress exposure effects on nociceptive behaviour and the endocannabinoid system in two rat strains differing in stress responsivity European College of Neuropsychopharmacology Congress European Neuropsychopharmacology Volume 24, Supplement 1, , pp.54-54 [Details]
(2013) Neurosceince Ireland
Burke, NN,Llorente, R,Marco, EM,Viveros, MP,Finn, DP,Roche, M (2013) Early life stress in rats is associated with sex-dependent alterations in affective and nociceptive behaviour Neurosceince Ireland IRISH JOURNAL OF MEDICAL SCIENCE, , pp.127-127 [Details]
(2013) Neuroscience Ireland Annual Meeting
Henry R, Ni Fhatharta C, Kerr D, Finn DP, Roche M. (2013) Inhibition of fatty acid amide hydrolase does not modulate TLR-3 induced neuroinflammation or reductions in hippocampal BDNF expression Neuroscience Ireland Annual Meeting Irish Journal of Medical Science, [Details]
(2013) Neuroscience Ireland Annual Meeting
Kerr DM, Finn DP, Roche M. (2013) Enhanced neuroinflammatory response to TLR-4 activation in the valproic acid rat model of autism Neuroscience Ireland Annual Meeting Irish Journal of Medical Science, [Details]
(2013) Neuroscience Ireland Annual Meeting September 2013
Fitzgibbon M, Burke NN, Finn DP, Roche M. (2013) The effects of repeated interferon- alpha administration on depressive-like and nociceptive responding in two different mouse strains Neuroscience Ireland Annual Meeting September 2013 Irish Journal of Medical Science, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Okine BN, Rea K, Price J, Olango WM, Roche M and Finn DP (2013) Investigating The Role Of Medial Prefrontal Cortex PPARα Signaling In Formalin-Evoked Nociceptive Responding In Rats 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Rea K, Olango WM, Roche M, Harhen B, Kerr D, Coyle C, Finn DP (2013) The Role Of CB1 Receptors In The RVM In Mediating The Antinociceptive Effects Of The FAAH Inhibitor URB597 In Wistar-Kyoto Rats 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Madasu MK, Okine BN, Olango WM, Roche M and Finn DP (2013) TRPV1 mRNA Expression within the CNS of two rat strains differing in nociceptive responsivity 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Jennings EM, Rea K, Okine BN, McGowan F, Roche M and Finn DP (2013) Bilateral Microinjection Of The CB1 Receptor Agonist ACEA Into The PAG Differentially Modulates Formalin-evoked Nociceptive Behaviour In Sprague-Dawley And Stress Hyper-responsive Wistar-Kyoto Rats 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Kerr DM, Downey L, Conboy M, Finn DP and Roche M (2013) Alterations in the endocannabinoid system in the valproic acid rat model of autism 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2013) Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting
Henry, R,Kerr, D,Finn, DP,Roche, M (2013) Pharmacological inhibition of FAAH alters poly I: C-induced increases in cytokine expression in the rat hippocampus Royal Academy of Medicine in Ireland Biomedical Sciences Annual Meeting IRISH JOURNAL OF MEDICAL SCIENCE, , pp.122-123 [Details]
(2013) Neuroscience Ireland Annual Meeting
Burke NN, Finn DP, Roche M. (2013) Inhibition of microglial activation attenuates peripheral nerve injury-induced allodynia and il-1beta expression in the prefrontal cortex: effects altered in the presence of a depressive phenotype Neuroscience Ireland Annual Meeting Irish Journal of Medical Sciences, [Details]
(2013) ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice
Jennings EM, Okine BO, Olango WM, Roche M, Finn DP. (2013) Effects of exposure to repeated homotypic stress on nociceptive behaviour and the endocannabinoid system in two rat strains differing in stress responsivity ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice Effects of exposure to repeated homotypic stress on nociceptive behaviour and the endocannabinoid system in two rat strains differing in stress responsivity, [Details]
(2013) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Henry R, Kerr DM, Finn DP, Roche M (2013) Central inhibition of fatty acid amide hydrolase attenuates TLR-3 induced expression of interferon-gamma and related genes in the rat Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, [Details]
(2013) 6th European Workshop on Cannabinoid Research, Dublin
Henry R, Kerr DM, Finn DP, Roche M (2013) Central inhibition of fatty acid amide hydrolase modulates expression of inflammatory mediators in discrete brain regions following a systemic bacterial infection 6th European Workshop on Cannabinoid Research, Dublin Proceedings, [Details]
(2012) 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Okine B, Olango WM, Harhen B, Roche M, Finn DP (2012) Characterisation of the endocannabinoid system within the descending pain pathway of two rat strains differing in nociceptive responsivity 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society , pp.3-47 [Details]
(2012) 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Olango WM, Roche M, Finn DP (2012) Pharmacological modulation of the endocannabinoid system in two rat strains differing in nociceptive responsivity: behavioural effects and RVM zif268 expression 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society , pp.3-32 [Details]
(2012) 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Kerr DM, Harhen B, Finn DP, Roche M (2012) Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society , pp.2-36 [Details]
(2012) 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Henry R, Kerr D, Finn DP, Roche M (2012) TLR-3 mediated cytokine expression in the rat hippocampus is altered following pharmacological inhibition of FAAH 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society , pp.3-32 [Details]
(2012) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
O’Donnell J, Kiely L, Burke NN, Finn DP, Roche M (2012) Chronic amitriptyline administration in the rat differentially alters neuropathic pain behaviour and spinal astrocyte activation depending on the presence or absence of a depressive phenotype Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Sciences Volume 182 Supplement 4, [Details]
(2012) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Henry R, Kerr D, Finn DP, Roche M. (2012) Pharmacological inhibition of FAAH alters poly I:C-induced increases in cytokine expression in the rat hippocampus Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, volume 182, Issue 4 supplement, , pp.117-142 [Details]
(2012) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Le A, Rea K, Madasu M, Roche M, Finn DP (2012) Effects of pharmacological inhibition of monoacylglycerol lipase on formalin-evoked nociception and fear-conditioned analgesia in rats Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, [Details]
(2012) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Burke NN, Llorente R, Marco EM, Finn DP, Viveros M-P, Roche M (2012) Early life stress in rats is associated with sex-dependent alterations in affective and nociceptive behaviour Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Sciences Volume 182 Supplement 4, [Details]
(2012) ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice
Burke NN, Henry R, Chui S, Finn DP, Roche M (2012) Alterations in nociceptive responding and prefrontal chemokine expression in a rat model of depression: effects of chronic amitriptyline ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice European Neuropsychopharmacology Vol 22 Supplement 2, , pp.S120-S121 [Details]
(2011) Neuroscience Ireland Meeting
Kerr DM, Finn DP, Roche M. (2011) Pharmacological inhibition of monoacylglycerol lipase attenuated LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action Neuroscience Ireland Meeting Irish Journal of Medical Science, [Details]
(2011) British Pharmacological Society meeting
Olango WM, Roche M, Harhen B, Finn DP (2011) Enhanced nociceptive responding in a rat model of anxiety is associated with alteration of in levels of endocannabinoids and related lipids in discrete brain regions British Pharmacological Society meeting Journal of Psychopharmacology, Vol. 25, Supplement 8, [Details]
(2011) Neuroscience Ireland Meeting
Moriarty O, Azeem A, Roche M, Rea K, McGuire BE, Finn DP. (2011) Investigation of monoamine levels and expression of the synaptic marker, synaptophysin, in discrete brain regions in a rat model of chronic neuropathic pain Neuroscience Ireland Meeting Irish Journal of Medical Science, [Details]
(2011) British Pharmacologcial Association summer meeting
Bree D, O’Mahony C, Morris B. Broom DC, Kelly JP, Roche M and Finn DP (2011) Investigation Of The Effects Of Diazepam And Amphetamine On Rat Locomotor Activity In The Home Cage And Open Field Using An Automated Approach British Pharmacologcial Association summer meeting Proceedings, [Details]
(2010) ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice
Moriarty O, Roche M, McGuire BE, Finn DP (2010) Validation of an air-puff passive avoidance paradigm to investigate aversive learning in a rat model of neuropathic pain ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice European Neuropsychopharmcology, [Details]
(2010) Federation of European Neuroscience
Roche M, Geoghegan E, Burke N, Moriarty O, Finn DP (2010) Enhanced interleukin-1beta expression in the prefrontal cortex is associated with altered nociceptive responding in an animal model of depression Federation of European Neuroscience Federation of European Neuroscience Forum Abstracts, [Details]
(2010) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Burke NN, Geoghegan E, Moriarty O, Kerr D, Finn DP, Roche M (2010) Altered nociceptive responding in a rat model of depression is associated with changes in monoamines and inflammatory mediators in prefrontal and limbic brain regions Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, Vol. 180 Supplement 9, [Details]
(2010) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Moriarty O, Gorman CL, Ford GK, Roche M, McGuire BE, Finn DP (2010) Assessment of cognitive performance following spinal nerve ligation in mid-aged rats Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, Vol. 180 Supplement 2, , pp.S37-S38 [Details]
(2010) 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Roche M , Kerr DM, Burke N, Olango WM, Harhen B, Ford GK, Finn DP (2010) Inhibiition of monoacylglycerol lipase and fatty acid amide hydrolyase in vivo modulates LPS-induce increases in cytokine expression in the rat prefrontal cortex 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, [Details]
(2010) European College of Neuropsychopharmacology Congress
Finn DP, Roche M, Ford GK, Rea K, Olango WM, Butler RK, Harhen B, Géranton SM, Hunt SP (2010) Neurobiology of fear-induced analgesia European College of Neuropsychopharmacology Congress European Neuropsychopharmcology, Vol 20, Supplement 3, [Details]
(2010) 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society
Olango WM, Roche M, Finn DP (2010) Modulation of nociception and fear-conditioned analgesia by the endocannabinoid system in the rat dorsolateral periaquaductal grey 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society 20th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, , pp.1-26 [Details]
(2010) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting June 2010
Kerr DM, Burke N, Olango WM, Harhen B, Ford GK, Finn DP, Roche M (2010) A differential role for monoacylglycerol lipase and fatty acid amide hydrolase in the modulation of LPS-induced increases in cytokine expression in the rat prefrontal cortex Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting June 2010 [Details]
(2010) British Pharmacological Society meeting
Moriarty O, Roche M, McGuire BE, Finn DP (2010) Validation of an air-puff passive avoidance paradigm to investigate aversive learning in rat models of chronic pain British Pharmacological Society meeting Journal of Psychopharmacology, [Details]
(2010) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Kerr DM, Ryan KM, Connor TJ, Harhen B, Finn DP, Roche M (2010) The effect of the anandamide re-uptake inhibitor AM404 on LPS-induced increases in cytokine gene expression and endocannabinoid content in the rat prefrontal cortex Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting . Irish Journal of Medical Science, Vol. 180 Suppl. 2, [Details]
(2009) European College of Neuropsychopharmacology Congress
Calpin P, Burke N, Finn DP, Roche M (2009) Evaluating nociceptive behaviour in the Wistar Kyoto rat model of depression European College of Neuropsychopharmacology Congress European Neuropsychopharmacology 19, , pp.S396-S397 [Details]
(2009) European Journal of Pain
Moriarty O, Roche M, Webber M, McGuire BE, Finn DP (2009) Cognitive behavioural characterisation of a rat model of neuropathic pain European Journal of Pain European Journal of Pain, 13(1), , pp.S117-S118 [Details]
(2009) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Olango WM, Roche M, Finn DP (2009) The role of the endocannabinoid system in the rat dorsolateral periaqueductal grey matter in pain- and fear-related behaviour Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science, [Details]
(2008) International Cannabinoid Research Society Symposium
Butler RK. Ford GK, Hogan M, Roche M, Robinson I, Barrett D, Kendall DA, Chapman V, Finn DP. (2008) Effects of the FAAH inhibitor URB597 on fear-conditioned analgesia and associated alterations in signal transduction proteins and endocannabinoid levels International Cannabinoid Research Society Symposium 18th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, [Details]
(2008) Neuroscience Ireland Meeting
Roche M, Hayes E, Finn DP (2008) Formalin-induced nociception is increased in the olfactory bulbectomised model of depression Neuroscience Ireland Meeting Irish Journal of Medical Science, [Details]
(2008) Neuroscience Ireland Meeting
Roche M, Finn DP (2008) The role of the endocannabinoids in the dorsal periaquaductal grey on nociception, conditioned fear and fear-conditioned analgesia Neuroscience Ireland Meeting Irish Journal of Medical Science, [Details]
(2008) International Cannabinoid Research Society Symposium
Roche M, Kelly JP, O'Driscoll M, Finn DP. (2008) Inhibition of endocannabinoid degradation or transport in vivo modulates LPS-induced increases in circulating cytokine levels International Cannabinoid Research Society Symposium 18th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, [Details]
(2008) International Society for Neuroimmunology Symposium
Roche M, Kelly JP, O’Driscoll M, Finn DP (2008) Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats International Society for Neuroimmunology Symposium Journal of Neuroimmunology 197 (2), [Details]
(2008) British Pharmacological Society meeting
Roche M, Finn DP (2008) Endocannabinoid modulation of conditioned fear in the presence and absence of nociceptive tone British Pharmacological Society meeting Journal of Psychopharmacology 22 (suppl 5), [Details]
(2008) European College of Neuropsychopharmacology Congress
Smith, KL; Roche, M; Jessop, DS, Finn DP (2008) Imidazoline2 (I2) binding site ligands increase Fos-like immunoreactivity in the naive and restraint-stressed rat brain European College of Neuropsychopharmacology Congress European Neuropsychopharmacology 18(4), , pp.S160-S161 [Details]
(2008) European Behavioural Pharmacology Workshop, Cork
Roche M, Finn DP (2008) Pain and conditioned fear are differentially modulated by the endocannabinoid system in the rat dorsal periaquaductal grey European Behavioural Pharmacology Workshop, Cork Behavioural Pharmacology 19, , pp.(5-6):671-671 [Details]
(2008) ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice
Smith KL, Roche M, Jessop DS, Finn DP (2008) Imidazoline2 (I2) binding site ligands increase Fos-like immunoreactivity in the naive and restraint-stressed rat brain ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice European Neuropsychopharmacology, 18(1), [Details]
(2007) British Pharmacological Society meeting
Roche M, O’Driscoll M, Diamond M, Kelly JP, Finn DP (2007) Modulation of LPS-induced alterations in peripheral cytokine levels by the endocannabinoid system British Pharmacological Society meeting Proceedings, [Details]
(2007) European College of Neuropsychopharmacology Congress
Roche M, Johnston P, Ní Mhuircheartaigh O, Finn DP (2007) Role of the CB1 receptors in the basolateral amygdala in conditioned aversion, associated analgesia and neuronal activation European College of Neuropsychopharmacology Congress European Neuropsychopharmacology 17, , pp.S259-S260 [Details]
(2006) Neuroscience Ireland Annual Meeting
Butler RK, Ford GK, Roche M, Finn DP (2006) Modulation of conditioned fear and fear-conditioned analgesia by inhibitors of endocannabinoid degradation Neuroscience Ireland Annual Meeting Irish Journal of Medical Science: Proceedings from the Neuroscience Ireland Inaugural Conference 175(3)es1:15, [Details]
(2006) British Pharmacological Society meeting
Roche M, Diamond M, Kelly JP, Finn DP (2006) Cannabinoid receptor-mediated modulation of lipopolysaccharide-induced alterations in cytokine levels in discrete brain regions and hypothalamo-pituitary-adrenal axis activity in rats British Pharmacological Society meeting Journal of Psychopharmacology 20(5), , pp.A14-A84 [Details]
(2006) British Pharmacological Society meeting
Ford G, Butler RK, Roche M, Finn DP (2006) The effects of inhibition of endocannabinoid degradation on fear-conditioned analgesia in rats British Pharmacological Society meeting Journal of Psychopharmacology 20(5), , pp.A15-A84 [Details]
(2006) International Cannabinoid Research Society Symposium
Roche M, Diamond M, Kelly JP, Finn DP (2006) Cannabinoid receptor-mediated modulation of lipopolysaccharide-induced alterations in peripheral cytokine levels, circulating lymphocytes and hypothalamo-pituitary-adrenal axis activity in rats International Cannabinoid Research Society Symposium 16th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, [Details]
(2006) International Cannabinoid Research Society Symposium
Roche M, O’Connor E, Diskin C, Kelly JP, Finn DP (2006) Effects of administration of the CB1 receptor antagonist SR141716A into the right basolateral amygdala on conditioned fear and associated analgesia in rats International Cannabinoid Research Society Symposium 16th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, [Details]
(2005) Royal Academy of Medicine in Ireland Biomedical Section Meeting. Galway
Roche M, Diamond M, Lonergan I, Keeney G, Kelly JP, Finn DP (2005) The effects of acute lipopolysaccharide injection on levels of pro- and anti-inflammatory cytokines in discrete rat brain regions Royal Academy of Medicine in Ireland Biomedical Section Meeting. Galway Proceedings, [Details]
(2005) British Pharmacological Society meeting
Roche M, Diamond M, Lonergan I, Keeney G, Kelly JP, Finn DP (2005) The effects of acute lipopolysaccharide injection on levels of pro- and anti-inflammatory cytokines in discrete rat brain regions British Pharmacological Society meeting Journal of Psychopharmacology 19(5), [Details]
(2005) European College of Neuropsychopharmacology Congress
Roche M, Harkin A, Kelly JP (2005) Chronic fluoxetine treatment attenuates stressor-induced changes in physiology and neuronal activation in the olfactory bulbectomized (OB) rat European College of Neuropsychopharmacology Congress European Neuropharmacology 15 (Suppl 3), [Details]
(2005) ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice
Roche M, Harkin A, Kelly JP (2005) Altered physiological responses to stress in the olfactory bulbectomized rat: normalisation by chronic fluoxetine treatment ECNP Workshop on Neuropsychopharmacology for Young Scientist, Nice European Neuropharmacology 15 (Suppl 1), [Details]
(2005) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Roche M, Kelly JP, Harkin A (2005) Chronic fluoxetine treatment normalises altered physiological responses to stress in the olfactory bulbectomized rat Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science 174(1)es2:21, [Details]
(2004) European College of Neuropsychopharmacology Congress
Roche M, Shanahan E, Harkin A, Kelly JP (2004) Chronic imipramine treatment reverses olfactory bulbectomized-induced hyperactivity in three rodent species European College of Neuropsychopharmacology Congress European Neuropharmacology 14 (Suppl 3), [Details]
(2004) Federation of European Neuroscience Forum
Roche M, Harkin A, Kelly JP (2004) Fluoxetine attenuates “open field”-induced neuronal c-FOS expression in a regionally dependent manner in the olfactory bulbectomised rat Federation of European Neuroscience Forum Federation of European Neuroscience Forum Abstracts Vol. 2, [Details]
(2004) Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting
Roche M, Harkin A, Kelly JP (2004) Comparison of novelty-induced activity in three rodent species following olfactory bulbectomy Royal Academy of Medicine in Ireland Biomedical Section Annual Meeting Irish Journal of Medical Science 173(2) e2:10, [Details]

Education

  Year Institution Qualification Subject
2015 National Univeristy of Ireland Galway POSTGRAD CERT OF EDUCATION Teaching and Learning
2005 National University of Ireland, Galway PhD Pharmacology
2001 National University of Ireland, Galway MASTERS OF SCIENCE Neuropharmacology
1999 National University of Ireland, Galway BACHELOR OF SCIENCE Physiology

Employment

  Employer Position From / To
NUI Galway Lecturer in Physiology (above the bar) 01-MAY-12 / 05-JUL-13
Physiology, NUI Galway Lecturer (below the bar) 01-SEP-08 / 01-MAY-12
Pharmacology and Therapeutics, NUI Galway Post Doctoral researcher 01-SEP-05 / 01-SEP-08
Pharmacology and Therapeutics, NUI Galway Contract Lecturer 01-SEP-04 / 01-SEP-05
Children's Hospital of Philadelphia, USA Research Assistant 18-JAN-01 / 18-DEC-01

Professional Associations

  Association Function From / To
European College of Neuropsychopharmacology Scientific Advisory Panel member 20-MAR-17 /
Neuroscience Ireland Communications Officer and Governing Council member 05-JAN-15 /
Irish Pain Society Council Member 01-JAN-14 /
Royal Academy of Medicine in Ireland, Biomedical Sciences Section Council Member 01-JUL-11 /
Irish Pain Research Network Council member 26-SEP-15 /

Committees

  Committee Function From / To
College of Medicine, Nursing and Health Science Graduate Studies Committee member 14-JAN-16 / 15-JAN-17
College of Science Research Committee Committee Member 01-SEP-11 / 02-MAR-15
College of Science Teaching and Learning Committee member 01-SEP-09 / 01-SEP-10
Galway Neuroscience Centre Secretary and Executive Council member 01-SEP-08 /
Centre for Pain Research, NUI Galway Council Member 01-JUN-12 /
Graduate Research Committee (GRC) GRC member for 6 PhD students /

Community Engagement

  Title Type From / To
Outreach Involved in NUI Galway undergraduate and postgraduate open days, providing information regarding studying Physiology, Science and Biomedical Science /
Outreach Public outreach at Brain Awareness Week and Science Festival /
Outreach Representing Neuroscience research interests at NUI Galway to delegations from pharmaceutical and biomedical companies /

Teaching Interests

I currently supervise a team of 1 Post doctoral researcher, 5 PhD students (2 as primary supervisor), and an MSc research student.  To date, I have successfully supervised 17 PhD and 3 MSc research student to completion.

I am the overall year coordinator for 3rd year Physiology (B.Sc. and B.Sc. Biomedical Science).

Module coordinator for Neurophysiology (SI311); Endocrinology (SI312/SI3102); Advanced Neurophysiology (SI422)

I use a multitude of teaching methodologies and formats from lectures and seminars, practicals and lab based projects, small group teaching, flipped classroom teaching, poster and oral presentations and case studies in my teaching.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2019 Jessica Gaspar PhD
2018 Louise Corcoran PhD
2018 MaryKate Killilea PhD
2017 Lisa Flannery PhD Y
2016 Manish Kumar Madasu
2015 Elaine Jennings PhD N
2015 Rebecca Henry PhD Y
2015 Marie Fitzgibbon PhD Y
2015 Fiona Mc Gowan N
2014 Dara Bree  PhD Y
2014 Daniel Kerr PhD Y
2013 Nikita Burke PhD Y
2011 Werede Olango PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Aoife Thornton Doctorate - Structured Ph.D (Medicine) Supervisor
Patricia Calcagno Masters - Research - Master of Science (by Research) Co-supervisor (2)
James Prendergast Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Grace O Sullivan Doctorate - Structured PhD in Psychology & Health Co-supervisor (1)
Rachel Humphrey Doctorate - Structured Ph.D (Medicine) Supervisor
Sarah Jarrin Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Edel Hughes Doctorate - Structured Ph.D (Medicine) Supervisor
Kelly Mc Hugh Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Mehnaz Ferdousi Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Emer Power Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2009-present Biological Sciences III NU306 Lectures on physiology of the endocrine and central nervous systems - 3rd yr Nursing students
2008-present The Cenrtral Nervous System MD224 Physiological functions of the brain and spinal cord - 2nd year medical students
2015-present Case-based Physiology SI4101 Integrative case-studies on pathophysiological conditions - 4th year Physiology Science students
2015-present Pathophysiology SI432 Lecture series on pathophysiology of CNS disorders - 4th yr Physiology Science students
2008-present Research Project SI435 Supervise final year BSc and Biomedical science research projects - 4th yr Physiology Science students
2008-present Endocrinology SI312/SI3102 Physiological functions of hormones - 3rd year Science students and 2nd year podiatry students
2008-present Advanced Neurophysiology SI422 Pathophysiology underlying neurological, psychiatric and neurodegenerative disorders
2008-present Neurophysiology SI311/SI209 Understanding the physiologial action of neurons, glia and the physiological processes underlying movement, sensation, hearing, vision, emotion, speech and language - 3rd year Sceince students and 2nd year Speech and Language & ocupational Therapty students
2009-2015 Advanced Research Methods SI442