Prof. Paul Murphy

B.Sc.,Ph.D.

 
researcher
 

Biography

Education BSc & PhD, Organic Chemistry, University College Galway (NUI Galway)  
Experience
1994-96 Chiroscience Postdoctoral Fellow, University of York, UK
1996-2004  Lecturer in Chemistry, University College Dublin
1997, 1998  Visiting Researcher, Chemistry Department, University of Pennsylvania, US

2003  Visiting Researcher, Universität Mainz, Germany (Horst Kunz)
Jan 2005-June 2006   Senior Lecturer in Chemistry, University College Dublin.
July
2006-8  Associate Professor in Bioorganic Chemistry, University College Dublin

2007-8  Head of Organic Chemistry, UCD
2007-8  Director of Postgraduate Studies in UCD School of Chemistry and Chemical Biology and Deputy Director of Dublin Chemistry Graduate School

2015  Research Scholar Beth Israel Deaconess Medical Centre, Harvard Medical School
2015     Visiting Research Scholar, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, USA
2008-13 and 2014-2017 Head of School of Chemistry, NUI Galway
2008-current   Established Professor of Chemistry NUI Galway 

For research publications, including those that may not as yet be updated on this website see:  

Journal Research Articles (click here for a link to Google Scholar)


Education BSc & PhD, Organic Chemistry, University College Galway (NUI Galway)  
Experience
1994-96 Chiroscience Postdoctoral Fellow, University of York, UK
1996-2004  Lecturer in Chemistry, University College Dublin
1997, 1998  Visiting Researcher, Chemistry Department, University of Pennsylvania, US

2003  Visiting Researcher, Universität Mainz, Germany (Horst Kunz)
Jan 2005-June 2006   Senior Lecturer in Chemistry, University College Dublin.
July
2006-8  Associate Professor in Bioorganic Chemistry, University College Dublin

2007-8  Head of Organic Chemistry, UCD
2007-8  Director of Postgraduate Studies in UCD School of Chemistry and Chemical Biology and Deputy Director of Dublin Chemistry Graduate School

2015  Research Scholar Beth Israel Deaconess Medical Centre, Harvard Medical School
2015     Visiting Research Scholar, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, USA
2008-13 and 2014-2017 Head of School of Chemistry, NUI Galway
2008-current   Established Professor of Chemistry NUI Galway 

For research publications, including those that may not as yet be updated on this website see:  

Journal Research Articles (click here for a link to Google Scholar)


Research Interests

Research in the Murphy group is currently financially supported by:

Science Foundation Ireland and co-funded by the European Regional Development Fund 

European Commission

Irish Research Council
 including an Enterprise Partnership Award supported by Pfizer Pharmaceuticals Ltd

Carbohydrates, glycoscience, synthesis of bioactive compounds

Journal Research Articles (click for a link to Google Scholar) 

The design, synthesis and evaluation of bioactive molecules, including natural products is being undertaken.  A major current interest is in the design and synthesis of glycomimetics.  Current projects are concerned with development of inhibtors of carbohydrate binding proteins such as galectins, macrophage galactose C-type lectin, siglecs and carbohydrate binding proteins involved in infection.  All of these targets are relevant to development of new therapeutics, vaccines or diagnostics for diseases.  In this regard we are interested in both structure based ligand design as well as synthesis of glycoclusters to improve potency and selectivity of inhibitors of carbohydrate binding proteins. 

In the area of glycoscience, and synthesis of smart glycomaterials, we are contributing to the SFI funded Centre for Medical Devices, Curam. (http://www.curamdevices.ie/).

In a contribution to the SFI funded research centre SSPC (www.sspc.ie) and have commenced projects on investigation of continuous flow techniques with a view to carbohydrate drug synthesis applications (e.g. glycomimetics, iminosugars).  

We are also interested in fundamental studies in carbohydrate chemistry and have published research on factors influencing anomer preference as well as reactivity and synthetic studies using anomerisation reactions.

Successes have included stereoselective synthesis of iminosugars, glycolipid synthesis, new peptidomimetics based on carbohydrates/macrocycles.  

We achieved the synthesis of analogues of migrastatin which inhibit tumour cell migration.

We have introduced intramolecular Huisgen azide alkene cycloadditions for heterocycle synthesis and applied it to iminosugar synthesis.  We have extended this to tandem reactions incorporating allylic azide rearrangement.

For a short presentation on Lewis acid promoted anomerisation, which has been an interest of our group, and its application click here: 




Research Projects

  Project Start Date End Date
CARBOHYDRATE-BASED SENSING MATERIALS AS PLATFORMS FOR 3-D PRINTED MICROFLUIDIC PATHOGEN DETECTION DEVICES WITH DIAGNOSTIC AND ENVIRONMENTAL MONITORING APPLICATIONS 01-APR-19 31-MAR-23
IRC ENTERPRISE PARTNERSHIP SCHEME (POSTGRADUATE) 2019 - Jack Bennett - New Synthesis For Glycomimetic Research: Comparing Traditional Batch Chemistry With Continuous Flow 01-MAR-19 28-FEB-23
IRC POSTGRADUATE SCHOLARSHIP 2018 AILBHE RYAN - DEVELOPMENT OF INFLUENZA VIRUS HEMAGGLUTININ INHIBITING COMPOUNDS - EMPLOYMENT OF THE STRUCURE BASED DESIGN APPROACH TO DEVELOP NOVEL CONSTRAINED GLYCOMIMETRICS 01-OCT-18 30-SEP-19
ENHANCING THE SCIENTIST¿S TOOLBOX USING SYNTHETIC CARBOHYDRATE CHEMISTRY 01-MAR-18 28-FEB-23
CONTINUOUS FLOW CHEMISTRY EQUIPMENT FOR SUGAR RESEARCH 01-DEC-17 30-OCT-18
CÚRAM ¿ MedTrain Co-fund ¿ Paul Murphy 01-AUG-17 31-DEC-20
IRC Postgrad 2016 ADELE GABBA - Design and synthesis inhibitors for macrophage galactose C-type lectin; chemical tools for immunological research. 01-OCT-16 30-SEP-19

Peer Reviewed Journals

  Year Publication
(2019) 'Ligand design for somatostatin receptor isoforms 4 and 5'
Arvind Negi and Jian Zhou and Sinclair Sweeney and Paul V. Murphy (2019) 'Ligand design for somatostatin receptor isoforms 4 and 5'. European Journal of Medicinal Chemistry, 163 :148-159 [DOI] [ARAN Link] [Details]
(2018) 'Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform'
Kaltner, Herbert and Manning, Joachim C. and García Caballero, Gabriel and Di Salvo, Claudia and Gabba, Adele and Romero-Hernández, Laura L. and Knospe, Clemens and Wu, Dan and Daly, Harrison C. and O'Shea, Donal F. and Gabius, Hans-Joachim and Murphy, Paul V. (2018) 'Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform'. RSC Adv, 8 :28716-28735 [DOI] [ARAN Link] [Details]
(2018) 'Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents'
Kerins, L,Byrne, S,Gabba, A,Murphy, PV (2018) 'Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents'. Journal Of Organic Chemistry, 83 :7714-7729 [DOI] [Details]
(2018) 'Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation'
Mark P. Farrell and Lisa M. Doyle and Paul V. Murphy (2018) 'Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation'. Tetrahedron Letters, 59 (28):2726-2731 [DOI] [ARAN Link] [Details]
(2017) 'Allylic azide rearrangement in tandem with intramolecular Huisgen cycloaddition for iminosugar and glycomimetic synthesis. Functionalized piperidine, pyrrolidine and pyrrolotriazoles from D-mannose'
Rekha Chadda, Patrick McArdle and Paul V. Murphy (2017) 'Allylic azide rearrangement in tandem with intramolecular Huisgen cycloaddition for iminosugar and glycomimetic synthesis. Functionalized piperidine, pyrrolidine and pyrrolotriazoles from D-mannose'. Synthesis, 49 (10):2138-2152 [DOI] [ARAN Link] [Details]
(2017) 'Stereoselective epimerizations of glycosyl thiols'
Lisa M. Doyle, Shane O’Sullivan, Claudia Di Salvo, Michelle McKinney, Patrick McArdle and Paul V. Murphy (2017) 'Stereoselective epimerizations of glycosyl thiols'. Organic Letters, 19 :5802-5805 [DOI] [ARAN Link] [Details]
(2017) 'Synthesis and Biological Evaluation of Migrastatin Macrotriazoles'
Gabba, A,Robakiewicz, S,Taciak, B,Ulewicz, K,Broggini, G,Rastelli, G,Krol, M,Murphy, PV,Passarella, D (2017) 'Synthesis and Biological Evaluation of Migrastatin Macrotriazoles'. European Journal Of Organic Chemistry, 2017 :60-69 [DOI] [Details]
(2017) 'Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design'
Roy, R,Cao, YH,Kaltner, H,Kottari, N,Shiao, TC,Belkhadem, K,Andre, S,Manning, JC,Murphy, PV,Gabius, HJ (2017) 'Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design'. Histochem Cell Biol, 147 :285-301 [DOI] [Details]
(2017) 'Synthesis of Benzoylated beta-D-Glucosamine Derivatives'
Di Salvo, C;Fox, KA;Murphy, PV;Langhanki, J (2017) 'Synthesis of Benzoylated beta-D-Glucosamine Derivatives'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 4 :99-107 [ARAN Link] [Details]
(2017) 'Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction'
Vogel, C;Murphy, PV (2017) 'Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 4 [Details]
(2017) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'
Jack Bennett, Amélie Roux, Paul V. Murphy (2017) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'. 2017 [DOI] [ARAN Link] [Details]
(2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'
Mahajan, N,Chadda, R,Calabro, K,Solanki, H,O'Connell, E,Murphy, PV,Thomas, OP (2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'. Tetrahedron Letters, 58 :1237-1239 [DOI] [Details]
(2016) 'Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition'
R. Roy, P. V. Murphy, and H.-J. Gabius (2016) 'Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition'. Molecules (Basel, Switzerland), 21 [ARAN Link] [Details]
(2016) 'Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose'
Lo Re, D,Jones, L,Giralt, E,Murphy, P (2016) 'Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose'. Chemistry-An Asian Journal, 11 :2035-2040 [DOI] [ARAN Link] [Details]
(2015) 'Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars'
Moynihan, L,Chadda, R,McArdle, P,Murphy, PV (2015) 'Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars'. Organic Letters, 17 :6226-6229 [DOI] [ARAN Link] [Details]
(2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'
Lo Re, D,Zhou, Y,Mucha, J,Jones, LF,Leahy, L,Santocanale, C,Krol, M,Murphy, PV (2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'. Chemistry-A European Journal, 21 :18109-18121 [DOI] [ARAN Link] [Details]
(2016) 'Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of alpha-Se-GalCer'
McDonagh, AW,Mahon, MF,Murphy, PV (2016) 'Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of alpha-Se-GalCer'. Organic Letters, 18 :552-555 [DOI] [ARAN Link] [Details]
(2016) 'Coiled coil type neoglycoproteins presenting three lactose residues'
Sweeney, SM,Bullen, GA,Gillis, RB,Adams, GG,Rowe, AJ,Harding, SE,Tucker, JHR,Peacock, AFA,Murphy, PV (2016) 'Coiled coil type neoglycoproteins presenting three lactose residues'. Tetrahedron Letters, 57 :1414-1417 [DOI] [ARAN Link] [Details]
(2014) 'Ultrasonic Energy Promoted Allylation to Generate 1-C-(2,3,4,6-Tetra-O-Benzyl-alpha-D-Glucopyranosyl)prop-2-ene'
Farrell, M,O'Reilly, C,Jarikote, DV,Murphy, PV,Rahkila, J,VanDerMarel, G,Codee, J (2014) 'Ultrasonic Energy Promoted Allylation to Generate 1-C-(2,3,4,6-Tetra-O-Benzyl-alpha-D-Glucopyranosyl)prop-2-ene'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 2 :33-37 [Details]
(2015) 'Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context'
Andr¿¿ S, Kaltner H;Kayser K;Murphy PV;Gabius HJ (2015) 'Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context'. Histochemistry and cell biology, [DOI] [Details]
(2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'
Lo Re D, Zhou Y;Mucha J;Jones LF;Leahy L;Santocanale C;Krol M;Murphy PV (2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'. Chemistry (Weinheim an der Bergstrasse, Germany), [DOI] [ARAN Link] [Details]
(2015) 'Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity'
Swanson MD, Boudreaux DM;Salmon L;Chugh J;Winter HC;Meagher JL;Andr¿¿ S;Murphy PV;Oscarson S;Roy R;King S;Kaplan MH;Goldstein IJ;Tarbet EB;Hurst BL;Smee DF;de la Fuente C;Hoffmann HH;Xue Y;Rice CM;Schols D;Garcia JV;Stuckey JA;Gabius HJ;Al-Hashimi HM;Markovitz DM (2015) 'Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity'. Cell, 163 (3):746-758 [DOI] [Details]
(2015) 'Lectins: Getting Familiar with Translators of the Sugar Code'
Andre, S,Kaltner, H,Manning, JC,Murphy, PV,Gabius, HJ (2015) 'Lectins: Getting Familiar with Translators of the Sugar Code'. Molecules (Basel, Switzerland), 20 :1788-1823 [DOI] [ARAN Link] [Details]
(2015) 'Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity'
Andre, S,O'Sullivan, S,Gabius, HJ,Murphy, PV (2015) 'Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity'. Tetrahedron, 71 :6867-6880 [DOI] [ARAN Link] [Details]
(2015) 'Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins'
Andre, S,O'Sullivan, S,Koller, C,Murphy, PV,Gabius, HJ (2015) 'Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins'. Organic & Biomolecular Chemistry, 13 :4190-4203 [DOI] [ARAN Link] [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [ARAN Link] [Details]
(2014) 'Synthesis of iminosugar derivatives presenting naphthyl and alkyl amine interacting groups and binding to somatostatin receptors'
Barron, S,Murphy, PV (2014) 'Synthesis of iminosugar derivatives presenting naphthyl and alkyl amine interacting groups and binding to somatostatin receptors'. Medchemcomm, 5 :1150-1158 [DOI] [ARAN Link] [Details]
(2014) 'Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)'
Andre, S,Wang, GN,Gabius, HJ,Murphy, PV (2014) 'Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)'. Carbohydrate Research, 389 :25-38 [DOI] [ARAN Link] [Details]
(2014) 'Synthesis of alpha-galactosyl ceramide analogues with an a-triazole at the anomeric carbon'
McDonagh, AW,Murphy, PV (2014) 'Synthesis of alpha-galactosyl ceramide analogues with an a-triazole at the anomeric carbon'. Tetrahedron, 70 :3191-3196 [DOI] [ARAN Link] [Details]
(2014) 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics'
Lo Re, D,Zhou, Y,Nobis, M,Anderson, KI,Murphy, PV (2014) 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics'. Chembiochem, 15 :1459-1464 [DOI] [ARAN Link] [Details]
(2013) 'Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation'
Pilgrim W, O'Reilly C, Murphy PV (2013) 'Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation'. Molecules (Basel, Switzerland), 18 (9):11198-11218 [DOI] [ARAN Link] [Details]
(2013) 'Migrastatin analogues inhibit canine mammary cancer cell migration and invasion'
Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, Pawłowski K, Motyl T, Murphy PV, Król M (2013) 'Migrastatin analogues inhibit canine mammary cancer cell migration and invasion'. Plos One, 8 (10) [DOI] [ARAN Link] [Details]
(2013) 'Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl4'
Farrell M, Zhou J, Murphy PV (2013) 'Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl4'. Chemistry (Weinheim an der Bergstrasse, Germany), 19 (44):14836-14851 [DOI] [ARAN Link] [Details]
(2013) 'Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths'
Breen EP, Pilgrim W, Clarke KJ, Yssel C, Farrell M, Zhou J, Murphy PV, Porter RK (2013) 'Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths'. Chemistry & Biology, 6 (3):121-133 [DOI] [Details]
(2013) 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'
Rainey MD, Harhen B, Wang GN, Murphy PV, Santocanale C (2013) 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'. Cell Cycle, 12 (10) [Details]
(2013) 'The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity'
Murphy PV, André S, Gabius HJ (2013) 'The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity'. Molecules (Basel, Switzerland), 18 (4):4026-4053 [DOI] [ARAN Link] [Details]
(2013) 'Multivalent glycoconjugates as anti-pathogenic agents'
Bernardi A, Jiménez-Barbero J, Casnati A, De Castro C, Darbre T, Fieschi F, Finne J, Funken H, Jaeger KE, Lahmann M, Lindhorst TK, Marradi M, Messner P, Molinaro A, Murphy PV, Nativi C, Oscarson S, Penadés S, Peri F, Pieters RJ, Renaudet O, Reymond JL, Richichi B, Rojo J, Sansone F, Schäffer C, Turnbull WB, Velasco-Torrijos T, Vidal S, Vincent S, Wennekes T, Zuilhof H, Imberty A (2013) 'Multivalent glycoconjugates as anti-pathogenic agents'. Chemical Society reviews, 42 (11):4709-4727 [DOI] [Details]
(2012) 'Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides'
Wright, C,Leyden, R,Murphy, PV,Callaghan, M,Velasco-Torrijos, T,McClean, S (2012) 'Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides'. Molecules (Basel, Switzerland), 17 :10065-10071 [DOI] [ARAN Link] [Details]
(2012) 'Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity'
Wang GN, André S, Gabius HJ, Murphy PV (2012) 'Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity'. Organic & Biomolecular Chemistry, 10 (34):6893-6907 [DOI] [ARAN Link] [Details]
(2012) 'Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons'
Andre, S,Jarikote, DV,Yan, DD,Vincenz, L,Wang, GN,Kaltner, H,Murphy, PV,Gabius, HJ (2012) 'Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons'. Bioorganic & Medicinal Chemistry Letters, 22 :313-318 [DOI] [ARAN Link] [Details]
(2012) 'Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori'
Yan D, Naughton J, Clyne M, Murphy PV (2012) 'Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori'. Carbohydrate research, 360 :1-7 [DOI] [ARAN Link] [Details]
(2011) 'Synthesis of α-S-glycosphingolipids based on uronic acids'
O'Reilly C, Murphy PV (2011) 'Synthesis of α-S-glycosphingolipids based on uronic acids'. Organic Letters, 13 (19):5168-5171 [DOI] [Details]
(2010) 'Ultrasound assisted synthesis of C-glycosides'
Jarikote,D.V., O'Reilly,C., Murphy,P.V. (2010) 'Ultrasound assisted synthesis of C-glycosides'. Tetrahedron Letters, 51 :6776-6778 [Details]
(2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'
Zhao, YX,Zhou, Y,O'Boyle, KM,Murphy, PV (2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'. Bioorganic & Medicinal Chemistry, 16 (1212):6333-6337 [Details]
(2008) 'Synthesis of sugar-lactams from azides of glucuronic acid (vol 342, pg 1953, 2007)'
Loukou, C,Tosin, M,Miiller-Bunz, H,Murphy, PV (2008) 'Synthesis of sugar-lactams from azides of glucuronic acid (vol 342, pg 1953, 2007)'. Carbohydrate Research, 343 (22):412-413 [Details]
(2008) 'Synthesis of somatostatin mimetics based on 1-deoxynojirimycin'
Chagnault, V,Lalot, J,Murphy, PV (2008) 'Synthesis of somatostatin mimetics based on 1-deoxynojirimycin'. Chemmedchem, 3 (77):1071-1076 [Details]
(2008) 'Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles'
Zhou, Y,Zhao, Y,O'Boyle, KM,Murphy, PV (2008) 'Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles'. Bioorganic & Medicinal Chemistry Letters, 18 (33):954-958 [Details]
(2007) 'Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids'
Matos, M.-C.,Murphy, P.V. (2007) 'Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids'. Journal of Organic Chemistry, 72 (5) [Details]
(2007) 'Selective protecting group manipulations on the 1-deoxynojirimycin scaffold'
Danieli,E.,Lalot, J.,Murphy, P.V. (2007) 'Selective protecting group manipulations on the 1-deoxynojirimycin scaffold'. Tetrahedron, 63 (29) [Details]
(2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'
O'Brien, C,Polakova, M,Pitt, N,Tosin, M,Murphy, PV (2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'. Chemistry-a European Journal, 13 (33):902-909 [Details]
(2006) 'Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds'
Murphy,P.V.,Dunne, J.L. (2006) 'Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds'. Current Organic Synthesis, 3 (4) [Details]
(2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'
Rawe, SL,Doyle, D,Zaric, V,Rozas, I,McMahon, K,Tosin, M,Bunz, HM,Murphy, EP,O'Boyle, KM,Murphy, PV (2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (1010):1370-1390 [Details]
(2005) 'Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins'
Gouin, SG,Pilgrim, W,Porter, RK,Murphy, PV (2005) 'Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins'. Carbohydrate Research, 340 (88):1547-1552 [Details]
(2005) 'Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding'
Tosin,M.,Gouin, S.G.,Murphy, P.V. (2005) 'Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding'. Organic Letters, 7 (2) [Details]
(2005) 'Synthesis and structural analysis of the anilides of glucuronic acid and orientation of the groups on the carbohydrate scaffolding'
Tosin, M.,O'Brien, C.,Fitzpatrick, G.M.,Muller-Bunz, H.,Glass, W.K.,Murphy, P.V. (2005) 'Synthesis and structural analysis of the anilides of glucuronic acid and orientation of the groups on the carbohydrate scaffolding'. Journal of Organic Chemistry, 70 (10) [Details]
(2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'
Murphy, PV,Muller-Bunz, H,Velasco-Torrijos, T (2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'. Carbohydrate Research, 340 (77):1437-1440 [Details]
(2004) 'A general synthesis of iminosugars'
McDonnell, C,Cronin, L,O'Brien, JL,Murphy, PV (2004) 'A general synthesis of iminosugars'. Journal of Organic Chemistry, 69 (1010):3565-3568 [Details]
(2004) 'Synthesis of peptidomimetics based on iminosugar and beta-D-glucopyranoside scaffolds and inhibiton of HIV-protease'
Chery, F,Cronin, L,O'Brien, JL,Murphy, PV (2004) 'Synthesis of peptidomimetics based on iminosugar and beta-D-glucopyranoside scaffolds and inhibiton of HIV-protease'. Tetrahedron, 60 (3131):6597-6608 [Details]
(2004) 'Synthesis of an iminosugar based peptidomimetic analogue'
Chery, F.,Murphy, P.V. (2004) 'Synthesis of an iminosugar based peptidomimetic analogue'. Tetrahedron Letters, 45 (10) [Details]
(2004) 'Metathesis of structurally preorganized bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'
Velasco-Torrijos,T.,Murphy, P.V. (2004) 'Metathesis of structurally preorganized bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'. Organic Letters, 6 (22) [Details]
(2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: Stereoselective synthesis of glycosides and 2-deoxyglycosides'
Polakova,M.,Pitt, N.,Tosin, M.,Murphy, P.V. (2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: Stereoselective synthesis of glycosides and 2-deoxyglycosides'. Angewandte Chemie - International Edition, 43 (19) [Details]
(2003) 'Development of carbohydrate-based scaffolds for restricted presentation of recognition groups. Extension to divalent ligands and implications for the structure of dimerized receptors'
Murphy, PV,Bradley, H,Tosin, M,Pitt, N,Fitzpatrick, GM,Glass, WK (2003) 'Development of carbohydrate-based scaffolds for restricted presentation of recognition groups. Extension to divalent ligands and implications for the structure of dimerized receptors'. Journal of Organic Chemistry, 68 (1414):5692-5704 [Details]
(2003) 'Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone'
Murphy, P.V.,McDonnell, C.,Hamig,L.,Paterson, D.E.,Taylor, R.J.K. (2003) 'Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone'. Tetrahedron Asymmetry, 14 (1) [Details]
(2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'
Murphy, PV,Pitt, N,O'Brien, A,Enright, PM,Dunne, A,Wilson, SJ,Duane, RM,O'Boyle, KM (2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'. Bioorganic & Medicinal Chemistry Letters, 12 (2222):3287-3290 [Details]
(2002) 'Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds'
Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB (2002) 'Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds'. Bioorganic & Medicinal Chemistry Letters, 12 (1313):1763-1766 [Details]
(2002) 'Synthesis of alpha-glucuronic acid and amide derivatives in the presence of a participating 2-acyl protecting group'
Tosin, M,Murphy, PV (2002) 'Synthesis of alpha-glucuronic acid and amide derivatives in the presence of a participating 2-acyl protecting group'. Organic Letters, 4 (2121):3675-3678 [Details]
(2002) 'A new route to exo-glycals using the Ramberg-Backlund rearrangement'
Griffin, FK,Paterson, DE,Murphy, PV,Taylor, RJK (2002) 'A new route to exo-glycals using the Ramberg-Backlund rearrangement'. European Journal of Organic Chemistry, (77):1305-1322 [Details]
(1996) 'Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-beta-L-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-beta-D-xylopyranosyl chloride'
Hubbard, RE,Montana, JG,Murphy, PV,Taylor, RJK (1996) 'Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-beta-L-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-beta-D-xylopyranosyl chloride'. Carbohydrate Research, 287 (22):247-253 [Details]
(2011) 'Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic'
Zhou, J,Matos, MC,Murphy, PV (2011) 'Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic'. Organic Letters, 13 :5716-5719 [DOI] [Details]
(2011) 'Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold'
Zhao, YX,Liu, M,Chagnault, V,Wang, JY,Zhang, XM,Murphy, PV (2011) 'Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold'. Bioorganic & Medicinal Chemistry Letters, 21 :824-828 [DOI] [Details]
(2010) 'N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells'
Zhao, Y,Liu, W,Zhou, Y,Zhang, X,Murphy, PV (2010) 'N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells'. Bioorganic & Medicinal Chemistry Letters, 20 :7540-7543 [DOI] [Details]
(2010) 'Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination'
Napolitano, C,McArdle, P,Murphy, PV (2010) 'Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination'. Journal Of Organic Chemistry, 75 :7404-7407 [DOI] [Details]
(2010) 'Biological study of the Angiogenesis Inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'
Zhao, YX,Zhou, Y,Boyle, KMO,Murphy, PV (2010) 'Biological study of the Angiogenesis Inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'. Chemical Biology & Drug Design, 75 :570-577 [DOI] [Details]
(2010) 'Synthesis of congeners of migrastatin and dorrigocin A from D-xylose'
Zhou, Y,Murphy, PV (2010) 'Synthesis of congeners of migrastatin and dorrigocin A from D-xylose'. Tetrahedron Letters, 51 :5262-5264 [DOI] [Details]
(2010) 'SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher alpha:beta Anomer Ratios and Reaction Rates'
Pilgrim, W,Murphy, PV (2010) 'SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher alpha:beta Anomer Ratios and Reaction Rates'. Journal Of Organic Chemistry, 75 :6747-6755 [DOI] [ARAN Link] [Details]
(2010) 'Synthesis of congeners of the migrastatin and dorrigocin: A core structures from D-xylose'
Zhou,Y., Murphy,P.V. (2010) 'Synthesis of congeners of the migrastatin and dorrigocin: A core structures from D-xylose'. Tetrahedron Letters, 51 :5262-5264 [Details]
(2010) 'Metathesis and macrocycles with embedded carbohydrates'
Jarikote,D.V, Murphy,P.V. (2010) 'Metathesis and macrocycles with embedded carbohydrates'. European Journal of Organic Chemistry Microreview), :4959-4970 [Details]
(2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'
Andre, S,Velasco-Torrijos, T,Leyden, R,Gouin, S,Tosin, M,Murphy, PV,Gabius, HJ (2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'. Organic & Biomolecular Chemistry, 7 :4715-4725 [DOI] [Details]
(2009) 'Glycotriazolophane Synthesis via Click Chemistry'
Leyden, R,Murphy, PV (2009) 'Glycotriazolophane Synthesis via Click Chemistry'. Synlett, :1949-1950 [DOI] [Details]
(2009) 'alpha-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives'
Pilgrim, W,Murphy, PV (2009) 'alpha-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives'. Organic Letters, 11 :939-942 [DOI] [Details]
(2009) 'Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from L-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition'
O'Reilly, C,O'Brien, C,Murphy, PV (2009) 'Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from L-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition'. Tetrahedron Letters, 50 :4427-4429 [DOI] [Details]
(2009) 'Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework'
Rountree, JSS,Murphy, PV (2009) 'Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework'. Organic Letters, 11 :871-874 [DOI] [Details]
(2009) 'Synthesis of bivalent lactosides based on terephthalamide, N,N’ diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'
Leyden,R., Velasco-Torrijos,T., ré,S., Gouin,S.G., Gabius,H.J., Murphy,P.V. (2009) 'Synthesis of bivalent lactosides based on terephthalamide, N,N’ diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'. Journal of Organic Chemistry, 74 :9010-9026 [DOI] [Details]
(2008) 'Monosaccharide scaffolds for the synthesis of novel compounds'
Murphy,P.V., Velasco-Torrijos,T. (2008) 'Monosaccharide scaffolds for the synthesis of novel compounds'. Glycoscience-Chemistry and Chemical Biology, :997-1027 [DOI] [Details]
(2008) 'Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds comprised of 1-deoxynojirimycin and 5-aryl-1,2,3-triazoles'
Zhou, Y.,Zhao,Y.,O' Boyle,K.M.,Murphy,P.V. (2008) 'Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds comprised of 1-deoxynojirimycin and 5-aryl-1,2,3-triazoles'. Bioorganic and Medicinal Chemistry Letters, 18 :954-958 [DOI] [Details]
(2008) 'Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener is a Potent Inhibitor of Gastric Cancer Cell Migration'
Anquetin,G, Horgan,G, Rawe,S, Murray,D, Madden,A, MacMathuna,P, Doran,P, Murphy,P.V. (2008) 'Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener is a Potent Inhibitor of Gastric Cancer Cell Migration'. European Journal of Organic Chemistry, 11 :1953-1958 [Details]
(2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'
Anquetin, G.,Rawe, S.L.,McMahon, K.,Murphy, E.P.,Murphy, P.V. (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry - A European Journal, 14 (5) [Details]
(2008) 'New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition'
Zhou, Y.,Murphy, P.V. (2008) 'New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition'. Organic Letters, 10 (17) [Details]
(2008) 'Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis'
Doyle,D.,Murphy, P.V. (2008) 'Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis'. Carbohydrate Research, 343 (15) [Details]
(2007) 'Peptidomimetics, glycomimetics and scaffolds from carbohydrate building blocks'
Murphy, P.V. (2007) 'Peptidomimetics, glycomimetics and scaffolds from carbohydrate building blocks'. European Journal of Organic Chemistry, (25) [Details]
(2007) 'Synthesis of sugar-lactams from azides of glucuronic acid'
Loukou, C, Tosin,M, Müller-Bunz,H, Murphy,P.V. (2007) 'Synthesis of sugar-lactams from azides of glucuronic acid'. Carbohydrate Research Special issue-Glycomimetics, 342 :1953-1959 [DOI] [Details]
(2007) 'The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions'
Cronin,L.,Tosin, M.,Muller-Bunz, H.,Murphy, P.V. (2007) 'The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions'. Carbohydrate Research, 342 (1) [Details]
(2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'
Zaric,V., Doyle, D., Murphy, P.V., O'Boyle, K.M. (2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'. Anticancer Research, 27 (3 A) [Details]
(2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'
Rawe, SL,Zaric, V,O'Boyle, KM,Murphy, PV (2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'. Bioorganic & Medicinal Chemistry Letters, 16 :1316-1319 [DOI] [Details]
(2005) 'Novel synthesis of castanospermine and 1-epicastanospermine'
Cronin, L,Murphy, PV (2005) 'Novel synthesis of castanospermine and 1-epicastanospermine'. Organic Letters, 7 :2691-2693 [DOI] [Details]
(2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'
Velasco-Torrijos, T,Murphy, PV (2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'. Tetrahedron-Asymmetry, 16 :261-272 [DOI] [Details]
(2005) 'Synthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide'
Tosin,M.,Murphy, P.V. (2005) 'Synthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide'. Journal of Organic Chemistry, 70 (10) [Details]
(2005) 'Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold'
Gouin, S.G.,Murphy, P.V. (2005) 'Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold'. Journal of Organic Chemistry, 70 (21) [Details]
(2005) 'A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors'
Killoran, J.,Gallagher, J.F.,Murphy, P.V.,O'Shea, D.F. (2005) 'A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors'. New Journal of Chemistry, 29 (10) [Details]
(2004) 'Synthesis and X-ray single crystal structure of a bivalent glycocluster'
Tosin, M,Muller-Bunz, H,Murphy, PV (2004) 'Synthesis and X-ray single crystal structure of a bivalent glycocluster'. Chemical Communications, :494-495 [DOI] [Details]
(2004) 'Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose'
McDonnell, C.,Lopez, O.,Murphy, P.,Fernandez Bolanos, J.G.,Hazell, R.,Bols, M. (2004) 'Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose'. Journal of the American Chemical Society, 126 (39) [Details]
(2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth'
Pitt,N.,Duane, R.M.,O' Brien, A.,Bradley, H.,Wilson, S.J.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth'. Carbohydrate Research, 339 (11) [Details]
(2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'
O' Brien, A.,Lynch, C.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'. Carbohydrate Research, 339 (14) [Details]
(2003) 'Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds'
Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB (2003) 'Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds'. Tetrahedron, 59 :2259-2271 [DOI] [Details]
(2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'
Enright, PM,Tosin, M,Nieuwenhuyzen, M,Cronin, L,Murphy, PV (2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'. Journal Of Organic Chemistry, 67 :3733-3741 [DOI] [Details]
(2002) 'A new route to exo-glycals using the Ramberg-Bäcklund rearrangement'
Griffin, F.K.,Paterson, D.E.,Murphy, P.V.,Taylor, R.J.K. (2002) 'A new route to exo-glycals using the Ramberg-Bäcklund rearrangement'. European Journal of Organic Chemistry, (7) [Details]
(2001) 'Application of Ugi reactions in synthesis of divalent neoglycoconjugates: Evidence that the sugars are presented in restricted conformation'
Bradley, H., Fitzpatrick, G.,Glass, W.K.,Kunz, H.,Murphy, P.V. (2001) 'Application of Ugi reactions in synthesis of divalent neoglycoconjugates: Evidence that the sugars are presented in restricted conformation'. Organic Letters, 3 (17) [Details]
(2001) 'Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose'
O'Brien, JL,Tosin, M,Murphy, PV (2001) 'Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose'. Organic Letters, 3 :3353-3356 [DOI] [Details]
(2001) 'Stereospecific synthesis of beta-D-allopyrano sides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides'
Murphy, PV,O'Brien, JL,Smith, AB (2001) 'Stereospecific synthesis of beta-D-allopyrano sides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides'. Carbohydrate Research, 334 :327-335 [Details]
(2000) 'The reactions of diazo compounds with lactones. Part 2. The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'
Murphy, PV,O'Sullivan, TJ,Kennedy, BD,Geraghty, NWA (2000) 'The reactions of diazo compounds with lactones. Part 2. The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'. Journal Of The Chemical Society-Perkin Transactions 1, :2121-2126 [DOI] [Details]
(2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'
Enright, PM,O'Boyle, KM,Murphy, PV (2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'. Organic Letters, 2 :3929-3932 [DOI] [Details]
(1998) 'Design, Synthesis and Testing of Novel Inhibitors of Cell Adhesion'
Manallack,D.T, Montana,J.G, Murphy, P.V, Hubbard,R.E, Taylor,R.J.K, (1998) 'Design, Synthesis and Testing of Novel Inhibitors of Cell Adhesion'. Proceedings of the European Symposium on Quantitative Structure Activity Relationships: Molecular Modelling and Prediction of Bioactivity, 12th, Copenhagen, Denmark 1998 2000), :371-372 [Details]
(1998) 'The synthesis of novel structural analogues of sialyl Lewis(x)'
Murphy P.V.,Hubbard, R.E.,Manallack, D.T.,Montana, J.G.,Taylor, R.J.K. (1998) 'The synthesis of novel structural analogues of sialyl Lewis(x)'. Tetrahedron Letters, 39 (20) [Details]
(1998) 'A Ramberg-Backlund approach to exo-glycals'
Griffin,F.K.,Murphy, P.V.,Paterson D.E., Taylor R.J.K. (1998) 'A Ramberg-Backlund approach to exo-glycals'. Tetrahedron Letters, 39 (44) [Details]
(1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with beta- and gamma-lactones: Formation of benzodioxepinones, benzodioxecinones and benzofurans'
Cunningham, PD,Geraghty, NWA,McArdle, PJ,Murphy, PV,OSullivan, TJ (1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with beta- and gamma-lactones: Formation of benzodioxepinones, benzodioxecinones and benzofurans'. Journal Of The Chemical Society-Perkin Transactions 1, :1-4 [Details]
(1994) 'Metal Catalysed Rearrangement of Cyclopropanespiro- -lactones to 2-Furanones'
Geraghty,N.W.A., Murphy,P.V. (1994) 'Metal Catalysed Rearrangement of Cyclopropanespiro- -lactones to 2-Furanones'. Tetrahedron Lett, (6737) [Details]

Edited Books

  Year Publication
(2017) Carbohydrate Chemistry: Proven Synthetic Methods (Volume 4).
Paul Kovac, Christian Vogel, Paul Murphy (Ed.). (2017) Carbohydrate Chemistry: Proven Synthetic Methods (Volume 4). Boca Raton, FL: CRC Press. [Details]

Editorial

  Year Publication
(2017) Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction.
Murphy, PV,Vogel, C,Murphy, PV (2017) Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction. Editorial [Details]

Reviews

  Year Publication
(2010) Metathesis and Macrocycles with Embedded Carbohydrates.
Jarikote, DV,Murphy, PV (2010) Metathesis and Macrocycles with Embedded Carbohydrates. Reviews [DOI] [Details]

Professional Associations

  Association Function From / To
Institute of Chemistry of Ireland Fellow /
Royal Society of Chemistry Fellow /
American Chemical Society Member /